Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: Implications in memory formation

Journal of Ethnopharmacology

Volumn 134, Issue 1, 2011, Pages 55-61

  Charles, Prisila Dulcy ^a   Ambigapathy, Ganesh ^a   Geraldine, Pitchairaj ^a   Akbarsha, Mohammad Abdulkadar ^a   Rajan, Koilmani Emmanuvel ^a  

^a BHARATHIDASAN UNIVERSITY   (India)

Author keywords

Bacopa monniera; Learning and memory; Serotonin; Serotonin transporter; Tryptophan hydroxylase

Indexed keywords

ACETYLCHOLINE; BACOPA MONNIERI EXTRACT; DOPAMINE; GLUTAMIC ACID; MESSENGER RNA; SEROTONIN; SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE 2;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; LEARNING; MAZE TEST; MEMORY CONSOLIDATION; NONHUMAN; OPTIMAL DRUG DOSE; PASSIVE AVOIDANCE; PERINATAL PERIOD; PLANT LEAF; PROTEIN EXPRESSION; RAT; SEROTONINERGIC SYSTEM; TASK PERFORMANCE; UPREGULATION;

ANIMALS; BACOPA; BASE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA PRIMERS; MEMORY; PLANT EXTRACTS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TRYPTOPHAN HYDROXYLASE; UP-REGULATION;

ACACIA; BACOPA MONNIERI; RATTUS;

EID: 79952697763     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.11.045     Document Type: Article

References (49)

