Photopolymerizable hydrogels for implants: Monte-Carlo modeling and experimental in vitro validation

Journal of Biomedical Optics

Volumn 19, Issue 3, 2014, Pages

  Schmocker, Andreas ^a   Khoushabi, Azadeh ^a   Schizas, Constantin ^b   Bourban, Pierre Etienne ^a   Pioletti, Dominique P ^a   Moser, Christophe ^a  

^a EPFL   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

fiber probe; hydrogel; intervertebral disc; Monte Carlo; photopolymerization; poly(ethylene glycol) dimethacrylate; scattering additive; simulation and modeling

Indexed keywords

COMPLEX NETWORKS; COMPUTER SIMULATION; DRUG DELIVERY; IMPLANTS (SURGICAL); LIGHT SOURCES; LIQUIDS; MONTE CARLO METHODS; PHOTOPOLYMERIZATION; POLYETHYLENE GLYCOLS; POLYMERIZATION; PROBES; SCATTERING; SCATTERING PARAMETERS; TISSUE ENGINEERING;

DYNAMIC ABSORPTION; FIBER PROBE; INTERVERTEBRAL DISCS; MONTE CARLO MODEL; MONTE CARLO MODELING; POLY(ETHYLENE GLYCOL) DIMETHACRYLATE; SIMULATION AND MODELING; SOLID-LIQUID BOUNDARY;

HYDROGELS;

BIOMATERIAL; MACROGOL DERIVATIVE; METHACRYLIC ACID DERIVATIVE; POLY(ETHYLENE GLYCOL) DIMETHACRYLATE; POLY(ETHYLENE GLYCOL)-DIMETHACRYLATE;

ARTICLE; BIOLOGICAL MODEL; HUMAN; INTERVERTEBRAL DISK; MATERIALS TESTING; MONTE CARLO METHOD; PHOTOCHEMISTRY; POLYMERIZATION; PROSTHESES AND ORTHOSES; REPRODUCIBILITY;

BIOCOMPATIBLE MATERIALS; HUMANS; INTERVERTEBRAL DISC; MATERIALS TESTING; METHACRYLATES; MODELS, BIOLOGICAL; MONTE CARLO METHOD; PHOTOCHEMICAL PROCESSES; POLYETHYLENE GLYCOLS; POLYMERIZATION; PROSTHESES AND IMPLANTS; REPRODUCIBILITY OF RESULTS;

EID: 84896332509     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.19.3.035004     Document Type: Article

References (32)

