Functional polymorphisms of GSTA1 and GSTO2 genes associated with asthma in Italian children

Clinical Chemistry and Laboratory Medicine

Volumn 50, Issue 2, 2012, Pages 311-315

  Piacentini, Sara ^a   Verrotti, Alberto ^b   Polimanti, Renato ^a,c   Giannini, Cosimo ^b   Saccucci, Patrizia ^a   Manfellotto, Dario ^c   Fuciarelli, Maria ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c FATEBENEFRATELLI HOSPITAL   (Italy)

Author keywords

childhood asthma; complex disease genes; detoxification enzymes; glutathione S transferases

Indexed keywords

ARTICLE; ASTHMA; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GSTA 1 GENE; GSTO 2 GENE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

ASTHMA; CHILD; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUTATHIONE TRANSFERASE; HUMANS; ITALY; MALE; POLYMORPHISM, GENETIC;

EID: 84860278354     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm.2011.774     Document Type: Article

References (28)

1. Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med 2006;355:2226-35. (Pubitemid 44791164)
2. Kabesch K. Gene by environment interactions and the development of asthma and allergy. Toxicol Lett 2006;162:43-8.
3. Basu K, Palmer CN, Tavendale R, Lipworth BJ, Mukhopadhyay S. Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol. J Allergy Clin Immunol 2009;124:1188-94.
4. Ober C, Hoffian S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 2006;7:95-100.
5. Palmer CN, Doney AS, Lee SP, Murrie I, Ismail T, Macgregor DF, et al. Glutathione S-transferase M1 and P1 genotype, passive smoking, and peak expiratory flow in asthma. Pediatrics 2006;118:710-6. (Pubitemid 46085429)
6. Curjuric I, Imboden M, Schindler C, Downs SH, Hersberger M, Liu SL, et al. HMOX1 and GST variants modify attenuation of FEF25-75 % decline due to PM10 reduction. Eur Respir J 2010;35:505-14.
7. Polimanti R, Piacentini S, Fuciarelli M. HapMap-based study of human soluble glutathione S-transferase enzymes: the role of natural selection in shaping the single nucleotide polymorphism diversity of xenobiotic-metabolizing genes. Pharmacogenet Genomics 2011;21:665-72.
8. Frova C. Glutathione transferases in the genomic era: New insights and perspectives. Biomol Engin 2006;23:149-69. (Pubitemid 44142335)
9. Polimanti R, Piacentini S, Lazzarin N, Re MA, Manfellotto D, Fuciarelli M. Glutathione S-transferase variants as risk factor for essential hypertension in Italian patients. Mol Cell Biochem 2011;357:227-33.
10. Polimanti R, Piacentini S, De Angelis F, De Stefano GF, Fuciarelli M. Human GST loci as markers of evolutionary forces: GSTO1*E155del and GSTO1*E208K polymorphisms may be under natural selection induced by environmental arsenic. Disease Markers 2011;DOI 10.3233/DMA-2011-0821.
11. Piacentini S, Polimanti R, Moscatelli B, Re MA, Fuciarelli R, Manfellotto D, et al. Glutathione S transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicenter Italian field study: a preliminary study. Ann Hum Biol 2010;37:427-39.
12. Minelli C, Granell C Newson R, Rose-Zerilli MJ, Torrent M, Ring SM, et al. Glutathione-S-transferase genes and asthma phenotypes: a Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data. Int J Epidemiol 2010;39:539-62.
13. Hanene C, Jihene L, Jamel A, Kamel H, Agnès H. Association of GST genes polymorphisms with asthma in Tunisian children. Mediat Inflamm 2007;2007:19564.
14. Hill TD, Graham LM, Divgi V. Racial disparities in pediatric asthma: a review of the literature. Curr Allergy Asthma Rep 2011;11:85-90.
15. Polimanti R, Piacentini S, Moscatelli B, Pellicciotti L, Manfellotto D, Fuciarelli M. GSTA1, GSTO1 and GSTO2 gene polymorphisms in Italian asthma patients. Clin Exp Pharmacol Physiol 2010;37:870-2.
16. GINA (Global INitiative for Asthma). Global strategy for asthma management and prevention. 2002. NHLBI/WHO: NIH Publication no. 01-3659. Available at: http://www.ginasthma. com. Accessed March 16, 2009.
17. Menashe I, Rosenberg PS, Chen BE. PGA: power calculator for case-control genetic association analyses. BMC Genet 2008;9:36.
18. Piacentini S, Polimanti R, Porreca F, Martìnez-Labarga C, De Stefano GF, Fuciarelli M. GSTT1 and GSTM1 gene polymorphisms in European and African populations. Mol Biol Rep 2011;38:1225-30.
19. Polimanti R, Piacentini S, Porreca F, Fuciarelli M. Glutathione S-transferase Omega class (GSTO) polymorphisms in a sample from Rome (Central Italy). Ann Hum Biol 2010;37:585-92.
20. Piipari R, Nurminen T, Savela K, Hirvonen A, Mäntylä T, Anttila S. Glutathione S-transferases and aromatic DNA adducts in smokers'bronchoalveolar macrophages. Lung Cancer 2003;39:265-72. (Pubitemid 36279446)
21. Coles BF, Morel F, Rauch C, Huber WW, Yang M, Teitel CH, et al. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. Pharmacogenetics 2001;11:663-9. (Pubitemid 33078235)
22. Coles BF, Kadlubar FF. Human alpha class glutathione S-transferases: Genetic polymorphism, xpression, and susceptibility to disease. Methods Enzymol 2005;401:9-42. (Pubitemid 43052384)
23. Whitbread AK, Masoumi A, Tetlow N, Schmuck E, Coggan M, Board PG. Characterization of the omega class of glutathione transferases. Methods Enzymol 2005;401:78-99. (Pubitemid 43052387)
24. Mukherjee B, Salavaggione OE, Pelleymounter LL, Moon I, Eckloff BW, Schaid DJ, et al. Glutathione S-transferase omega 1 and omega 2 pharmacogenomics. Drug Metab Dispos 2006;34:1237-46.
25. Nadeem A, Masood A, Siddiqui N. Oxidant-antioxidant imbalance in asthma: scientific evidence, epidemiological data and possible therapeutic options. Ther Adv Respir Dis 2008;2: 215-35.
26. Moore JH, Williams SM. Epistasis and its implications for personal genetics. Am J Hum Genet 2009;85:309-20.
27. Moore JH, Asselbergs FW, Williams SM. Bioinformatics challenges for genome-wide association studies. Bioinformatics 2010;26:445-55.
28. Stranger BE, Stahl EA, Raj T. Progress and promise of genome-wide association studies for human complex trait genetics. Genetics 2011;187:367-83.