메뉴 건너뛰기




Volumn 16, Issue 4, 2014, Pages 473-481

Hsp90-dependent regulatory circuitry controlling temperature-dependent fungal development and virulence

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CYCLIC AMP; CYCLIN DEPENDENT KINASE; FUNGAL PROTEIN; G PROTEIN COUPLED RECEPTOR; HEAT SHOCK PROTEIN 90; PROTEIN TYROSINE PHOSPHATASE;

EID: 84896400831     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/cmi.12266     Document Type: Review
Times cited : (36)

References (72)
  • 1
    • 45849118012 scopus 로고    scopus 로고
    • Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling
    • Alaamery, M.A., and Hoffman, C.S. (2008) Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling. Genetics 178: 1927-1936.
    • (2008) Genetics , vol.178 , pp. 1927-1936
    • Alaamery, M.A.1    Hoffman, C.S.2
  • 2
    • 23744469420 scopus 로고    scopus 로고
    • Cell cycle arrest during S or M phase generates polarized growth via distinct signals in Candida albicans
    • Bachewich, C., Nantel, A., and Whiteway, M. (2005) Cell cycle arrest during S or M phase generates polarized growth via distinct signals in Candida albicans. Mol Microbiol 57: 942-959.
    • (2005) Mol Microbiol , vol.57 , pp. 942-959
    • Bachewich, C.1    Nantel, A.2    Whiteway, M.3
  • 3
    • 33745625877 scopus 로고    scopus 로고
    • Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain
    • Bader, T., Schroppel, K., Bentink, S., Agabian, N., Kohler, G., and Morschhauser, J. (2006) Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain. Infect Immun 74: 4366-4369.
    • (2006) Infect Immun , vol.74 , pp. 4366-4369
    • Bader, T.1    Schroppel, K.2    Bentink, S.3    Agabian, N.4    Kohler, G.5    Morschhauser, J.6
  • 5
    • 33751331633 scopus 로고    scopus 로고
    • Morphogenesis and cell cycle progression in Candida albicans
    • Berman, J. (2006) Morphogenesis and cell cycle progression in Candida albicans. Curr Opin Microbiol 9: 595-601.
    • (2006) Curr Opin Microbiol , vol.9 , pp. 595-601
    • Berman, J.1
  • 6
    • 23944511215 scopus 로고    scopus 로고
    • Calcineurin is required for Candida albicans to survive calcium stress in serum
    • Blankenship, J.R., and Heitman, J. (2005) Calcineurin is required for Candida albicans to survive calcium stress in serum. Infect Immun 73: 5767-5774.
    • (2005) Infect Immun , vol.73 , pp. 5767-5774
    • Blankenship, J.R.1    Heitman, J.2
  • 7
    • 0034013217 scopus 로고    scopus 로고
    • TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans
    • Braun, B.R., and Johnson, A.D. (2000) TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans. Genetics 155: 57-67.
    • (2000) Genetics , vol.155 , pp. 57-67
    • Braun, B.R.1    Johnson, A.D.2
  • 8
    • 79957942182 scopus 로고    scopus 로고
    • Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis
    • Chen, Y.-L., Brand, A., Morrison, E.L., Silao, F.G.S., Bigol, U.G., Malbas, F.F., etal. (2011) Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis. Eukaryot Cell 10: 803-819.
    • (2011) Eukaryot Cell , vol.10 , pp. 803-819
    • Chen, Y.-L.1    Brand, A.2    Morrison, E.L.3    Silao, F.G.S.4    Bigol, U.G.5    Malbas, F.F.6
  • 9
    • 84883416226 scopus 로고    scopus 로고
    • Convergent evolution of calcineurin pathway roles in thermotolerance and virulence in Candida glabrata
    • Chen, Y.-L., Konieczka, J.H., Springer, D.J., Bowen, S.E., Zhang, J., Silao, F.G.S., etal. (2012) Convergent evolution of calcineurin pathway roles in thermotolerance and virulence in Candida glabrata. G3 (Bethesda) 2: 675-691.
