메뉴 건너뛰기




Volumn 12, Issue 4, 2014, Pages 401-417

Nemonoxacin (TG-873870) for treatment of community-acquired pneumonia

Author keywords

antimicrobial resistance; atypical pathogens; in vitro activity; methicillin resistant Staphylococcus aureus; pharmacokinetics; quinolones; Streptococcus pneumoniae

Indexed keywords

ALANINE AMINOTRANSFERASE; AMYLASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CREATINE KINASE; LEVOFLOXACIN; NEMONOXACIN; PLACEBO; TRIACYLGLYCEROL LIPASE; ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE;

EID: 84896385409     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.2014.894881     Document Type: Article
Times cited : (10)

References (82)
  • 1
    • 78751672379 scopus 로고    scopus 로고
    • Management of community-acquired pneumonia: A review and update
    • Brar NK, Niederman MS. Management of community-acquired pneumonia: a review and update. Ther Adv Respir Dis 2011; 5(1):61-78
    • (2011) Ther Adv Respir Dis , vol.5 , Issue.1 , pp. 61-78
    • Brar, N.K.1    Niederman, M.S.2
  • 2
    • 70350065937 scopus 로고    scopus 로고
    • Clinical policy: Critical issues in the management of adult patients presenting to the emergency department with community-acquired pneumonia
    • Nazarian DJ, Eddy OL, Lukens TW, et al. Clinical policy: critical issues in the management of adult patients presenting to the emergency department with community-acquired pneumonia. Ann Emerg Med 2009;54(5):704-31
    • (2009) Ann Emerg Med , vol.54 , Issue.5 , pp. 704-731
    • Nazarian, D.J.1    Eddy, O.L.2    Lukens, T.W.3
  • 3
    • 77950344427 scopus 로고    scopus 로고
    • Burden of Community-acquired Pneumonia in North American Adults
    • File TM Jr, Marrie TJ. Burden of community-acquired pneumonia in North American adults. Postgrad Med 2010; 122(2):130-41
    • (2010) Postgrad Med , vol.122 , Issue.2 , pp. 130-141
    • File, T.M.J.R.1    Marrie, T.J.2
  • 4
    • 70350353411 scopus 로고    scopus 로고
    • New perspectives on community-acquired pneumonia in 388 406 patients. Results from a nationwide mandatory performance measurement programme in healthcare quality
    • Ewig S, Birkner N, Strauss R, et al. New perspectives on community-acquired pneumonia in 388 406 patients. Results from a nationwide mandatory performance measurement programme in healthcare quality. Thorax 2009;64(12):1062-9
    • (2009) Thorax , vol.64 , Issue.12 , pp. 1062-1069
    • Ewig, S.1    Birkner, N.2    Strauss, R.3
  • 5
    • 0030814756 scopus 로고    scopus 로고
    • Incidence of community-acquired pneumonia requiring hospitalization. Results of a population-based active surveillance Study in Ohio
    • The Community-Based Pneumonia Incidence Study Group
    • Marston BJ, Plouffe JF, File TM Jr, et al. Incidence of community-acquired pneumonia requiring hospitalization. Results of a population-based active surveillance Study in Ohio. The Community-Based Pneumonia Incidence Study Group. Arch Intern Med 1997;157(15):1709-18
    • (1997) Arch Intern Med , vol.157 , Issue.15 , pp. 1709-1718
    • Marston, B.J.1    Plouffe, J.F.2    File, T.M.J.R.3
  • 6
    • 0343092060 scopus 로고    scopus 로고
    • Epidemiology of community-acquired pneumonia in adults: A population-based study
    • Almirall J, Bolibar I, Vidal J, et al. Epidemiology of community-acquired pneumonia in adults: a population-based study. Eur Respir J 2000;15(4):757-63
    • (2000) Eur Respir J , vol.15 , Issue.4 , pp. 757-763
    • Almirall, J.1    Bolibar, I.2    Vidal, J.3
  • 7
    • 34547925249 scopus 로고    scopus 로고
    • Approaches to estimate the population-based incidence of community acquired pneumonia
    • Schnoor M, Hedicke J, Dalhoff K, et al. Approaches to estimate the population-based incidence of community acquired pneumonia. J Infect 2007;55(3): 233-9
    • (2007) J Infect , vol.55 , Issue.3 , pp. 233-239
    • Schnoor, M.1    Hedicke, J.2    Dalhoff, K.3
  • 8
    • 78650172478 scopus 로고    scopus 로고
    • Trends in mortality and medical spending in patients hospitalized for community-acquired pneumonia: 1993-2005
