메뉴 건너뛰기




Volumn 11, Issue 11, 2010, Pages 868-875

The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response

Author keywords

DNA damage response; DNA repair; G2 checkpoint; PNUTS; PP1

Indexed keywords

CHECKPOINT KINASE 1; GREEN FLUORESCENT PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN PHOSPHATASE 1 NUCLEAR TARGETING SUBUNIT; RAD51 PROTEIN; REPLICATION FACTOR A; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 78049342712     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2010.134     Document Type: Article
Times cited : (56)

References (34)
  • 1
    • 0032512720 scopus 로고    scopus 로고
    • Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit
    • DOI 10.1074/jbc.273.7.4089
    • Allen PB, Kwon YG, Nairn AC, Greengard P (1998) Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit. J Biol Chem 273: 4089-4095 (Pubitemid 28103276)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.7 , pp. 4089-4095
    • Allen, P.B.1    Kwon, Y.-G.2    Nairn, A.C.3    Greengard, P.4
  • 2
    • 44449136965 scopus 로고    scopus 로고
    • HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
    • Ayoub N, Jeyasekharan AD, Bernal JA, Venkitaraman AR (2008) HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response. Nature 453: 682-686
    • (2008) Nature , vol.453 , pp. 682-686
    • Ayoub, N.1    Jeyasekharan, A.D.2    Bernal, J.A.3    Venkitaraman, A.R.4
  • 4
    • 70349333819 scopus 로고    scopus 로고
    • Mitotic phosphatases: From entry guards to exit guides
    • Bollen M, Gerlich DW, Lesage B (2009) Mitotic phosphatases: from entry guards to exit guides. Trends Cell Biol 19: 531-541
    • (2009) Trends Cell Biol , vol.19 , pp. 531-541
    • Bollen, M.1    Gerlich, D.W.2    Lesage, B.3
  • 5
    • 46749089975 scopus 로고    scopus 로고
    • Reduced expression of PNUTS leads to activation of Rb-phosphatase-and caspase-mediated apoptosis
    • De Leon G, Sherry TC, Krucher NA (2008) Reduced expression of PNUTS leads to activation of Rb-phosphatase-and caspase-mediated apoptosis. Cancer Biol Ther 7: 833-841
    • (2008) Cancer Biol Ther , vol.7 , pp. 833-841
    • De Leon, G.1    Sherry, T.C.2    Krucher, N.A.3
  • 6
    • 1842614272 scopus 로고    scopus 로고
    • Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1
    • Den Elzen NR, O'Connell MJ (2004) Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1. EMBO J 23: 908-918
    • (2004) EMBO J , vol.23 , pp. 908-918
    • Den Elzen, N.R.1    O'Connell, M.J.2
  • 7
    • 4644303544 scopus 로고    scopus 로고
    • Resisting arrest: Recovery from checkpoint arrest through dephosphorylation of Chk1 by PP1
    • Den Elzen N, Kosoy A, Christopoulos H, O'Connell MJ (2004) Resisting arrest: recovery from checkpoint arrest through dephosphorylation of Chk1 by PP1. Cell Cycle 3: 529-533 (Pubitemid 40278178)
    • (2004) Cell Cycle , vol.3 , Issue.5 , pp. 529-533
    • Den Elzen, N.1    Kosoy, A.2    Christopoulos, H.3    O'Connell, M.J.4
  • 8
    • 70349122544 scopus 로고    scopus 로고
    • Phosphatase inhibition and cell survival after DNA damage induced by radiation
    • Hamilton J, Grawenda AM, Bernhard EJ (2009) Phosphatase inhibition and cell survival after DNA damage induced by radiation. Cancer Biol Ther 8: 1577-1586
    • (2009) Cancer Biol Ther , vol.8 , pp. 1577-1586
    • Hamilton, J.1    Grawenda, A.M.2    Bernhard, E.J.3
  • 9
    • 13444302537 scopus 로고    scopus 로고
    • Distinct functions of condensin i and II in mitotic chromosome assembly