    • (2012) G3 (Bethesda) , vol.2 , pp. 675-691
    • Chen, Y.-L.1    Konieczka, J.H.2    Springer, D.J.3    Bowen, S.E.4    Zhang, J.5    Silao, F.G.S.6
  • 10
    • 84883250066 scopus 로고    scopus 로고
    • Calcineurin governs thermotolerance and virulence of Cryptococcus gattii
    • Chen, Y.-L., Lehman, V.N., Lewit, Y., Averette, A.F., and Heitman, J. (2013) Calcineurin governs thermotolerance and virulence of Cryptococcus gattii. G3 (Bethesda) 3: 527-539.
    • (2013) G3 (Bethesda) , vol.3 , pp. 527-539
    • Chen, Y.-L.1    Lehman, V.N.2    Lewit, Y.3    Averette, A.F.4    Heitman, J.5
  • 11
    • 25844530060 scopus 로고    scopus 로고
    • Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi
    • Cowen, L.E., and Lindquist, S. (2005) Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 309: 2185-2189.
    • (2005) Science , vol.309 , pp. 2185-2189
    • Cowen, L.E.1    Lindquist, S.2
  • 13
    • 47049104386 scopus 로고    scopus 로고
    • Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus
    • Cramer, R.A., Perfect, B.Z., Pinchai, N., Park, S., Perlin, D.S., Asfaw, Y.G., etal. (2008) Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryot Cell 7: 1085-1097.
    • (2008) Eukaryot Cell , vol.7 , pp. 1085-1097
    • Cramer, R.A.1    Perfect, B.Z.2    Pinchai, N.3    Park, S.4    Perlin, D.S.5    Asfaw, Y.G.6
  • 14
    • 0035282771 scopus 로고    scopus 로고
    • Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans
    • Cruz, M.C., Fox, D.S., and Heitman, J. (2001) Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. EMBO J 20: 1020-1032.
    • (2001) EMBO J , vol.20 , pp. 1020-1032
    • Cruz, M.C.1    Fox, D.S.2    Heitman, J.3
  • 15
    • 0036692080 scopus 로고    scopus 로고
    • Sgt1p contributes to cyclic AMP pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast
    • Dubacq, C., Guerois, R.L., Courbeyrette, R.G., Kitagawa, K., and Mann, C. (2002) Sgt1p contributes to cyclic AMP pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast. Eukaryot Cell 1: 568-582.
    • (2002) Eukaryot Cell , vol.1 , pp. 568-582
    • Dubacq, C.1    Guerois, R.L.2    Courbeyrette, R.G.3    Kitagawa, K.4    Mann, C.5
  • 16
    • 20544457473 scopus 로고    scopus 로고
    • Toxoplasma gondii Hsp90 is a potential drug target whose expression and subcellular localization are developmentally regulated
    • Echeverria, P.C., Matrajt, M., Harb, O.S., Zappia, M.P., Costas, M.A., Roos, D.S., etal. (2005) Toxoplasma gondii Hsp90 is a potential drug target whose expression and subcellular localization are developmentally regulated. J Mol Biol 350: 723-734.
    • (2005) J Mol Biol , vol.350 , pp. 723-734
    • Echeverria, P.C.1    Matrajt, M.2    Harb, O.S.3    Zappia, M.P.4    Costas, M.A.5    Roos, D.S.6
  • 17
    • 79961103495 scopus 로고    scopus 로고
    • Discovery of a role for Hsp82 in Histoplasma virulence through a quantitative screen for macrophage lethality
    • Edwards, J.A., Zemska, O., and Rappleye, C.A. (2011) Discovery of a role for Hsp82 in Histoplasma virulence through a quantitative screen for macrophage lethality. Infect Immun 79: 3348-3357.
    • (2011) Infect Immun , vol.79 , pp. 3348-3357
    • Edwards, J.A.1    Zemska, O.2    Rappleye, C.A.3
  • 18
    • 0034116761 scopus 로고    scopus 로고
    • Dominant active alleles of RIM101(PRR2) bypass the pH restriction on filamentation of Candida albicans
    • El Barkani, A., Kurzai, O., Fonzi, W.A., Ramon, A., Porta, A., Frosch, M., and Muhlschlegel, F.A. (2000) Dominant active alleles of RIM101(PRR2) bypass the pH restriction on filamentation of Candida albicans. Mol Cell Biol 20: 4635-4647.