    • Ruhnke GW, Coca-Perraillon M, Kitch BT, Cutler DM. Trends in mortality and medical spending in patients hospitalized for community-acquired pneumonia: 1993-2005. Med Care 2010;48(12):1111-16
    • (2010) Med Care , vol.48 , Issue.12 , pp. 1111-1116
    • Ruhnke, G.W.1    Coca-Perraillon, M.2    Kitch, B.T.3    Cutler, D.M.4
  • 9
    • 80051542653 scopus 로고    scopus 로고
    • Community-acquired pneumonia as an emergency: Time for an aggressive intervention to lower mortality
    • Ewig S, Torres A. Community-acquired pneumonia as an emergency: time for an aggressive intervention to lower mortality. Eur Respir J 2011;38(2):253-60
    • (2011) Eur Respir J , vol.38 , Issue.2 , pp. 253-260
    • Ewig, S.1    Torres, A.2
  • 10
    • 78149360198 scopus 로고    scopus 로고
    • Study of community-acquired pneumonia: Incidence, patterns of care, and outcomes in primary and hospital care
    • Capelastegui A, Espana PP, Bilbao A, et al. Study of community-acquired pneumonia: incidence, patterns of care, and outcomes in primary and hospital care. J Infect 2010; 61(5):364-71
    • (2010) J Infect , vol.61 , Issue.5 , pp. 364-371
    • Capelastegui, A.1    Espana, P.P.2    Bilbao, A.3
  • 11
    • 0036724321 scopus 로고    scopus 로고
    • Severe community-acquired pneumonia: Use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteria
    • Angus DC, Marrie TJ, Obrosky DS, et al. Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteria. Am J Respir Crit Care Med 2002;166(5):717-23
    • (2002) Am J Respir Crit Care Med , vol.166 , Issue.5 , pp. 717-723
    • Angus, D.C.1    Marrie, T.J.2    Obrosky, D.S.3
  • 12
    • 84862823940 scopus 로고    scopus 로고
    • Cardiac complications in patients with community-acquired pneumonia: Incidence timing risk factors and association with short-term mortality
    • Corrales-Medina VF, Musher DM, Wells GA, et al. Cardiac complications in patients with community-acquired pneumonia: incidence, timing, risk factors, and association with short-term mortality. Circulation 2012;125(6):773-81
    • (2012) Circulation , vol.125 , Issue.6 , pp. 773-781
    • Corrales-Medina, V.F.1    Musher, D.M.2    Wells, G.A.3
  • 13
    • 79959806330 scopus 로고    scopus 로고
    • Cardiac complications in patients with community-acquired pneumonia: A systematic review and meta-analysis of observational studies
    • Corrales-Medina VF, Suh KN, Rose G, et al. Cardiac complications in patients with community-acquired pneumonia: a systematic review and meta-analysis of observational studies. PLoS Med 2011;8(6): e1001048
    • (2011) PLoS Med , vol.8 , Issue.6
    • Corrales-Medina, V.F.1    Suh, K.N.2    Rose, G.3
  • 14
    • 58149185394 scopus 로고    scopus 로고
    • Long-term morbidity and mortality after hospitalization with communityacquired pneumonia: A population-based cohort study
    • Johnstone J, Eurich DT, Majumdar SR, et al. Long-term morbidity and mortality after hospitalization with communityacquired pneumonia: a population-based cohort study. Medicine 2008;87(6):329-34
    • (2008) Medicine , vol.87 , Issue.6 , pp. 329-334
    • Johnstone, J.1    Eurich, D.T.2    Majumdar, S.R.3
  • 15
    • 84874936811 scopus 로고    scopus 로고
    • Long-term prognosis in community-acquired pneumonia
    • Restrepo MI, Faverio P, Anzueto A. Long-term prognosis in community-acquired pneumonia. Curr Opin Infect Dis 2013;26(2):151-8
    • (2013) Curr Opin Infect Dis , vol.26 , Issue.2 , pp. 151-158
    • Restrepo, M.I.1    Faverio, P.2    Anzueto, A.3
  • 16
    • 70350464262 scopus 로고    scopus 로고
    • Geography and the aetiology of community-acquired pneumonia
    • Brown JS. Geography and the aetiology of community-acquired pneumonia. Respirology 2009;14(8):1068-71
    • (2009) Respirology , vol.14 , Issue.8 , pp. 1068-1071
    • Brown, J.S.1
  • 17
    • 84862499347 scopus 로고    scopus 로고
    • Community-acquired pneumonia guidelines: A global perspective
    • Niederman MS, Luna CM. Community-acquired pneumonia guidelines: a global perspective. Semin Respir Crit Care Med 2012;33(3):298-310
    • (2012) Semin Respir Crit Care Med , vol.33 , Issue.3 , pp. 298-310
    • Niederman, M.S.1    Luna, C.M.2
  • 18
    • 78649873377 scopus 로고    scopus 로고