1. Chakravarty, A.K., Garai, S., Masuda, K., Nakane, T., Kawahara, N., 2003. Bacopasides III-V: three new triterpenoid glycosides from Bacopa monniera. Chemical and Pharmaceutical Bulletin 51, 215-217. (Pubitemid 41701998)
2. Chakravarty, A.K., Sarkar, T., Masuda, K., Shiojima, K., Nakane, T., Kawahara, N., 2001. Bacopasides I and II: two pseudojujubogenin glycosides from Bacopa monniera. Phytochemistry 58, 553-556. (Pubitemid 32904871)
3. Chamas, F., Serova, L., Sabban, E.L., 1999. Tryptophan hydroxylase mRNA levels are elevated by repeated immobilization stress in rat raphe nuclei but not in pineal gland. Neuroscience Letters 267, 157-160. (Pubitemid 29254085)
4. Chamizo, C., Rubio, J.M., Moreno, J., Alvar, J., 2001. Semi-quantitative analysis of multiple cytokines in canine peripheral blood mononuclear cells by a single tube RT-PCR. Veterinary Immunology and Immunopathology 83, 191-202. (Pubitemid 33112011)
5. Chandel, R.S., Kulshreshtha, D.K., Rastogi, R.P., 1977. Bacogenin-A3: a new sapogenin from Bacopa monniera. Phytochemistry 16, 141-143.
6. Chatterji, N., Rastogi, R.P., Dhar, M.L., 1963. Chemical examination of Bacopa monniera Wettst: isolation of chemical constituents. Indian Journal of Chemistry 1, 212-215.
7. Chatterji, N., Rastogi, R.P., Dhar, M.L., 1965. Chemical examination of Bacopa monniera Wettst: the constitution of bacoside A. Indian Journal of Chemistry 3, 24-29.
8. Consolo, S., Bertorelli, R., Russi, G., Zambelli, M., Ladinsky, H., 1994. Serotonergic facilitation of acetylcholine release in vivo from rat dorsal hippocampus via serotonin 5-HT3 receptors. Journal of Neurochemistry 62, 2254-2261. (Pubitemid 24179506)
9. Das, A., Rai, D., Dikshit, M., Palit, G., Nath, C., 2005. Nature of stress: differential effects on brain acetylcholinesterase activity and memory in rats. Life Science 77, 2299-2311. (Pubitemid 41169964)
10. Das, A., Shanker, G., Nath, C., Pal, R., Singh, S., Singh, H., 2002. A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba: anticholinesterase and cognitive enhancing activities. Pharmacology Biochemistry and Behavior 73, 893-900. (Pubitemid 35246239)
11. Deepak, M., Sangli, G.K., Arun, P.C., Amit, A., 2005. Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC. Phytochemical Analysis 16, 24-29.
12. Fioravante, D., Smolen, P.D., Byrne, J.H., 2006. The 5-HT-and FMRFa-activated signaling pathways interact at the level of the Erk MAPK cascade: potential inhibitory constraints on memory formation. Neuroscience Letters 396, 235-240. (Pubitemid 43331038)
13. Fujita, M., Shimada, S., Maeno, H., Nishimura, T., Tohyama, M., 1993. Cellular localization of serotonin transportermRNAin the rat brain. Neuroscience Letters 162, 59-62. (Pubitemid 23347945)
14. Gainetdinov, R.R., Caron, M.G., 2003. Monoamine transporters: form genes to behavior. Annual Review of Pharmacology and Toxicology 43, 261-284. (Pubitemid 37372642)
15. Greengard, P., 2001. The neurobiology of slow synaptic transmission. Science 294, 1024-1030. (Pubitemid 33041850)
16. Hota, S.K., Barhwal, K., Baitharu, I., Prasad, D., Singh, S.B., Ilavazhagan, G., 2009. Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment. Neurobiology of Disease 34, 23-39.
17. Joshi, H., Parle, M., 2006. Brahmi rasayana improves learning and memory in mice. Evidence-based Complementary and Alternative Medicine 3, 79-85. (Pubitemid 43999655)
18. Kant, G.J., Wylie, R.M., Vasilakis, A.A., Ghosh, S., 1996. Effects of triazolam and diazepam on learning and memory as assessed using a water maze. Pharmacology Biochemistry and Behaviour 53, 317-322. (Pubitemid 26059195)
19. Karakuyu, D., Herold, C., Güntürkün, O., Diekamp, B., 2007. Differential increase of extracellular dopamine and serotonin in the prefrontal cortex and striatum of pigeons during working memory. European Journal of Neuroscience 26, 2293-2302. (Pubitemid 47620488)
20. Khan, R., Krishnakumar, A., Paulose, C.S., 2008. Decreased glutamate receptor binding and NMDA R1 gene expression in hippocampus of pilocarpine-induced epileptic rats: neuroprotective role of Bacopa monnieri extract. Epilepsy & Behavior 12, 54-60. (Pubitemid 350246380)
21. Khalifa, A.E., 2001. Hypericum perforatum as a nootropic drug: enhancement of retrieval memory of a passive avoidance conditioning paradigm in mice. Journal of Ethnopharmacology 76, 49-57. (Pubitemid 32510730)
22. Kim, S.W., Park, S.Y., Hwang, O., 2002. Up-regulation of tryptophan hydroxylase expression and serotonin synthesis by sertraline. Molecular Pharmacology 61, 778-785. (Pubitemid 34273157)
23. Kimani, S.T., Nyongesa, A.W., 2008. Effects of single daily khat (Catha edulis) extract on spatial learning and memory in CBA mice. Behavioural Brain Research 195, 192-197.
24. 1: a novel dammerane triterpene sapogenin from Bacopa monniera. Phytochemistry 12, 887-892.
25. 2: a new sapogenin from bacosides. Phytochemistry 13, 1205-1206.