    • (2000) Mol Cell Biol , vol.20 , pp. 4635-4647
    • El Barkani, A.1    Kurzai, O.2    Fonzi, W.A.3    Ramon, A.4    Porta, A.5    Frosch, M.6    Muhlschlegel, F.A.7
  • 19
    • 0033974108 scopus 로고    scopus 로고
    • Cdc37 promotes the stability of protein kinases Cdc28 and Cak1
    • Farrell, A., and Morgan, D.O. (2000) Cdc37 promotes the stability of protein kinases Cdc28 and Cak1. Mol Cell Biol 20: 749-754.
    • (2000) Mol Cell Biol , vol.20 , pp. 749-754
    • Farrell, A.1    Morgan, D.O.2
  • 20
    • 84863719776 scopus 로고    scopus 로고
    • Identification of an Hsp90 mutation that selectively disrupts cAMP/PKA signaling in Saccharomyces cerevisiae
    • Flom, G., Langner, E., and Johnson, J. (2012) Identification of an Hsp90 mutation that selectively disrupts cAMP/PKA signaling in Saccharomyces cerevisiae. Curr Genet 58: 149-163.
    • (2012) Curr Genet , vol.58 , pp. 149-163
    • Flom, G.1    Langner, E.2    Johnson, J.3
  • 21
    • 79551670802 scopus 로고    scopus 로고
    • Divergent protein kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus
    • Fuller, K.K., Richie, D.L., Feng, X., Krishnan, K., Stephens, T.J., Wikenheiser-Brokamp, K.A., etal. (2011) Divergent protein kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus. Mol Microbiol 79: 1045-1062.
    • (2011) Mol Microbiol , vol.79 , pp. 1045-1062
    • Fuller, K.K.1    Richie, D.L.2    Feng, X.3    Krishnan, K.4    Stephens, T.J.5    Wikenheiser-Brokamp, K.A.6
  • 22
    • 67651205627 scopus 로고    scopus 로고
    • Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans
    • Giles, S.S., Dagenais, T.R.T., Botts, M.R., Keller, N.P., and Hull, C.M. (2009) Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans. Infect Immun 77: 3491-3500.
    • (2009) Infect Immun , vol.77 , pp. 3491-3500
    • Giles, S.S.1    Dagenais, T.R.T.2    Botts, M.R.3    Keller, N.P.4    Hull, C.M.5
  • 25
    • 66949118944 scopus 로고    scopus 로고
    • Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry
    • Horn, D.L., Neofytos, D., Anaissie, E.J., Fishman, J.A., Steinbach, W.J., Olyaei, A.J., etal. (2009) Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry. Clin Infect Dis 48: 1695-1703.
    • (2009) Clin Infect Dis , vol.48 , pp. 1695-1703
    • Horn, D.L.1    Neofytos, D.2    Anaissie, E.J.3    Fishman, J.A.4    Steinbach, W.J.5    Olyaei, A.J.6
  • 26
    • 50049125079 scopus 로고    scopus 로고
    • Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection
    • Hu, G., Cheng, P.-Y., Sham, A., Perfect, J.R., and Kronstad, J.W. (2008) Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection. Mol Microbiol 69: 1456-1475.
    • (2008) Mol Microbiol , vol.69 , pp. 1456-1475
    • Hu, G.1    Cheng, P.-Y.2    Sham, A.3    Perfect, J.R.4    Kronstad, J.W.5
  • 27
    • 0034458959 scopus 로고    scopus 로고
    • Role of HSP90 in salt stress tolerance via stabilization and regulation of calcineurin
    • Imai, J., and Yahara, I. (2000) Role of HSP90 in salt stress tolerance via stabilization and regulation of calcineurin. Mol Cell Biol 20: 9262-9270.
    • (2000) Mol Cell Biol , vol.20 , pp. 9262-9270
    • Imai, J.1    Yahara, I.2
  • 28
    • 33846181647 scopus 로고    scopus 로고
    • Nucleotide-dependent interaction of Saccharomyces cerevisiae Hsp90 with the cochaperone proteins Sti1, Cpr6, and Sba1
    • Johnson, J.L., Halas, A., and Flom, G. (2007) Nucleotide-dependent interaction of Saccharomyces cerevisiae Hsp90 with the cochaperone proteins Sti1, Cpr6, and Sba1. Mol Cell Biol 27: 768-776.