    • Integrated analysis of FOCUS 1 and FOCUS 2: Randomized doubled-blinded multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia
    • File TM Jr, Low DE, Eckburg PB, et al. Integrated analysis of FOCUS 1 and FOCUS 2: randomized, doubled-blinded, multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia. Clin Infect Dis 2010;51(12):1395-405
    • (2010) Clin Infect Dis , vol.51 , Issue.12 , pp. 1395-1405
    • File, T.M.J.R.1    Low, D.E.2    Eckburg, P.B.3
  • 19
    • 84859066905 scopus 로고    scopus 로고
    • Prevalence of methicillin-resistant staphylococcus aureus as an etiology of community-acquired pneumonia
    • Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Prevalence of methicillin-resistant Staphylococcus aureus as an etiology of community-acquired pneumonia. Clin Infect Dis 2012;54(8):1126-33
    • (2012) Clin Infect Dis , vol.54 , Issue.8 , pp. 1126-1133
    • Moran, G.J.1    Krishnadasan, A.2    Gorwitz, R.J.3
  • 20
    • 0037048257 scopus 로고    scopus 로고
    • Community-acquired pneumonia due to gram-negative bacteria and pseudomonas aeruginosa: Incidence, risk, and prognosis
    • Arancibia F, Bauer TT, Ewig S, et al. Community-acquired pneumonia due to gram-negative bacteria and pseudomonas aeruginosa: incidence, risk, and prognosis. Arch Intern Med 2002;162(16):1849-58
    • (2002) Arch Intern Med , vol.162 , Issue.16 , pp. 1849-1858
    • Arancibia, F.1    Bauer, T.T.2    Ewig, S.3
  • 21
    • 34248363207 scopus 로고    scopus 로고
    • A worldwide perspective of atypical pathogens in community-acquired pneumonia
    • Arnold FW, Summersgill JT, Lajoie AS, et al. A worldwide perspective of atypical pathogens in community-acquired pneumonia. Am J Respir Crit Care Med 2007;175(10):1086-93
    • (2007) Am J Respir Crit Care Med , vol.175 , Issue.10 , pp. 1086-1093
    • Arnold, F.W.1    Summersgill, J.T.2    Lajoie, A.S.3
  • 22
    • 79953025876 scopus 로고    scopus 로고
    • Microbial aetiology of community-acquired pneumonia and its relation to severity
    • Cilloniz C, Ewig S, Polverino E, et al. Microbial aetiology of community-acquired pneumonia and its relation to severity. Thorax 2011;66(4):340-6
    • (2011) Thorax , vol.66 , Issue.4 , pp. 340-346
    • Cilloniz, C.1    Ewig, S.2    Polverino, E.3
  • 23
    • 77950976619 scopus 로고    scopus 로고
    • Q fever in the Netherlands: An update on the epidemiology and control measures
    • van der HW, Dijkstra F, Schimmer B, et al. Q fever in the Netherlands: an update on the epidemiology and control measures. Euro Surveill 2010;15(12):1-4
    • (2010) Euro Surveill , vol.15 , Issue.12 , pp. 1-4
    • Van Der, H.W.1    Dijkstra, F.2    Schimmer, B.3
  • 24
    • 33847155159 scopus 로고    scopus 로고
    • Infectious Diseases Society of America/ American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults
    • Mandell LA, Wunderink RG, Anzueto A, et al. Infectious Diseases Society of America/ American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007;44(Suppl 2):S27-72
    • (2007) Clin Infect Dis , vol.44 , Issue.SUPPL. 2
    • Mandell, L.A.1    Wunderink, R.G.2    Anzueto, A.3
  • 25
    • 79953801623 scopus 로고    scopus 로고
    • Diagnostic tests for agents of community-acquired pneumonia
    • Bartlett JG. Diagnostic tests for agents of community-acquired pneumonia. Clin Infect Dis 2011;52(Suppl 4):S296-304
    • (2011) Clin Infect Dis , vol.52 , Issue.SUPPL. 4
    • Bartlett, J.G.1
  • 26
    • 23744472099 scopus 로고    scopus 로고
    • Comparison between pathogen directed antibiotic treatment and empirical broad spectrum antibiotic treatment in patients with community acquired pneumonia: A prospective randomised study
    • van der Eerden MM, Vlaspolder F, De Graaff CS, et al. Comparison between pathogen directed antibiotic treatment and empirical broad spectrum antibiotic treatment in patients with community acquired pneumonia: a prospective randomised study. Thorax 2005;60(8):672-8
    • (2005) Thorax , vol.60 , pp. 672-678
    • Van Der Eerden, M.M.1    Vlaspolder, F.2    De Graaff, C.S.3
  • 27
    • 84873535709 scopus 로고    scopus 로고
    • Does empiric therapy for atypical pathogens improve outcomes for patients with CAP?
