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Volumn 73, Issue 12, 2013, Pages 1236-1240

New insights into the pathogenesis of preeclampsia - The role of Nrf2 activators and their potential therapeutic impact

Author keywords

heme oxygenase 1; Nrf2; preeclampsia

Indexed keywords

HEME OXYGENASE 1; TRANSCRIPTION FACTOR NRF2; VASCULOTROPIN;

EID: 84896534877     PISSN: 00165751     EISSN: 14388804     Source Type: Journal    
DOI: 10.1055/s-0033-1360133     Document Type: Article
Times cited : (25)

References (60)
  • 2
    • 79952504686 scopus 로고    scopus 로고
    • Saving Mothers Lives: Reviewing maternal deaths to make motherhood safer: 2006-2008. the Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom
    • Cantwell R., Clutton-Brock T., Cooper G. et al. Saving Mothers Lives: Reviewing maternal deaths to make motherhood safer: 2006-2008. The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. BJOG: 2011; 118 01 1 203
    • (2011) BJOG , vol.118 , Issue.1 , pp. 1-203
    • Cantwell, R.1    Clutton-Brock, T.2    Cooper, G.3
  • 3
    • 79955745537 scopus 로고    scopus 로고
    • ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia
    • ACOG
    • ACOG ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Obstet Gynecol: 2002; 99 159 167
    • (2002) Obstet Gynecol , vol.99 , pp. 159-167
  • 4
    • 84873383507 scopus 로고    scopus 로고
    • Cardiovascular disease risk in women with pre-eclampsia: Systematic review and meta-analysis
    • Brown M. C., Best K. E., Pearce M. S. et al. Cardiovascular disease risk in women with pre-eclampsia: systematic review and meta-analysis. Eur J Epidemiol: 2013; 28 1 19
    • (2013) Eur J Epidemiol , vol.28 , pp. 1-19
    • Brown, M.C.1    Best, K.E.2    Pearce, M.S.3
  • 5
  • 6
    • 84879093091 scopus 로고    scopus 로고
    • Cardiovascular disease risk factors in women with a history of early-onset preeclampsia
    • van Rijn B. B., Nijdam M. E., Bruinse H. W. et al. Cardiovascular disease risk factors in women with a history of early-onset preeclampsia. Obstet Gynecol: 2013; 121 1040 1048
    • (2013) Obstet Gynecol , vol.121 , pp. 1040-1048
    • Van Rijn, B.B.1    Nijdam, M.E.2    Bruinse, H.W.3
  • 7
    • 3843081608 scopus 로고    scopus 로고
    • Pre-eclampsia-still a disease of theories
    • Schlembach D. Pre-eclampsia-still a disease of theories. Fukushima J Med Sci: 2003; 49 69 115
    • (2003) Fukushima J Med Sci , vol.49 , pp. 69-115
    • Schlembach, D.1
  • 8
    • 84871191383 scopus 로고    scopus 로고
    • Preeclampsia - Aetiology, current diagnostics and clinical management, new therapy options and future perspectives
    • Tallarek A-C, Huppertz B., Stepan H. Preeclampsia - aetiology, current diagnostics and clinical management, new therapy options and future perspectives. Geburtsh Frauenheilk: 2012; 72 1107 1116
    • (2012) Geburtsh Frauenheilk , vol.72 , pp. 1107-1116
    • Tallarek, A.-C.1    Huppertz, B.2    Stepan, H.3
  • 9
    • 20444409135 scopus 로고    scopus 로고
    • Latest advances in understanding preeclampsia
    • DOI 10.1126/science.1111726
    • Redman C. W., Sargent I. L. Latest advances in understanding preeclampsia. Science: 2005; 308 1592 1594 (Pubitemid 40807500)
    • (2005) Science , vol.308 , Issue.5728 , pp. 1592-1594
    • Redman, C.W.1    Sargent, I.L.2
  • 10
    • 0038113155 scopus 로고    scopus 로고
    • Endovascular trophoblast invasion: Implications for the pathogenesis of intrauterine growth retardation and preeclampsia
    • DOI 10.1095/biolreprod.102.014977
    • Kaufmann P., Black S., Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod: 2003; 69 1 7 (Pubitemid 36806800)
    • (2003) Biology of Reproduction , vol.69 , Issue.1 , pp. 1-7
    • Kaufmann, P.1    Black, S.2    Huppertz, B.3
  • 11
    • 84869090811 scopus 로고    scopus 로고
    • Oxygen delivery and fetal-placental growth: Beyond a question of supply and demand
    • Murray A. J. Oxygen delivery and fetal-placental growth: beyond a question of supply and demand? Placenta: 2012; 33 02 e16 e22