    • (2007) Mol Cell Biol , vol.27 , pp. 768-776
    • Johnson, J.L.1    Halas, A.2    Flom, G.3
  • 29
    • 21144444486 scopus 로고    scopus 로고
    • HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
    • Kovacs, J.J., Murphy, P.J.M., Gaillard, S., Zhao, X., Wu, J.-T., Nicchitta, C.V., etal. (2005) HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell 18: 601-607.
    • (2005) Mol Cell , vol.18 , pp. 601-607
    • Kovacs, J.J.1    Murphy, P.J.M.2    Gaillard, S.3    Zhao, X.4    Wu, J.-T.5    Nicchitta, C.V.6
  • 30
    • 80053439003 scopus 로고    scopus 로고
    • Association of Calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics
    • Kozubowski, L., Thompson, J.W., Cardenas, M.E., Moseley, M.A., and Heitman, J. (2011) Association of Calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics. PLoS ONE 6: e25280.
    • (2011) PLoS ONE , vol.6
    • Kozubowski, L.1    Thompson, J.W.2    Cardenas, M.E.3    Moseley, M.A.4    Heitman, J.5
  • 31
    • 0242690174 scopus 로고    scopus 로고
    • Coping with stress: calmodulin and calcineurin in model and pathogenic fungi
    • Kraus, P.R., and Heitman, J. (2003) Coping with stress: calmodulin and calcineurin in model and pathogenic fungi. Biochem Biophys Res Commun 311: 1151-1157.
    • (2003) Biochem Biophys Res Commun , vol.311 , pp. 1151-1157
    • Kraus, P.R.1    Heitman, J.2
  • 32
    • 84868130707 scopus 로고    scopus 로고
    • Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus
    • Lamoth, F., Juvvadi, P.R., Fortwendel, J.R., and Steinbach, W.J. (2012) Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus. Eukaryot Cell 11: 1324-1332.
    • (2012) Eukaryot Cell , vol.11 , pp. 1324-1332
    • Lamoth, F.1    Juvvadi, P.R.2    Fortwendel, J.R.3    Steinbach, W.J.4
  • 33
    • 84892648838 scopus 로고    scopus 로고
    • Transcriptional activation of Heat Shock Protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus
    • doi:10.1093/infdis/jit530
    • Lamoth, F., Juvvadi, P.R., Gehrke, C., Asfaw, Y.G., and Steinbach, W.J. (2013) Transcriptional activation of Heat Shock Protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus. J Infect Dis. doi:10.1093/infdis/jit530
    • (2013) J Infect Dis
    • Lamoth, F.1    Juvvadi, P.R.2    Gehrke, C.3    Asfaw, Y.G.4    Steinbach, W.J.5
  • 34
    • 0034811675 scopus 로고    scopus 로고
    • The basic helix-loop-helix transcription factor Cph2 regulates hyphal development in Candida albicans partly via Tec1
    • Lane, S., Zhou, S., Pan, T., Dai, Q., and Liu, H. (2001) The basic helix-loop-helix transcription factor Cph2 regulates hyphal development in Candida albicans partly via Tec1. Mol Cell Biol 21: 6418-6428.
    • (2001) Mol Cell Biol , vol.21 , pp. 6418-6428
    • Lane, S.1    Zhou, S.2    Pan, T.3    Dai, Q.4    Liu, H.5
  • 35
    • 0035423126 scopus 로고    scopus 로고
    • The pathobiology of Aspergillus fumigatus
    • Latge, J.-P. (2001) The pathobiology of Aspergillus fumigatus. Trends Microbiol 9: 382-389.
    • (2001) Trends Microbiol , vol.9 , pp. 382-389
    • Latge, J.-P.1
  • 36
    • 84858665548 scopus 로고    scopus 로고
    • Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans
    • Leach, M.D., Tyc, K.M., Brown, A.J.P., and Klipp, E. (2012) Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans. PLoS ONE 7: e32467.
