Therapeutic potential of atorvastatin-modified dendritic cells in experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells and NKR-P1+ cells

Journal of Neuroimmunology

Volumn 269, Issue 1-2, 2014, Pages 28-37

  Xu, Hua ^a,b   Li, Xiao Li ^a   Yue, Long Tao ^a   Li, Heng ^a   Zhang, Min ^a   Wang, Shan ^a   Wang, Cong Cong ^a   Duan, Rui Sheng ^a  

^a SHANDONG UNIVERSITY   (China)

^b TAIAN CITY CENTRAL HOSPITAL   (China)

Author keywords

Cytokines; Dendritic cells; Experimental autoimmune neuritis; Statins

Indexed keywords

ATORVASTATIN; B7 ANTIGEN; CD161 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL COUNT; CELL THERAPY; CONTROLLED STUDY; DENDRITIC CELL; DISEASE SEVERITY; EXPERIMENTAL AUTOIMMUNE NEURITIS; FEMALE; IMMUNOLOGICAL TOLERANCE; INFLAMMATORY CELL; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY T LYMPHOCYTE;

CYTOKINES; DENDRITIC CELLS; EXPERIMENTAL AUTOIMMUNE NEURITIS; NKR-P1(+) CELLS; STATINS;

ANIMALS; CATTLE; CYTOKINES; DENDRITIC CELLS; FEMALE; HEPTANOIC ACIDS; NEURITIS, AUTOIMMUNE, EXPERIMENTAL; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY B; PYRROLES; RATS; RATS, INBRED LEW; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH17 CELLS; UP-REGULATION;

EID: 84896391744     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2014.02.002     Document Type: Article

References (53)

