Peripheral interleukin-2 level is associated with negative symptoms and cognitive performance in schizophrenia

Physiology and Behavior

Volumn 129, Issue , 2014, Pages 194-198

  Asevedo, Elson ^a   Rizzo, Lucas B ^a   Gadelha, Ary ^a   Mansur, Rodrigo B ^a   Ota, Vanessa K ^a   Berberian, Arthur A ^a   Scarpato, Bruno S ^a   Teixeira, Antônio L ^b   Bressan, Rodrigo A ^a   Brietzke, Elisa ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Behavioral symptoms; Biological markers; Cognition; Interleukin 2; Schizophrenia

Indexed keywords

EDETIC ACID; INTERLEUKIN 2; IL2 PROTEIN, HUMAN;

ADULT; ARTICLE; BLOOD ANALYSIS; CALGARY DEPRESSION SCALE; CLINICAL ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; COGNITION; COGNITIVE PERFORMANCE; CONTROLLED STUDY; DSM-IV; ENZYME BLOOD LEVEL; EXECUTIVE FUNCTION; FEMALE; GLOBAL ASSESSMENT OF FUNCTIONING; HUMAN; INHIBITION (PSYCHOLOGY); INTELLIGENCE; LEARNING; MALE; MENTAL DETERIORATION; NEGATIVE SYNDROME; OUTPATIENT; PERIPHERAL LYMPHOCYTE; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; SCHIZOPHRENIA; TASK PERFORMANCE; VEIN PUNCTURE; WECHSLER INTELLIGENCE SCALE; WORKING MEMORY; BLOOD; INTELLIGENCE TEST; LANGUAGE; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; SHORT TERM MEMORY;

ADULT; BLOOD CHEMICAL ANALYSIS; COGNITION; EXECUTIVE FUNCTION; FEMALE; HUMANS; INTELLIGENCE TESTS; INTERLEUKIN-2; LANGUAGE; LEARNING; MALE; MEMORY, SHORT-TERM; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 84896348847     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2014.02.032     Document Type: Article

References (50)