    • File TM Jr, Marrie TJ. Does empiric therapy for atypical pathogens improve outcomes for patients with CAP? Infect Dis Clin North Am 2013;27(1):99-114
    • (2013) Infect Dis Clin North Am , vol.27 , Issue.1 , pp. 99-114
    • File, T.M.J.R.1    Marrie, T.J.2
  • 28
    • 58149218489 scopus 로고    scopus 로고
    • Is activity against "atypical" pathogens necessary in the treatment protocols for community-acquired pneumonia? Issues with combination therapy
    • Bartlett JG. Is activity against "atypical" pathogens necessary in the treatment protocols for community-acquired pneumonia? Issues with combination therapy. Clin Infect Dis 2008;47(Suppl 3): S232-6
    • (2008) Clin Infect Dis , vol.47 , Issue.SUPPL. 3
    • Bartlett, J.G.1
  • 29
    • 47049124628 scopus 로고    scopus 로고
    • Antibacterial class is not obviously important in outpatient pneumonia: A meta-analysis
    • Maimon N, Nopmaneejumruslers C, Marras TK. Antibacterial class is not obviously important in outpatient pneumonia: a meta-analysis. Eur Respir J 2008;31(5):1068-76
    • (2008) Eur Respir J , vol.31 , Issue.5 , pp. 1068-1076
    • Maimon, N.1    Nopmaneejumruslers, C.2    Marras, T.K.3
  • 30
    • 14644394235 scopus 로고    scopus 로고
    • Effectiveness of beta lactam antibiotics compared with antibiotics active against atypical pathogens in non-severe community acquired pneumonia: Meta-analysis
    • Mills GD, Oehley MR, Arrol B. Effectiveness of beta lactam antibiotics compared with antibiotics active against atypical pathogens in non-severe community acquired pneumonia: meta-analysis. BMJ 2005;330(7489):456
    • (2005) BMJ , vol.330 , Issue.7489 , pp. 456
    • Mills, G.D.1    Oehley, M.R.2    Arrol, B.3
  • 31
    • 21844477598 scopus 로고    scopus 로고
    • Empiric antibiotic coverage of atypical pathogens for community acquired pneumonia in hospitalized adults
    • Shefet D, Robenshtock E, Paul M, Leibovici L. Empiric antibiotic coverage of atypical pathogens for community acquired pneumonia in hospitalized adults. Cochrane Database Syst Rev 2005;2:CD004418
    • (2005) Cochrane Database Syst Rev , vol.2
    • Shefet, D.1    Robenshtock, E.2    Paul, M.3    Leibovici, L.4
  • 32
    • 25444486112 scopus 로고    scopus 로고
    • Empirical atypical coverage for inpatients with community-acquired pneumonia: Systematic review of randomized controlled trials
    • Shefet D, Robenshtok E, Paul M, Leibovici L. Empirical atypical coverage for inpatients with community-acquired pneumonia: systematic review of randomized controlled trials. Arch Intern Med 2005;165(17):1992-2000
    • (2005) Arch Intern Med , vol.165 , Issue.17 , pp. 1992-2000
    • Shefet, D.1    Robenshtok, E.2    Paul, M.3    Leibovici, L.4
  • 33
    • 0141894026 scopus 로고    scopus 로고
    • How good is the evidence for the recommended empirical antimicrobial treatment of patients hospitalized because of community-acquired pneumonia? A systematic review
    • Oosterheert JJ, Bonten MJ, Hak E, et al. How good is the evidence for the recommended empirical antimicrobial treatment of patients hospitalized because of community-acquired pneumonia? A systematic review. J Antimicrob Chemother 2003;52(4):555-63
    • (2003) J Antimicrob Chemother , vol.52 , Issue.4 , pp. 555-563
    • Oosterheert, J.J.1    Bonten, M.J.2    Hak, E.3
  • 34
    • 80053284682 scopus 로고    scopus 로고
    • Guidelines for the management of adult lower respiratory tract infections-full version
    • Woodhead M, Blasi F, Ewig S, et al. Guidelines for the management of adult lower respiratory tract infections-full version. Clin Microbiol Infect 2011; 17(Suppl 6):E1-59
    • (2011) Clin Microbiol Infect , vol.17 , Issue.SUPPL. 6
    • Woodhead, M.1    Blasi, F.2    Ewig, S.3
  • 35
    • 77349095417 scopus 로고    scopus 로고
    • BTS guidelines for the management of community acquired pneumonia in adults: Update 2009
    • Lim WS, Baudouin SV, George RC, et al. BTS guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax 2009;64(Suppl 3): iii1-55
    • (2009) Thorax , vol.64 , Issue.SUPPL. 3
    • Lim, W.S.1    Baudouin, S.V.2    George, R.C.3
  • 36
    • 84873534405 scopus 로고    scopus 로고
    • Does empirical therapy with a fluoroquinolone or the combination of a beta-lactam plus a macrolide result in better outcomes for patients admitted to the general ward?
    • Ruhe J, Mildvan D. Does empirical therapy with a fluoroquinolone or the combination of a beta-lactam plus a macrolide result in better outcomes for patients admitted to the general ward? Infect Dis Clin North Am 2013;27(1):115-32
    • (2013) Infect Dis Clin North Am , vol.27 , Issue.1 , pp. 115-132
    • Ruhe, J.1    Mildvan, D.2
  • 37
    • 35848941214 scopus 로고    scopus 로고
    • Comparison of beta-lactam and macrolide combination therapy versus fluoroquinolone monotherapy in hospitalized Veterans Affairs patients with community-acquired pneumonia
    • Lodise TP, Kwa A, Cosler L, et al. Comparison of beta-lactam and macrolide combination therapy versus fluoroquinolone monotherapy in hospitalized Veterans Affairs patients with community-acquired pneumonia. Antimicrob Agents Chemother 2007;51(11):3977-82
    • (2007) Antimicrob Agents Chemother , vol.51 , Issue.11 , pp. 3977-3982
    • Lodise, T.P.1    Kwa, A.2    Cosler, L.3
  • 38
    • 33847173420 scopus 로고    scopus 로고
