Co-electrospun gelatin-poly(L-lactic acid) scaffolds: Modulation of mechanical properties and chondrocyte response as a function of composition

Materials Science and Engineering C

Volumn 36, Issue 1, 2014, Pages 130-138

  Torricelli, Paola ^a   Gioffrè, Michela ^b   Fiorani, Andrea ^b   Panzavolta, Silvia ^b   Gualandi, Chiara ^b   Fini, Milena ^a   Focarete, Maria Letizia ^b,c   Bigi, Adriana ^b  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c Health Sciences and Technologies Interdepartmental Center for Industrial Research (HST ICIR)   (Italy)

Author keywords

Chondrocytes; Electrospun scaffolds; Gelatin; Mineralization; Poly(lactic acid)

Indexed keywords

BODY FLUIDS; CARTILAGE; ELECTROSPINNING; MECHANICAL PROPERTIES; MINERALOGY; ORGANIC POLYMERS; PHOSPHATE MINERALS; SCAFFOLDS;

CHONDROCYTES; ELECTROSPUN SCAFFOLDS; GELATIN; MINERALIZATION; POLY LACTIC ACID;

SCAFFOLDS (BIOLOGY);

CROSS LINKING REAGENT; GELATIN; LACTATE DEHYDROGENASE; LACTIC ACID; POLYLACTIC ACID; POLYMER; TISSUE SCAFFOLD;

ANIMAL; ARTICLE; BONE MINERALIZATION; CARTILAGE CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ELECTROSPUN SCAFFOLDS; ENZYMOLOGY; HUMAN; INFRARED SPECTROSCOPY; MECHANICS; METABOLISM; METHODOLOGY; MINERALIZATION; SWINE; TENSILE STRENGTH; TISSUE ENGINEERING; ULTRASTRUCTURE;

CHONDROCYTES; ELECTROSPUN SCAFFOLDS; GELATIN; MINERALIZATION; POLY(LACTIC ACID);

ANIMALS; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; CELLS, CULTURED; CHONDROCYTES; CROSS-LINKING REAGENTS; GELATIN; HUMANS; L-LACTATE DEHYDROGENASE; LACTIC ACID; MECHANICAL PHENOMENA; POLYMERS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SUS SCROFA; TENSILE STRENGTH; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84896534486     PISSN: 09284931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.msec.2013.11.050     Document Type: Article

References (42)

