A liquid chromatography-tandem mass spectrometry assay for the determination of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, in human plasma and urine and its application to a single-dose pharmacokinetic study in healthy Chinese volunteers

Biomedical Chromatography

Volumn 26, Issue 11, 2012, Pages 1333-1340

  Guo, Beining ^a,b   Zhang, Jing ^a,b   Yu, Jicheng ^a,b   Wu, Xiaojie ^a,b   Shi, Yaoguo ^a,b   Tsai, Cheng Yuan ^c  

^a FUDAN UNIVERSITY   (China)

^b BEIJING HOSPITAL   (China)

^c TaiGen Biopharmaceuticals Co (Beijing) Ltd   (China)

Author keywords

Human plasma; Human urine; LC MS MS; Method validation; Nemonoxacin

Indexed keywords

BACTERIA; DATA ACQUISITION; EXTRACTION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN); PLASMA STABILITY; POSITIVE IONS;

HUMAN PLASMAS; HUMAN URINE; ITS APPLICATIONS; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY ASSAYS; METHOD VALIDATIONS; NEMONOXACIN; PHARMACOKINETIC STUDIES; QUINOLONES;

ELECTROSPRAY IONIZATION;

ACETONITRILE; FORMIC ACID; GATIFLOXACIN; NEMONOXACIN;

ADULT; ARTICLE; CALIBRATION; CHINESE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG SELECTIVITY; DRUG STABILITY; DRUG URINE LEVEL; ELECTROSPRAY; FEMALE; HUMAN; HUMAN EXPERIMENT; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; OPEN STUDY; PRECIPITATION; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 84867142730     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2699     Document Type: Article

References (9)

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