Taurolidine-citrate lock solution (TauroLock) significantly reduces CVAD-associated grampositive infections in pediatric cancer patients

BMC Infectious Diseases

Volumn 8, Issue , 2008, Pages

  Simon, Arne ^a   Ammann, Roland A ^b   Wiszniewsky, Gertrud ^a   Bode, Udo ^a   Fleischhack, Gudrun ^a   Besuden, Mette M ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CANUSAL; CITRATE SODIUM; COAGULASE; HEPARIN; METICILLIN; SODIUM CHLORIDE; TAUROLIDINE; TAUROLOCK; ANTIINFECTIVE AGENT; DRUG DERIVATIVE; TAURINE; THIADIAZINE DERIVATIVE;

ADOLESCENT; ANTIMICROBIAL ACTIVITY; ARTICLE; CANCER PATIENT; CATHETER INFECTION; CATHETER REMOVAL; CENTRAL VENOUS CATHETER; CHILD; CHILDHOOD CANCER; COAGULASE NEGATIVE STAPHYLOCOCCUS; COHORT ANALYSIS; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; ESCHERICHIA COLI; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; INCIDENCE; INFECTION PREVENTION; INJECTION SITE PAIN; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PATIENT SAFETY; STATISTICAL SIGNIFICANCE; TASTE DISORDER; TREATMENT OUTCOME; VASCULAR ACCESS; ADULT; BACTERIAL INFECTION; CENTRAL VENOUS CATHETERIZATION; INFANT; NEOPLASM; NEWBORN; PRESCHOOL CHILD; PROSPECTIVE STUDY;

ADOLESCENT; ADULT; ANTI-INFECTIVE AGENTS; CATHETERIZATION, CENTRAL VENOUS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; INFANT; INFANT, NEWBORN; MALE; NEOPLASMS; PROSPECTIVE STUDIES; TAURINE; THIADIAZINES;

EID: 49749108849     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-8-102     Document Type: Article

References (38)

