Electrospun gelatin nanofibers: Optimization of genipin cross-linking to preserve fiber morphology after exposure to water

Acta Biomaterialia

Volumn 7, Issue 4, 2011, Pages 1702-1709

  Panzavolta, Silvia ^a   Gioffrè, Michela ^a   Focarete, Maria Letizia ^a   Gualandi, Chiara ^a   Foroni, Laura ^a   Bigi, Adriana ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Cross linking; Electrospinning; Gelatin; Genipin; Scaffold

Indexed keywords

BIOMIMETICS; CELL CULTURE; MORPHOLOGY; NANOFIBERS; SCAFFOLDS (BIOLOGY); SCANNING ELECTRON MICROSCOPY; STEM CELLS;

CROSS LINKING; ELECTROSPUN MATS; ELECTROSPUNS; FIBER MORPHOLOGY; GELATIN; GELATIN NANOFIBERS; GENIPIN; GENIPIN CROSS-LINKING; OPTIMISATIONS; THREE-DIMENSIONAL SCAFFOLDS;

ELECTROSPINNING;

ACETIC ACID; GELATIN; GENIPIN; MOLECULAR SCAFFOLD; NANOFIBER; PHOSPHATE BUFFERED SALINE; TISSUE SCAFFOLD; WATER;

ARTICLE; BLOOD VESSEL WALL; CELL ADHESION; CELL VIABILITY; CROSS LINKING; ELECTRON MICROSCOPY; ELECTROSPINNING; IN VITRO STUDY; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; STRESS STRAIN RELATIONSHIP; TEMPERATURE SENSITIVITY; TISSUE ENGINEERING; YOUNG MODULUS;

EID: 79952189383     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.11.021     Document Type: Article

References (37)