1. van Os J., Kapur S. Schizophrenia. Lancet 2009, 374:635-645.
2. Goff D.C., Hill M., Barch D. The treatment of cognitive impairment in schizophrenia. Pharmacol Biochem Behav 2011, 99:245-253.
3. Green M.F., Kern R.S., Heaton R.K. Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophr Res 2004, 72:41-51.
4. Fioravanti M., Carlone O., Vitale B., Cinti M.E., Clare L. A meta-analysis of cognitive deficits in adults with a diagnosis of schizophrenia. Neuropsychol Rev 2005, 15:73-95.
5. Sawa A., Snyder S.H. Schizophrenia: diverse approaches to a complex disease. Science 2002, 296:692-695.
6. Miller B.J., Buckley P., Seabolt W., Mellor A., Kirkpatrick B. Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry 2011, 70:663-671.
7. Grassi-Oliveira R., Brietzke E., Pezzi J.C., Lopes R.P., Teixeira A.L., Bauer M.E. Increased soluble tumor necrosis factor-alpha receptors in patients with major depressive disorder. Psychiatry Clin Neurosci 2009, 63:202-208.
8. Noto C.S., Gadelha A., Belangero S.I., Smith M.A., de Aguiar B.W., Panizzuti B., et al. Association of biomarkers and depressive symptoms in schizophrenia. Neurosci Lett 2011, 505:282-285.
9. Modabbernia A., Taslimi S., Brietzke E., Ashrafi M. Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies. Biol Psychiatry 2013, 74:15-25.
10. Pedrini M., Massuda R., Fries G.R., de Bittencourt Pasquali M.A., Schnorr C.E., Moreira J.C., et al. Similarities in serum oxidative stress markers and inflammatory cytokines in patients with overt schizophrenia at early and late stages of chronicity. J Psychiatr Res 2012, 46:819-824.
11. Brietzke E., Kapczinski F. TNF-alpha as a molecular target in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32:1355-1361.
12. Akdis M., Burgler S., Crameri R., Eiwegger T., Fujita H., Gomez E., et al. Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases. J Allergy Clin Immunol 2011, 127:701-721. [e1-70].
13. Mahendran R., Chan Y.H. Interleukin-2 levels in chronic schizophrenia patients. Ann Acad Med Singapore 2004, 33:320-323.
14. Potvin S., Stip E., Sepehry A.A., Gendron A., Bah R., Kouassi E. Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry 2008, 63:801-808.
15. Ganguli R., Rabin B.S., Belle S.H. Decreased interleukin-2 production in schizophrenic patients. Biol Psychiatry 1989, 26:427-430.
16. Hornberg M., Arolt V., Wilke I., Kruse A., Kirchner H. Production of interferons and lymphokines in leukocyte cultures of patients with schizophrenia. Schizophr Res 1995, 15:237-242.
17. Kim Y.K., Lee M.S., Suh K.Y. Decreased interleukin-2 production in Korean schizophrenic patients. Biol Psychiatry 1998, 43:701-704.
18. Na K.S., Kim Y.K. Monocytic, Th1 and th2 cytokine alterations in the pathophysiology of schizophrenia. Neuropsychobiology 2007, 56:55-63.
19. Noto C., Gadelha A., Belangero S.I., Spindola L.M., Rocha N.P., de Miranda A.S., et al. Circulating levels of sTNFR1 as a marker of severe clinical course in schizophrenia. J Psychiatr Res 2013, 47:467-471.
20. Asevedo E., Gadelha A., Noto C., Mansur R.B., Zugman A., Belangero S.I., et al. Impact of peripheral levels of chemokines. BDNF and oxidative markers on cognition in individuals with schizophrenia, J Psychiatr Res 2013, 47:1376-1382.
21. Brandt J. The hopkins verbal learning test: development of a new memory test with six equivalent forms. Clin Neuropsychol 1991, 5:125-142.
22. Primi R. Bateria informatizada de capacidades cognitivas. Bateria Informatizada de Capacidades cognitivas 2002.
23. Salthouse T.A., Babcock R.L., Shaw R.J. Effects of adult age on structural and operational capacities in working memory. Psychol Aging 1991, 6:118-127.
24. Yntema D.B. Keeping track of several things at once. Hum Factors 1963, 5:7-17.
25. Morris N., Jones D.M. Memory updating in working memory: the role of the central executive. Br J Psychol 1990, 81:111-121.
26. Wechsler D. The psychometric tradition: developing the Wechsler adult intelligence scale. Contemp Educ Psychol 1981, 6:82-85.
27. Jersild A.T. Mental set and shift. Arch Psychol 1927, 14(89):81.
