Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 11, 2014, Pages 4097-4102

  Choy, Meng S ^a   Hieke, Martina ^a   Kumar, Ganesan Senthil ^a   Lewis, Greyson R ^b   Gonzalez DeWhitt, Kristofer R ^a   Kessler, Rene P ^a   Stein, Benjamin J ^a   Hessenberger, Manuel ^b   Nairn, Angus C ^c   Peti, Wolfgang ^a   Page, Rebecca ^a  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Enzyme regulation; Enzyme specificity; Nuclear magnetic resonance; Nuclear phosphatases; X ray crystal structure

Indexed keywords

ARGININE; CELL CYCLE PROTEIN; HOLOENZYME; INTRINSICALLY DISORDERED PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 1 NUCLEAR TARGETING SUBUNIT; PROTEIN MDM2; PROTEIN P53; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN; SERINE THREONINE PHOSPHOPROTEIN PHOSPHATASE 1; SPINOPHILIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIOCHEMISTRY; CRYSTAL STRUCTURE; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DOCKING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; RETINOBLASTOMA; RNA PROCESSING; SEQUENCE ALIGNMENT; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY;

ENZYME REGULATION; ENZYME SPECIFICITY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR PHOSPHATASES; X-RAY CRYSTAL STRUCTURE;

AMINO ACID SEQUENCE; CALORIMETRY; CHROMATIN ASSEMBLY AND DISASSEMBLY; CLONING, MOLECULAR; COMPUTATIONAL BIOLOGY; CRYSTALLIZATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN PHOSPHATASE 1; PROTO-ONCOGENE PROTEINS C-MDM2; RETINOBLASTOMA PROTEIN; RNA-BINDING PROTEINS; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

EID: 84896537912     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1317395111     Document Type: Article

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