1,2,4-thiadiazol-5(4H)-ones: A new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 28, Issue 5, 2013, Pages 981-989

  Alvarez, Guzmán ^a   Aguirre López, Beatriz ^b   Cabrera, Nallely ^b   Marins, Eliã B ^c   Tinoco, Luzineide ^c   Batthyány, Carlos Ignacio ^d   De Gómez Puyou, Marieta Tuena ^b   Puyou, Armando Gómez ^b   Pérez Montfort, Ruy ^b   Cerecetto, Hugo ^a   González, Mercedes ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d INSTITUT PASTEUR DE MONTEVIDEO   (Uruguay)

Author keywords

Chagas disease; Inactivation mechanism; TcTIM; Thiadiazol

Indexed keywords

1,2,4 THIADIAZOL 5(4H) ONE DERIVATIVE; 1,2,4 THIADIAZOLE DERIVATIVE; BENZNIDAZOLE; LIPOSOME; MONOMER; MUTANT PROTEIN; NIFURTIMOX; TRIOSEPHOSPHATE ISOMERASE; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMICAL COMPOSITION; CONTROLLED STUDY; COVALENT BOND; DIMERIZATION; DRUG INHIBITION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INACTIVATION; ENZYME INHIBITION; EPIMASTIGOTE; GROWTH INHIBITION; IC 50; KINETOPLASTIDA; LEISHMANIA MEXICANA; MUTANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; WILD TYPE;

DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; TRIOSE-PHOSPHATE ISOMERASE; TRYPANOSOMA CRUZI;

EID: 84874589088     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2012.700928     Document Type: Article

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