    • Antibiotics for bacteremic pneumonia: Improved outcomes with macrolides but not fluoroquinolones
    • Metersky ML, Ma A, Houck PM, Bratzler DW. Antibiotics for bacteremic pneumonia: improved outcomes with macrolides but not fluoroquinolones. Chest 2007;131(2):466-73
    • (2007) Chest , vol.131 , Issue.2 , pp. 466-473
    • Metersky, M.L.1    Ma, A.2    Houck, P.M.3    Bratzler, D.W.4
  • 39
    • 64649103441 scopus 로고    scopus 로고
    • Impact of intravenous {beta}-lactam/ macrolide versus {beta}-lactam monotherapy on mortality in hospitalized patients with community-acquired pneumonia
    • Tessmer A, Welte T, Martus P, et al. Impact of intravenous {beta}-lactam/ macrolide versus {beta}-lactam monotherapy on mortality in hospitalized patients with community-acquired pneumonia. J Antimicrob Chemother 2009;63(5):1025-33
    • (2009) J Antimicrob Chemother , vol.63 , Issue.5 , pp. 1025-1033
    • Tessmer, A.1    Welte, T.2    Martus, P.3
  • 40
    • 84863933351 scopus 로고    scopus 로고
    • Macrolide-based regimens and mortality in hospitalized patients with community-acquired pneumonia: A systematic review and meta-analysis
    • Asadi L, Sligl WI, Eurich DT, et al. Macrolide-based regimens and mortality in hospitalized patients with community-acquired pneumonia: a systematic review and meta-analysis. Clin Infect Dis 2012;55(3):371-80
    • (2012) Clin Infect Dis , vol.55 , Issue.3 , pp. 371-380
    • Asadi, L.1    Sligl, W.I.2    Eurich, D.T.3
  • 41
    • 57349155272 scopus 로고    scopus 로고
    • Respiratory fluoroquinolones for the treatment of community-acquired pneumonia: A meta-analysis of randomized controlled trials
    • Vardakas KZ, Siempos IL, Grammatikos A, et al. Respiratory fluoroquinolones for the treatment of community-acquired pneumonia: a meta-analysis of randomized controlled trials. CMAJ 2008;179(12): 1269-77
    • (2008) CMAJ , vol.179 , Issue.12 , pp. 1269-1277
    • Vardakas, K.Z.1    Siempos, I.L.2    Grammatikos, A.3
  • 42
    • 84875800303 scopus 로고    scopus 로고
    • Clinical effects of gemifloxacin on the delay of tuberculosis treatment
    • Kim SY, Yim JJ, Park JS, et al. Clinical effects of gemifloxacin on the delay of tuberculosis treatment. J Korean Med Sci 2013;28(3):378-82
    • (2013) J Korean Med Sci , vol.28 , Issue.3 , pp. 378-382
    • Kim, S.Y.1    Yim, J.J.2    Park, J.S.3
  • 43
    • 77952634376 scopus 로고    scopus 로고
    • Activity of ceftaroline against recent emerging serotypes of streptococcus pneumoniae in the United States
    • Jacobs MR, Good CE, Windau AR, et al. Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. Antimicrob Agents Chemother 2010;54(6): 2716-19
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.6 , pp. 2716-2719
    • Jacobs, M.R.1    Good, C.E.2    Windau, A.R.3
  • 44
    • 0043269792 scopus 로고    scopus 로고
    • An international prospective study of pneumococcal bacteremia: Correlation with in vitro resistance, antibiotics administered, and clinical outcome
    • Yu VL, Chiou CC, Feldman C, et al. An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome. Clin Infect Dis 2003; 37(2):230-7
    • (2003) Clin Infect Dis , vol.37 , Issue.2 , pp. 230-237
    • Yu, V.L.1    Chiou, C.C.2    Feldman, C.3
  • 45
    • 30144441160 scopus 로고    scopus 로고
    • Penicillins for treatment of pneumococcal pneumonia: Does in vitro resistance really matter?
    • Peterson LR. Penicillins for treatment of pneumococcal pneumonia: does in vitro resistance really matter? Clin Infect Dis 2006;42(2):224-33
    • (2006) Clin Infect Dis , vol.42 , Issue.2 , pp. 224-233
    • Peterson, L.R.1
  • 46
    • 33746608911 scopus 로고    scopus 로고
    • Macrolide resistance in bacteremic pneumococcal disease: Implications for patient management
    • Toronto Invasive Bacterial Diseases N
    • Daneman N, Mcgeer A, Green K, Low DE; Toronto Invasive Bacterial Diseases N. Macrolide resistance in bacteremic pneumococcal disease: implications for patient management. Clin Infect Dis 2006; 43(4):432-8
    • (2006) Clin Infect Dis , vol.43 , Issue.4 , pp. 432-438
    • Daneman, N.1    McGeer, A.2    Green, K.3    Low, D.E.4
  • 47
    • 0037035122 scopus 로고    scopus 로고
    • Resistance to levofloxacin and failure of treatment of pneumococcal pneumonia
    • Davidson R, Cavalcanti R, Brunton JL, et al. Resistance to levofloxacin and failure of treatment of pneumococcal pneumonia. N Engl J Med 2002;346(10):747-50
    • (2002) N Engl J Med , vol.346 , Issue.10 , pp. 747-750
    • Davidson, R.1    Cavalcanti, R.2    Brunton, J.L.3
  • 48
    • 84873561593 scopus 로고    scopus 로고
    • What is the relevance of antimicrobial resistance on the outcome of community-acquired pneumonia caused by streptococcus pneumoniae? (should Macrolide Monotherapy Be Used for Mild Pneumonia?)
    • Low DE. What is the relevance of antimicrobial resistance on the outcome of community-acquired pneumonia caused by Streptococcus pneumoniae? (should macrolide monotherapy be used for mild pneumonia?). Infect Dis Clin North Am 2013;27(1):87-97
    • (2013) Infect Dis Clin North Am , vol.27 , Issue.1 , pp. 87-97
    • Low, D.E.1
  • 49
    • 84873582490 scopus 로고    scopus 로고
    • How important is methicillin-resistant Staphylococcus aureus as a cause of community-acquired pneumonia and what is best antimicrobial therapy?
