Genetic variability of glutathione S-transferase enzymes in human populations: Functional inter-ethnic differences in detoxification systems

Gene

Volumn 512, Issue 1, 2013, Pages 102-107

  Polimanti, Renato ^a   Carboni, Cinzia ^a   Baesso, Ilenia ^a   Piacentini, Sara ^a   Iorio, Andrea ^b   De Stefano, Gian Franco ^a   Fuciarelli, Maria ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b SAN GIOVANNI CALIBITA FATEBENEFRATELLI HOSPITAL   (Italy)

Author keywords

Ecuador; Ethiopia; Genetic polymorphism; Italy; Pharmacogenetics; Population demography

Indexed keywords

GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE O1; GLUTATHIONE TRANSFERASE O2; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; UNCLASSIFIED DRUG;

ARTICLE; ECUADOR; ETHIOPIA; ETHNIC DIFFERENCE; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; MALE; PRIORITY JOURNAL; RISK FACTOR;

ALLELES; ETHNIC GROUPS; GENE FREQUENCY; GENETIC VARIATION; GENETICS, POPULATION; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS;

EID: 84868622293     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2012.09.113     Document Type: Article

References (40)

1. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
2. Ben Salah G., et al. Polymorphisms of glutathione S-transferases M1, T1, P1 and A1 genes in the Tunisian population: an intra and interethnic comparative approach. Gene 2012, 498:317-322.
3. Board P.G. The omega-class glutathione transferases: structure, function, and genetics. Drug Metab. Rev. 2011, 43:226-235.
4. Bolt H.M., Thier R. Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology. Curr. Drug Metab. 2006, 7:613-628.
5. Coles B.F., Kadlubar F.F. Human alpha class glutathione S-transferases: genetic polymorphism, expression, and susceptibility to disease. Methods Enzymol. 2005, 401:9-42.
6. Coles B.F., et al. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. Pharmacogenetics 2001, 11:663-669.
7. De Angelis F., Garzoli A., Battistini A., Iorio A., De Stefano G.F. Genetic response to an environmental pathogenic agent: HLA-DQ and onchocerciasis in northwestern Ecuador. Tissue Antigens 2012, 79:123-129.
8. De Stefano G.F., et al. Analysis of three RFLPs of the COL1A2 (Type I Collagen) in the Amhara and the Oromo of Ethiopia. Ann. Hum. Biol. 2002, 29:432-441.
9. Di Pietro G., Magno L.A., Rios-Santos F. Glutathione S-transferases: an overview in cancer research. Expert Opin. Drug Metab. Toxicol. 2010, 6:153-170.
10. Excoffier L., Lischer H.E. Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Mol. Ecol. Resour. 2010, 10:564-567.
11. Frova C. Glutathione transferases in the genomics era: new insights and perspectives. Biomol. Eng. 2006, 23:149-169.
12. Fuciarelli M., Caccuri A., De Francesca M., Ferazzoli F., Piacentini S., Porreca F. Modulation of the GSTT1 activity by the GSTM1 phenotype in a sample of Italian farm-workers. Arch. Toxicol. 2009, 83:115-120.
13. Gabriel S.B., et al. The structure of haplotype blocks in the human genome. Science 2002, 296:2225-2229.
14. Gaspar P.A., et al. Polymorphisms of CYP1a1, CYP2e1, GSTM1, GSTT1, and TP53 genes in Amerindians. Am. J. Phys. Anthropol. 2002, 119:249-256.
15. Greenacre M. Correspondence analysis in medical research. Stat. Methods Med. Res. 1992, 1:97-117.
16. Hayes J.D., Flanagan J.U., Jowsey I.R. Glutathione transferases. Ann. Rev. Pharm. Toxicol. 2005, 45:51-88.
17. Hunley K., Healy M. The impact of founder effects, gene flow, and European admixture on native American genetic diversity. Am. J. Phys. Anthropol. 2011, 146:530-538.
18. International HapMap 3 Consortium, et al. Integrating common and rare genetic variation in diverse human populations. Nature 2010, 467:52-58.