1. Adorini L. Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting autoimmune diabetes. Ann. N. Y. Acad. Sci. 2003, 987:258-261.
2. Araki M., Kondo T., Gumperz J.E., Brenner M.B., Miyake S., Yamamura T. Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission. Int. Immunol. 2003, 15:279-288.
3. Bai X.F., Zhu J., Zhang G.X., Kaponides G., Hojeberg B., van der Meide P.H., Link H. IL-10 suppresses experimental autoimmune neuritis and down-regulates TH1-type immune responses. Clin. Immunol. Immunopathol. 1997, 83:117-126.
4. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature 1998, 392:245-252.
5. Bao L., Lindgren J.U., van der Meide P., Zhu S., Ljunggren H.G., Zhu J. The critical role of IL-12p40 in initiating, enhancing, and perpetuating pathogenic events in murine experimental autoimmune neuritis. Brain Pathol. 2002, 12:420-429.
6. Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., McGrady G., Wahl S.M. Conversion of peripheral CD4+ CD25-naive T cells to CD4+ CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 2003, 198:1875-1886.
7. Chi L.J., Wang H.B., Zhang Y., Wang W.Z. Abnormality of circulating CD4(+)CD25(+) regulatory T cell in patients with Guillain-Barre syndrome. J. Neuroimmunol. 2007, 192:206-214.
8. Chong W.P., Ling M.T., Liu Y., Caspi R.R., Wong W.M., Wu W., Tu W., Lau Y.L. Essential role of NK cells in IgG therapy for experimental autoimmune encephalomyelitis. PLoS One 2013, 8:e60862.
9. Coquet J.M., Ribot J.C., Babala N., Middendorp S., van der Horst G., Xiao Y., Neves J.F., Fonseca-Pereira D., Jacobs H., Pennington D.J., Silva-Santos B., Borst J. Epithelial and dendritic cells in the thymic medulla promote CD4 + Foxp3+ regulatory T cell development via the CD27-CD70 pathway. J. Exp. Med. 2013, 210:715-728.
10. Cowan J.E., Parnell S.M., Nakamura K., Caamano J.H., Lane P.J., Jenkinson E.J., Jenkinson W.E., Anderson G. The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development. J. Exp. Med. 2013, 210:675-681.
11. Deretzi G., Zou L.P., Pelidou S.H., Nennesmo I., Levi M., Wahren B., Mix E., Zhu J. Nasal administration of recombinant rat IL-4 ameliorates ongoing experimental autoimmune neuritis and inhibits demyelination. J. Autoimmun. 1999, 12:81-89.
12. Duan R.S., Adikari S.B., Huang Y.M., Link H., Xiao B.G. Protective potential of experimental autoimmune myasthenia gravis in Lewis rats by IL-10-modified dendritic cells. Neurobiol. Dis. 2004, 16:461-467.
13. Duan R.S., Link H., Xiao B.G. Long-term effects of IFN-gamma, IL-10, and TGF-beta-modulated dendritic cells on immune response in Lewis rats. J. Clin. Immunol. 2005, 25:50-56.
14. Fontenot J.D., Dooley J.L., Farr A.G., Rudensky A.Y. Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 2005, 202:901-906.
15. Goldstein J.L., Brown M.S. Regulation of the mevalonate pathway. Nature 1990, 343:425-430.
16. Gross C.C., Wiendl H. Dendritic cell vaccination in autoimmune disease. Curr. Opin. Rheumatol. 2013, 25:268-274.
17. Hanabuchi S., Ito T., Park W.R., Watanabe N., Shaw J.L., Roman E., Arima K., Wang Y.H., Voo K.S., Cao W., Liu Y.J. Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus. J. Immunol. 2010, 184:2999-3007.
18. Harness J., McCombe P.A. Increased levels of activated T-cells and reduced levels of CD4/CD25+ cells in peripheral blood of Guillain-Barre syndrome patients compared to controls. J. Clin. Neurosci. 2008, 15:1031-1035.
19. Hsieh C.S., Lee H.M., Lio C.W. Selection of regulatory T cells in the thymus. Nat. Rev. Immunol. 2012, 12:157-167.
20. Jiang Q., Su H., Knudsen G., Helms W., Su L. Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP. BMC Immunol. 2006, 7:6.
21. Kadowaki N. Immunotherapy exploiting the versatility of dendritic cells. Ther. Apher. Dial. 2003, 7:312-317.
22. Khattri S., Zandman-Goddard G. Statins and autoimmunity. Immunol. Res. 2013, 56:348-357.
23. Kiessling R., Klein E., Pross H., Wigzell H. "Natural" killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell. Eur. J. Immunol. 1975, 5:117-121.
24. Klein L., Jovanovic K. Regulatory T cell lineage commitment in the thymus. Semin. Immunol. 2011, 23:401-409.
25. Li X.L., Dou Y.C., Liu Y., Shi C.W., Cao L.L., Zhang X.Q., Zhu J., Duan R.S. Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells. Cell. Immunol. 2011, 271:455-461.
26. Li S., Yu M., Li H., Zhang H., Jiang Y. IL-17 and IL-22 in cerebrospinal fluid and plasma are elevated in Guillain-Barre syndrome. Mediators Inflamm. 2012, 2012:260473.
27. Li X.L., Liu Y., Cao L.L., Li H., Yue L.T., Wang S., Zhang M., Li X.H., Dou Y.C., Duan R.S. Atorvastatin-modified dendritic cells in vitro ameliorate experimental autoimmune myasthenia gravis by up-regulated Treg cells and shifted Th1/Th17 to Th2 cytokines. Mol. Cell. Neurosci. 2013, 56C:85-95.