    • (2012) PLoS ONE , vol.7
    • Leach, M.D.1    Tyc, K.M.2    Brown, A.J.P.3    Klipp, E.4
  • 37
    • 27144478905 scopus 로고    scopus 로고
    • Divergence of Stp1 and Stp2 transcription factors in Candida albicans places virulence factors required for proper nutrient acquisition under amino acid control
    • Martinez, P., and Ljungdahl, P.O. (2005) Divergence of Stp1 and Stp2 transcription factors in Candida albicans places virulence factors required for proper nutrient acquisition under amino acid control. Mol Cell Biol 25: 9435-9446.
    • (2005) Mol Cell Biol , vol.25 , pp. 9435-9446
    • Martinez, P.1    Ljungdahl, P.O.2
  • 38
    • 84876273797 scopus 로고    scopus 로고
    • Hsp90 regulates Paracoccidioides brasiliensis proliferation and ROS levels under thermal stress and cooperates with calcineurin to control yeast to mycelium dimorphism
    • Matos, T.G.F., Morais, F.V., and Campos, C.B.L. (2013) Hsp90 regulates Paracoccidioides brasiliensis proliferation and ROS levels under thermal stress and cooperates with calcineurin to control yeast to mycelium dimorphism. Med Mycol 51: 413-421.
    • (2013) Med Mycol , vol.51 , pp. 413-421
    • Matos, T.G.F.1    Morais, F.V.2    Campos, C.B.L.3
  • 40
    • 0026582040 scopus 로고
    • Molecular cloning and expression of hsp82 gene of the dimorphic pathogenic fungus Histoplasma capsulatum
    • Minchiotti, G., Gargano, S., and Maresca, B. (1992) Molecular cloning and expression of hsp82 gene of the dimorphic pathogenic fungus Histoplasma capsulatum. Biochim Biophys Acta 1131: 103-107.
    • (1992) Biochim Biophys Acta , vol.1131 , pp. 103-107
    • Minchiotti, G.1    Gargano, S.2    Maresca, B.3
  • 41
    • 0032241050 scopus 로고    scopus 로고
    • Dimorphism and virulence in Candida albicans
    • Mitchell, A.P. (1998) Dimorphism and virulence in Candida albicans. Curr Opin Microbiol 1: 687-692.
    • (1998) Curr Opin Microbiol , vol.1 , pp. 687-692
    • Mitchell, A.P.1
  • 42
    • 0033628520 scopus 로고    scopus 로고
    • Functions of Pho85 cyclin-dependent kinases in budding yeast
    • Moffat, J., Huang, D., and Andrews, B. (2000) Functions of Pho85 cyclin-dependent kinases in budding yeast. Prog Cell Cycle Res 4: 97-106.
    • (2000) Prog Cell Cycle Res , vol.4 , pp. 97-106
    • Moffat, J.1    Huang, D.2    Andrews, B.3
  • 43
    • 52949145211 scopus 로고    scopus 로고
    • The stress responsive and morphologically regulated hsp90 gene from Paracoccidioides brasiliensis is essential to cell viability
    • Nicola, A., Andrade, R., Dantas, A., Andrade, P., Arraes, F., Fernandes, L., etal. (2008) The stress responsive and morphologically regulated hsp90 gene from Paracoccidioides brasiliensis is essential to cell viability. BMC Microbiol 8: 158.
    • (2008) BMC Microbiol , vol.8 , pp. 158
    • Nicola, A.1    Andrade, R.2    Dantas, A.3    Andrade, P.4    Arraes, F.5    Fernandes, L.6
  • 44
    • 0031008864 scopus 로고    scopus 로고
    • Calcineurin is required for virulence of Cryptococcus neoformans
    • Odom, A., Muir, S., Lim, E., Toffaletti, D.L., Perfect, J., and Heitman, J. (1997) Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J 16: 2576-2589.
    • (1997) EMBO J , vol.16 , pp. 2576-2589
    • Odom, A.1    Muir, S.2    Lim, E.3    Toffaletti, D.L.4    Perfect, J.5    Heitman, J.6
  • 45
    • 84861683800 scopus 로고    scopus 로고
    • Titan cells confer protection from phagocytosis in Cryptococcus neoformans infections
    • Okagaki, L.H., and Nielsen, K. (2012) Titan cells confer protection from phagocytosis in Cryptococcus neoformans infections. Eukaryot Cell 11: 820-826.