1. S. Samavedi, C. Olsen Horton, S.A. Guelcher, A.S. Goldstein, and A.R. Whittington Fabrication of a model continuously graded co-electrospun mesh for regeneration of the ligament-bone interface Acta Biomater. 7 2006 4131 4138
2. H.H. Lu, and J. Jiang Interface tissue engineering and the formulation of multiple-tissue systems K. Lee, D.L. Kaplan, Advances in Biochemical Engineering and Biotechnology vol. 102 2006 Springer Verlag New York 91
3. M.R. Ladd, S.J. Lee, J.D. Stitzel, A. Atala, and J.J. Yoo Co-electrospun dual scaffolding system with potential for muscle-tendon junction tissue engineering Biomaterials 32 2011 1549 1559
4. A. Sionkowska Current research on the blends of natural and synthetic polymers as new biomaterials: review Prog. Polym. Sci. 36 2011 1254 1276
5. S. Agarwal, J.H. Wendorff, and A. Greiner Use of electrospinning technique for biomedical applications Polymer 49 2008 5603 5621
6. T.J. Sill, and H.A. von Recum Electrospinning: applications in drug delivery and tissue engineering Biomaterials 29 2008 1989 2006
7. Q.P. Pham, U. Sharma, and A.G. Mikos Electrospinning of polymeric nanofibers for tissue engineering applications: a review Tissue Eng. 12 2006 1197 1211 (Pubitemid 44024491)
8. J. Han, P. Lazarovici, C. Pomerantz, X. Chen, Y. Wei, and P.I. Lelkes Co-electrospun blends of PLGA, gelatin, and elastin as potential nonthrombogenic scaffolds for vascular tissue engineering Biomacromolecules 12 2010 399 408
9. K. Kwon II, and T. Matsuda Co-electrospun nanofiber fabrics of poly(l-lactide-co-ε-caprolactone) with type I collagen or heparin Biomacromolecules 6 2005 2096 2105 (Pubitemid 41052204)
10. J. Lin, C. Li, Y. Zhao, J. Hu, and L.M. Zhang Co-electrospun nanofibrous membranes of collagen and zein for wound healing ACS Appl. Mater. Interfaces 4 2012 1050 1057
11. S.Y. Gu, Z.M. Wang, J. Ren, and C.Y. Zhang Electrospinning of gelatin and gelatin/poly(l-lactide) blend and its characteristics for wound dressing Mater. Sci. Eng. C 29 2009 1822 1828
12. S.E. Kim, D.N. Heo, J.B. Lee, J.R. Kim, S.H. Park, S. Jeon, and K. Kwon II Electrospun gelatin/polyurethane blended nanofibers for wound healing Biomed. Mater. 4 2009 044106
13. M. Deng, S.G. Kumbar, L.S. Nair, A.L. Weikel, and H.R. Allcock Biomimetic structures: biological implications of dipeptide-substituted polyphosphazene-polyester blend nanofiber matrices for load-bearing bone regeneration Adv. Funct. Mater. 21 2011 2641 2651
14. M.P. Prabhakaran, J. Venugopal, and S. Ramakrishna Electrospun nanostructured scaffolds for bone tissue engineering Acta Biomater. 5 2009 2884 2893
15. J.H. Jang, O. Castano, and H.W. Kim Electrospun materials as potential platforms for bone tissue engineering Adv. Drug Deliv. Rev. 61 2009 1065 1083
16. J.P. Chen, and C.H. Su Surface modification of electrospun PLLA nanofibers by plasma treatment and cationized gelatin immobilization for cartilage tissue engineering Acta Biomater. 7 2011 234 243
17. R. Ravichandran, J.R. Venugopal, S. Sundarrajan, S. Mukherjee, and S. Ramakrishna Precipitation of nanohydroxyapatite on PLLA/PBLG/Collagen nanofibrous structures for the differentiation of adipose derived stem cells to osteogenic lineage Biomaterials 33 2012 846-846
18. M.S. Kim, I. Jun, Y.M. Shin, W. Jang, S.I. Kim, and H. Shin The development of genipin-crosslinked poly(caprolactone) (PCL)/gelatin nanofibers for tissue engineering applications Macromol. Biosci. 10 2010 91 100
19. Z.X. Meng, X.X. Xu, W. Zheng, H.M. Zhou, L. Li, Y.F. Zheng, and X. Lou Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system Colloids Surf. B 84 2011 97 102
20. Y.J. Lin, Q. Cai, L. Li, Q.F. Li, X.P. Yang, and R.J. Jin Co-electrospun composite nanofibers of blends of poly[(amino acid ester)phosphazene] and gelatin Polym. Int. 59 2010 610 616
21. H.W. Kim, H.S. Yu, and H.H. Lee Nanofibrous matrices of poly(lactic acid) and gelatin polymeric blends for the improvement of cellular responses J. Biomed. Mater. Res. A 87 2007 25 32
22. B.M. Baker, A.O. Gee, R.B. Metter, A.S. Nathan, R.A. Marklein, J.A. Burdick, and R.L. Mauck The potential to improve cell infiltration in composite fiber-aligned electrospun scaffolds by the selective removal of sacrificial fibers Biomaterials 29 2008 2348 2358
