Association of interleukin 2 (IL-2), interleukin 6 (IL-6), and TNF-alpha (TNFα) gene polymorphisms with paranoid schizophrenia in a Polish population

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 25, Issue 1, 2013, Pages 72-82

  Paul Samojedny, Monika ^a   Owczarek, Aleksander ^a   Kowalczyk, Małgorzata ^a   Suchanek, Renata ^a   Palacz, Marta ^a   Kucia, Krzysztof ^a   Fila Daniłow, Anna ^a   Borkowska, Paulina ^a   Kowalski, Jan ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PARANOID SCHIZOPHRENIA; POLAND; POLYMERASE CHAIN REACTION; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; ANALYSIS OF VARIANCE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-2; INTERLEUKIN-6; KAPLAN-MEIER ESTIMATE; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLAND; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA, PARANOID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84883265730     PISSN: 08950172     EISSN: 15457222     Source Type: Journal    
DOI: 10.1176/appi.neuropsych.12020021     Document Type: Article

References (53)

1. Leonard B: Is there an immunologic basis for schizophrenia? Expert Rev Clin Immunol 2005; 1:103-112
2. Allen NC, Bagade S, McQueen MB, et al: Systematic metaanalysis and field synopsis of the genetic association studies in schizophrenia: the SzGene database. Nat Genet 2008; 40:827-834
3. Deverman BE, Patterson PH: Cytokines and CNS development. Neuron 2009; 64:61-78
4. Garay PA, McAllister AK: Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders. Front Synaptic Neuroscience 2010; 2:1-16
5. Szelényi J, Vizi ES: The catecholamine-cytokine balance: interaction between the brain and the immune system. Ann N Y Acad Sci 2007; 1113:311-324
6. Liu YL, Liu CM, Fann CS, et al: Genetic variants of IL-6 and its receptor are not associated with schizophrenia in Taiwan. Neurosci Lett 2010; 468:330-333
7. Maes M, Bocchio Chiavetto L, Bignotti S, et al: Effects of atypical antipsychotics on the inflammatory response system in schizophrenic patients resistant to treatment with typical neuroleptics. Eur Neuropsychopharmacol 2000; 10:119-124
8. Muller N, Riedel M, Gruber R, et al: The immune system and schizophrenia: an integrative view. Ann N Y Acad Sci 2000; 917:456-467
9. Schwarz MJ, Chiang S, Muller N, et al: T-helper-1 and T-helper-2 responses in psychiatric disorders. Brain Behav Immun 2001; 15:340-370
10. Feghali CA, Wright TM: Cytokines in acute and chronic inflammation. Front Biosci 1997; 2:12-26
11. Arolt V, Rothermundt M, Wandinger KP, et al: Decreased invitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment. Mol Psychiatry 2000; 5:150-158
12. Cazzullo CL, Sacchetti E, Galluzzo A, et al: Cytokine profiles in schizophrenic patients treated with risperidone: a 3-month follow-up study. Prog Neuropsychopharmacol Biol Psychiatry 2002; 26:33-39
13. Müller N, Reidel M, Ackenheil M, et al: The role of immune function in schizophrenia: an overview. Eur Arch Psychiatry Clin Neurosci 1999; 249:62-68
14. Unfried G, Böcskör S, Endler G, et al: A polymorphism of interleukin-6 gene promoter and idiopathic recurrent miscarriage. Hum Reprod 2003; 18:267-270
15. García-Miss MR, Pérez-Mutul J, López-Canul B, et al: Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia. J Psychiatr Res 2010; 44:441-446
16. Dunn AJ: Effects of cytokines and infections on brain neurochemistry. Clin Neurosci Res 2006; 6:52-68
17. Behrens MM, Sejnowski TJ: Does schizophrenia arise from oxidative dysregulation of parvalbumin-interneurons in the developing cortex? Neuropharmacology 2009; 57:193-200
18. Zhang XY, Zhou DF, Cao LY, et al: Cortisol and cytokines in chronic and treatment-resistant patients with schizophrenia: association with psychopathology and response to antipsychotics. Neuropsychopharmacology 2005; 30:1532-1538
19. Stellwagen D, Malenka RC: Synaptic scaling mediated by glial TNF-alpha. Nature 2006; 440:1054-1059
20. Purcell SM, Wray NR, Stone JL, et al: Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009; 460:748-752
21. Na KS, Kim YK: Monocytic, Th1 and Th2 cytokine alterations in the pathophysiology of schizophrenia. Neuropsychobiology 2007; 56:55-63
22. Baker I, Masserano J, Wyatt RJ: Serum cytokine concentrations in patients with schizophrenia. Schizophr Res 1996; 20:199-203
23. First MB, Spitzer RL, Gibbon M, et al: Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Clinician Version. Washington, DC, American Psychiatric Press, 1997
24. Kay SR, Fiszbein A, Opler LA: The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13:261-276
25. Paul-Samojedny M, Kowalczyk M, Suchanek R, et al: Functional polymorphism in the interleukin-6 and interleukin-10 genes in patients with paranoid schizophrenia: a case-control study. J Mol Neurosci 2010; 42:112-119
