Epigenetic downregulation of RUNX3 by DNA methylation induces docetaxel chemoresistance in human lung adenocarcinoma cells by activation of the AKT pathway

International Journal of Biochemistry and Cell Biology

Volumn 45, Issue 11, 2013, Pages 2369-2378

  Zheng, Yun ^a   Wang, Rui ^b   Song, Hai Zhu ^b   Pan, Ban Zhou ^b   Zhang, You Wei ^b   Chen, Long Bang ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

AKT; Chemoresistance; DNA methylation; Docetaxel; RUNX3

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; BETA CATENIN; DOCETAXEL; PROTEIN KINASE B; TRANSCRIPTION FACTOR RUNX3; RUNX3 PROTEIN, HUMAN; TAXOID;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHEMOSENSITIVITY; COLONY FORMATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; G1 PHASE CELL CYCLE CHECKPOINT; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; UPREGULATION; ADENOCARCINOMA; ANIMAL; CELL CYCLE; DRUG EFFECTS; DRUG RESISTANCE; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; LUNG NEOPLASMS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PATHOLOGY; PROGNOSIS; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CORE BINDING FACTOR ALPHA 3 SUBUNIT; DNA METHYLATION; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TAXOIDS;

EID: 84883539367     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2013.07.013     Document Type: Article

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