Resveratrol induces apoptosis associated with mitochondrial dysfunction in bladder carcinoma cells

International Journal of Urology

Volumn 19, Issue 8, 2012, Pages 757-764

  Lin, Xi ^a   Wu, Gang ^a   Huo, Wen Qian ^a   Zhang, Yao ^a   Jin, Feng Shuo ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bladder carcinoma; Mitochondrial dysfunction; Resveratrol

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 9; CYTOCHROME C; REACTIVE OXYGEN METABOLITE; RESVERATROL;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLADDER CARCINOMA; CARCINOMA CELL; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CYTOCHROMES C; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; REACTIVE OXYGEN SPECIES; STILBENES; URINARY BLADDER NEOPLASMS;

EID: 84864307152     PISSN: 09198172     EISSN: 14422042     Source Type: Journal    
DOI: 10.1111/j.1442-2042.2012.03024.x     Document Type: Article

References (34)

1. Cote RJ, Datar RH. Therapeutic approaches to bladder cancer: identifying targets and mechanisms. Crit. Rev. Oncol. Hematol. 2003; 46: S67-83.
2. Garcia JA, Dreicer R. Systemic chemotherapy for advanced bladder cancer: update and controversies. J. Clin. Oncol. 2006; 24: 5545-51.
3. Fulda S, Debatin KM. Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review. Cancer Detect. Prev. 2006; 30: 217-23.
4. Pervaiz S, Holme AL. Resveratrol: its biologic targets and functional activity. Antioxid. Redox Signal. 2009; 11: 2851-97.
5. Lee KW, Lee HJ. The roles of polyphenols in cancer chemoprevention. Biofactors 2006; 26: 105-21.
6. Sareen D, van Ginkel PR, Takach JC etal. Mitochondria as the primary target of resveratrol-induced apoptosis in human retinoblastoma cells. Invest. Ophthalmol. Vis. Sci. 2006; 47: 3708-16.
7. Sareen D, Darjatmoko SR, Albert DM, Polans AS. Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancer. Mol. Pharmacol. 2007; 72: 1466-75.
8. Van Ginkel PR, Sareen D, Subramanian L etal. Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria. Clin. Cancer Res. 2007; 13: 5162-9.
9. Tinhofer I, Bernhard D, Senfter M etal. Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2. FASEB J. 2001; 15: 1613-5.
10. Zunino SJ, Storms DH. Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore. Cancer Lett. 2006; 240: 123-34.
11. Shankar S, Siddiqui I, Srivastava RK. Molecular mechanisms of resveratrol (3, 4, 5-trihydroxy-trans-stilbene) and its interaction with TNF-related apoptosis inducing ligand (TRAIL) in androgen-insensitive prostate cancer cells. Mol. Cell. Biochem. 2007; 304: 273-85.
12. Sun WM, Wang W, Kim J etal. Anti-cancer effect of resveratrol is associated with induction of apoptosis via a mitochondrial pathway alignment. Adv. Exp. Med. Biol. 2008; 614: 179-86.
13. van Ginkel PR, Darjatmoko SR, Sareen D etal. Resveratrol inhibits uveal melanoma tumor growth via early mitochondrial dysfunction. Invest. Ophthalmol. Vis. Sci. 2008; 49: 1299-306.
14. Alkhalaf M. Resveratrol-induced apoptosis is associated with activation of p53 and inhibition of protein translation in T47D human breast cancer cells. Pharmacology 2007; 80: 134-43.
15. Hadi SM, Asad SF, Singh S, Ahmad A. Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds. IUBMB Life 2000; 50: 167-71.
16. Lowndes SA, Harris AL. Copper chelation as an antiangiogenic therapy. Oncol. Res. 2004; 14: 529-39.
17. Kim AL, Zhu Y, Zhu H etal. Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways. Exp. Dermatol. 2006; 15: 538-46.
18. Fulda S, Debatin KM. Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol. Oncogene 2004; 23: 6702-11.
19. Garg AK, Buchholz TA, Aggarwal BB. Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid. Redox Signal. 2005; 7: 1630-47.
20. Colquhoun A. Mechanisms of action of eicosapentaenoic acid in bladder cancer cells in vitro: alterations in mitochondrial metabolism, reactive oxygen species generation and apoptosis induction. J. Urol. 2009; 181: 1885-93.
21. Fulda S, Galluzzi L, Kroemer G. Targeting mitochondria for cancer therapy. Nat. Rev. Drug Discov. 2010; 9: 447-64.
22. Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria as targets for cancer chemotherapy. Semin. Cancer Biol. 2009; 19: 57-66.
23. Aranha O, Zhu LP, Alhasan S, Wood DP, Kuo TH, Sarkar FH. Role of mitochondria in ciprofloxacin induced apoptosis in bladder cancer cells. J. Urol. 2002; 167: 1288-94.
24. Low ICC, Chen ZX, Pervaiz S. Bcl-2 modulates resveratrol-induced ROS production by regulating mitochondrial respiration in tumor cells. Antioxid. Redox Signal. 2010; 13: 807-19.
25. Zheng JB, Ramirez VD. Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals. Br. J. Pharmacol. 2000; 130: 1115-23.
26. Zini R, Morin C, Bertelli A, Bertelli AAE, Tillement JP. Effects of resveratrol on the rat brain respiratory chain. Drugs Exp. Clin. Res. 1999; 25: 87-97.
27. Choi BS, Alberti DB, Schelman WR etal. Antitumor effects of recombinant human Interleukin-6 on mouse bladder carcinoma through Fas-mediated apoptosis. Cancer Chemother. Pharmacol. 2010; 66: 973-80.
28. Frezza C, Cipolat S, Scorrano L. Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts. Nat. Protoc. 2007; 2: 287-95.
29. Benhar M, Engelberg D, Levitzki A. ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep. 2002; 3: 420-5.
30. Xu SC, He MD, Zhong M etal. Melatonin protects against Nickel-induced neurotoxicity in vitro by reducing oxidative stress and maintaining mitochondrial function. J. Pineal Res. 2010; 49: 86-94.
31. Biasutto L, Mattarei A, Marotta E etal. Development of mitochondria-targeted derivatives of resveratrol. Bioorg. Med. Chem. Lett. 2008; 18: 5594-7.
32. Xu RH, Pelicano H, Zhou Y etal. Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res. 2005; 65: 613-21.
33. Faber AC, Dufort FJ, Blair D, Wagner D, Roberts MF, Chiles TC. Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas. Biochem. Pharmacol. 2006; 72: 1246-56.
34. Kueck A, Opipari AW, Griffith KA etal. Resveratrol inhibits glucose metabolism in human ovarian cancer cells. Gynecol. Oncol. 2007; 107: 450-7.