GSTA1*-69C/T and GSTO2*N142D as asthma- and allergy-related risk factors in Italian adult patients

Clinical and Experimental Pharmacology and Physiology

Volumn 41, Issue 3, 2014, Pages 180-184

  Piacentini, Sara ^a   Polimanti, Renato ^a   Iorio, Andrea ^b   Cortesi, Maurizio ^b   Papa, Fabrizio ^b   Rongioletti, Mauro ^b   Liumbruno, Giancarlo M ^b   Manfellotto, Dario ^b   Fuciarelli, Maria ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b SAN GIOVANNI CALIBITA FATEBENEFRATELLI HOSPITAL   (Italy)

Author keywords

Genetic factors; Glutathione S transferases; GSTA1; GSTO2; Respiratory diseases; Single nucleotide polymorphisms

Indexed keywords

GENOMIC DNA; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE O2; UNCLASSIFIED DRUG; GSTA1 PROTEIN, HUMAN; GSTO2 PROTEIN, HUMAN;

ADULT; AGE DISTRIBUTION; ARTICLE; ASTHMA; BODY MASS; CHEEK; CONTROLLED STUDY; DNA EXTRACTION; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HEREDITY; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; RESPIRATORY TRACT ALLERGY; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; GENETIC FACTORS; GENETIC PREDISPOSITION; GENETICS; GLUTATHIONE S-TRANSFERASES; GSTA1; GSTO2; HYPERSENSITIVITY; RESPIRATORY DISEASES; SINGLE NUCLEOTIDE POLYMORPHISMS;

GENETIC FACTORS; GLUTATHIONE S-TRANSFERASES; GSTA1; GSTO2; RESPIRATORY DISEASES; SINGLE NUCLEOTIDE POLYMORPHISMS;

ADULT; ASTHMA; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUTATHIONE TRANSFERASE; HUMANS; HYPERSENSITIVITY; ITALY; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84896337118     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/1440-1681.12201     Document Type: Article

References (37)