    • Hirota T, Gerlich D, Koch B, Ellenberg J, Peters JM (2004) Distinct functions of condensin I and II in mitotic chromosome assembly. J Cell Sci 117: 6435-6445
    • (2004) J Cell Sci , vol.117 , pp. 6435-6445
    • Hirota, T.1    Gerlich, D.2    Koch, B.3    Ellenberg, J.4    Peters, J.M.5
  • 10
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson SP, Bartek J (2009) The DNA-damage response in human biology and disease. Nature 461: 1071-1078
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 11
    • 0029083171 scopus 로고
    • Subunit structure and regulation of protein phosphatase-1 in rat liver nuclei
    • Jagiello I, Beullens M, Stalmans W, Bollen M (1995) Subunit structure and regulation of protein phosphatase-1 in rat liver nuclei. J Biol Chem 270: 17257-17263
    • (1995) J Biol Chem , vol.270 , pp. 17257-17263
    • Jagiello, I.1    Beullens, M.2    Stalmans, W.3    Bollen, M.4
  • 12
    • 16444379514 scopus 로고    scopus 로고
    • Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis
    • Jin ZH, Kurosu T, Yamaguchi M, Arai A, Miura O (2005) Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis. Oncogene 24: 1973-1981
    • (2005) Oncogene , vol.24 , pp. 1973-1981
    • Zh, J.1    Kurosu, T.2    Yamaguchi, M.3    Arai, A.4    Miura, O.5
  • 14
    • 23744447715 scopus 로고    scopus 로고
    • Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells
    • Kim JS, Krasieva TB, Kurumizaka H, Chen DJ, Taylor AM, Yokomori K (2005) Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol 170: 341-347
    • (2005) J Cell Biol , vol.170 , pp. 341-347
    • Kim, J.S.1    Krasieva, T.B.2    Kurumizaka, H.3    Chen, D.J.4    Taylor, A.M.5    Yokomori, K.6
  • 15
    • 0037515628 scopus 로고    scopus 로고
    • PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1-and RNA-binding domains and regulation by phosphorylation
    • Kim YM, Watanabe T, Allen PB, Kim YM, Lee SJ, Greengard P, Nairn AC, Kwon YG (2003) PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1-and RNA-binding domains and regulation by phosphorylation. J Biol Chem 278: 13819-13828
    • (2003) J Biol Chem , vol.278 , pp. 13819-13828
    • Kim, Y.M.1    Watanabe, T.2    Allen, P.B.3    Kim, Y.M.4    Lee, S.J.5    Greengard, P.6    Nairn, A.C.7    Kwon, Y.G.8
  • 16
    • 0031583952 scopus 로고    scopus 로고
    • Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity
    • Kreivi JP, Trinkle-Mulcahy L, Lyon CE, Morrice NA, Cohen P, Lamond AI (1997) Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity. FEBS Lett 420: 57-62
    • (1997) FEBS Lett , vol.420 , pp. 57-62
    • Kreivi, J.P.1    Trinkle-Mulcahy, L.2    Lyon, C.E.3    Morrice, N.A.4    Cohen, P.5    Lamond, A.I.6
  • 18
    • 25844468586 scopus 로고    scopus 로고
    • PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner
    • Landsverk HB, Kirkhus M, Bollen M, Kuntziger T, Collas P (2005) PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. Biochem J 390: 709-717
    • (2005) Biochem J , vol.390 , pp. 709-717
    • Landsverk, H.B.1    Kirkhus, M.2    Bollen, M.3    Kuntziger, T.4    Collas, P.5
  • 19
    • 34249050483 scopus 로고    scopus 로고
    • Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: Its role in post-translational modification of p53 and MDM2
    • Lee SJ, Lim CJ, Min JK, Lee JK, Kim YM, Lee JY, Won MH, Kwon YG (2007) Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2. Cell Death Differ 14: 1106-1116
    • (2007) Cell Death Differ , vol.14 , pp. 1106-1116
    • Lee, S.J.1    Lim, C.J.2    Min, J.K.3    Lee, J.K.4    Kim, Y.M.5    Lee, J.Y.6    Won, M.H.7    Kwon, Y.G.8