    • (2012) Eukaryot Cell , vol.11 , pp. 820-826
    • Okagaki, L.H.1    Nielsen, K.2
  • 47
    • 80053441636 scopus 로고    scopus 로고
    • Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli
    • Okagaki, L.H., Wang, Y., Ballou, E.R., O'Meara, T.R., Bahn, Y.-S., Alspaugh, J.A., etal. (2011) Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli. Eukaryot Cell 10: 1306-1316.
    • (2011) Eukaryot Cell , vol.10 , pp. 1306-1316
    • Okagaki, L.H.1    Wang, Y.2    Ballou, E.R.3    O'Meara, T.R.4    Bahn, Y.-S.5    Alspaugh, J.A.6
  • 48
    • 84874614624 scopus 로고    scopus 로고
    • Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses
    • pii: e00522-12. doi:10.1128/mBio.00522-12
    • O'Meara, T.R., Holmer, S.M., Selvig, K., Dietrich, F., and Alspaugh, J.A. (2013) Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses. MBio 4. pii: e00522-12. doi:10.1128/mBio.00522-12
    • (2013) MBio , vol.4
    • O'Meara, T.R.1    Holmer, S.M.2    Selvig, K.3    Dietrich, F.4    Alspaugh, J.A.5
  • 49
    • 62349130224 scopus 로고    scopus 로고
    • Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS
    • Park, B.J., Wannemuehler, K.A., Marston, B.J., Govender, N., Pappas, P.G., and Chiller, T.M. (2009) Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23: 525-530.
    • (2009) AIDS , vol.23 , pp. 525-530
    • Park, B.J.1    Wannemuehler, K.A.2    Marston, B.J.3    Govender, N.4    Pappas, P.G.5    Chiller, T.M.6
  • 50
    • 84875478111 scopus 로고    scopus 로고
    • Candida albicans commensalism and pathogenicity are intertwined traits directed by a tightly knit transcriptional regulatory circuit
    • Perez, J.C., Kumamoto, C.A., and Johnson, A.D. (2013) Candida albicans commensalism and pathogenicity are intertwined traits directed by a tightly knit transcriptional regulatory circuit. PLoS Biol 11: e1001510.
    • (2013) PLoS Biol , vol.11
    • Perez, J.C.1    Kumamoto, C.A.2    Johnson, A.D.3
  • 51
    • 84868125083 scopus 로고    scopus 로고
    • Lysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance
    • Robbins, N., Leach, M.D., and Cowen, L.E. (2012) Lysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance. Cell Rep 2: 878-888.
    • (2012) Cell Rep , vol.2 , pp. 878-888
    • Robbins, N.1    Leach, M.D.2    Cowen, L.E.3
  • 52
    • 70449723683 scopus 로고    scopus 로고
    • Vertebrate endothermy restricts most fungi as potential pathogens
    • Robert, V.A., and Casadevall, A. (2009) Vertebrate endothermy restricts most fungi as potential pathogens. J Infect Dis 200: 1623-1626.
    • (2009) J Infect Dis , vol.200 , pp. 1623-1626
    • Robert, V.A.1    Casadevall, A.2
  • 53
    • 77956799388 scopus 로고    scopus 로고
    • Adaptations of Candida albicans for growth in the mammalian intestinal tract
    • Rosenbach, A., Dignard, D., Pierce, J.V., Whiteway, M., and Kumamoto, C.A. (2010) Adaptations of Candida albicans for growth in the mammalian intestinal tract. Eukaryot Cell 9: 1075-1086.
    • (2010) Eukaryot Cell , vol.9 , pp. 1075-1086
    • Rosenbach, A.1    Dignard, D.2    Pierce, J.V.3    Whiteway, M.4    Kumamoto, C.A.5
  • 54
    • 0038016755 scopus 로고    scopus 로고
    • Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence
    • Sanglard, D., Ischer, F., Marchetti, O., Entenza, J., and Bille, J. (2003) Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence. Mol Microbiol 48: 959-976.