1. Ober C, Hoffjan S. Asthma genetics 2006: The long and winding road to gene discovery. Genes Immun. 2006; 7: 95-100.
2. Rackeman FM. A working classification of asthma. Am. J. Med. 1947; 3: 601-6.
3. Godard P, Bousquet J, Michel FB. Extrinsic and intrinsic asthma: Still a matter of debate? Clin. Asthma Rev. 1997; 1: 19-22.
4. Humbert M, Menz G, Ying S et al. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: More similarities than differences. Immunol. Today 1999; 20: 528-33.
5. Nieves A, Magnan A, Boniface S et al. Phenotypes of asthma revisited upon the presence of atopy. Respir. Med. 2005; 99: 347-54.
6. EFA. EFA Book on Respiratory Allergy in Europe: Relieve the Burden. 2011. Available from: http://www.efanet.org/category/publications/ (accessed 2 April 2013).
7. Binia A, Kabesch M. Respiratory medicine: Genetic base for allergy and asthma. Swiss Med. Wkly 2012; 142: w13612.
8. Gorska K, Krenke R, Domagala-Kulawik J et al. Comparison of cellular and biochemical markers of airway inflammation in patients with mild-to-moderate asthma and chronic obstructive pulmonary disease: An induced sputum and bronchoalveolar lavage fluid study. J. Physiol. Pharmacol. 2008; 59: 271-84.
9. Moffatt MF, Gut IG, Demenais F et al. A large-scale, consortium-based genomewide association study of asthma. N. Engl. J. Med. 2010; 363: 1211-21.
10. Wjst M, Sargurupremraj M, Arnold M. Genome-wide association studies in asthma: What they really told us about pathogenesis. Curr. Opin. Allergy Clin. Immunol. 2013; 13: 112-18.
11. Stranger BE, Stahl EA, Raj T. Progress and promise of genomewide association studies for human complex trait genetics. Genetics 2011; 187: 367-83.
12. Polimanti R, Piacentini S, Fuciarelli M. HapMap-based study of human soluble glutathione S-transferase enzymes. The role of natural selection in shaping the single nucleotide polymorphism diversity of xenobiotic-metabolizing genes. Pharmacogenet. Genomics 2011; 21: 665-72.
13. Piacentini S, Polimanti R, Squitti R et al. GSTO1GSTO1*EE 155del polymorphism associated with increased risk for late-onset Alzheimer's disease: Association hypothesis for an uncommon genetic variant. Neurosci. Lett. 2012; 506: 203-7.
14. Piacentini S, Monaci PM, Polimanti R, Manfellotto D, Fuciarelli M. GSTO2GSTO2*N142DN142D gene polymorphism associated with hypothyroidism in Italian patients. Mol. Biol. Rep. 2013; 40: 1967-71.
15. Polimanti R, Piacentini S, Lazzarin N, Re MA, Manfellotto D, Fuciarelli M. Glutathione S-transferase variants as risk factor for essential hypertension in Italian patients. Mol. Cell. Biochem. 2011; 357: 227-33.
16. Polimanti R, Piacentini S, Lazzarin N et al. Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women. Fertil. Steril. 2012; 98: 396-400.
17. Gilliland FD, Li YF, Saxon A, Diaz-Sanchez D. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: Randomised, placebo-controlled crossover study. Lancet 2004; 363: 119-25.
18. Piacentini S, Polimanti R, Moscatelli B, Re MA, Manfellotto D, Fuciarelli M. Lack of association between GSTM1, GSTP1, and GSTT1 gene polymorphisms and asthma in adult patients from Rome, central Italy. J. Investig. Allergol. Clin. Immunol. 2012; 22: 252-6.
19. Karam RA, Pasha HF, El-Shal AS, Rahman HM, Gad DM. Impact of glutathione-S-transferase gene polymorphisms on enzyme activity, lung function and bronchial asthma susceptibility in Egyptian children. Gene 2012; 497: 314-19.
20. Piacentini S, Polimanti R, Simonelli I et al. Glutathione S-transferase polymorphisms, asthma susceptibility and confounding variables: A meta-analysis. Mol. Biol. Rep. 2013; 40: 3299-313.
21. Minelli C, Granell R, Newson R et al. Glutathione S-transferase genes and asthma phenotypes. A Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data. Int. J. Epidemiol. 2010; 39: 539-62.
22. Piacentini S, Polimanti R, Moscatelli B et al. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicenter Italian field study: A preliminary study. Ann. Hum. Biol. 2010; 37: 427-39.
23. Piacentini S, Verrotti A, Polimanti R et al. Functional polymorphisms of GSTA1 and GSTO2 genes associated with asthma in Italian children. Clin. Chem. Lab. Med. 2012; 50: 311-15.
24. Wilk JB, Walter RE, Laramie JM, Gottlieb DJ, O'Connor GT. Framingham Heart Study genome-wide association: Results for pulmonary function measures. BMC Med. Genet. 2007; 8: S8.
25. Sohn SW, Jung JW, Lee SY et al. Expression pattern of GSTP1 and GSTA1 in the pathogenesis of asthma. Exp. Lung Res. 2013; 39: 173-81.
26. Polimanti R, Carboni C, Baesso I et al. Genetic variability of glutathione S-transferase enzymes in human populations: Functional inter-ethnic differences in detoxification systems. Gene 2013; 512: 102-7.
27. Kauffmann F, Demenais F. Gene-environment interactions in asthma and allergic diseases. Challenges and perspectives. J. Allergy Clin. Immunol. 2012; 130: 1229-40.
28. Bousquet J, Khaltaev N, Cruz AA. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update. Allergy 2008; 63: 8-160.
29. Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention. 2011. Available from: http://www.ginasthma.org/ (accessed 25 March 2012).
30. Coles BF, Kadlubar FF. Human alpha class glutathione S-transferases: Genetic polymorphism, expression, and susceptibility to disease. Methods Enzymol. 2005; 401: 9-42.
31. Morel F, Rauch C, Coles B, Le Ferrec E, Guillouzo A. The human glutathione transferase alpha locus: Genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter. Pharmacogenetics 2002; 12: 277-86.
32. Schmuck EM, Board PG, Whitbread AK et al. Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: Implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases. Pharmacogenet. Genomics 2005; 15: 493-501.
33. Mukherjee B, Salavaggione OE, Pelleymounter LL et al. Glutathione S-transferase omega 1 and omega 2 pharmacogenomics. Drug Metab. Dispos. 2006; 34: 1237-46.
34. Yanbaeva DG, Wouters EF, Dentener MA, Spruit MA, Reynaert NL. Association of glutathione-S-transferase omega haplotypes with susceptibility to chronic obstructive pulmonary disease. Free Radic. Res. 2009; 43: 738-43.
35. Polimanti R, Piacentini S, Moscatelli B, Pellicciotti L, Manfellotto D, Fuciarelli M. GSTA1, GSTO1, GSTO2 gene polymorphisms in Italian asthma patients. Clin. Exp. Pharmacol. Physiol. 2010; 37: 870-2.
36. Budowle B, Moretti T, Smith J, Dizinno J. DNA Typing Protocols. Molecular Biology and Forensic Analysis. Eaton Publishing, Natick, MA, 2000.
37. Menashe I, Rosenberg PS, Chen B. EPGA power calculator for case-control genetic association analyses. BMC Genet. 2008; 9: 36.