19. Josephy P.D. Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicology. Hum. Genomics Proteomics 2010, 2010:876940.
20. Lampe J.W. Diet, genetic polymorphisms, detoxification, and health risks. Altern. Ther. Health Med. 2007, 13:S108-S111.
21. Li M., Peng R.S., Wei C., Lu Q. A U-Statistic-based random forest approach for genetic association study. Front. Biosci. 2012, 4:2707-2717.
22. Mroziewicz M., Tyndale R.F. Pharmacogenetics: a tool for identifying genetic factors in drug dependence and response to treatment. Addict. Sci. Clin. Pract. 2010, 5:17-29.
23. Mukherjee B., et al. Glutathione S-transferase Omega 1 and Omega 2 pharmacogenomics. Drug Metab. Dispos. 2006, 34:1237-1246.
24. Omiecinski C.J., Vanden Heuvel J.P., Perdew G.H., Peters J.M. Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities. Toxicol. Sci. 2011, (Suppl. 1):S49-S75.
25. Paiva L., Marcos R., Creus A., Coggan M., Oakley A.J., Board P.G. Polymorphism of glutathione transferase Omega 1 in a population exposed to a high environmental arsenic burden. Pharmacogenet. Genomics 2008, 18:1-10.
26. Paiva L., Hernández A., Martínez V., Creus A., Quinteros D., Marcos R. Association between GSTO2 polymorphism and the urinary arsenic profile in copper industry workers. Environ. Res. 2010, 110:463-468.
27. Piacentini S., et al. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: a preliminary study. Ann. Hum. Biol. 2010, 37:427-439.
28. Piacentini S., Polimanti R., Porreca F., Martínez-Labarga C., De Stefano G.F., Fuciarelli M. GSTT1 and GSTM1 gene polymorphisms in European and African populations. Mol. Biol. Rep. 2011, 38:1225-1230.
29. Piacentini S., et al. GSTO1*E155del polymorphism associated with increased risk for late-onset Alzheimer's disease: association hypothesis for an uncommon genetic variant. Neurosci. Lett. 2012, 506:203-207.
30. Piacentini S., et al. GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients. J. Neurol. Sci. 2012, 317:137-140.
31. Piacentini S., et al. Functional polymorphisms of GSTA1 and GSTO2 genes associated with asthma in Italian children. Clin. Chem. Lab. Med. 2012, 50:311-315.
32. Polimanti R., Piacentini S., Porreca F., Fuciarelli M. Glutathione S-transferase ω class (GSTO) polymorphisms in a sample from Rome (Central Italy). Ann. Hum. Biol. 2010, 37:585-592.
33. Polimanti R., Piacentini S., Fuciarelli M. HapMap-based study of human soluble glutathione S-transferase enzymes: the role of natural selection in shaping the single nucleotide polymorphism diversity of xenobiotic-metabolizing genes. Pharmacogenet. Genomics 2011, 21:665-672.
34. Polimanti R., Piacentini S., Lazzarin N., Re M.A., Manfellotto D., Fuciarelli M. Glutathione S-transferase variants as risk factor for essential hypertension in Italian patients. Mol. Cell. Biochem. 2011, 357:227-233.
35. Polimanti R., Piacentini S., De Angelis F., De Stefano G.F., Fuciarelli M. Human GST loci as markers of evolutionary forces: GSTO1*E155del and GSTO1*E208K polymorphisms may be under natural selection induced by environmental arsenic. Dis. Markers 2011, 31:231-239.
36. Polimanti R., et al. Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women. Fertil. Steril. 2012, 98:396-400.
37. Schmuck E., et al. Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs. Int. J. Biochem. Cell Biol. 2008, 40:2553-2559.
38. Thier R., et al. Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes. Int. J. Hyg. Environ. Health 2003, 206:149-171.
39. Yuan H.Y., et al. FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res. 2006, 34:W635-W641.
40. Zhou H., Brock J., Liu D., Board P.G., Oakley A.J. Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases. J. Mol. Biol. 2012, 420:190-203.