    • Wunderink RG. How important is methicillin-resistant Staphylococcus aureus as a cause of community-acquired pneumonia and what is best antimicrobial therapy? Infect Dis Clin North Am 2013; 27(1):177-88
    • (2013) Infect Dis Clin North Am , vol.27 , Issue.1 , pp. 177-188
    • Wunderink, R.G.1
  • 50
    • 73849121375 scopus 로고    scopus 로고
    • Dose escalation study of the safety tolerability and pharmacokinetics of nemonoxacin (TG-873870) a novel potent broad-spectrum nonfluorinated quinolone in healthy volunteers
    • Lin L, Chang LW, Tsai CY, et al. Dose escalation study of the safety, tolerability, and pharmacokinetics of nemonoxacin (TG-873870), a novel potent broad-spectrum nonfluorinated quinolone, in healthy volunteers. Antimicrob Agents Chemother 2010;54(1):405-10
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.1 , pp. 405-410
    • Lin, L.1    Chang, L.W.2    Tsai, C.Y.3
  • 51
    • 76349114472 scopus 로고    scopus 로고
    • Nemonoxacin
    • Arjona A. Nemonoxacin. Drugs Future 2009;34(3):196-203
    • (2009) Drugs Future , vol.34 , Issue.3 , pp. 196-203
    • Arjona, A.1
  • 52
    • 0035017582 scopus 로고    scopus 로고
    • In vitro activities of three nonfluorinated quinolones against representative bacterial isolates
    • Barry AL, Fuchs PC, Brown SD. In vitro activities of three nonfluorinated quinolones against representative bacterial isolates. Antimicrob Agents Chemother 2001;45(6): 1923-7
    • (2001) Antimicrob Agents Chemother , vol.45 , Issue.6 , pp. 1923-1927
    • Barry, A.L.1    Fuchs, P.C.2    Brown, S.D.3
  • 53
    • 84862015266 scopus 로고    scopus 로고
    • Safety and clinical pharmacokinetics of nemonoxacin a novel non-fluorinated quinolone in healthy Chinese volunteers following single and multiple oral doses
    • Guo B, Wu X, Zhang Y, et al. Safety and clinical pharmacokinetics of nemonoxacin, a novel non-fluorinated quinolone, in healthy Chinese volunteers following single and multiple oral doses. Clin Drug Investig 2012;32(7):475-86
    • (2012) Clin Drug Investig , vol.32 , Issue.7 , pp. 475-486
    • Guo, B.1    Wu, X.2    Zhang, Y.3
  • 54
    • 0031459911 scopus 로고    scopus 로고
    • DNA topoisomerase targets of the fluoroquinolones: A strategy for avoiding bacterial resistance
    • Zhao X, Xu C, Domagala J, Drlica K. DNA topoisomerase targets of the fluoroquinolones: a strategy for avoiding bacterial resistance. Proc Natl Acad Sci USA 1997;94(25):13991-6
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.25 , pp. 13991-13996
    • Zhao, X.1    Xu, C.2    Domagala, J.3    Drlica, K.4
  • 55
    • 73849145677 scopus 로고    scopus 로고
    • Multiple-dose safety tolerability and pharmacokinetics of oral nemonoxacin (TG-873870) in healthy volunteers
    • Chung DT, Tsai CY, Chen SJ, et al. Multiple-dose safety, tolerability, and pharmacokinetics of oral nemonoxacin (TG-873870) in healthy volunteers. Antimicrob Agents Chemother 2010;54(1): 411-17
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.1 , pp. 411-417
    • Chung, D.T.1    Tsai, C.Y.2    Chen, S.J.3
  • 56
    • 84867142730 scopus 로고    scopus 로고
    • A liquid chromatography-tandem mass spectrometry assay for the determination of nemonoxacin (TG-873870) A novel nonfluorinated quinolone in human plasma and urine and its application to a single-dose pharmacokinetic study in healthy chinese volunteers
    • Guo B, Zhang J, Yu J, et al. A liquid chromatography-tandem mass spectrometry assay for the determination of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, in human plasma and urine and its application to a single-dose pharmacokinetic study in healthy Chinese volunteers. Biomed Chromatogr 2012; 26(11):1333-40
    • (2012) Biomed Chromatogr , vol.26 , Issue.11 , pp. 1333-1340
    • Guo, B.1    Zhang, J.2    Yu, J.3
  • 57
    • 84868285647 scopus 로고    scopus 로고
    • The use of moxifloxacin for acute exacerbations of chronic obstructive pulmonary disease and chronic bronchitis
    • Wilson R, Macklin-Doherty A. The use of moxifloxacin for acute exacerbations of chronic obstructive pulmonary disease and chronic bronchitis. Expert Rev Respir Med 2012;6(5):481-92
    • (2012) Expert Rev Respir Med , vol.6 , Issue.5 , pp. 481-492
    • Wilson, R.1    Macklin-Doherty, A.2
  • 58
    • 77952271412 scopus 로고    scopus 로고
    • Levofloxacin in the treatment of community-acquired pneumonia
    • Noreddin AM, Elkhatib WF. Levofloxacin in the treatment of community-acquired pneumonia. Expert Rev Anti Infect Ther 2010;8(5):505-14