23. Z. Chen, L. Cao, L. Wang, H. Zhu, and H. Jiang Effect of fiber structure on the properties of the electrospun hybrid membranes composed of poly(ε-caprolactone) and gelatin J. Appl. Polym. Sci. 127 2013 4225 4232
24. N. Detta, C. Errico, D. Dinucci, D. Puppi, D. Clarke, G. Reilly, and F. Chiellini Novel electrospun polyurethane/gelatin composite meshes for vascular grafts J. Mater. Sci. Mater. Med. 21 2010 1761 1769
25. B. Ding, E. Kimura, T. Sato, S. Fujita, and S. Shiratori Fabrication of blend biodegradable nanofibrous nonwoven mats via multi-jet electrospinning Polymer 45 2004 1895 1902 (Pubitemid 38224321)
26. B. Duan, L. Wu, X. Yuan, Z. Hu, X. Li, Y. Zhang, K. Yao, and M. Wang Hybrid nanofibrous membranes of PLGA/chitosan fabricated via an electrospinning array J. Biomed. Mater. Res. A 83 2007 868 878 (Pubitemid 350086315)
27. S. Kidoaki, I.K. Kwon, and T. Matsuda Mesoscopic spatial designs of nano- and microfiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques Biomaterials 26 2005 37 46 (Pubitemid 38759470)
28. C.H. Kim, M.S. Khil, H.Y. Kim, H.U. Lee, and K.Y. Jahng An improved hydrophilicity via electrospinning for enhanced cell attachment and proliferation J. Biomed. Mater. Res. B 78 2006 283 290 (Pubitemid 44167730)
29. S. Madhugiri, A. Dalton, J. Gutierrez, J.P. Ferraris, and K.J. Balkus Electrospun MEH-PPV/SBA-15 composite nanofibers using a dual syringe method J. Am. Chem. Soc. 125 2003 14531 14538 (Pubitemid 37452389)
30. S. Soliman, S. Pagliari, A. Rinaldi, G. Forte, R. Fiaccavento, F. Pagliari, O. Franzese, M. Minieri, P. Di Nardo, S. Licoccia, and E. Traversa Multiscale three-dimensional scaffolds for soft tissue engineering via multimodal electrospinning Acta Biomater. 6 2010 1227 1237
31. S. Panzavolta, M. Gioffrè, M.L. Focarete, C. Gualandi, L. Foroni, and A. Bigi Electrospun gelatin nanofibers: optimization of genipin cross-linking to preserve fiber morphology after exposure to water Acta Biomater. 7 2011 1702 1709
32. A. Bigi, E. Boanini, B. Bracci, A. Facchini, S. Panzavolta, F. Segatti, and L. Sturba Nanocrystalline hydroxyapatite coatings on titanium: a new fast biomimetic method Biomaterials 26 2005 4085 4089 (Pubitemid 40138655)
33. G. Janairo, M.L. Sy, L. Yap, N. Llanos-Lazaro, and J. Robles Determination of the sensitivity range of Biuret test for undergraduate biochemistry experiments e-JST 6 2011 81 87
34. P. Bergo, and P.J.A. Sobral Effects of plasticizer on physical properties of pigskin gelatin films Food Hydrocoll. 21 2012 1285 1289 (Pubitemid 46719561)
35. D.M. Hashim, Y.B. Che Man, R. Norakasha, M. Shuhaimi, Y. Salmah, and Z.A. Syahariza Potential use of Fourier transform infrared spectroscopy for differentiation of bovine and porcine gelatins Food Chem. 118 2010 856 860
36. R. Touyama, Y. Takeda, K. Inoue, I. Kawamura, M. Yatsuzuka, T. Ikumoto, T. Shingu, T. Yokoi, and H. Inouye Studies on the blue pigments produced from genipin and methylamine. I. Structures of the brownish-red pigments, intermediates leading to the blue pigments Chem. Pharm. Bull. 42 1994 668 673 (Pubitemid 24156290)
37. J.-W. Lu, Z.P. Zhang, X.Z. Ren, Y.Z. Chen, J. Yu, and Z.X. Guo High-elongation fiber mats by electrospinning of polyoxymethylene Macromolecules 41 2008 3762 3764
38. A. Baici, A. Lang, R. Horler, and M. Knopfel Cathepsin B as a marker of the dedifferentiated chondrocyte phenotype Ann. Rheum. Dis. 47 1988 684 691
39. T. Andric, L.D. Wright, and J.W. Freeman Rapid mineralization of electrospun scaffolds for bone tissue engineering J. Biomater. Sci. Polym. Ed. 22 2011 1535 1550
40. 2 bubbling Appl. Surf. Sci. 257 2011 10109 10118
41. X. Yang, Q. Xu, N. Yan, G. Sui, Q. Cai, and X. Deng Structure and wettability relationship of coelectrospun poly (l-lactic acid)/gelatin composite fibrous mats Polym. Adv. Technol. 22 2011 2222 2230
42. A. Bigi, N. Nicoli-Aldini, B. Bracci, B. Zavan, E. Boanini, F. Sbaiz, S. Panzavolta, G. Zorzato, R. Giardino, A. Facchini, G. Abatangelo, and R. Cortivo In vitro culture of mesenchymal cells onto nanocrystalline hydroxyapatite-coated Ti13Nb13Zr alloy J. Biomed. Mater. Res. 82 2007 213 221 (Pubitemid 46906508)