Inhibition of LXRα signaling by vitamin D receptor: Possible role of VDR in bile acid synthesis

Biochemical and Biophysical Research Communications

Volumn 351, Issue 1, 2006, Pages 176-184

  Jiang, Wei ^b   Miyamoto, Takahide ^a   Kakizawa, Tomoko ^a   Nishio, Shin ich ^a   Oiwa, Ako ^a   Takeda, Teiji ^a   Suzuki, Satoru ^a   Hashizume, Kiyoshi ^a  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

1,25 (OH)2D3; Bile acid; Cholesterol 7 hydroxylase; Liver X receptor; Vitamin D receptor

Indexed keywords

BILE ACID; CALCITRIOL; CHOLESTEROL 7ALPHA MONOOXYGENASE; LIVER X RECEPTOR ALPHA; MESSENGER RNA; VITAMIN D RECEPTOR; 1,25 DIHYDROXY 23 AZAVITAMIN D3; 1,25-DIHYDROXY-23-AZAVITAMIN D3; CALCITRIOL RECEPTOR; CELL RECEPTOR; DNA BINDING PROTEIN; DRUG DERIVATIVE; LIVER X RECEPTOR;

ANIMAL CELL; ARTICLE; BILE ACID SYNTHESIS; CONTROLLED STUDY; DNA BINDING MOTIF; GENE ACTIVITY; GENE DELETION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; RAT; REGULATORY MECHANISM; REPORTER GENE; ANIMAL; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; DRUG EFFECT; LIVER CELL CARCINOMA; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BILE ACIDS AND SALTS; CALCITRIOL; CARCINOMA, HEPATOCELLULAR; CELL LINE; CERCOPITHECUS AETHIOPS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; COS CELLS; DNA-BINDING PROTEINS; HUMANS; RATS; RECEPTORS, CALCITRIOL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION;

EID: 33750344127     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.10.027     Document Type: Article

References (28)

