HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress

Nature Communications

Volumn 5, Issue , 2014, Pages

  Zhang, Liyong ^a,b   Chen, Xin ^a,b   Sharma, Parveen ^b   Moon, Mark ^a,b   Sheftel, Alex D ^a   Dawood, Fayez ^a,b   Nghiem, Mai P ^b   Wu, Jun ^b   Li, Ren Ke ^b   Gramolini, Anthony O ^b,c   Sorensen, Poul H ^d   Penninger, Josef M ^e   Brumell, John H ^c,f   Liu, Peter P ^a,b,c  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^b HEART AND STROKE FOUNDATION OF CANADA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; CYTOSKELETON PROTEIN; HACE1 PROTEIN; MESSENGER RNA; PROTEIN P62; RAC1 PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG; HACE1 PROTEIN, MOUSE; HEAT SHOCK PROTEIN; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

BIODEGRADATION; CARDIOVASCULAR DISEASE; ENZYME ACTIVITY; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CARDIOVASCULAR MORTALITY; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; GENE EXPRESSION; GENE LOSS; HEART FAILURE; HEART LEFT VENTRICLE FAILURE; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HEMODYNAMIC STRESS; HUMAN; HUMAN TISSUE; MALE; MOUSE; NEWBORN; NONHUMAN; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; UPREGULATION; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; CYTOLOGY; FLUORESCENCE MICROSCOPY; GENETICS; HEART; HEART MUSCLE; HEART MUSCLE CELL; HEMODYNAMICS; IMMUNOBLOTTING; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; WEIGHT BEARING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANIMALS, NEWBORN; AUTOPHAGY; CELLS, CULTURED; GENE EXPRESSION; HEART; HEART FAILURE; HEAT-SHOCK PROTEINS; HEMODYNAMICS; IMMUNOBLOTTING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; MYOCARDIUM; MYOCYTES, CARDIAC; PROTEOLYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STRESS, PHYSIOLOGICAL; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; WEIGHT-BEARING;

EID: 84896340741     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4430     Document Type: Article

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