    • (2012) Placenta , vol.33 , Issue.2
    • Murray, A.J.1
  • 12
    • 12344299190 scopus 로고    scopus 로고
    • Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae
    • DOI 10.1016/j.placenta.2004.04.002, PII S0143400404001043
    • Vanderlelie J., Venardos K., Clifton V. L. et al. Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae. Placenta: 2005; 26 53 58 (Pubitemid 40123676)
    • (2005) Placenta , vol.26 , Issue.1 , pp. 53-58
    • Vanderlelie, J.1    Venardos, K.2    Clifton, V.L.3    Gude, N.M.4    Clarke, F.M.5    Perkins, A.V.6
  • 13
    • 70349843323 scopus 로고    scopus 로고
    • Nrf2:INrf2 (Keap1) signaling in oxidative stress
    • Kaspar J. W., Niture S. K., Jaiswal A. K. Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med: 2009; 47 1304 1309
    • (2009) Free Radic Biol Med , vol.47 , pp. 1304-1309
    • Kaspar, J.W.1    Niture, S.K.2    Jaiswal, A.K.3
  • 14
    • 79952997672 scopus 로고    scopus 로고
    • Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter
    • Wruck C. J., Streetz K., Pavic G. et al. Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter. J Biol Chem: 2011; 286 4493 4499
    • (2011) J Biol Chem , vol.286 , pp. 4493-4499
    • Wruck, C.J.1    Streetz, K.2    Pavic, G.3
  • 15
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler T. W., Wakabayashi N., Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol: 2007; 47 89 116
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 16
    • 68049146045 scopus 로고    scopus 로고
    • Role of a fetal defence mechanism against oxidative stress in the aetiology of preeclampsia
    • Wruck C. J., Huppertz B., Bose P. et al. Role of a fetal defence mechanism against oxidative stress in the aetiology of preeclampsia. Histopathology: 2009; 55 102 106
    • (2009) Histopathology , vol.55 , pp. 102-106
    • Wruck, C.J.1    Huppertz, B.2    Bose, P.3
  • 17
    • 83355174048 scopus 로고    scopus 로고
    • Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): Implications for preeclampsia
    • Kweider N., Fragoulis A., Rosen C. et al. Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia. J Biol Chem: 2011; 286 42863 42872
    • (2011) J Biol Chem , vol.286 , pp. 42863-42872
    • Kweider, N.1    Fragoulis, A.2    Rosen, C.3
  • 18
    • 84867307268 scopus 로고    scopus 로고
    • A role for Nrf2 in redox signalling of the invasive extravillous trophoblast in severe early onset IUGR associated with preeclampsia
    • Kweider N., Huppertz B., Wruck C. J. et al. A role for Nrf2 in redox signalling of the invasive extravillous trophoblast in severe early onset IUGR associated with preeclampsia. PloS One: 2012; 7 e47055
    • (2012) PloS One , vol.7
    • Kweider, N.1    Huppertz, B.2    Wruck, C.J.3
  • 19
    • 8644286324 scopus 로고    scopus 로고
    • LDL size, total antioxidant status and oxidised LDL in normal human pregnancy: A longitudinal study
    • DOI 10.1016/j.atherosclerosis.2004.07.023, PII S0021915004003958
    • Belo L., Caslake M., Santos-Silva A. et al. LDL size, total antioxidant status and oxidised LDL in normal human pregnancy: a longitudinal study. Atherosclerosis: 2004; 177 391 399 (Pubitemid 39505273)
    • (2004) Atherosclerosis , vol.177 , Issue.2 , pp. 391-399
    • Belo, L.1    Caslake, M.2    Santos-Silva, A.3    Castro, E.M.B.4    Pereira-Leite, L.5    Quintanilha, A.6    Rebelo, I.7
  • 20
    • 79956262845 scopus 로고    scopus 로고
    • Preeclampsia: A multi-stress disorder
    • Redman C. W. Preeclampsia: a multi-stress disorder. Rev Med Interne: 2011; 32 01 S41 S44
    • (2011) Rev Med Interne , vol.32 , Issue.1
    • Redman, C.W.1
  • 23
    • 33947725523 scopus 로고    scopus 로고
    • Placental Angiogenesis, Maternal and Fetal Vessels - A Workshop Report
    • DOI 10.1016/j.placenta.2007.01.015, PII S014340040700029X
    • Huppertz B., Abe E., Murthi P. et al. Placental angiogenesis, maternal and fetal vessels - a workshop report. Placenta: 2007; 28 (Suppl. A) S94 S96 (Pubitemid 46506057)
    • (2007) Placenta , vol.28 , Issue.SUPPL.