    • (2010) Expert Rev Anti Infect Ther , vol.8 , Issue.5 , pp. 505-514
    • Noreddin, A.M.1    Elkhatib, W.F.2
  • 59
    • 76249084411 scopus 로고    scopus 로고
    • In vitro activity of nemonoxacin (TG-873870), a novel non-fluorinated quinolone, against clinical isolates of Staphylococcus aureus, enterococci and Streptococcus pneumoniae with various resistance phenotypes in Taiwan
    • Chen YH, Liu CY, Lu JJ, et al. In vitro activity of nemonoxacin (TG-873870), a novel non-fluorinated quinolone, against clinical isolates of Staphylococcus aureus, enterococci and Streptococcus pneumoniae with various resistance phenotypes in Taiwan. J Antimicrob Chemother 2009; 64(6):1226-9
    • (2009) J Antimicrob Chemother , vol.64 , Issue.6 , pp. 1226-1229
    • Chen, Y.H.1    Liu, C.Y.2    Lu, J.J.3
  • 60
    • 70350279545 scopus 로고    scopus 로고
    • In vitro activity of nemonoxacin, a novel nonfluorinated quinolone, against 2,440 clinical isolates
    • Adam HJ, Laing NM, King CR, et al. In vitro activity of nemonoxacin, a novel nonfluorinated quinolone, against 2,440 clinical isolates. Antimicrob Agents Chemother 2009;53(11):4915-20
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.11 , pp. 4915-4920
    • Adam, H.J.1    Laing, N.M.2    King, C.R.3
  • 61
    • 77149137042 scopus 로고    scopus 로고
    • Comparative in vitro activities of nemonoxacin (TG-873870) a novel nonfluorinated quinolone and other quinolones against clinical isolates
    • Lauderdale TL, Shiau YR, Lai JF, et al. Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. Antimicrob Agents Chemother 2010;54(3): 1338-42
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.3 , pp. 1338-1342
    • Lauderdale, T.L.1    Shiau, Y.R.2    Lai, J.F.3
  • 62
    • 67249150477 scopus 로고    scopus 로고
    • Comparative in vitro activities of nemonoxacin, doripenem, tigecycline and 16 other antimicrobials against Nocardia brasiliensis, Nocardia asteroides and unusual Nocardia species
    • Lai CC, Tan CK, Lin SH, et al. Comparative in vitro activities of nemonoxacin, doripenem, tigecycline and 16 other antimicrobials against Nocardia brasiliensis, Nocardia asteroides and unusual Nocardia species. J Antimicrob Chemother 2009;64(1):73-8
    • (2009) J Antimicrob Chemother , vol.64 , Issue.1 , pp. 73-78
    • Lai, C.C.1    Tan, C.K.2    Lin, S.H.3
  • 63
    • 79955538256 scopus 로고    scopus 로고
    • Multicenter study in Taiwan of the in vitro activities of nemonoxacin tigecycline doripenem and other antimicrobial agents against clinical isolates of various nocardia species
    • Lai CC, Liu WL, Ko WC, et al. Multicenter study in Taiwan of the in vitro activities of nemonoxacin, tigecycline, doripenem, and other antimicrobial agents against clinical isolates of various Nocardia species. Antimicrob Agents Chemother 2011;55(5):2084-91
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.5 , pp. 2084-2091
    • Lai, C.C.1    Liu, W.L.2    Ko, W.C.3
  • 64
    • 80054742519 scopus 로고    scopus 로고
    • Clinical and microbiological characteristics of infections caused by various Nocardia species in Taiwan: A multicenter study from
    • Liu WL, Lai CC, Ko WC, et al. Clinical and microbiological characteristics of infections caused by various Nocardia species in Taiwan: a multicenter study from 1998 to 2010. Eur J Clin Microbiol Infect Dis 2011;30(11):1341-7
    • (1998) Eur J Clin Microbiol Infect Dis , vol.30 , Issue.11 , pp. 1341-1347
    • Liu, W.L.1    Lai, C.C.2    Ko, W.C.3
  • 65
    • 78449242529 scopus 로고    scopus 로고
    • In vitro activity of nemonoxacin, tigecycline, and other antimicrobial agents against Helicobacter pylori isolates in Taiwan, 1998-2007
    • Yang JC, Lee PI, Hsueh PR. In vitro activity of nemonoxacin, tigecycline, and other antimicrobial agents against Helicobacter pylori isolates in Taiwan, 1998-2007. Eur J Clin Microbiol Infect Dis 2010;29(11):1369-75
    • (2010) Eur J Clin Microbiol Infect Dis , vol.29 , Issue.11 , pp. 1369-1375
    • Yang, J.C.1    Lee, P.I.2    Hsueh, P.R.3
  • 66
    • 79953203949 scopus 로고    scopus 로고
    • Antimicrobial susceptibilities and molecular epidemiology of clinical isolates of clostridium difficile in Taiwan
    • Lin YC, Huang YT, Tsai PJ, et al. Antimicrobial susceptibilities and molecular epidemiology of clinical isolates of Clostridium difficile in taiwan. Antimicrob Agents Chemother 2011;55(4):1701-5
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.4 , pp. 1701-1705
