Resveratrol induces apoptosis of bladder cancer cells via miR-21 regulation of the Akt/Bcl-2 signaling pathway

Molecular Medicine Reports

Volumn 9, Issue 4, 2014, Pages 1467-1473

  Zhou, Chenxi ^a   Ding, Jun ^a   Wu, Yuanwen ^a  

^a The 101 Hospital of Chinese PLA   (China)

Author keywords

Akt Bcl 2 signaling pathway; Apoptosis; Bladder cancer; miR 21; Resveratrol

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; MICRORNA 21; PROTEIN BCL 2; PROTEIN KINASE B; RESVERATROL; SOMATOMEDIN C;

APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MTT ASSAY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; STILBENES; URINARY BLADDER NEOPLASMS;

EID: 84896531799     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.1950     Document Type: Article

References (25)

1. Kirkali Z, Chan T, Manoharan M, Algaba F, et al: Bladder cancer: epidemiology, staging and grading, and diagnosis. Urology 66: 4-34, 2005. (Pubitemid 43049607)
2. Lei AQ, Cheng L and Pan CX: Current treatment of metastatic bladder cancer and future directions. Expert Rev Anticancer Ther 11: 1851-1862, 2011.
3. Borriello A, Cucciolla V, Della Raqione F and Galletti P: Dietary polyphenols: Focus on resveratrol, a promising agent in the prevention of cardiovascular diseases and control of glucose homeostasis. Nutr Metab Cardiovasc Dis 20: 618-625, 2010.
4. Albani D, Polito L and Forloni G: Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence. J Alzheimers Dis 19: 11-26, 2010.
5. Harikumar KB and Aggarwal BB: Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle 7: 1020-1035, 2008.
6. Lin X, Wu G, Huo WQ, Zhang Y and Jin FS: Resveratrol induces apoptosis associated with mitochondrial dysfunction in bladder carcinoma cells. Int J Urol 19: 757-764, 2012.
7. Bai Y, Mao QQ, Qin J, Zheng XY, Wang YB, Yang K, Shen HF and Xie LP: Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo. Cancer Sci, 101: 488-493, 2010.
8. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
9. Winter J, Jung S, Keller S, Gregory RI and Diederich S: Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11: 228-234, 2009.
10. Si ML, Zhu S, Wu H, Lu Z, Wu F and Mo YY: miR-21-mediated tumor growth. Oncogene 26: 2799-2803, 2007. (Pubitemid 46663837)
11. Link A, Becker V, Goel A, Wex T and Malfertheiner P: Feasibility of fecal microRNAs as novel biomarkers for pancreatic cancer. PLoS One 7: e42933, 2012.
12. Buscaglia LE and Li Y: Apoptosis and the target genes of microRNA-21. Chin J Cancer 30: 371-380, 2011.
13. Tili E, Michaille JJ, Alder H, Volinia S, Delmas D, Latruffe N and Croce CM: Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells. Biochem Pharmacol 80: 2057-2065, 2010.
14. Liu P, Liang H, Xia Q, Li P, Kong H, Lei P, Wang S and Tu Z: Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR-21 regulation of BCL-2 expression. Clin Transl Oncol: 15, 741-746, 2013.
15. Tao J, Lu Q, Wu D, Li P, Xu B, Qing W, Wang M, Zhang Z and Zhang W: microRNA-21 modulates cell proliferation and sensitivity to doxorubicin in bladder cancer cells. Oncol Rep 25: 1721-1729, 2011.
16. Ching CB and Hansel DE: Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway. Lab Invest 90: 1406-1414, 2010.
17. Oka N, Tanimoto S, Taue R, Nakatsuji H, Kishimoto T, Izaki H, Fukumori T, Takahashi M, Nishitani M and Kanayama HO: Role of phosphatidylinositol-3 kinase/Akt pathway in bladder cancer cell apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand. Cancer Sci 97: 1093-1098, 2006. (Pubitemid 44322559)
18. Pietenpol JA, Paradopoulos N, Markowitz S, Willson JK, Kinzler KW and Vogelstein B: Paradoxical inhibition of solid tumor cell growth by bcl2. Cancer Res 54: 3714-3717, 1994. (Pubitemid 24241185)
19. Kunze D, Wuttig D, Fuessel S, Kraemer K, Kotzsch M, Meye A, Grimm MO, Hakenberg OW and Wirth MP: Multitarget siRNA inhibition of antiapoptotic genes (XIAP, BCL2, BCL-XL) in bladder cancer cells. Anticancer Res 28: 2259-2263, 2008.
20. Riedl SJ and Shi Y: Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 5: 897-907, 2004. (Pubitemid 39486541)
21. Jung JI, Cho HJ, Kim J, Kwon DY and Park JH: trans-10, cis-12 conjugated linoleic acid inhibits insulin-like growth factor-I receptor signaling in TSU-Pr1 human bladder cancer cells. J Med Food 13: 13-19, 2010.
22. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, et al: Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218-220, 1997. (Pubitemid 127696281)
23. Baur JA and Sinclair DA: Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5: 493-506, 2006. (Pubitemid 44136961)
24. Wang YB, Qin J, Zheng XY, Bai Y, Yang K and Xie LP: Diallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cells. Phytomedicine 17: 363-368, 2010.
25. Shahjee HM, Koch KR, Guo L, Zhang CO and Keay SK: Antiproliferative factor decreases Akt phosphorylation and alters gene expression via CKAP4 in T24 bladder carcinoma cells. J Exp Clin Cancer Res 29: 160, 2010.