    • Huppertz, B.1    Abe, E.2    Murthi, P.3    Nagamatsu, T.4    Szukiewicz, D.5    Salafia, C.6
  • 24
    • 31844440452 scopus 로고    scopus 로고
    • Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia/intrauterine growth restriction
    • DOI 10.1016/j.ajog.2005.07.035, PII S0002937805010756
    • Kadyrov M., Kingdom J. C., Huppertz B. Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia/intrauterine growth restriction. Am J Obstet Gynecol: 2006; 194 557 563 (Pubitemid 43183716)
    • (2006) American Journal of Obstetrics and Gynecology , vol.194 , Issue.2 , pp. 557-563
    • Kadyrov, M.1    Kingdom, J.C.P.2    Huppertz, B.3
  • 25
    • 84857949088 scopus 로고    scopus 로고
    • Abnormal levels of antioxidant defenses in a large sample of patients with hypertensive disorders of pregnancy
    • Miranda Guisado M. L., Vallejo-Vaz A. J., Garcia Junco P. S. et al. Abnormal levels of antioxidant defenses in a large sample of patients with hypertensive disorders of pregnancy. Hypertens Res: 2012; 35 274 278
    • (2012) Hypertens Res , vol.35 , pp. 274-278
    • Miranda Guisado, M.L.1    Vallejo-Vaz, A.J.2    Garcia Junco, P.S.3
  • 26
    • 3042660261 scopus 로고    scopus 로고
    • Reduced antioxidant capacity in second-trimester pregnancies with pathological uterine perfusion
    • DOI 10.1002/uog.1045
    • Stepan H., Heihoff-Klose A., Faber R. Reduced antioxidant capacity in second-trimester pregnancies with pathological uterine perfusion. Ultrasound Obstet Gynecol: 2004; 23 579 583 (Pubitemid 38829867)
    • (2004) Ultrasound in Obstetrics and Gynecology , vol.23 , Issue.6 , pp. 579-583
    • Stepan, H.1    Heihoff-Klose, A.2    Faber, R.3
  • 27
    • 0033523435 scopus 로고    scopus 로고
    • Is oxidative stress the link in the two-stage model of pre-eclampsia?
    • DOI 10.1016/S0140-6736(99)80002-6
    • Roberts J. M., Hubel C. A. Is oxidative stress the link in the two-stage model of pre-eclampsia? Lancet: 1999; 354 788 789 (Pubitemid 29415578)
    • (1999) Lancet , vol.354 , Issue.9181 , pp. 788-789
    • Roberts, J.M.1    Hubel, C.A.2
  • 28
    • 0034843821 scopus 로고    scopus 로고
    • In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies
    • Hung T. H., Skepper J. N., Burton G. J. In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies. Am J Pathol: 2001; 159 1031 1043 (Pubitemid 32847193)
    • (2001) American Journal of Pathology , vol.159 , Issue.3 , pp. 1031-1043
    • Hung, T.-H.1    Skepper, J.N.2    Burton, G.J.3
  • 29
    • 78751703950 scopus 로고    scopus 로고
    • Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
    • Taguchi K., Motohashi H., Yamamoto M. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells: 2011; 16 123 140
    • (2011) Genes Cells , vol.16 , pp. 123-140
    • Taguchi, K.1    Motohashi, H.2    Yamamoto, M.3
  • 30
    • 21744445077 scopus 로고    scopus 로고
    • Nrf2, a multi-organ protector
    • Lee J. M., Li J., Johnson D. A. et al. Nrf2, a multi-organ protector? FASEB J: 2005; 19 1061 1066
    • (2005) FASEB J , vol.19 , pp. 1061-1066
    • Lee, J.M.1    Li, J.2    Johnson, D.A.3
  • 31
    • 77953324869 scopus 로고    scopus 로고
    • Sulforaphane suppresses LPS-induced inflammation in primary rat microglia
    • Brandenburg L. O., Kipp M., Lucius R. et al. Sulforaphane suppresses LPS-induced inflammation in primary rat microglia. Inflamm Res: 2010; 59 443 450
    • (2010) Inflamm Res , vol.59 , pp. 443-450
    • Brandenburg, L.O.1    Kipp, M.2    Lucius, R.3
