-
1
-
-
57049148690
-
Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleoside reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects
-
Anderson, M. S., T. N. Kakuda, W. Hanley, J. Miller, J. T. Kost, R. Stoltz, L. A. Wenning, J. A. Stone, R. M. Hoetelmans, J. A. Wagner, and M. Iwamoto. 2008. Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleoside reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects. Antimicrob. Agents Chemother. 52:4228-4232.
-
(2008)
Antimicrob. Agents Chemother
, vol.52
, pp. 4228-4232
-
-
Anderson, M.S.1
Kakuda, T.N.2
Hanley, W.3
Miller, J.4
Kost, J.T.5
Stoltz, R.6
Wenning, L.A.7
Stone, J.A.8
Hoetelmans, R.M.9
Wagner, J.A.10
Iwamoto, M.11
-
2
-
-
0032601403
-
HIV-1 integrase: Structural organization, conformational changes, and catalysis
-
Asante-Appiah, E., and A. M. Skalka. 1999. HIV-1 integrase: structural organization, conformational changes, and catalysis. Adv. Virus Res. 52:351-369.
-
(1999)
Adv. Virus Res
, vol.52
, pp. 351-369
-
-
Asante-Appiah, E.1
Skalka, A.M.2
-
3
-
-
47949114939
-
-
Cooper, D. A., R. T. Steigbigel, J. M. Gatell, J. K. Rockstroh, C. Katlama, P. Yeni, A. Lazzarin, B. Clotet, P. N. Kumar, J. E. Eron, M. Schechter, M. Markowitz, M. R. Loutfy, J. L. Lennox, J. Zhao, J. Chen, D. M. Ryan, R. R. Rhodes, J. A. Killar, L. R. Gilde, K. M. Strohmaier, A. R. Meibohm, M. D. Miller, D. J. Hazuda, M. L. Nessly, M. J. DiNubile, R. D. Isaacs, H. Teppler, B. Y. Nguyen, and the BENCHMRK Study Teams. 2008. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N. Engl. J. Med. 359:355-365.
-
Cooper, D. A., R. T. Steigbigel, J. M. Gatell, J. K. Rockstroh, C. Katlama, P. Yeni, A. Lazzarin, B. Clotet, P. N. Kumar, J. E. Eron, M. Schechter, M. Markowitz, M. R. Loutfy, J. L. Lennox, J. Zhao, J. Chen, D. M. Ryan, R. R. Rhodes, J. A. Killar, L. R. Gilde, K. M. Strohmaier, A. R. Meibohm, M. D. Miller, D. J. Hazuda, M. L. Nessly, M. J. DiNubile, R. D. Isaacs, H. Teppler, B. Y. Nguyen, and the BENCHMRK Study Teams. 2008. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N. Engl. J. Med. 359:355-365.
-
-
-
-
4
-
-
0032601402
-
HIV integrase structure and function
-
Esposito, D., and R. Craigie. 1999. HIV integrase structure and function. Adv. Virus Res. 52:319-333.
-
(1999)
Adv. Virus Res
, vol.52
, pp. 319-333
-
-
Esposito, D.1
Craigie, R.2
-
5
-
-
34147136222
-
-
Grinsztejn, B., B. Y. Nguyen, C. Katlama, J. M. Gatell, A. Lazzarin, D. Vittecoq, C. J. Gonzalez, J. Chen, C. M. Harvey, R. D. Isaacs, and the Protocol 005 Team. 2007. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet 369:1261-1269.
-
Grinsztejn, B., B. Y. Nguyen, C. Katlama, J. M. Gatell, A. Lazzarin, D. Vittecoq, C. J. Gonzalez, J. Chen, C. M. Harvey, R. D. Isaacs, and the Protocol 005 Team. 2007. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet 369:1261-1269.
-
-
-
-
6
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
Hazuda, D. J., P. Felock, M. Witmer, A. Wolfe, K. Stillmock, J. A. Grobler, A. Espeseth, L. Gabryelski, W. Schleif, C. Blau, and M. D. Miller. 2000. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 287:646-650.
