New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: A deeper insight into the mechanism of inhibition

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 29, Issue 2, 2014, Pages 198-204

  Alvarez, Guzmán ^a   Martínez, Jennyfer ^a   Aguirre López, Beatriz ^b   Cabrera, Nallely ^b   Pérez Díaz, Leticia ^a   Gómez Puyou, Marietta Tuena De ^b   Gómez Puyou, Armando ^b   Pérez Montfort, Ruy ^b   Garat, Beatriz ^a   Merlino, Alicia ^a   González, Mercedes ^a   Cerecetto, Hugo ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

1,2,6 thiadiazine; Chagas disease; Non competitive inhibitors; Phenazine; Trypanosoma cruzi triosephosphate isomerase

Indexed keywords

1,2,4 THIADIAZOLE DERIVATIVE; ANTIPROTOZOAL AGENT; DIMER; MONOMER; PHENAZINE DERIVATIVE; THIADIAZINE DERIVATIVE; TRIOSEPHOSPHATE ISOMERASE; TRIOSEPHOSPHATE ISOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; BINDING SITE; CHAGAS DISEASE; CHEMICAL STRUCTURE; DOSE RESPONSE; DRUG EFFECT; DRUG SELECTIVITY; ENZYME INHIBITION; LIGAND BINDING; MACROMOLECULE; MOLECULAR DOCKING; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ANTIPROTOZOAL AGENTS; BINDING, COMPETITIVE; CHAGAS DISEASE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; ESCHERICHIA COLI; MODELS, BIOLOGICAL; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PHENAZINES; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; THIADIAZINES; TRIOSE-PHOSPHATE ISOMERASE; TRYPANOSOMA CRUZI;

EID: 84896349759     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2013.765415     Document Type: Article

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