28. Liang S.L., Wang W.Z., Huang S., Wang X.K., Zhang S., Wu Y. Th17 helper cell and T-cell immunoglobulin and mucin domain 3 involvement in Guillain-Barre syndrome. Immunopharmacol. Immunotoxicol. 2012, 34:1039-1046.
29. Linsen L., Somers V., Stinissen P. Immunoregulation of autoimmunity by natural killer T cells. Hum. Immunol. 2005, 66:1193-1202.
30. Lio C.W., Hsieh C.S. A two-step process for thymic regulatory T cell development. Immunity 2008, 28:100-111.
31. Lio C.W., Hsieh C.S. Becoming self-aware: the thymic education of regulatory T cells. Curr. Opin. Immunol. 2011, 23:213-219.
32. Liu Y.J. A unified theory of central tolerance in the thymus. Trends Immunol. 2006, 27:215-221.
33. Lyons A.B., Blake S.J., Doherty K.V. Flow cytometric analysis of cell division by dilution of CFSE and related dyes. Curr. Protoc. Cytom. 2013, 9.11:1-12.
34. Mercer J.C., Ragin M.J., August A. Natural killer T cells: rapid responders controlling immunity and disease. Int. J. Biochem. Cell Biol. 2005, 37:1337-1343.
35. Miller S.D., Vanderlugt C.L., Lenschow D.J., Pope J.G., Karandikar N.J., Dal Canto M.C., Bluestone J.A. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity 1995, 3:739-745.
36. Morelli A.E., Thomson A.W. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat. Rev. Immunol. 2007, 7:610-621.
37. Munschauer F.E., Hartrich L.A., Stewart C.C., Jacobs L. Circulating natural killer cells but not cytotoxic T lymphocytes are reduced in patients with active relapsing multiple sclerosis and little clinical disability as compared to controls. J. Neuroimmunol. 1995, 62:177-181.
38. Nomura T., Sakaguchi S. Foxp3 and Aire in thymus-generated Treg cells: a link in self-tolerance. Nat. Immunol. 2007, 8:333-334.
39. Norton W.T., Poduslo S.E. Myelination in rat brain: method of myelin isolation. J. Neurochem. 1973, 21:749-757.
40. Roelen D.L., Schuurhuis D.H., van den Boogaardt D.E., Koekkoek K., van Miert P.P., van Schip J.J., Laban S., Rea D., Melief C.J., Offringa R., Ossendorp F., Claas F.H. Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells. Transplantation 2003, 76:1608-1615.
41. Sejvar J.J., Baughman A.L., Wise M., Morgan O.W. Population incidence of Guillain-Barre syndrome: a systematic review and meta-analysis. Neuroepidemiology 2011, 36:123-133.
42. Shi F.D., Van Kaer L. Reciprocal regulation between natural killer cells and autoreactive T cells. Nat. Rev. Immunol. 2006, 6:751-760.
43. Sun B., Li H.L., Wang J.H., Wang G.Y., Zhao R., Mu L.L., Jin L.H. Passive transfer of experimental autoimmune neuritis by IL-12 and IL-18 synergistically potentiated lymphoid cells is regulated by NKR-P1+ cells. Scand. J. Immunol. 2007, 65:412-420.
44. Tsakiri A., Tsiantoulas D., Frederiksen J., Svane I.M. Increased immunopotency of monocyte derived dendritic cells from patients with optic neuritis is inhibited in vitro by simvastatin. Exp. Neurol. 2010, 221:320-328.
45. Wakkach A., Fournier N., Brun V., Breittmayer J.P., Cottrez F., Groux H. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 2003, 18:605-617.
46. Watanabe N., Wang Y.H., Lee H.K., Ito T., Cao W., Liu Y.J. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature 2005, 436:1181-1185.
47. Xiao B.G., Duan R.S., Link H., Huang Y.M. Induction of peripheral tolerance to experimental autoimmune myasthenia gravis by acetylcholine receptor-pulsed dendritic cells. Cell. Immunol. 2003, 223:63-69.
48. Xu W., Fazekas G., Hara H., Tabira T. Mechanism of natural killer (NK) cell regulatory role in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2005, 163:24-30.
49. Yarilin D., Duan R., Huang Y.M., Xiao B.G. Dendritic cells exposed in vitro to TGF-beta1 ameliorate experimental autoimmune myasthenia gravis. Clin. Exp. Immunol. 2002, 127:214-219.
50. Yilmaz A., Reiss C., Weng A., Cicha I., Stumpf C., Steinkasserer A., Daniel W.G., Garlichs C.D. Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J. Leukoc. Biol. 2006, 79:529-538.
51. Zhang H., Wu L.M., Wu J. Cross-talk between apolipoprotein E and cytokines. Mediators Inflamm. 2011, 2011:949072.
52. Zhu J., Bai X.F., Mix E., Link H. Cytokine dichotomy in peripheral nervous system influences the outcome of experimental allergic neuritis: dynamics of mRNA expression for IL-1 beta, IL-6, IL-10, IL-12, TNF-alpha, TNF-beta, and cytolysin. Clin. Immunol. Immunopathol. 1997, 84:85-94.
53. Zhu J., Mix E., Link H. Cytokine production and the pathogenesis of experimental autoimmune neuritis and Guillain-Barre syndrome. J. Neuroimmunol. 1998, 84:40-52.