-
(2000)
Science
, vol.287
, pp. 646-650
-
-
Hazuda, D.J.1
Felock, P.2
Witmer, M.3
Wolfe, A.4
Stillmock, K.5
Grobler, J.A.6
Espeseth, A.7
Gabryelski, L.8
Schleif, W.9
Blau, C.10
Miller, M.D.11
-
7
-
-
38349182976
-
Lack of a pharmacokinetic effect of raltegravir on midazolam: In vitro/in vivo correlation
-
Iwamoto, M., K. Kassahun, M. D. Troyer, W. D. Hanley, P. Lu, A. Rhoton, A. S. Petry, K. Ghosh, E. Mangin, E. P. DeNoia, L. A. Wenning, J. A. Stone, K. M. Gottesdiener, and J. A. Wagner. 2008. Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation. J. Clin. Pharmacol. 48:209-214.
-
(2008)
J. Clin. Pharmacol
, vol.48
, pp. 209-214
-
-
Iwamoto, M.1
Kassahun, K.2
Troyer, M.D.3
Hanley, W.D.4
Lu, P.5
Rhoton, A.6
Petry, A.S.7
Ghosh, K.8
Mangin, E.9
DeNoia, E.P.10
Wenning, L.A.11
Stone, J.A.12
Gottesdiener, K.M.13
Wagner, J.A.14
-
8
-
-
57049123891
-
Minimal effect of ritonavir and efavirenz on the pharmacokinetics of raltegravir
-
Iwamoto, M., L. A. Wenning, A. S. Petry, T. Laethem, M. De Smet, J. T. Kost, S. A. Breidinger, E. C. Mangin, N. Azrolan, H. E. Greenberg, W. Haazen, J. Stone, K. M. Gottesdiener, and J. A. Wagner. 2008. Minimal effect of ritonavir and efavirenz on the pharmacokinetics of raltegravir. Antimicrob. Agents Chemother. 52:4338-4343.
-
(2008)
Antimicrob. Agents Chemother
, vol.52
, pp. 4338-4343
-
-
Iwamoto, M.1
Wenning, L.A.2
Petry, A.S.3
Laethem, T.4
De Smet, M.5
Kost, J.T.6
Breidinger, S.A.7
Mangin, E.C.8
Azrolan, N.9
Greenberg, H.E.10
Haazen, W.11
Stone, J.12
Gottesdiener, K.M.13
Wagner, J.A.14
-
9
-
-
34548065793
-
Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the HIV-1 integrase enzyme
-
Kassahun, K., I. McIntosh, D. Cui, D. Hreniuk, S. Merschman, K. Lasseter, N. Azrolan, M. Iwamoto, J. A. Wagner, and L. A. Wenning. 2007. Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the HIV-1 integrase enzyme. Drug Metab. Dispos. 35:1657-1663.
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 1657-1663
-
-
Kassahun, K.1
McIntosh, I.2
Cui, D.3
Hreniuk, D.4
Merschman, S.5
Lasseter, K.6
Azrolan, N.7
Iwamoto, M.8
Wagner, J.A.9
Wenning, L.A.10
-
10
-
-
33745603209
-
Tipranavir - a novel nonpeptidic protease inhibitor of HIV
-
King, J., and E. Acosta. 2006. Tipranavir - a novel nonpeptidic protease inhibitor of HIV. Clin. Pharmacokinet. 45:665-682.
-
(2006)
Clin. Pharmacokinet
, vol.45
, pp. 665-682
-
-
King, J.1
Acosta, E.2
-
11
-
-
33845366857
-
Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
-
Markowitz, M., J. O. Morales-Ramirez, B. Y. Nguyen, C. M. Kovacs, R. T. Steigbigel, D. A. Cooper, R. Liporace, R. Schwartz, R. Isaacs, L. R. Gilde, L. Wenning, J. Zhao, and H. Teppler. 2006. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J. Acquir. Immune Defic. Syndr. 43:509-515.