1. Gaur AH Flynn PM Shenep JL Optimum management of pediatric patients with fever and neutropenia Indian J Pediatr 2004, 71(9):825-835 10.1007/ BF02730723 15448391
2. Simon A Bode U Beutel K Diagnosis and treatment of catheter-related infections in paediatric oncology: An update Clin Microbiol Infect 2006, 12(7):606-620 10.1111/j.1469-0691.2006.01416.x 16774556
3. Viscoli C Castagnola E Giacchino M Cesaro S Properzi E Tucci F Mura RM Alvisi P Zanazzo G Surico G Bonetti F De Sio L Izzi G Di Cataldo A Ziino O Massolo F Nardi M Santoro N Binda S Bloodstream infections in children with cancer: A multicentre surveillance study of the Italian Association of Paediatric Haematology and Oncology. Supportive Therapy Group-Infectious Diseases Section Eur J Cancer 1999, 35(5):770-774 10.1016/S0959-8049(99)00052-0 10505037
4. Morrison VA Peterson BA Bloomfield CD Nosocomial septicemia in the cancer patient: The influence of central venous access devices, neutropenia, and type of malignancy Med Pediatr Oncol 1990, 18(3):209-216 10.1002/mpo.2950180309 2329966
5. Rackoff WR Ge J Sather HN Cooper HA Hutchinson RJ Lange BJ Central venous catheter use and the risk of infection in children with acute lymphoblastic leukemia: A report from the Children's Cancer Group J Pediatr Hematol Oncol 1999, 21(4):260-267 10.1097/ 00043426-199907000-00005 10445887
6. Simon A Groger N Wilkesmann A Hasan C Wiszniewsky G Engelhart S Kramer MH Bode U Ammann RA Fleischhack G Restricted use of glycopeptides in paediatric cancer patients with fever and neutropenia Int J Antimicrob Agents 2006, 28(5):417-422 10.1016/j.ijantimicag.2006.08.007 17046210
7. Fratino G Molinari AC Parodi S Longo S Saracco P Castagnola E Haupt R Central venous catheter-related complications in children with oncological/hematological diseases: An observational study of 418 devices Ann Oncol 2005, 16(4):648-654 10.1093/annonc/mdi111 15677621
8. Tunkel AR Sepkowitz KA Infections caused by viridans streptococci in patients with neutropenia Clin Infect Dis 2002, 34(11):1524-1529 10.1086/ 340402 12015700
9. Lehrnbecher T Marshall D Gao C Chanock SJ A second look at anorectal infections in cancer patients in a large cancer institute: The success of early intervention with antibiotics and surgery Infection 2002, 30(5):272-276 10.1007/s15010-002-2197-8 12382085
10. Simon A Ammann RA Bode U Fleischhack G Wenchel HM Schwamborn D Gravou C Schlegel PG Rutkowski S Dannenberg C Körholz D Laws HJ Kramer MH Nosocomial infections in pediatric cancer patients: Results of a prospective surveillance study from 7 University hospitals in Germany and Switzerland BMC Infect Dis 2008 E-Pub May 23, 2008, 8:70 10.1186/ 1471-2334-8-70
11. Droste JC Jeraj HA MacDonald A Farrington K Stability and in vitro efficacy of antibiotic-heparin lock solutions potentially useful for treatment of central venous catheter-related sepsis J Antimicrob Chemother 2003, 51(4):849-855 10.1093/jac/dkg179 12654743
12. Shah CB Mittelman MW Costerton JW Parenteau S Pelak M Arsenault R Mermel LA Antimicrobial activity of a novel catheter lock solution Antimicrob Agents Chemother 2002, 46(6):1674-1679 127259 12019075 10.1128/ AAC.46.6.1674-1679.2002
13. Traub WH Leonhard B Bauer D Taurolidine: In vitro activity against multiple-antibiotic-resistant, nosocomially significant clinical isolates of Staphylococcus aureus, Enterococcus faecium, and diverse Enterobacteriaceae Chemotherapy 1993, 39(5):322-330 8370323
14. Torres-Viera C Thauvin-Eliopoulos C Souli M DeGirolami P Farris MG Wennersten CB Sofia RD Eliopoulos GM Activities of taurolidine in vitro and in experimental enterococcal endocarditis Antimicrob Agents Chemother 2000, 44(6):1720-1724 89943 10817739 10.1128/ AAC.44.6.1720-1724.2000
15. Allon M Prophylaxis against dialysis catheter-related bacteremia with a novel antimicrobial lock solution Clin Infect Dis 2003, 36(12):1539-1544 10.1086/375234 12802753
16. Betjes MG van Agteren M Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution Nephrol Dial Transplant 2004, 19(6):1546-1551 10.1093/ndt/gfh014 14993498
17. Johnston DA Phillips G Perry M McAlpine H Roichards J Pennintton CR Taurolin for the prevention of parenetral nutrition related infection: antimicrobial activity and long-term use. Clinical Nutrition 1993, 12:365-368 10.1016/0261-5614(93)90034-2 16843340
18. Jurewitsch B Lee T Park J Jeejeebhoy K Taurolidine 2% as an antimicrobial lock solution for prevention of recurrent catheter-related bloodstream infections JPEN J Parenter Enteral Nutr 1998, 22(4):242-244 10.1177/0148607198022004242 9661127