    • Lin, Y.C.1    Huang, Y.T.2    Tsai, P.J.3
  • 67
    • 84862525707 scopus 로고    scopus 로고
    • Characterizations of clinical isolates of clostridium difficile by toxin genotypes and by susceptibility to 12 antimicrobial agents including fidaxomicin (OPT-80) and rifaximin: A multicenter study in Taiwan
    • Liao CH, Ko WC, Lu JJ, Hsueh PR. Characterizations of clinical isolates of clostridium difficile by toxin genotypes and by susceptibility to 12 antimicrobial agents, including fidaxomicin (OPT-80) and rifaximin: a multicenter study in Taiwan. Antimicrob Agents Chemother 2012;56(7): 3943-9
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.7 , pp. 3943-3949
    • Liao, C.H.1    Ko, W.C.2    Lu, J.J.3    Hsueh, P.R.4
  • 68
    • 84896358291 scopus 로고    scopus 로고
    • In Vitro Activity of Nemonoxacin, a Novel Nonfluorinated Quinolone Antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae
    • [Epub ahead of print]
    • Chotikanatis K, Kohlhoff SA, Hammerschlag MR. In Vitro Activity of Nemonoxacin, a Novel Nonfluorinated Quinolone Antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae. Antimicrob Agents Chemother 2013. [Epub ahead of print]
    • (2013) Antimicrob Agents Chemother
    • Chotikanatis, K.1    Kohlhoff, S.A.2    Hammerschlag, M.R.3
  • 69
    • 67650763489 scopus 로고    scopus 로고
    • Comparative in vitro activities of the new quinolone nemonoxacin (TG-873870), gemifloxacin and other quinolones against clinical isolates of Mycobacterium tuberculosis
    • Tan CK, Lai CC, Liao CH, et al. Comparative in vitro activities of the new quinolone nemonoxacin (TG-873870), gemifloxacin and other quinolones against clinical isolates of Mycobacterium tuberculosis. J Antimicrob Chemother 2009; 64(2):428-9
    • (2009) J Antimicrob Chemother , vol.64 , Issue.2 , pp. 428-429
    • Tan, C.K.1    Lai, C.C.2    Liao, C.H.3
  • 73
    • 77957863841 scopus 로고    scopus 로고
    • In vivo antibacterial activity of nemonoxacin, a novel non-fluorinated quinolone
    • Li CR, Li Y, Li GQ, et al. In vivo antibacterial activity of nemonoxacin, a novel non-fluorinated quinolone. J Antimicrob Chemother 2010;65(11): 2411-15
    • (2010) J Antimicrob Chemother , vol.65 , Issue.11 , pp. 2411-2415
    • Li, C.R.1    Li, Y.2    Li, G.Q.3
  • 74
    • 77957351208 scopus 로고    scopus 로고
    • Efficacy and safety of nemonoxacin versus levofloxacin for community-acquired pneumonia
    • van Rensburg DJ, Perng RP, Mitha IH, et al. Efficacy and safety of nemonoxacin versus levofloxacin for community-acquired pneumonia. Antimicrob Agents Chemother 2010;54(10):4098-106
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.10 , pp. 4098-4106
    • Van Rensburg, D.J.1    Perng, R.P.2    Mitha, I.H.3
  • 75
    • 57749098203 scopus 로고    scopus 로고
    • Position paper: Recommended design features of future clinical trials of antibacterial agents for community-acquired pneumonia
    • Spellberg B, Talbot GH, Brass EP, et al. Position paper: recommended design features of future clinical trials of antibacterial agents for community-acquired pneumonia. Clin Infect Dis 2008; 47(Suppl 3):S249-65
    • (2008) Clin Infect Dis , vol.47 , Issue.SUPPL. 3
    • Spellberg, B.1    Talbot, G.H.2    Brass, E.P.3
  • 77
    • 21844444791 scopus 로고    scopus 로고
    • Antimicrobial safety: Focus on fluoroquinolones
    • Owens RC Jr, Ambrose PG. Antimicrobial safety: focus on fluoroquinolones. Clin Infect Dis 2005;41(Suppl 2):S144-57
    • (2005) Clin Infect Dis , vol.41 , Issue.SUPPL. 2
    • Owens Jr., R.C.1    Ambrose, P.G.2
  • 81
    • 45449094597 scopus 로고    scopus 로고
    • Ibis T5000: A universal biosensor approach for microbiology
    • Ecker DJ, Sampath R, Massire C, et al. Ibis T5000: a universal biosensor approach for microbiology. Nat Rev Microbiol 2008; 6(7):553-8
    • (2008) Nat Rev Microbiol , vol.6 , Issue.7 , pp. 553-558
    • Ecker, D.J.1    Sampath, R.2    Massire, C.3
  • 82
    • 73649093453 scopus 로고    scopus 로고
    • Etiology of community-acquired pneumonia: Increased microbiological yield with new diagnostic methods
    • Johansson N, Kalin M, Tiveljung-Lindell A, et al. Etiology of community-acquired pneumonia: increased microbiological yield with new diagnostic methods. Clin Infect Dis 2010;50(2):202-9
    • (2010) Clin Infect Dis , vol.50 , Issue.2 , pp. 202-209
    • Johansson, N.1    Kalin, M.2    Tiveljung-Lindell, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.