1. Fitzgerald M.L., Moore K.J., and Freeman M.W. Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home. J. Mol. Med. 80 (2002) 271-281
2. Chiang J.Y. Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr. Rev. 23 (2002) 443-463
3. Kitada H., Miyata M., Nakamura T., Tozawa A., Honma W., Shimada M., Nagata K., Sinal C.J., Guo G.L., Gonzalez F.J., and Yamazoe Y. Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity. J. Biol. Chem. 278 (2003) 17838-17844
4. Makishima M., Okamoto A.Y., Repa J.J., Tu H., Learned R.M., Luk A., Hull M.V., Lustig K.D., Mangelsdorf D.J., and Shan B. Identification of a nuclear receptor for bile acids. Science 284 (1999) 1362-1365
5. Lehmann J.M., Kliewer S.A., Moore L.B., Smith-Oliver T.A., Oliver B.B., Su J.L., Sundseth S.S., Winegar D.A., Blanchard D.E., Spencer T.A., and Willson T.M. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272 (1997) 3137-3140
6. Wagner B.L., Valledor A.F., Shao G., Daige C.L., Bischoff E.D., Petrowski M., Jepsen K., Baek S.H., Heyman R.A., Rosenfeld M.G., Schulman I.G., and Glass C.K. Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Mol. Cell Biol. 23 (2003) 5780-5789
7. Peet D.J., Turley S.D., Ma W., Janowski B.A., Lobaccaro J.M., Hammer R.E., and Mangelsdorf D.J. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93 (1998) 693-704
8. Sinal C.J., Tohkin M., Miyata M., Ward J.M., Lambert G., and Gonzalez F.J. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102 (2000) 731-744
9. Goodwin B., Jones S.A., Price R.R., Watson M.A., McKee D.D., Moore L.B., Galardi C., Wilson J.G., Lewis M.C., Roth M.E., Maloney P.R., Willson T.M., and Kliewer S.A. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol. Cell 6 (2000) 517-526
10. Seol W., Choi H.S., and Moore D.D. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science 272 (1996) 1336-1339
11. Nitta M., Ku S., Brown C., Okamoto A.Y., and Shan B. CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene. Proc. Natl. Acad. Sci. USA 96 (1999) 6660-6665
12. Lu T.T., Makishima M., Repa J.J., Schoonjans K., Kerr T.A., Auwerx J., and Mangelsdorf D.J. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol. Cell 6 (2000) 507-515
13. Wang L., Lee Y.K., Bundman D., Han Y., Thevananther S., Kim C.S., Chua S.S., Wei P., Heyman R.A., Karin M., and Moore D.D. Redundant pathways for negative feedback regulation of bile acid production. Dev. Cell 2 (2002) 721-731
14. Kerr T.A., Saeki S., Schneider M., Schaefer K., Berdy S., Redder T., Shan B., Russell D.W., and Schwarz M. Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev. Cell 2 (2002) 713-720
15. Abrahamsson A., Gustafsson U., Ellis E., Nilsson L.M., Sahlin S., Bjorkhem I., and Einarsson C. Feedback regulation of bile acid synthesis in human liver: importance of HNF-4alpha for regulation of CYP7A1. Biochem. Biophys. Res. Commun. 330 (2005) 395-399
16. Kato S., Yoshizazawa T., Kitanaka S., Murayama A., and Takeyama K. Molecular genetics of vitamin D-dependent hereditary rickets. Horm. Res. 57 (2002) 73-78
17. Makishima M., Lu T.T., Xie W., Whitfield G.K., Domoto H., Evans R.M., Haussler M.R., and Mangelsdorf D.J. Vitamin D receptor as an intestinal bile acid sensor. Science 296 (2002) 1313-1316
18. Adachi R., Honma Y., Masuno H., Kawana K., Shimomura I., Yamada S., and Makishima M. Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative. J. Lipid Res. 46 (2005) 46-57
19. Sakuma T., Miyamoto T., Jiang W., Kakizawa T., Nishio S.I., Suzuki S., Takeda T., Oiwa A., and Hashizume K. Inhibition of peroxisome proliferator-activated receptor alpha signaling by vitamin D receptor. Biochem. Biophys. Res. Commun. 312 (2003) 513-519
20. Kakizawa T., Miyamoto T., Ichikawa K., Takeda T., Suzuki S., Mori J., Kumagai M., Yamashita K., and Hashizume K. Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor. J. Biol. Chem. 276 (2001) 9720-9725
21. Holt J.A., Luo G., Billin A.N., Bisi J., McNeill Y.Y., Kozarsky K.F., Donahee M., Wang da Y., Mansfield T.A., Kliewer S.A., Goodwin B., and Jones S.A. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev. 17 (2003) 1581-1591
22. Willy P.J., Umesono K., Ong E.S., Evans R.M., Heyman R.A., and Mangelsdorf D.J. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9 (1995) 1033-1045
23. Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., Jones S.A., Goodwin B., Richardson J.A., Gerard R.D., Repa J.J., Mangelsdorf D.J., and Kliewer S.A. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab. 2 (2005) 217-225
24. Juge-Aubry C.E., Gorla-Bajszczak A., Pernin A., Lemberger T., Wahli W., Burger A.G., and Meier C.A. Peroxisome proliferator-activated receptor mediates cross-talk with thyroid hormone receptor by competition for retinoid X receptor. Possible role of a leucine zipper-like heptad repeat. J. Biol. Chem. 270 (1995) 18117-18122
25. Miyamoto T., Kakizawa T., Ichikawa K., Nishio S., Takeda T., Suzuki S., Kaneko A., Kumagai M., Mori J., Yamashita K., Sakuma T., and Hashizume K. The role of hinge domain in heterodimerization and specific DNA recognition by nuclear receptors. Mol. Cell Endocrinol. 181 (2001) 229-238
26. Guo G.L., Lambert G., Negishi M., Ward J.M., Brewer Jr. H.B., Kliewer S.A., Gonzalez F.J., and Sinal C.J. Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J. Biol. Chem. 278 (2003) 45062-45071
27. Drocourt L., Ourlin J.C., Pascussi J.M., Maurel P., and Vilarem M.J. Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J. Biol. Chem. 277 (2002) 25125-25132
28. Whitfield G.K., Dang H.T., Schluter S.F., Bernstein R.M., Bunag T., Manzon L.A., Hsieh G., Dominguez C.E., Youson J.H., Haussler M.R., and Marchalonis J.J. Cloning of a functional vitamin D receptor from the lamprey (Petromyzon marinus), an ancient vertebrate lacking a calcified skeleton and teeth. Endocrinology 144 (2003) 2704-2716