-
(2006)
J. Acquir. Immune Defic. Syndr
, vol.43
, pp. 509-515
-
-
Markowitz, M.1
Morales-Ramirez, J.O.2
Nguyen, B.Y.3
Kovacs, C.M.4
Steigbigel, R.T.5
Cooper, D.A.6
Liporace, R.7
Schwartz, R.8
Isaacs, R.9
Gilde, L.R.10
Wenning, L.11
Zhao, J.12
Teppler, H.13
-
12
-
-
34548384292
-
Determination of the HIV integrase inhibitor, MK-0518 (raltegravir), in human plasma using 96-well liquid-liquid extraction and HPLC-MS/MS
-
Merschman, S. A., P. T. Vallano, L. A. Wenning, B. K. Matuszewski, and E. J. Woolf. 2007. Determination of the HIV integrase inhibitor, MK-0518 (raltegravir), in human plasma using 96-well liquid-liquid extraction and HPLC-MS/MS. J. Chromatogr. B 857:15-19.
-
(2007)
J. Chromatogr. B
, vol.857
, pp. 15-19
-
-
Merschman, S.A.1
Vallano, P.T.2
Wenning, L.A.3
Matuszewski, B.K.4
Woolf, E.J.5
-
13
-
-
47949120697
-
-
Steigbigel, R. T., D. A. Cooper, P. N. Kumar, J. E. Eron, M. Schechter, M. Markowitz, M. R. Loutfy, J. L. Lennox, J. M. Gatell, J. K. Rockstroh, C. Katlama, P. Yeni, A. Lazzarin, B. Clotet, J. Zhao, J. Chen, D. M. Ryan, R. R. Rhodes, J. A. Killar, L. R. Gilde, K. M. Strohmaier, A. R. Meibohm, M. D. Miller, D. J. Hazuda, M. L. Nessly, M. J. DiNubile, R. D. Isaacs, B. Y. Nguyen, H. Teppler, and the BENCHMRK Study Teams. 2008. Raltegravir with optimized background therapy for resistant HIV-1 infection. N. Engl. J. Med. 359:339-354.
-
Steigbigel, R. T., D. A. Cooper, P. N. Kumar, J. E. Eron, M. Schechter, M. Markowitz, M. R. Loutfy, J. L. Lennox, J. M. Gatell, J. K. Rockstroh, C. Katlama, P. Yeni, A. Lazzarin, B. Clotet, J. Zhao, J. Chen, D. M. Ryan, R. R. Rhodes, J. A. Killar, L. R. Gilde, K. M. Strohmaier, A. R. Meibohm, M. D. Miller, D. J. Hazuda, M. L. Nessly, M. J. DiNubile, R. D. Isaacs, B. Y. Nguyen, H. Teppler, and the BENCHMRK Study Teams. 2008. Raltegravir with optimized background therapy for resistant HIV-1 infection. N. Engl. J. Med. 359:339-354.
-
-
-
-
14
-
-
67649909955
-
-
Wenning, L. A., H. Hanley, J. Stone, A. Moreau, J. T. Kost, E. Mangin, T. Shamp, N. Azrolan, K. M. Gottesdiener, J. A. Wagner, and M. Iwamoto. 2006. Effect of tipranavir + ritonavir (tpv + Rtv) on pharmacokinetics of MF-0518, abstr. A-374, p. 20. Abstr. 46th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
-
Wenning, L. A., H. Hanley, J. Stone, A. Moreau, J. T. Kost, E. Mangin, T. Shamp, N. Azrolan, K. M. Gottesdiener, J. A. Wagner, and M. Iwamoto. 2006. Effect of tipranavir + ritonavir (tpv + Rtv) on pharmacokinetics of MF-0518, abstr. A-374, p. 20. Abstr. 46th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
-
-
-
|