  • 32
    • 84867280729 scopus 로고    scopus 로고
    • Decreased lectin-like oxidized LDL receptor 1 (LOX-1) and low Nrf2 activation in placenta are involved in preeclampsia
    • Chigusa Y., Tatsumi K., Kondoh E. et al. Decreased lectin-like oxidized LDL receptor 1 (LOX-1) and low Nrf2 activation in placenta are involved in preeclampsia. J Clin Endocrinol Metab: 2012; 97 E1862 E1870
    • (2012) J Clin Endocrinol Metab , vol.97
    • Chigusa, Y.1    Tatsumi, K.2    Kondoh, E.3
  • 33
    • 35648946184 scopus 로고    scopus 로고
    • Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: Implications for atherosclerosis and preeclampsia
    • Mann G. E., Niehueser-Saran J., Watson A. et al. Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia. Sheng Li Xue Bao: 2007; 59 117 127
    • (2007) Sheng Li Xue Bao , vol.59 , pp. 117-127
    • Mann, G.E.1    Niehueser-Saran, J.2    Watson, A.3
  • 34
    • 84866346444 scopus 로고    scopus 로고
    • Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: Implications for microvascular aging
    • Valcarcel-Ares M. N., Gautam T., Warrington J. P. et al. Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging. J Gerontol A Biol Sci Med Sci: 2012; 67 821 829
    • (2012) J Gerontol A Biol Sci Med Sci , vol.67 , pp. 821-829
    • Valcarcel-Ares, M.N.1    Gautam, T.2    Warrington, J.P.3
  • 35
    • 78650684089 scopus 로고    scopus 로고
    • A transcriptional profile of the decidua in preeclampsia
    • Loset M., Mundal S. B., Johnson M. P. et al. A transcriptional profile of the decidua in preeclampsia. Am J Obstet Gynecol: 2011; 204 84e81 84e27
    • (2011) Am J Obstet Gynecol , vol.204
    • Loset, M.1    Mundal, S.B.2    Johnson, M.P.3
  • 36
    • 59649093035 scopus 로고    scopus 로고
    • Identification of novel trophoblast invasion-related genes: Heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma
    • Bilban M., Haslinger P., Prast J. et al. Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma. Endocrinology: 2009; 150 1000 1013
    • (2009) Endocrinology , vol.150 , pp. 1000-1013
    • Bilban, M.1    Haslinger, P.2    Prast, J.3
  • 37
    • 84872183989 scopus 로고    scopus 로고
    • Potential therapeutic effects of natural heme oxygenase-1 inducers in cardiovascular diseases
    • Barbagallo I., Galvano F., Frigiola A. et al. Potential therapeutic effects of natural heme oxygenase-1 inducers in cardiovascular diseases. Antioxid Redox Signal: 2013; 18 507 521
    • (2013) Antioxid Redox Signal , vol.18 , pp. 507-521
    • Barbagallo, I.1    Galvano, F.2    Frigiola, A.3
  • 38
    • 0014348401 scopus 로고
    • The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase
    • Tenhunen R., Marver H. S., Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci U S A: 1968; 61 748 755
    • (1968) Proc Natl Acad Sci U S A , vol.61 , pp. 748-755
    • Tenhunen, R.1    Marver, H.S.2    Schmid, R.3
  • 39
    • 84875211376 scopus 로고    scopus 로고
    • Heme oxygenase-1 in placental development and pathology
    • Levytska K., Kingdom J., Baczyk D. et al. Heme oxygenase-1 in placental development and pathology. Placenta: 2013; 34 291 298
    • (2013) Placenta , vol.34 , pp. 291-298
    • Levytska, K.1    Kingdom, J.2    Baczyk, D.3
  • 41
    • 84455208308 scopus 로고    scopus 로고
    • The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients
    • Verlohren S., Herraiz I., Lapaire O. et al. The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients. Am J Obstet Gynecol: 2012; 206 58e51 58e58