28. Rogers R.D., Monsell S. Costs of a predictable switch between simple cognitive tasks. J Exp Psychol Gen 1995, 124:207-231.
29. Krikorian R., Bartok J., Gay N. Tower of London procedure: a standard method and developmental data. J Clin Exp Neuropsychol 1994, 16:840-850.
30. Kongs S.K., L.L.T., L.IG, Heaton R.K. Wisconsin card sorting test-64 card version: professional manual 2000, Psychological Assessment Resources Inc., Lutz.
31. Capovilla A.G.S., Capovilla F.C., Dos Santos Assef E.C. Computerized stroop test to assess selective attention in children with attention deficit hyperactivity disorder 2007, Universidad Complutense: Facultad de Psicología.
32. Seabra A.G., Muniz M., Primi R. Validity evidence for the reading competence test of words and non-words. Span J Psychol 2009, 12:788-798.
33. Thompson-Schill S.L., D'Esposito M., Aguirre G.K., Farah M.J. Role of left inferior prefrontal cortex in retrieval of semantic knowledge: a reevaluation. Proc Natl Acad Sci U S A 1997, 94:14792-14797.
34. Oliveira R. Teste não verbal de inteligência 2002, Editora Psico-pedagógica, São Paulo.
35. Gattaz W.F., Dalgalarrondo P., Schroder H.C. Abnormalities in serum concentrations of interleukin-2, interferon-alpha and interferon-gamma in schizophrenia not detected. Schizophr Res 1992, 6:237-241.
36. Kim Y.K., Myint A.M., Verkerk R., Scharpe S., Steinbusch H., Leonard B. Cytokine changes and tryptophan metabolites in medication-naive and medication-free schizophrenic patients. Neuropsychobiology 2009, 59:123-129.
37. Singh B., Bera N.K., Nayak C.R., Chaudhuri T.K. Decreased serum levels of interleukin-2 and interleukin-6 in Indian Bengalee schizophrenic patients. Cytokine 2009, 47:1-5.
38. Ebrinc S., Top C., Oncul O., Basoglu C., Cavuslu S., Cetin M. Serum interleukin 1 alpha and interleukin 2 levels in patients with schizophrenia. J Int Med Res 2002, 30:314-317.
39. Zhang X.Y., Zhou D.F., Zhang P.Y., Wu G.Y., Cao L.Y., Shen Y.C. Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology. Schizophr Res 2002, 57:247-258.
40. Zhang X.Y., Zhou D.F., Cao L.Y., Zhang P.Y., Wu G.Y., Shen Y.C. Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia. J Clin Psychiatry 2004, 65:940-947.
41. Schwarz M.J., Kronig H., Riedel M., Dehning S., Douhet A., Spellmann I., et al. IL-2 and IL-4 polymorphisms as candidate genes in schizophrenia. Eur Arch Psychiatry Clin Neurosci 2006, 256:72-76.
42. Paul-Samojedny M., Owczarek A., Kowalczyk M., Suchanek R., Palacz M., Kucia K., et al. Association of interleukin 2 (IL-2), interleukin 6 (IL-6), and TNF-alpha (TNFalpha) gene polymorphisms with paranoid schizophrenia in a Polish population. J Neuropsychiatry Clin Neurosci 2013, 25:72-82.
43. Hoffmann S.C., Stanley E.M., Darrin Cox E., Craighead N., DiMercurio B.S., Koziol D.E., et al. Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes. Transplantation 2001, 72:1444-1450.
44. Himmerich H., Schonherr J., Fulda S., Sheldrick A.J., Bauer K., Sack U. Impact of antipsychotics on cytokine production in-vitro. J Psychiatr Res 2011, 45:1358-1365.
45. Drzyzga L., Obuchowicz E., Marcinowska A., Herman Z.S. Cytokines in schizophrenia and the effects of antipsychotic drugs. Brain Behav Immun 2006, 20:532-545.
46. Pae C.U., Yoon C.H., Kim T.S., Kim J.J., Park S.H., Lee C.U., et al. Antipsychotic treatment may alter T-helper (TH) 2 arm cytokines. Int Immunopharmacol 2006, 6:666-671.
47. Bresee C., Rapaport M.H. Persistently increased serum soluble interleukin-2 receptors in continuously ill patients with schizophrenia. Int J Neuropsychopharmacol 2009, 12:861-865.
48. Sarder M., Saito H., Abe K. Interleukin-2 promotes survival and neurite extension of cultured neurons from fetal rat brain. Brain Res 1993, 625:347-350.
49. Awatsuji H., Furukawa Y., Nakajima M., Furukawa S., Hayashi K. Interleukin-2 as a neurotrophic factor for supporting the survival of neurons cultured from various regions of fetal rat brain. J Neurosci Res 1993, 35:305-311.
50. Araujo D.M., Lapchak P.A. Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: selective effects on specific interleukins and interleukin receptors. Neuroscience 1994, 61:745-754.