1. E.S. Place, N.D. Evans, and M.M. Stevens Complexity in biomaterials for tissue engineering Nat Mater 8 2009 457 470
2. M.M. Stevens, and J.H. George Exploring and engineering the cell surface interface Science 310 2005 1135 1138 (Pubitemid 41681731)
3. P.X. Ma Biomimetic materials for tissue engineering Adv Drug Delivery Rev 60 2008 184 198 (Pubitemid 350245692)
4. S. Agarwal, J.H. Wendorff, and A. Greiner Use of electrospinning technique for biomedical applications Polymer 49 2008 5603 5621
5. C.L. Casper, W. Yang, M.C. Farach-Carson, and J.F. Rabolt Coating electrospun collagen and gelatin fibers with perlecan domain I for increased growth factor binding Biomacromolecules 8 2007 1116 1123 (Pubitemid 46672688)
6. J.A. Matthews, G.E. Wnek, D.G. Simpson, and G.L. Bowlin Electrospinning of collagen nanofibers Biomacromolecules 3 2002 232 238 (Pubitemid 34257140)
7. K.S. Rho Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing Biomaterials 27 2006 1452 1461 (Pubitemid 41739571)
8. S. Torres-Giner, J.V. Gimeno-Alcanaiz, M.J. Ocio, and J.M. Lagaron Comparative performance of electrospun collagen nanofibers cross-linked by means of different methods ACS Appl Mater Interfaces 1 2009 218 223
9. Y.Z. Zhang, J. Venugopal, Z.M. Huang, C.T. Lim, and S. Ramakrishna Crosslinking of the electrospun gelatin nanofibers Polymer 47 2006 2911 2917
10. A. Bigi, G. Cojazzi, S. Panzavolta, N. Roveri, and K. Rubini Stabilization of gelatin films by crosslinking with genipin Biomaterials 23 2002 4827 4832 (Pubitemid 35286704)
11. J.F. Mano Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends J R Soc Interface 4 2007 999 1030 (Pubitemid 350303872)
12. M. Li, M.J. Mondrinos, M.R. Gandhi, F.K. Ko, A.S. Weiss, and P.I. Lelkes Electrospun protein fibers as matrices for tissue engineering Biomaterials 26 2005 5999 6008 (Pubitemid 40805606)
13. Z.M. Huang, Y.Z. Zhang, S. Ramakrishna, and C.T. Lim Electrospinning and mechanical characterization of gelatin nanofibers Polymer 45 2004 5361 5368 (Pubitemid 38834116)
14. S.Y. Gu, Z.M. Wang, J. Ren, and C.Y. Zhang Electrospinning of gelatin and gelatin/poly(l-lactide) blend and its characteristics for wound dressing Mater Sci Eng C 29 2009 1822 1828
15. J.H. Song, H.E. Kim, and H.W. Kim Production of electrospun gelatin nanofiber by water-based co-solvent approach J Mater Sci Mater Med 19 2008 95 102
16. A. Bigi, B. Bracci, G. Cojazzi, S. Panzavolta, and N. Roveri Drawn gelatin films with improved mechanical properties Biomaterials 19 1998 2335 2340 (Pubitemid 28550400)
17. I. Rault, V. Frei, D. Herbage, N. Abdul-Malak, and A. Huc Evaluation of different chemical methods for cross-linking collagen gel, films and sponges J Mater Sci Mater Med 7 1996 215 221 (Pubitemid 26260989)
18. E. Khor Methods for the treatment of collagenous tissues for bioprostheses Biomaterials 18 1997 95 103
19. K. Sisson, C. Zhang, M.C. Farach-Carson, D.B. Chase, and J.F. Rabolt Evaluation of cross-linking methods for electrospun gelatin on cell growth and viability Biomacromolecules 10 2009 1675 1680
20. L.H.H. Olde Damink, P.J. Dijkstra, M.J.A. Van Luyn, P.B. Van Wachem, P. Nieuwenhuis, and J. Feijen Glutaraldehyde as a crosslinking agent for collagen-based biomaterials J Mater Sci Mater Med 6 1995 460 472
21. H.W. Sung, D.M. Huang, W.H. Chang, L.L. Huang, C.C. Tsai, and I.L. Liang Gelatin-derived bioadhesives for closing skin wounds: an in vivo study J Biomater Sci Polym Ed 10 1999 751 771 (Pubitemid 29312761)
22. H.W. Sung, D.M. Huang, W.H. Chang, R.N. Huang, and J.C. Hsu Evaluation of gelatin hydrogel crosslinked with various crosslinking agents as bioadhesives: in vitro study J Biomed Mater Res 46 1999 520 530
23. H.W. Sung, I.L. Liang, C.N. Chen, R.N. Huang, and H.F. Liang Stability of a biological tissue fixed with a naturally occurring crosslinking agent (genipin) J Biomed Mater Res 55 2001 538 546 (Pubitemid 32336284)
24. M.S. Kim, I. Jun, Y.M. Shin, W. Jang, and H. Shin The development of genipin-crosslinked poly(caprolactone) (PCL)/gelatin nanofibers for tissue engineering applications Macromol Biosci 10 2010 91 100
25. J. Ko, H.Y. Yin, J. An, D. Chung, J.H. Kim, and S. Lee Characterization of cross-linked gelatin nanofibers through electrospinning Macromol Res 18 2010 137 143
26. C.M. Ofner III, and W.A. Bubnis Chemical and swelling evaluations of amino group crosslinking in gelatin and modified gelatin matrices Pharm Res 13 1996 1821 1827 (Pubitemid 27034113)
27. G. Pasquinelli Multidistrict human mesenchymal vascular cells: pluripotency and stemness characteristics Cytotherapy 12 2010 275 287
28. D.M. Hashim, Y.B. Che Man, R. Norakasha, M. Shuhaimi, Y. Salmah, and Z.A. Syahariza Potential use of Fourier transform infrared spectroscopy for differentiation of bovine and porcine gelatins Food Chem 118 2010 856 860
29. K. Okuyama Revisiting the molecular structure of collagen connective tissue Tissue Res 49 2008 299 310
30. H.W. Sung, R.N. Huang, L.L.H. Huang, C.C. Tsai, and C.T. Chiu Feasibility study of a natural crosslinking reagent for biological tissue fixation J Biomed Mater Res 42 1998 560 567 (Pubitemid 28503761)
31. L.L. Huang, H.W. Sung, C.C. Tsai, and D.M. Huang Biocompatibility study of a biological tissue fixed with a naturally occurring crosslinking reagent J Biomed Mater Res 42 1998 568 576 (Pubitemid 28503762)
32. C.C. Tsai, R.N. Huang, H.W. Sung, and H.C. Liang In vitro evaluation of the genotoxicity of a naturally occurring crosslinking agent (genipin) for biologic tissue fixation J Biomed Mater Res 52 2000 58 65 (Pubitemid 30490980)
33. P. Bergo, and P.J.A. Sobral Effects of plasticizer on physical properties of pigskin gelatin films Food Hydrocolloids 21 2007 1285 1289 (Pubitemid 46719561)
34. J.H. Muyonga, C.G.B. Cole, and K.G. Duodu Extraction and physico-chemical characterisation of Nile perch (Lates niloticus) skin and bone gelatin Food Hydrocolloids 18 2004 581 592
35. C.S. Ki, D.H. Baek, K.D. Gang, K.H. Lee, I.C. Um, and Y.H. Park Characterization of gelatin nanofiber prepared from gelatin-formic acid solution Polymer 46 2005 5094 5102 (Pubitemid 40759052)
36. S.B. Ross-Murphy Structure and rheology of gelatin gels: recent progress Polymer 33 1992 2622 2627
37. A. Veis The macromolecular chemistry of gelatin 1964 Academic Press New York