The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells

Genes and Development

Volumn 28, Issue 6, 2014, Pages 576-593

  Gerhardt, Dawson M ^a,b   Pajcini, Kostandin V ^a,b   D'altri, Teresa ^c   Tu, LiLi ^a,b   Jain, Rajan ^b   Xu, Lanwei ^a,b   Chen, Michael J ^a,b   Rentschler, Stacey ^b   Shestova, Olga ^a,b   Wertheim, Gerald B ^a,b   Tobias, John W ^b   Kluk, Michael ^d   Wood, Antony W ^e   Aster, Jon C ^d   Gimotty, Phyllis A ^b   Epstein, Jonathan A ^b   Speck, Nancy ^a,b   Bigas, Anna ^c   Pear, Warren S ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c HOSPITAL DEL MAR   (Spain)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e CELL SIGNALING TECHNOLOGY   (United States)

Author keywords

Hematopoietic stem cell; Notch; Transcriptional activation domain

Indexed keywords

NOTCH1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FETUS CELL; FETUS DEVELOPMENT; FETUS LIVER; GENETIC MODEL; GENOTYPE; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROTEIN ASSEMBLY; PROTEIN DOMAIN; SURVIVAL; SYSTEMATIC REVIEW; TRANSCRIPTION INITIATION; WILD TYPE;

HEMATOPOIETIC STEM CELL; NOTCH; TRANSCRIPTIONAL ACTIVATION DOMAIN;

ANIMALS; CELL LINE; FETAL STEM CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCK-IN TECHNIQUES; GENE KNOCKOUT TECHNIQUES; HEMATOPOIETIC STEM CELLS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; MICE; MUTATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS;

EID: 84896344790     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.227496.113     Document Type: Article

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