    • (2003) Mol Microbiol , vol.48 , pp. 959-976
    • Sanglard, D.1    Ischer, F.2    Marchetti, O.3    Entenza, J.4    Bille, J.5
  • 55
    • 33846014703 scopus 로고    scopus 로고
    • An acetylation site in the middle domain of Hsp90 regulates chaperone function
    • Scroggins, B.T., Robzyk, K., Wang, D., Marcu, M.G., Tsutsumi, S., Beebe, K., etal. (2007) An acetylation site in the middle domain of Hsp90 regulates chaperone function. Mol Cell 25: 151-159.
    • (2007) Mol Cell , vol.25 , pp. 151-159
    • Scroggins, B.T.1    Robzyk, K.2    Wang, D.3    Marcu, M.G.4    Tsutsumi, S.5    Beebe, K.6
  • 56
    • 84855879659 scopus 로고    scopus 로고
    • Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans
    • Senn, H., Shapiro, R.S., and Cowen, L.E. (2012) Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans. Mol Biol Cell 23: 268-283.
    • (2012) Mol Biol Cell , vol.23 , pp. 268-283
    • Senn, H.1    Shapiro, R.S.2    Cowen, L.E.3
  • 57
    • 65049086509 scopus 로고    scopus 로고
    • Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling
    • Shapiro, R.S., Uppuluri, P., Zaas, A.K., Collins, C., Senn, H., Perfect, J.R., etal. (2009) Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling. Curr Biol 19: 621-629.
    • (2009) Curr Biol , vol.19 , pp. 621-629
    • Shapiro, R.S.1    Uppuluri, P.2    Zaas, A.K.3    Collins, C.4    Senn, H.5    Perfect, J.R.6
  • 58
    • 84858703485 scopus 로고    scopus 로고
    • Pho85, Pcl1, and Hms1 signaling governs Candida albicans morphogenesis induced by high temperature or Hsp90 compromise
    • Shapiro, R.S., Sellam, A., Tebbji, F., Whiteway, M., Nantel, A., and Cowen, L.E. (2012a) Pho85, Pcl1, and Hms1 signaling governs Candida albicans morphogenesis induced by high temperature or Hsp90 compromise. Curr Biol 22: 461-470.
    • (2012) Curr Biol , vol.22 , pp. 461-470
    • Shapiro, R.S.1    Sellam, A.2    Tebbji, F.3    Whiteway, M.4    Nantel, A.5    Cowen, L.E.6
  • 59
    • 84866114557 scopus 로고    scopus 로고
    • The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance
    • Shapiro, R.S., Zaas, A.K., Betancourt-Quiroz, M., Perfect, J.R., and Cowen, L.E. (2012b) The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance. PLoS ONE 7: e44734.
    • (2012) PLoS ONE , vol.7
    • Shapiro, R.S.1    Zaas, A.K.2    Betancourt-Quiroz, M.3    Perfect, J.R.4    Cowen, L.E.5
  • 60
    • 70049109583 scopus 로고    scopus 로고
    • Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin
    • Singh, S.D., Robbins, N., Zaas, A.K., Schell, W.A., Perfect, J.R., and Cowen, L.E. (2009) Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. PLoS Pathog 5: e1000532.
    • (2009) PLoS Pathog , vol.5
    • Singh, S.D.1    Robbins, N.2    Zaas, A.K.3    Schell, W.A.4    Perfect, J.R.5    Cowen, L.E.6
  • 61
    • 84863666582 scopus 로고    scopus 로고
    • Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata
    • Singh-Babak, S.D., Babak, T., Diezmann, S., Hill, J.A., Xie, J.L., Chen, Y.-L., etal. (2012) Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. PLoS Pathog 8: e1002718.
