Central venous catheters and catheter locks in children with cancer: A prospective randomized trial of taurolidine versus heparin

Pediatric Blood and Cancer

Volumn 60, Issue 8, 2013, Pages 1292-1298

  Handrup, Mette Møller ^a   Møller, Jens Kjølseth ^a   Schrøder, Henrik ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Catheter lock; Catheter related bloodstream infections; Central venous catheter; Pediatric; Taurolidine

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; FLUCONAZOLE; GENTAMICIN; HEPARIN; PIPERACILLIN PLUS TAZOBACTAM; TAUROLIDINE; TAUROLOCK; UNCLASSIFIED DRUG; VANCOMYCIN;

ADOLESCENT; ADULT; ANTIMICROBIAL THERAPY; ARTICLE; BACTEREMIA; CANCER PATIENT; CANCER SURVIVAL; CATHETER INFECTION; CATHETER REMOVAL; CENTRAL VENOUS CATHETER; CHILD; CHILDHOOD CANCER; CONTROLLED STUDY; FEBRILE NEUTROPENIA; FEMALE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MORBIDITY; OPEN STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PYREXIA IDIOPATHICA; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; STANDARD; TREATMENT DURATION;

ADOLESCENT; ADULT; ANTI-INFECTIVE AGENTS; ANTICOAGULANTS; CENTRAL VENOUS CATHETERS; CHILD; CHILD, PRESCHOOL; FEMALE; HEPARIN; HUMANS; INFANT; INFANT, NEWBORN; INFECTION; INFECTION CONTROL; MALE; NEOPLASMS; PROSPECTIVE STUDIES; TAURINE; THIADIAZINES;

EID: 84879201165     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.24482     Document Type: Article

References (29)

1. Raad I, Hanna H, Maki D. Intravascular catheter-related infections: Advances in diagnosis, prevention, and management. Lancet Infect Dis 2007; 7:645-657.
2. Mermel LA, Allon M, Bouza E, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis 2009; 49:1-45.
3. Simon A, Ammann RA, Bode U, et al. Healthcare-associated infections in pediatric cancer patients: Results of a prospective surveillance study from university hospitals in Germany and Switzerland. BMC Infect Dis 2008; 8:70.
4. Cesaro S, Tridello G, Cavaliere M, et al. Prospective, randomized trial of two different modalities of flushing central venous catheters in pediatric patients with cancer. J Clin Oncol 2009; 20:2059-2065.
5. Raad I, Costerton W, Sabharwal U, et al. Ultrastructural analysis of indwelling vascular catheters: A quantitative relationship between luminal colonization and duration of placement. J Infect Dis 1993; 168:400-407.
6. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: A common cause of persistent infections. Science 1999; 284:1318-1322.
7. Shanks RM, Donegan NP, Graber ML, et al. Heparin stimulates Staphylococcus aureus biofilm formation. Infect Immun 2005; 73:4596-4606.
8. van de Wetering MD, van Woensel JB. Prophylactic antibiotics for preventing early central venous catheter Gram positive infections in oncology patients. Cochrane Database Syst Rev 2007; CD003295.
9. O'Grady NP, Alexander M, Dellinger EP, et al. Guidelines for the prevention of intravascular catheter-related infections. Infect Control Hosp Epidemiol 2002; 23:759-769.
10. Gong L, Greenberg HE, Perhach JL, et al. The pharmacokinetics of taurolidine metabolites in healthy volunteers. J Clin Pharmacol 2007; 47:697-703.
11. Dofferhoff AS, Esselink MT, de Vries-Hospers HG, et al. The release of endotoxin from antibiotic-treated Escherichia coli and the production of tumour necrosis factor by human monocytes. J Antimicrob Chemother 1993; 31:373-384.
12. Jacobi CA, Menenakos C, Braumann C. Taurolidine-A new drug with anti-tumor and anti-angiogenic effects. Anticancer Drugs 2005; 16:917-921.
13. Tarhan OR, Barut I, Sezik M. An evaluation of normal saline and taurolidine on intra-abdominal adhesion formation and peritoneal fibrinolysis. J Surg Res 2008; 144:151-157.
14. Quarello F, Forneris G. Prevention of hemodialysis catheter-related bloodstream infection using an antimicrobial lock. Blood Purif 2002; 20:87-92.
15. Torres-Viera C, Thauvin-Eliopoulos C, Souli M, et al. Activities of taurolidine in vitro and in experimental enterococcal endocarditis. Antimicrob Agents Chemother 2000; 44:1720-1724.
16. Dumichen MJ, Seeger K, Lode HN, et al. Randomized controlled trial of taurolidine citrate versus heparin as catheter lock solution in paediatric patients with haematological malignancies. J Hosp Infect 2012; 80:304-309.
17. Allon M. Prophylaxis against dialysis catheter-related bacteremia with a novel antimicrobial lock solution. Clin Infect Dis 2003; 36:1539-1544.
18. Betjes MG, van Agteren M. Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution. Nephrol Dial Transplant 2004; 19:1546-1551.
19. Simon A, Ammann RA, Wiszniewsky G, et al. Taurolidine-citrate lock solution (TauroLock) significantly reduces CVAD-associated grampositive infections in pediatric cancer patients. BMC Infect Dis 2008; 8:102.
20. Shah CB, Mittelman MW, Costerton JW, et al. Antimicrobial activity of a novel catheter lock solution. Antimicrob Agents Chemother 2002; 46:1674-1679.
21. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008; 36:309-332.
22. Safdar N, Maki DG. Use of vancomycin-containing lock or flush solutions for prevention of bloodstream infection associated with central venous access devices: A meta-analysis of prospective, randomized trials. Clin Infect Dis 2006; 43:474-484.
23. Barbaric D, Curtin J, Pearson L, et al. Role of hydrochloric acid in the treatment of central venous catheter infections in children with cancer. Cancer 2004; 101:1866-1872.
24. Allen RC, Holdsworth MT, Johnson CA, et al. Risk determinants for catheter-associated blood stream infections in children and young adults with cancer. Pediatr Blood Cancer 2008; 51:53-58.
25. Adler A, Yaniv I, Steinberg R, et al. Infectious complications of implantable ports and Hickman catheters in paediatric haematology-oncology patients. J Hosp Infect 2006; 62:358-365.
26. Handrup MM, Moller JK, Frydenberg M, et al. Placing of tunneled central venous catheters prior to induction chemotherapy in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 2010; 55:309-313.
27. Solomon LR, Cheesbrough JS, Ebah L, et al. A randomized double-blind controlled trial of taurolidine-citrate catheter locks for the prevention of bacteremia in patients treated with hemodialysis. Am J Kidney Dis 2010; 55:1060-1068.
28. Scheinemann K, Ethier MC, Dupuis LL, et al. Utility of peripheral blood cultures in bacteremic pediatric cancer patients with a central line. Support Care Cancer 2010; 18:913-919.
29. Handrup MM, Fuursted K, Funch P, et al. Biofilm formation in long-term central venous catheters in children with cancer: A randomized controlled open-labelled trial of taurolidine versus heparin. APMIS 2012; 120:794-801.