  • 21
    • 17644432403 scopus 로고    scopus 로고
    • Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
    • Liu Q et al (2000) Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 14: 1448-1459
    • (2000) Genes Dev , vol.14 , pp. 1448-1459
    • Liu, Q.1
  • 22
    • 33845484385 scopus 로고    scopus 로고
    • Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
    • Mari PO et al (2006) Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc Natl Acad Sci USA 103: 18597-18602
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 18597-18602
    • Mari, P.O.1
  • 24
    • 14844302793 scopus 로고    scopus 로고
    • CAMP-mediated inhibition of DNA replication and S-phase progression: Involvement of Rb, p21Cip1, and PCNA
    • Naderi S, Wang JY, Chen TT, Gutzkow KB, Blomhoff HK (2005) cAMP-mediated inhibition of DNA replication and S-phase progression: involvement of Rb, p21Cip1, and PCNA. Mol Biol Cell 16: 1527-1542
    • (2005) Mol Biol Cell , vol.16 , pp. 1527-1542
    • Naderi, S.1    Wang, J.Y.2    Chen, T.T.3    Gutzkow, K.B.4    Blomhoff, H.K.5
  • 25
    • 77649178662 scopus 로고    scopus 로고
    • Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation
    • Peng A, Lewellyn AL, Schiemann WP, Maller JL (2010) Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation. Curr Biol 20: 387-396
    • (2010) Curr Biol , vol.20 , pp. 387-396
    • Peng, A.1    Lewellyn, A.L.2    Schiemann, W.P.3    Maller, J.L.4
  • 26
    • 0035144407 scopus 로고    scopus 로고
    • Re-staging mitosis: A contemporary view of mitotic progression
    • Pines J, Rieder CL (2001) Re-staging mitosis: a contemporary view of mitotic progression. Nat Cell Biol 3: E3-E6
    • (2001) Nat Cell Biol , vol.3
    • Pines, J.1    Rieder, C.L.2
  • 27
    • 0034739853 scopus 로고    scopus 로고
    • P53-binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
    • Schultz LB, Chehab NH, Malikzay A, Halazonetis TD (2000) p53-binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol 151: 1381-1390
    • (2000) J Cell Biol , vol.151 , pp. 1381-1390
    • Schultz, L.B.1    Chehab, N.H.2    Malikzay, A.3    Halazonetis, T.D.4
  • 30
    • 42149114544 scopus 로고    scopus 로고
    • A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage
    • Tang X, Hui ZG, Cui XL, Garg R, Kastan MB, Xu B (2008) A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. Mol Cell Biol 28: 2559-2566
    • (2008) Mol Cell Biol , vol.28 , pp. 2559-2566
    • Tang, X.1    Hui, Z.G.2    Cui, X.L.3    Garg, R.4    Kastan, M.B.5    Xu, B.6
  • 31
    • 0032994412 scopus 로고    scopus 로고
    • Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors
    • Trinkle-Mulcahy L, Ajuh P, Prescott A, Claverie-Martin F, Cohen S, Lamond AI, Cohen P (1999) Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors. J Cell Sci 112: 157-168
    • (1999) J Cell Sci , vol.112 , pp. 157-168
    • Trinkle-Mulcahy, L.1    Ajuh, P.2    Prescott, A.3    Claverie-Martin, F.4    Cohen, S.5    Lamond, A.I.6    Cohen, P.7
  • 34
    • 0036389746 scopus 로고    scopus 로고
    • PNUTS (phosphatase nuclear targeting subunit) inhibits retinoblastoma-directed PP1 activity
    • Udho E, Tedesco VC, Zygmunt A, Krucher NA (2002) PNUTS (phosphatase nuclear targeting subunit) inhibits retinoblastoma-directed PP1 activity. Biochem Biophys Res Commun 297: 463-467
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 463-467
    • Udho, E.1    Tedesco, V.C.2    Zygmunt, A.3    Krucher, N.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.