Methylated cysteine dioxygenase-1 gene promoter in the serum is a potential biomarker for hepatitis B virus-related hepatocellular carcinoma

Tohoku Journal of Experimental Medicine

Volumn 232, Issue 3, 2014, Pages 187-194

  Yang, Yang ^a,b   Fan, Yu Chen ^a,b   Gao, Shuai ^a   Dou, Cheng Yun ^a   Zhang, Jian Jun ^a   Sun, Feng Kai ^a   Wang, Kai ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Cysteine dioxygenase 1; Hepatitis B virus; Hepatocellular carcinoma; Methylation; fetoprotein

Indexed keywords

ALPHA FETOPROTEIN; GENOMIC DNA;

ADULT; ARTICLE; BLOOD SAMPLING; CANCER STAGING; CDO1 GENE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DNA EXTRACTION; DNA METHYLATION; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PROMOTER REGION; SENSITIVITY AND SPECIFICITY; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

ALPHA-FETOPROTEINS; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; CYSTEINE DIOXYGENASE; DIAGNOSIS, DIFFERENTIAL; DNA METHYLATION; FEMALE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 84896452154     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.232.187     Document Type: Article

References (32)

1. Andresen, K., Boberg, K.M., Vedeld, H.M., Honne, H., Hektoen, M., Wadsworth, C.A., Clausen, O.P., Karlsen, T.H., Foss, A., Mathisen, O., Schrumpf, E., Lothe, R.A. & Lind, G.E. (2012) Novel target genes and a valid biomarker panel identified for cholangiocarcinoma. Epigenetics, 7, 1249-1257.
2. Bossuyt, P.M., Reitsma, J.B., Bruns, D.E., Gatsonis, C.A., Glasziou, P.P., Irwig, L.M., Lijmer, J.G., Moher, D., Rennie, D. & de Vet, H.C.; Standards for Reporting of Diagnostic, Accuracy (2003) Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Standards for Reporting of Diagnostic Accuracy. Clin. Chem., 49, 1-6.
3. Brait, M., Ling, S., Nagpal, J.K., Chang, X., Park, H.L., Lee, J., Okamura, J., Yamashita, K., Sidransky, D. & Kim, M.S. (2012) Cysteine dioxygenase 1 is a tumor suppressor gene silenced by promoter methylation in multiple human cancers. PLoS One, 7, e44951.
4. Bruix, J., Boix, L., Sala, M. & Llovet, J.M. (2004) Focus on hepatocellular carcinoma. Cancer Cell, 5, 215-219.
5. Bruix, J., Sherman, M., Llovet, J.M., Beaugrand, M., Lencioni, R., Burroughs, A.K., Christensen, E., Pagliaro, L., Colombo, M. & Rodes, J.; EASL Panel of Experts on HCC (2001) Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J. Hepatol., 35, 421-430.
6. Bruix, J. & Sherman, M.; Practice Guidelines Committee; American Association for the Study of Liver Diseases (2005) Management of hepatocellular carcinoma. Hepatology, 42, 1208-1236.
7. Dietrich, D., Krispin, M., Dietrich, J., Fassbender, A., Lewin, J., Harbeck, N., Schmitt, M., Eppenberger-Castori, S., Vuaroqueaux, V., Spyratos, F., Foekens, J.A., Lesche, R. & Martens, J.W. (2010) CDO1 promoter methylation is a biomarker for outcome prediction of anthracycline treated, estrogen receptor-positive, lymph node-positive breast cancer patients. BMC Cancer, 10, 247.
8. Edmondson, H.A. & Steiner, P.E. (1954) Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer, 7, 462-503.
9. Fraga, M.F. & Esteller, M. (2002) DNA methylation: a profile of methods and applications. Biotechniques, 33, 632, 634, 636-649.
10. Fukushige, S. & Horii, A. (2013) DNA methylation in cancer: a gene silencing mechanism and the clinical potential of its biomarkers. Tohoku J. Exp. Med., 229, 173-185.
11. Guan, Z., Zhang, J., Song, S. & Dai, D. (2013) Promoter methylation and expression of TIMP3 gene in gastric cancer. Diagn. Pathol., 8, 110.
12. Issa, J.P., Ottaviano, Y.L., Celano, P., Hamilton, S.R., Davidson, N.E. & Baylin, S.B. (1994) Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat. Genet., 7, 536-540.
13. Jahr, S., Hentze, H., Englisch, S., Hardt, D., Fackelmayer, F.O., Hesch, R.D. & Knippers, R. (2001) DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res., 61, 1659-1665.