    • (2012) Am J Obstet Gynecol , vol.206
    • Verlohren, S.1    Herraiz, I.2    Lapaire, O.3
  • 42
    • 60549111966 scopus 로고    scopus 로고
    • Serum levels of angiopoietin-related growth factor are increased in preeclampsia
    • Stepan H., Ebert T., Schrey S. et al. Serum levels of angiopoietin-related growth factor are increased in preeclampsia. Am J Hypertens: 2009; 22 314 318
    • (2009) Am J Hypertens , vol.22 , pp. 314-318
    • Stepan, H.1    Ebert, T.2    Schrey, S.3
  • 43
    • 60549087158 scopus 로고    scopus 로고
    • Angiogenic factors and pre-eclampsia: An early marker is needed
    • Stepan H. Angiogenic factors and pre-eclampsia: an early marker is needed. Clin Sci: 2009; 116 231 232
    • (2009) Clin Sci , vol.116 , pp. 231-232
    • Stepan, H.1
  • 45
    • 84878854626 scopus 로고    scopus 로고
    • Heme oxygenase inhibition increases blood pressure in pregnant rats
    • George E. M., Hosick P. A., Stec D. E. et al. Heme oxygenase inhibition increases blood pressure in pregnant rats. Am J Hypertens: 2013; 26 924 930
    • (2013) Am J Hypertens , vol.26 , pp. 924-930
    • George, E.M.1    Hosick, P.A.2    Stec, D.E.3
  • 46
    • 77956638593 scopus 로고    scopus 로고
    • Heme oxygenase-1 in neovascularisation: A diabetic perspective
    • Grochot-Przeczek A., Dulak J., Jozkowicz A. Heme oxygenase-1 in neovascularisation: a diabetic perspective. Thromb Haemost: 2010; 104 424 431
    • (2010) Thromb Haemost , vol.104 , pp. 424-431
    • Grochot-Przeczek, A.1    Dulak, J.2    Jozkowicz, A.3
  • 47
    • 70149083005 scopus 로고    scopus 로고
    • Effect of heme oxygenase-1 deficiency on placental development
    • Zhao H., Wong R. J., Kalish F. S. et al. Effect of heme oxygenase-1 deficiency on placental development. Placenta: 2009; 30 861 868
    • (2009) Placenta , vol.30 , pp. 861-868
    • Zhao, H.1    Wong, R.J.2    Kalish, F.S.3
  • 49
    • 4644290036 scopus 로고    scopus 로고
    • Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1
    • DOI 10.1161/01.CIR.0000142610.10530.25
    • Deng Y. M., Wu B. J., Witting P. K. et al. Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1. Circulation: 2004; 110 1855 1860 (Pubitemid 39299229)
    • (2004) Circulation , vol.110 , Issue.13 , pp. 1855-1860
    • Deng, Y.-M.1    Wu, B.J.2    Witting, P.K.3    Stocker, R.4
  • 50
    • 44249103744 scopus 로고    scopus 로고
    • Kavalactones protect neural cells against amyloid β peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation
    • DOI 10.1124/mol.107.042499
    • Wruck C. J., Gotz M. E., Herdegen T. et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol: 2008; 73 1785 1795 (Pubitemid 351724366)
    • (2008) Molecular Pharmacology , vol.73 , Issue.6 , pp. 1785-1795
    • Wruck, C.J.1    Gotz, M.E.2    Herdegen, T.3    Varoga, D.4    Brandenburg, L.-O.5    Pufe, T.6
  • 51
    • 0034809630 scopus 로고    scopus 로고
    • The impaired glutathione system and its up-regulation by sulforaphane in vascular smooth muscle cells from spontaneously hypertensive rats
    • DOI 10.1097/00004872-200110000-00016
    • Wu L., Juurlink B. H. The impaired glutathione system and its up-regulation by sulforaphane in vascular smooth muscle cells from spontaneously hypertensive rats. J Hypertens: 2001; 19 1819 1825 (Pubitemid 32924948)
    • (2001) Journal of Hypertension , vol.19 , Issue.10 , pp. 1819-1825
    • Wu, L.1    Juurlink, B.H.J.2