19. Koldehoff M Zakrzewski JL Taurolidine is effective in the treatment of central venous catheter-related bloodstream infections in cancer patients Int J Antimicrob Agents 2004, 24(5):491-495 10.1016/ j.ijantimicag.2004.06.006 15519483
20. Quarello F Forneris G Prevention of hemodialysis catheter-related bloodstream infection using an antimicrobial lock Blood Purif 2002, 20(1):87-92 10.1159/000046990 11803164
21. Danese PN Antibiofilm approaches: Prevention of catheter colonization Chem Biol 2002, 9(8):873-880 10.1016/S1074-5521(02)00192-8 12204686
22. Sherertz RJ Boger MS Collins CA Mason L Raad Comparative in vitro efficacies of various catheter lock solutions Antimicrob Agents Chemother 2006, 50(5):1865-1868 1472229 16641463 10.1128/ AAC.50.5.1865-1868.2006
23. Jurewitsch B Jeejeebhoy KN Taurolidine lock: The key to prevention of recurrent catheter-related bloodstream infections Clin Nutr 2005, 24(3):462-465 10.1016/j.clnu.2005.02.001 15896434
24. Willatts SM Radford S Leitermann M Effect of the antiendotoxic agent, taurolidine, in the treatment of sepsis syndrome: A placebo-controlled, double-blind trial Crit Care Med 1995, 23(6):1033-1039 10.1097/ 00003246-199506000-00007 7774213
25. O'Grady NP Alexander M Dellinger EP Gerberding JL Heard SO Maki DG Masur H McCormick RD Mermel LA Pearson ML Raad Randolph A Weinstein RA Guidelines for the prevention of intravascular catheter-related infections. The Hospital Infection Control Practices Advisory Committee, Center for Disese Control and Prevention, u.s Pediatrics 2002, 110(5):e51 10.1542/peds.110.5.e51 12415057
26. Tietz A Frei R Dangel M Bolliger D Passweg JR Gratwohl A Widmer AE Octenidine hydrochloride for the care of central venous catheter insertion sites in severely immunocompromised patients Infect Control Hosp Epidemiol 2005, 26(8):703-707 10.1086/502606 16156327
27. Dettenkofer M Jonas D Wiechmann C Rossner R Frank U Zentner J Daschner FD Effect of skin disinfection with octenidine dihydrochloride on insertion site colonization of intravascular catheters Infection 2002, 30(5):282-285 10.1007/s15010-002-2182-2 12382087
28. Simon A Fleischhack G Wiszniewsky G Hasan C Bode U Kramer MH Influence of Prolonged Use of Intravenous Administration Sets in Paediatric Cancer Patients on CVAD-related Bloodstream Infection Rates and Hospital Resources Infection 2006, 34(5):258-263 10.1007/s15010-006-5646-y 17033749
29. Bundesärztekammer Richtlinien zur Gewinnung von Blut und Blutbestandteilen und zur Anwendung von Blutprodukten (Hämatotherapie) 2005 http://www.bundesaerztekammer.de
30. Isenberg HD Clinical Microbiology Procedures Handbook. ASM Press 2nd 2004
31. Beutel K Simon A [Diagnostic and Management of Central Venous Line Infections in Pediatric Cancer Patients.] Klin Padiatr 2005, 217(Suppl 1):91-100 10.1055/s-2005-872503
32. Simon A Beutel K Hasan C Bode U [Evidence-based recommendation for the management of long-term central venous access devices in pediatric patients] Bonn, German Society of Pediatric Hematology and Oncology (GPOH) 2nd 2005
33. Simon A Fleischhack G Hasan C Bode U Engelhart S Kramer MH Surveillance for nosocomial and central line-related infections among pediatric hematology-oncology patients Infect Control Hosp Epidemiol 2000, 21(9):592-596 10.1086/501809 11001263
34. Gaur AH Flynn PM Giannini MA Shenep JL Hayden RT Difference in time to detection: A simple method to differentiate catheter-related from non-catheter-related bloodstream infection in immunocompromised pediatric patients Clin Infect Dis 2003, 37(4):469-475 10.1086/376904 12905129
35. Gaur AH Flynn PM Heine DJ Giannini MA Shenep JL Hayden RT Diagnosis of catheter-related bloodstream infections among pediatric oncology patients lacking a peripheral culture, using differential time to detection Pediatr Infect Dis J 2005, 24(5):445-449 10.1097/ 01.inf.0000160950.83583.7f 15876945
36. Christensen ML Hancock ML Gattuso J Hurwitz CA Smith C McCormick J Mirro J Jr. Parenteral nutrition associated with increased infection rate in children with cancer Cancer 1993, 72(9):2732-2738 10.1002/ 1097-0142(19931101)72:9<2732::AID-CNCR2820720934>3.0.CO;2-E 8402497
37. Hanna HA Raad I Blood products: A significant risk factor for long-term catheter-related bloodstream infections in cancer patients Infect Control Hosp Epidemiol 2001, 22(3):165-166 10.1086/501885 11310696
38. Paulus SC van Saene HK Hemsworth S Hughes J Ng A Pizer BL A prospective study of septicaemia on a paediatric oncology unit: A three-year experience at The Royal Liverpool Children's Hospital, Alder Hey, UK Eur J Cancer 2005, 41(14):2132-2140 10.1016/j.ejca.2005.04.037 16129600