14. Jeschke, J., O'Hagan, H.M., Zhang, W., Vatapalli, R., Calmon, M.F., Danilova, L., Nelkenbrecher, C., Van Neste, L., Bijsmans, I.T., Van Engeland, M., Gabrielson, E., Schuebel, K.E., Winterpacht, A., Baylin, S.B., Herman, J.G. & Ahuja, N. (2013) Frequent inactivation of cysteine dioxygenase type 1 contributes to survival of breast cancer cells and resistance to anthracyclines. Clin. Cancer Res., 19, 3201-3211.
15. Jung, K., Fleischhacker, M. & Rabien, A. (2010) Cell-free DNA in the blood as a solid tumor biomarker: a critical appraisal of the literature. Clin. Chim. Acta, 411, 1611-1624.
16. Kwon, Y.J., Lee, S.J., Koh, J.S., Kim, S.H., Lee, H.W., Kang, M.C., Bae, J.B., Kim, Y.J. & Park, J.H. (2012) Genome-wide analysis of DNA methylation and the gene expression change in lung cancer. J. Thorac. Oncol., 7, 20-33.
17. Lee, S., Lee, H.J., Kim, J.H., Lee, H.S., Jang, J.J. & Kang, G.H. (2003) Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am. J. Pathol., 163, 1371-1378.
18. Lok, A.S., Sterling, R.K., Everhart, J.E., Wright, E.C., Hoefs, J.C., Di Bisceglie, A.M., Morgan, T.R., Kim, H.Y., Lee, W.M., Bonkovsky, H.L. & Dienstag, J.L.; HALT-C Trial Group (2010) Des-gamma-carboxy prothrombin and alpha-fetoprotein as biomarkers for the early detection of hepatocellular carcinoma. Gastroenterology, 138, 493-502.
19. Nishida, N., Arizumi, T., Takita, M., Nagai, T., Kitai, S., Yada, N., Hagiwara, S., Inoue, T., Minami, Y., Ueshima, K., Sakurai, T., Ida, H. & Kudo, M. (2013) Quantification of tumor DNA in serum and vascular invasion of human hepatocellular carcinoma. Oncology, 84 Suppl 1, 82-87.
20. Nishida, N., Nagasaka, T., Nishimura, T., Ikai, I., Boland, C.R. & Goel, A. (2008) Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology, 47, 908-918.
21. Pugh, R.N., Murray-Lyon, I.M., Dawson, J.L., Pietroni, M.C. & Williams, R. (1973) Transection of the oesophagus for bleeding oesophageal varices. Br. J. Surg., 60, 646-649.
22. Robertson, K.D. (2005) DNA methylation and human disease. Nat. Rev. Genet., 6, 597-610.
23. Satsu, H., Terasawa, E., Hosokawa, Y. & Shimizu, M. (2003) Functional characterization and regulation of the taurine transporter and cysteine dioxygenase in human hepatoblastoma HepG2 cells. Biochem. J., 375, 441-447.
24. Shen, Q., Fan, J., Yang, X.R., Tan, Y., Zhao, W., Xu, Y., Wang, N., Niu, Y., Wu, Z., Zhou, J., Qiu, S.J., Shi, Y.H., Yu, B., Tang, N., Chu, W., et al. (2012) Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study. Lancet Oncol., 13, 817-826.
25. Shivapurkar, N. & Gazdar, A.F. (2010) DNA methylation based biomarkers in non-invasive cancer screening. Curr. Mol. Med., 10, 123-132.
26. Tischoff, I., Hengge, U.R., Vieth, M., Ell, C., Stolte, M., Weber, A., Schmidt, W.E. & Tannapfel, A. (2007) Methylation of SOCS-3 and SOCS-1 in the carcinogenesis of Barrett's adenocarcinoma. Gut, 56, 1047-1053.
27. Tsuboyama-Kasaoka, N., Hosokawa, Y., Kodama, H., Matsumoto, A., Oka, J. & Totani, M. (1999) Human cysteine dioxygenase gene: structural organization, tissue-specific expression and downregulation by phorbol 12-myristate 13-acetate. Biosci. Biotechnol. Biochem., 63, 1017-1024.
28. Um, T.H., Kim, H., Oh, B.K., Kim, M.S., Kim, K.S., Jung, G. & Park, Y.N. (2011) Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis. J. Hepatol., 54, 939-947.
29. Venook, A.P., Papandreou, C., Furuse, J. & de Guevara, L.L. (2010) The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective. Oncologist, 15 Suppl 4, 5-13.
30. Wang, J., Qin, Y., Li, B., Sun, Z. & Yang, B. (2006) Detection of aberrant promoter methylation of GSTP1 in the tumor and serum of Chinese human primary hepatocellular carcinoma patients. Clin. Biochem., 39, 344-348.
31. Zhang, Y.J., Wu, H.C., Shen, J., Ahsan, H., Tsai, W.Y., Yang, H.I., Wang, L.Y., Chen, S.Y., Chen, C.J. & Santella, R.M. (2007) Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA. Clin. Cancer Res., 13, 2378-2384.
32. Zheng, Y., Wang, R., Song, H.Z., Pan, B.Z., Zhang, Y.W. & Chen, L.B. (2013) Epigenetic downregulation of RUNX3 by DNA methylation induces docetaxel chemoresistance in human lung adenocarcinoma cells by activation of the AKT pathway. Int. J. Biochem. Cell Biol., 45, 2369-2378.