Extravasation during bladder cancer metastasis requires cortactin-mediated invadopodia formation

Molecular Medicine Reports

Volumn 9, Issue 4, 2014, Pages 1142-1146

  Tokui, Noriko ^a   Yoneyama, Mihoko Sutoh ^a,b   Hatakeyama, Shingo ^a   Yamamoto, Hayato ^a   Koie, Takuya ^a   Saitoh, Hisao ^c   Yamaya, Kanemitsu ^c   Funyu, Tomihisa ^c   Nakamura, Toshiya ^d   Ohyama, Chikara ^a   Tsuboi, Shigeru ^a,b  

^a HIROSAKI UNIVERSITY   (Japan)

^b Department of Cancer Immunology and Cell Biology ^*  (Japan)

^c Oyokyo Kidney Research Institute   (Japan)

^d HIROSAKI UNIVERSITY   (Japan)

Author keywords

Bladder cancer; Cortactin; Extravasation; Invadopodia; Metastasis

Indexed keywords

CORTACTIN; GELATINASE A; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CANCER; CANCER CELL; CANCER CELL CULTURE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME RELEASE; EXTRACELLULAR MATRIX; GENE SILENCING; HUMAN; HUMAN CELL; INVADOPODIUM; LUNG METASTASIS; MEMBRANE FORMATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; TUMOR INVASION;

ANIMALS; CELL LINE, TUMOR; CORTACTIN; GENE KNOCKDOWN TECHNIQUES; HUMANS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASES; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; PSEUDOPODIA; URINARY BLADDER NEOPLASMS;

EID: 84896541506     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.1965     Document Type: Article

References (18)

1. Steeg PS: Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 12: 895-904, 2006.
2. Caldieri G, Ayala I, Attanasio F and Buccione R: Cell and molecular biology of invadopodia. Int Rev Cell Mol Biol 275: 1-34, 2009.
3. Linder S, Wiesner C and Himmel M: Degrading devices: invadosomes in proteolytic cell invasion. Annu Rev Cell Dev Biol 27: 185-211, 2011.
4. Murphy DA and Courtneidge SA: The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol 12: 413-426, 2011.
5. Yamaguchi H, Lorenz M, Kempiak S, et al: Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol 168: 441-452, 2005. (Pubitemid 40205066)
6. Smith SC, Nicholson B, Nitz M, et al: Profiling bladder cancer organ site-specific metastasis identifies LAMC2 as a novel biomarker of hematogenous dissemination. Am J Pathol 174: 371-379, 2009.
7. Tsuboi S, Sutoh M, Hatakeyama S, et al: A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans. EMBO J 30: 3173-3185, 2011.
8. Artym VV, Zhang Y, Seillier-Moiseiwitsch F, Yamada KM and Mueller SC: Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res 66: 3034-3043, 2006.
9. Ayala I, Baldassarre M, Giacchetti G, et al: Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation. J Cell Sci 121: 369-378, 2008. (Pubitemid 351356708)
10. Oser M, Yamaguchi H, Mader CC, et al: Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J Cell Biol 186: 571-587, 2009.
11. Sugiyama N, Yoneyama MS, Hatakeyama S, et al: In vivo selection of high-metastatic subline of bladder cancer cell and its characterization. Oncol Res 20: 289-295, 2013.
12. Hatakeyama S, Yamamoto H and Ohyama C: Tumor formation assays. Methods Enzymol 479: 397-411, 2010.
13. Mader CC, Oser M, Magalhaes MA, et al : An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Res 71: 1730-1741, 2011.
14. Oser M, Mader CC, Gil-Henn H, et al: Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia. J Cell Sci 123: 3662-3673, 2010.
15. Clark ES and Weaver AM: A new role for cortactin in invadopodia: regulation of protease secretion. Eur J Cell Biol 87: 581-590, 2008.
16. Kirkbride KC, Sung BH, Sinha S and Weaver AM: Cortactin: a multifunctional regulator of cellular invasiveness. Cell Adh Migr 5: 187-198, 2011.
17. Gligorijevic B, Wyckoff J, Yamaguchi H, Wang Y, Roussos ET and Condeelis J: N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors. J Cell Sci 125: 724-734, 2012.
18. Al-Mehdi AB, Tozawa K, Fisher AB, Shientag L, Lee A and Muschel RJ: Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nat Med 6: 100-102, 2000. (Pubitemid 30048535)