1. J. S. Owens, "US patent: Photopolymerization methode," US patent US2344785 (1944).
2. G. Oster, "Dye-sensitized photopolymerization," Nature 173(4398), 300-301 (1954).
3. G. Odian, Principles of Polymerization, 4th ed., pp. 198-349, John Wiley & sons, Inc. (2004).
4. M. Sangermano et al., "One-pot photoinduced synthesis of conductive polythiophene-epoxy network films," Polymer (Guildf) 54(8), 2077-2080 (2013).
5. K. S. Anseth, C. M. Wang, and C. N. Bowman, "Kinetic evidence of reaction diffusion during the polymerization of multi(meth)acrylate monomers," Macromolecules 27(3), 650-655 (1994).
6. H. Zhang et al., "In situ solvothermal synthesis and characterization of transparent epoxy/TiO2 nanocomposites," J. Appl. Polym. Sci. 125(2), 1152-1160 (2012).
7. K. Ikemura et al., "UV-VIS spectra and photoinitiation behaviors of acylphosphine oxide and bisacylphosphine oxide derivatives in unfilled, light-cured dental resins," Dent. Mater. J. 27(6), 765-774 (2008).
8. M. P. Lutolf and J. A. Hubbell, "Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering," Nat. Biotechnol. 23(1), 47-55 (2005). (Pubitemid 41724624)
9. S. J. Bryant, G. D. Nicodemus, and I. Villanueva, "Designing 3D photopolymer hydrogels to regulate biomechanical cues and tissue growth for cartilage tissue engineering," Pharm. Res. 25(10), 2379-2386 (2008).
10. D.-A. Wang et al., "Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration," Nat. Mater. 6(5), 385-392 (2007). (Pubitemid 46693196)
11. Y. An and J. A. Hubbell, "Intraarterial protein delivery via intimally-adherent bilayer hydrogels," J. Control. Release 64(1-3), 205-215 (2000). (Pubitemid 30035320)
12. J. Vernengo et al., "Synthesis and characterization of injectable bioadhesive hydrogels for nucleus pulposus replacement and repair of the damaged intervertebral disc," J. Biomed. Mater. Res. B. Appl. Biomater. 93(2), 309-317 (2010).
13. H. M. Simms et al., "In situ fabrication of macroporous polymer networks within microfluidic devices by living radical photopolymerization and leaching," Lab Chip 5(2), 151-157 (2005). (Pubitemid 40260856)
14. K. T. Nguyen and J. L. West, "Photopolymerizable hydrogels for tissue engineering applications," Biomaterials 23(22), 4307-4314 (2002).
15. K. Yamaguchi and T. Nakamoto, "Micro fabrication by UV laser photopolymerization," Mem. Sch. Eng. Nagoya Univ. 50(1/2), 33-82 (1998).
16. L. Wang, S. L. Jacques, and L. Zheng, "MCML-Monte Carlo modeling of light transport in multi-layered tissues," Comput. Methods Programs Biomed. 47(2), 131-146 (1995).
17. L. Wang and S. Jacques, "Monte Carlo modeling of light transport in multi-layered tissues in standard C," Ph.D. Thesis, University of Texas, MD Anderson (1992).
18. A. C. Thompson et al., "Modeling of light absorption in tissue during infrared neural stimulation," J. Biomed. Opt. 17(7), 075002 (2012).
19. X.Wang, G. Yao, and L. V.Wang, "Monte Carlo model and single-scattering approximation of the propagation of polarized light in turbid media containing glucose," Appl. Opt. 41(4), 792-801 (2002). (Pubitemid 34636206)
20. K. Steenland and S. Greenland, "Monte Carlo sensitivity analysis and Bayesian analysis of smoking as an unmeasured confounder in a study of silica and lung cancer,"Am. J.Epidemiol. 160(4), 384-392 (2004). (Pubitemid 39045270)
21. Y. Brulle et al., "Industrial photochemistry XXI. Chemical, transport and refractive index effects in space-resolved laser photopolymerization," J. Photochem. Photobiol. A Chem. 83(1), 29-37 (1994).
22. S. J. Bryant et al., "Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain," J. Orthop. Res. 22(5), 1143-1149 (2004). (Pubitemid 39145135)
23. B. D. Fairbanks et al., "Photoinitiated polymerization of PEG-diacrylate with lithium phenyl-2,4,6-trimethylbenzoylphosphinate: polymerization rate and cytocompatibility," Biomaterials 30(35), 6702-6707 (2009).
24. C. Eyholzer et al., "Biocomposite hydrogels with carboxymethylated, nanofibrillated cellulose powder for replacement of the nucleus pulposus," Biomacromolecules 12(5), 1419-1427 (2011).
25. M. Heuberger, T. Drobek, and N. D. Spencer, "Interaction forces and morphology of a protein-resistant poly(ethylene glycol) layer," Biophys. J. 88(1), 495-504 (2005). (Pubitemid 40070695)
26. S. Lin-Gibson et al., "Synthesis and characterization of PEG dimethacrylates and their hydrogels," Biomacromolecules 5(4), 1280-1287 (1994).
27. Y. Hiraku et al., "Photosensitized DNA damage and its protection via a novel mechanism," Photochem. Photobiol. 83(1), 205-212 (2007). (Pubitemid 46697241)
28. N. B. O. S. Counselors, "Report on carcinogens background document for ultraviolet (UV) radiation and UVA, and UVB, and UVC," Report on Carcinogens Background Document for Broad Spectrum Ultraviolet (UV) Radiation and UVA, and UVB, and UVC (2000).
29. A. Schmocker et al., "Multi-scale modeling of photopolymerization for medical hydrogel-implant design," Proc. SPIE 8592, 85921D (2013).
30. H. J. Naghash, O. Okay, and Y. Ya?ci, "Gel formation by chaincrosslinking photopolymerization of methyl methacrylate and ethylene glycol dimethacrylate," Polymer (Guildf) 38(5), 1187-1196 (1997). (Pubitemid 127418943)
31. V. V. Krongauz and R. M. Yohannan, "Photopolymerization kinetics and monomer diffusion in polymer matrix," Polymer (Guildf) 31(6), 1130-1136 (1990).
32. S. C. W. Chan et al., "Papain-induced in vitro disc degeneration model for the study of injectable nucleus pulposus therapy," Spine J. 13(3), 273-283 (2013).