    • (2012) PLoS Pathog , vol.8
    • Singh-Babak, S.D.1    Babak, T.2    Diezmann, S.3    Hill, J.A.4    Xie, J.L.5    Chen, Y.-L.6
  • 63
    • 77953916528 scopus 로고    scopus 로고
    • HSP90 at the hub of protein homeostasis: emerging mechanistic insights
    • Taipale, M., Jarosz, D.F., and Lindquist, S. (2010) HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol 11: 515-528.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 515-528
    • Taipale, M.1    Jarosz, D.F.2    Lindquist, S.3
  • 64
    • 33745203517 scopus 로고    scopus 로고
    • Repression of CDC28 reduces the expression of the morphology-related transcription factors, Efg1p, Nrg1p, Rbf1p, Rim101p, Fkh2p and Tec1p and induces cell elongation in Candida albicans
    • Umeyama, T., Kaneko, A., Niimi, M., and Uehara, Y. (2006) Repression of CDC28 reduces the expression of the morphology-related transcription factors, Efg1p, Nrg1p, Rbf1p, Rim101p, Fkh2p and Tec1p and induces cell elongation in Candida albicans. Yeast 23: 537-552.
    • (2006) Yeast , vol.23 , pp. 537-552
    • Umeyama, T.1    Kaneko, A.2    Niimi, M.3    Uehara, Y.4
  • 65
    • 84855199285 scopus 로고    scopus 로고
    • The fungal pathogen Candida albicans autoinduces hyphal morphogenesis by raising extracellular pH
    • e00055-e00011
    • Vylkova, S., Carman, A.J., Danhof, H.A., Collette, J.R., Zhou, H., and Lorenz, M.C. (2011) The fungal pathogen Candida albicans autoinduces hyphal morphogenesis by raising extracellular pH. MBio 2: e00055-11.
    • (2011) MBio , vol.2
    • Vylkova, S.1    Carman, A.J.2    Danhof, H.A.3    Collette, J.R.4    Zhou, H.5    Lorenz, M.C.6
  • 67
    • 0035203992 scopus 로고    scopus 로고
    • Heat shock protein 90 homeostasis controls stage differentiation in Leishmania donovani
    • Wiesgigl, M., and Clos, J. (2001) Heat shock protein 90 homeostasis controls stage differentiation in Leishmania donovani. Mol Biol Cell 12: 3307-3316.
    • (2001) Mol Biol Cell , vol.12 , pp. 3307-3316
    • Wiesgigl, M.1    Clos, J.2
  • 68
    • 0038707628 scopus 로고    scopus 로고
    • Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States
    • Wisplinghoff, H., Seifert, H., Wenzel, R.P., and Edmond, M.B. (2003) Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States. Clin Infect Dis 36: 1103-1110.
    • (2003) Clin Infect Dis , vol.36 , pp. 1103-1110
    • Wisplinghoff, H.1    Seifert, H.2    Wenzel, R.P.3    Edmond, M.B.4
  • 69
    • 33847607044 scopus 로고    scopus 로고
    • Differentially expressed proteins of pathogenic Penicillium marneffei in yeast and mycelial phases
    • Xi, L., Xu, X., Liu, W., Li, X., Liu, Y., Li, M., etal. (2007) Differentially expressed proteins of pathogenic Penicillium marneffei in yeast and mycelial phases. J Med Microbiol 56: 298-304.
    • (2007) J Med Microbiol , vol.56 , pp. 298-304
    • Xi, L.1    Xu, X.2    Liu, W.3    Li, X.4    Liu, Y.5    Li, M.6
  • 71
    • 84865626877 scopus 로고    scopus 로고
    • Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae
    • Zhang, J., Silao, F.G.S., Bigol, U.G., Bungay, A.A.C., Nicolas, M.G., Heitman, J., and Chen, Y.-L. (2012) Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae. PLoS ONE 7: e44192.
    • (2012) PLoS ONE , vol.7
    • Zhang, J.1    Silao, F.G.S.2    Bigol, U.G.3    Bungay, A.A.C.4    Nicolas, M.G.5    Heitman, J.6    Chen, Y.-L.7
  • 72
    • 20044382800 scopus 로고    scopus 로고
    • Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the Hsp90 chaperone
    • Zhao, R., Davey, M., Hsu, Y.-C., Kaplanek, P., Tong, A., Parsons, A.B., etal. (2005) Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the Hsp90 chaperone. Cell 120: 715-727.
    • (2005) Cell , vol.120 , pp. 715-727
    • Zhao, R.1    Davey, M.2    Hsu, Y.-C.3    Kaplanek, P.4    Tong, A.5    Parsons, A.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.