  • 52
    • 84875139247 scopus 로고    scopus 로고
    • Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity
    • Guan S. P., Tee W., Ng D. S. et al. Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity. Br J Pharmacol: 2013; 168 1707 1718
    • (2013) Br J Pharmacol , vol.168 , pp. 1707-1718
    • Guan, S.P.1    Tee, W.2    Ng, D.S.3
  • 53
    • 33645988840 scopus 로고    scopus 로고
    • Vitamin C and vitamin e in pregnant women at risk for pre-eclampsia (VIP trial): Randomised placebo-controlled trial
    • Poston L., Briley A. L., Seed P. T. et al. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet: 2006; 367 1145 1154
    • (2006) Lancet , vol.367 , pp. 1145-1154
    • Poston, L.1    Briley, A.L.2    Seed, P.T.3
  • 54
    • 33646114512 scopus 로고    scopus 로고
    • Vitamins C and e and the risks of preeclampsia and perinatal complications
    • Rumbold A. R., Crowther C. A., Haslam R. R. et al. Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med: 2006; 354 1796 1806
    • (2006) N Engl J Med , vol.354 , pp. 1796-1806
    • Rumbold, A.R.1    Crowther, C.A.2    Haslam, R.R.3
  • 55
    • 84866547978 scopus 로고    scopus 로고
    • 2 as possible risk factors for preeclampsia - Under consideration of the PROPER study (Prevention of preeclampsia by high-dose riboflavin supplementation)
    • 2 as possible risk factors for preeclampsia - under consideration of the PROPER study (Prevention of preeclampsia by high-dose riboflavin supplementation). Geburtsh Frauenheilk: 2012; 72 846 852
    • (2012) Geburtsh Frauenheilk , vol.72 , pp. 846-852
    • Elsen, C.1    Rivas-Echeverría, C.2    Sahland, K.3
  • 56
    • 84875941102 scopus 로고    scopus 로고
    • Antioxidants for the treatment of patients with severe angioproliferative pulmonary hypertension
    • Voelkel N. F., Bogaard H. J., Al Husseini A. et al. Antioxidants for the treatment of patients with severe angioproliferative pulmonary hypertension? Antioxid Redox Signal: 2013; 18 1810 1817
    • (2013) Antioxid Redox Signal , vol.18 , pp. 1810-1817
    • Voelkel, N.F.1    Bogaard, H.J.2    Al Husseini, A.3
  • 57
    • 84655165055 scopus 로고    scopus 로고
    • Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension
    • Gomez-Guzman M., Jimenez R., Sanchez M. et al. Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension. Free Radic Biol Med: 2012; 52 70 79
    • (2012) Free Radic Biol Med , vol.52 , pp. 70-79
    • Gomez-Guzman, M.1    Jimenez, R.2    Sanchez, M.3
  • 59
    • 84866175152 scopus 로고    scopus 로고
    • Antioxidants in kidney diseases: The impact of bardoxolone methyl
    • Rojas-Rivera J., Ortiz A., Egido J. Antioxidants in kidney diseases: the impact of bardoxolone methyl. Int J Nephrol: 2012; 2012 321714
    • (2012) Int J Nephrol , vol.2012 , pp. 321714
    • Rojas-Rivera, J.1    Ortiz, A.2    Egido, J.3
  • 60
    • 84873718905 scopus 로고    scopus 로고
    • Intrauterine exposure to flavonoids modifies antioxidant status at adulthood and decreases oxidative stress-induced DNA damage
    • Vanhees K., van Schooten F. J., van Waalwijk van Doorn-Khosrovani S. B. et al. Intrauterine exposure to flavonoids modifies antioxidant status at adulthood and decreases oxidative stress-induced DNA damage. Free Radic Biol Med: 2013; 57 154 161
    • (2013) Free Radic Biol Med , vol.57 , pp. 154-161
    • Vanhees, K.1    Van Schooten, F.J.2    Van Waalwijk Van Doorn-Khosrovani, S.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.