26. Michael, D., Martin, K.C., Seger, R., Ning, M.M., Baston, R., Kandel, E.R., 1998. Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia. Proceedings of the National Academy of Sciences of the United States of America 95, 1864-1869. (Pubitemid 28103485)
27. Mohandas Rao, K.G., Muddanna Rao, S., Gurumadhva Rao, S., 2005. Centella asiatica (Linn.) induced behavioural changes during growth spurt period in neonatal rats. Neuroanatomy 4, 18-23.
28. Muthumary, J., Sashirekha, S., 2007. Detection of taxol, an anticancer drug, from selected coelomycetous fungi. Indian Journal of Science and Technology 1, 1-10.
29. Prabhakar, S., Saraf, M.K., Pandhi, P., Anand, A., 2008. Bacopa monniera exerts antiamnesic effect on diazepam-induced anterograde amnesia in mice. Psychopharmacology 200, 27-37.
30. Phrompittayarat, W., Putalun, W., Tanaka, H., Jetiyanon, K., Wittaya-areekul, S., Ingkaninan, K., 2007. Comparison of various extraction methods of Bacopa monnieri. Naresuan University Journal 15, 29-34.
31. Rai, K.S., Murthy, K.D., Karanth, K.S., Rao, M.S., 2001. Clitoria ternatea (Linn.) root extract treatment during growth spurt period enhances learning and memory in rats. Indian Journal of Physiology and Pharmacology 45, 305-313. (Pubitemid 32776798)
32. Reis, H.J., Guatimosim, C., Paquest, M., Santos, M., Ribeiro, F.M., Kummer, A., Schenatto, G., Vsalgado, J.V., Vieira, L.B., Teixeira, A.L., Palotás, A., 2009. Neurotransmitters in the central nervous system and their implication in learning and memory processes. Current Medicinal Chemistry 16, 796-840.
33. Russo, A., Borrelli, F., 2005. Bacopa monniera, a reputed nootropic plant: an overview. Phytomedicine 12, 305-317. (Pubitemid 40471030)
34. Saitoh, A., Hirose, N., Yamada, M., Yamada, M., Nozaki, C., Oka, T., Kamei, J., 2006. Changes in emotional behavior of mice in the hole-board test after olfactory bulbectomy. Journal of Pharmacological Sciences 102, 377-386. (Pubitemid 44954597)
35. Sakuma, R., Nishina, T., Kitamura, M., 1987. Deproteinizing methods evaluated for determination of uric acid in serum by reversed-phase liquid chromatography with ultraviolet detection. Clinical Chemistry 33, 1427-1430. (Pubitemid 18041985)
36. Saraf, M.K., Prabhakar, S., Pandhi, P., Anand, A., 2008. Bacopa monniera ameliorates amnesic effects of diazepam qualifying behavioural-molecular partitioning. Neuroscience 155, 476-484.
37. ω-nitro-L- arginine-induced but not MK-801-induced amnesia: a mouse Morris water maze study. Neuroscience 160, 149-155.
38. Saraf, M.K., Anand, A., Prabhakar, S., 2010. Scopolamine induced amnesia is reversed by Bacopa monniera through participation of kinase-CREB pathway. Neurochemical Research 35, 279-287.
39. Sheikh, N., Ahmad, A., Siripurapu, K.B., Kuchibhotla, V.K., Singh, S., Palit, G., 2007. Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in rats. Journal of Ethnopharmacology 111, 671-676. (Pubitemid 46617115)
40. Singh, H.K., Dhawan, B.N., 1982. Effect of Bacopa monniera Linn. (Brahmi) extract on avoidance responses in rat. Journal of Ethnopharmacology 5, 205-214. (Pubitemid 12126680)
41. Singh, H.K., Dhawan, B.N., 1997. Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian Journal of Pharmacology 29, S359-S365. (Pubitemid 27479532)
42. Tiwari, R.K., Chanda, S., Deepak, M., Murli, B., Agarwal, A., 2010. HPLC method validation for simultaneous estimation ofmadecassoside, asiaticoside and asiatic acid in Centella asiatica. Journal of Chemical and Pharmaceutical Research 2, 223-229.
43. Toth, L.A., Gardiner, T.W., 2000. Food and water restriction protocols: physiological and behavioural considerations. Contemporary Topic 39, 9-17.
44. Uabundit, N., Wattanathorn, J., Mucimapura, S., Ingkaninan, K., 2010. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model. Journal of Ethanopharmacology 127, 26-31.
45. Van der Borght, K., Havakes, R., Bos, T., Eggen, B.J.L., Van der Zee, E.A., 2007. Exercise improves memory acquisition and retrieval in the Y-maze task: relationship with hippocampal neurogenesis. Behavioral Neuroscience 121, 324-334. (Pubitemid 47445083)
46. van der Veen, F.M., Evers, E.A., van Deursen, J.A., Deutz, N.E., Backes, W.H., Schmitt, J.A., 2006. Acute tryptophan depletion reduces activation in the right hippocampus during encoding in an episodic memory task. Neuroimage 31, 1188-1196. (Pubitemid 43851332)
47. Vollala, V.R., Upadhya, S., Nayak, S., 2010. Effect of Bacopa monniera Linn. (Brahmi) extract on learning and memory in rats: a behavioural study. Journal of Veterinary Behavior 5, 69-74.
48. Zhao, S., Edwards, J., Carroll, J., Wiedholz, L., Millstein, R.A., Jaing, C., Murphy, D.L., Lanthorn, T.H., Holmes, A., 2006. Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice. Neuroscience 140, 321-334. (Pubitemid 43668455)
49. Zhou, Y., Peng, L., Zhang, W.D., Kong, D.Y., 2009. Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in mice. Planta Medica 75, 568-574.