26. Kowalczyk T, Pleszczy-nska E, Ruland F: Grade Models and Methods for Data Analysis, With Applications for the Analysis of Data Populations. New York, Springer Verlag, 2004
27. John S, Turner D, Donn R, et al: Two novel biallelic polymorphisms in the IL-2 gene. Eur J Immunogenet 1998; 25:419-420
28. Hoffmann SC, Stanley EM, Cox ED, et al: Association of cytokine polymorphic inheritance and in-vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes. Transplantation 2001; 72:1444-1450
29. Terry CF, Loukacis V, Green FR: Cooperative influence of genetic polymorphisms of interleukin 6 transcriptional regulation. J Biol Chem 2000; 275:18138-18144
30. Veres A, Prohászka Z, Kilpinen S, et al: The promoter polymorphism of the IL-6 gene is associated with levels of antibodies to 60-kDa heat-shock proteins. Immunogenetics 2002; 53:851-856
31. Wilson AG, Symons JA, McDowell TL, et al: Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A 1997; 94:3195-3199
32. Bayley JP, Ottenhoff TH, Verweij CL: Is there a future for TNF promoter polymorphisms? Genes Immun 2004; 5:315-329
33. Shirts BH, Bamne M, Kim JJ, et al: A comprehensive genetic association and functional study of TNF in schizophrenia risk. Schizophr Res 2006; 83:7-13
34. Penner JD, Brown AS: Prenatal infectious and nutritional factors and risk of schizophrenia. Expert Rev Neurother 2007; 7:797-805
35. Meyer U, Yee BK, Feldon J: The neurodevelopmental impact of prenatal infections at different times in pregnancy: the earlier, the worse. Neuroscientist 2007; 13:241-266
36. Brown AS, Schaefer CA, Quesenberry CP Jr, et al: Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry 2005; 162:767-773
37. Ashdown H, Dumont Y, Ng M, et al: The role of cytokines in mediating effects of prenatal infection in the fetus: implications for schizophrenia. Mol Psychiatry 2006; 11:47-55
38. Fatemi SH, Folsom TD: The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr Bull 2009; 35:528-548
39. Schwarz MJ, Krönig H, Riedel M, et al: IL-2 and IL-4 polymorphisms as candidate genes in schizophrenia. Eur Arch Psychiatry Clin Neurosci 2006; 256:72-76
40. Carlson NG, Wieggel WA, Chen J, et al: Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. J Immunol 1999; 163:3963-3968
41. Chertoff M, Di Paolo N, Schoeneberg A, et al: Neuroprotective and neurodegenerative effects of the chronic expression of tumor necrosis factor α in the nigrostriatal dopaminergic circuit of adult mice. Exp Neurol 2011; 227:237-251
42. McGuire SO, Ling ZD, Lipton JW, et al: Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons. Exp Neurol 2001; 169:219-230
43. Theodoropoulou S, Spanakos G, Baxevanis CN, et al: Cytokine serum levels, autologous mixed lymphocyte reaction and surface marker analysis in never medicated and chronically medicated schizophrenic patients. Schizophr Res 2001; 47:13-25
44. Paterson GJ, Ohashi Y, Reynolds GP, et al: Selective increases in the cytokine, TNFa, in the prefrontal cortex of PCP-treated rats and human schizophrenic subjects: influence of antipsychotic drugs. J Psychopharmacol 2006; 20:636-642
45. Boin F, Zanardini R, Pioli R, et al: Association between-G308A tumor necrosis factor alpha gene polymorphism and schizophrenia. Mol Psychiatry 2001; 6:79-82
46. Hashimoto R, Yoshida M, Ozaki N, et al: Association analysis of the-308G/A promoter polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene in Japanese patients with schizophrenia. J Neural Transm 2004; 111:217-221
47. Kampman O, Anttila S, Illi A, et al: Interaction of tumor necrosis alpha-G308A and epidermal growth factor gene polymorphisms in early-onset schizophrenia. Eur Arch Psychiatry Clin Neurosci 2005; 255:279-283
48. Watanabe Y, Muratake T, Kaneko N, et al: No association between the tumor necrosis factor-alpha gene promoter polymorphisms and schizophrenia in a Japanese population. Psychiatry Res 2007; 153:1-6
49. Lang UE, Puls I, Müller DJ, et al: Molecular mechanisms of schizophrenia. Cell Physiol Biochem 2007; 20:687-702
50. Kim YK, Kim L, Lee MS: Relationships between interleukins, neurotransmitters and psychopathology in drug-free male schizophrenics. Schizophr Res 2000; 44:165-175
51. Licinio J, Seibyl JP, Altemus M, et al: Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients. Am J Psychiatry 1993; 150:1408-1410
52. Hänninen K, Katila H, Rontu R, et al: Tumor necrosis factoralpha-G308A polymorphism in schizophrenia in a Finnish population. Neurosci Lett 2005; 385:76-81
53. Naudin J, Capo C, Giusano B, et al: A differential role for interleukin-6 and tumor necrosis factor-a in schizophrenia? Schizophr Res 1997; 26:227-233