Synthesis and characterization of injectable bioadhesive hydrogels for nucleus pulposus replacement and repair of the damaged intervertebral disc

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 93, Issue 2, 2010, Pages 309-317

  Vernengo, J ^a   Fussell, G W ^b   Smith, N G ^b   Lowman, A M ^a  

^a Drexel University   (United States)

^b Synthes Technical Center   (United States)

Author keywords

Bioadhesive; Glutaraldehyde; PEG; PEI; PNIPAAm

Indexed keywords

AMINE FUNCTIONALITY; BIOADHESIVE FORCE; BIOADHESIVE POLYMERS; BIOADHESIVES; BRANCHED COPOLYMER; COMPRESSIVE MODULI; COVALENT CROSSLINKING; FTIR DIFFERENCE SPECTROSCOPY; GLUTARALDEHYDES; IN-VITRO; INJECTABLE SYSTEMS; INTERVERTEBRAL DISCS; MECHANICAL CHARACTERIZATIONS; NUCLEUS PULPOSUS; PHYSIOLOGICAL TEMPERATURE; PNIPAAM; POLY-N-ISOPROPYL ACRYLAMIDE; POLYETHYLENEIMINE; PORCINE SKIN; SOFT TISSUE; SYNTHESIS AND CHARACTERIZATION; SYNTHETIC MATERIALS; SYNTHETIC REPLACEMENT; THREE COMPONENT;

ALDEHYDES; BLENDING; COPOLYMERIZATION; COPOLYMERS; ETHYLENE; ETHYLENE GLYCOL; FOURIER TRANSFORM INFRARED SPECTROSCOPY; GELS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGELS; NATURAL POLYMERS; PHASE TRANSITIONS; POLYETHYLENE OXIDES; POLYMER BLENDS;

POLYETHYLENE GLYCOLS;

ALDEHYDE; AMINE; GLUTARALDEHYDE; MACROGOL; POLY(N ISOPROPYLACRYLAMIDE); POLYETHYLENEIMINE; TISSUE ADHESIVE;

ADHESION; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; COVALENT BOND; CROSS LINKING; HYDROGEL; INFRARED SPECTROSCOPY; INJECTION; INTERVERTEBRAL DISK DISEASE; NONHUMAN; NUCLEUS PULPOSUS; PHASE TRANSITION; SYNTHESIS; TISSUE REPAIR;

ACRYLIC RESINS; ADHESIVES; ANIMALS; HUMANS; HYDROGELS; IMINES; IMPLANTS, EXPERIMENTAL; INTERVERTEBRAL DISK; MATERIALS TESTING; PHASE TRANSITION; POLYETHYLENE GLYCOLS; POLYETHYLENES; SKIN; SPINAL DISEASES; SWINE;

EID: 77951201690     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31547     Document Type: Article

References (37)

1. Duffy T, Bloom JN, McNally-Heintzelman KM, Heintzelman DL, Soller EC, Hoffman GT. Sutureless ophthalmic surgery: A scaffold-enhanced bioadhesive technique. J AAPOS 2005;9:315-320.
2. Seewald S, Sriram PVJ, Nagra M, Fennerty MB, Boyer J, Oberti F, Soehendra N. The expert approach: Cyanoacrylate glue in gastric variceal bleeding. Endoscopy 2002;34:926-932.
3. Kaufman H, Insler MS, Ibrahim-Elzembely HA, Kaufman SC. Human fibrin tissue adhesive for sutureless lamellar keratoplasty and scleral patch adhesion. Ophthalmology 2003;110:2168-2172. (Pubitemid 37337854)
4. FrenchBattaglia G, Morbin T, Patarnello E. Visceral fistula as a complication of endoscopic treatment of esophageal and gastric varices using isobutyl-2-cyanoacrylate: Report of two cases. Gastrointestinal Endoscopy 2000;52:267-270. (Pubitemid 30650271)
5. Holtmann H, Stein HJ. Experimentelle Untersuchungen zur Hornhautwundverklebung mittels hochkonzentriertem Fibrinogen [Experimental studies on corneal adhesion using highly concentrated fibrinogen]. Ber Zusammenkunft Dtsch Ophthalmol Ges 1978;75:220.
6. Spotnitz W, Prabbu R. Fibrin sealant tissue adhesive: Review and update. J Long-Term Effects Med Implants 2005;15:245-270. (Pubitemid 40826599)
7. Masayuki H, Ishiko O, Honda K, Yamane T, Ohta K, Takuba T. Transmission of symptomatic parvovirus B19 infection by Fibrin sealant used during surgery. Br J Haematol 2000;108:194-195. (Pubitemid 30089954)
8. Wade LG. Organic Chemistry. Upper Saddle River, NJ: Prentice Hall; 1999.
9. Fürst W, Banerjee A. Release of glutaraldehyde from an albumin-glutaraldehyde tissue adhesive causes significant in vitro and in vivo toxicity. Ann Thorac Surg 2005;79:1522-1529. (Pubitemid 40614559)
10. Vernengo J, Fussell GW, Smith NG, Lowman AM. Evaluation of novel injectable hydrogels for nucleus pulposus replacement. J Biomed Mater Res B Appl Biomater 2008;84B:64-69.
11. Jagur-Grodzinkski J. Biomedical application of functional polymers. React Funct Polym 1999;39:99-138.
12. Perrine T, Landis WR. Analysis of polyethylenimine by spectrophotometry of its copper chelate. J Polym Sci A Polym Chem 1967;5:1993-2003.
13. Sawicki E, Hauser TR, Stanley TW, Elbert W. The 3-methyl-2- benzothiazolone hydrazone test. Sensitive new methods for the detection, rapid estimation, and determination of aliphatic aldehydes. Anal Chem 1961;33:93-96.
14. Yu H, Feng Z, Zhang A, Hou D, Sun L. Novel triblock copolymers synthesized via radical telomerization of N-isopropylacrylamide in the presence of polypseudorotaxanes made from thiolated PEG and a-CDs. Polymer 2006;47:6066-6071. (Pubitemid 44093648)
15. Sammon C, Li C, Armes SP, Lewis AL. ATR-FTIR studies of a thermo-responsive ABA triblock copolymer gelator in aqueous solution. Polymer 2006;47:6123-6130. (Pubitemid 44160484)
16. Zhang R. Synthesis, characterization and reversible transport of thermo-sensitive carboxyl methyl dextran/poly (N-isopropylacrylamide) hydrogel. Polymer 2005;46:2443-2451. (Pubitemid 40353674)
17. Deng S, Ting Y. Characterization of PEI-modified biomass and biosorption of Cu(II). Pb(II) andNi(II). Water Res 2005;39:2167-2177.
18. Guibal E, Milot C, Eterradossi O, Gauffier C, Domard A. Study of molybdate ion sorption on chitosan gel beads by different spectrometric analyses. Int J Biol Macromol 1999;24:49-59. (Pubitemid 29038102)
19. Karreman R, Dague E, Gaboriaud F, Quiles F, Duval JF, Lindsey G. The stress response protein Hsp12p increases the flexibility of the yeast Saccharomyces cerevisiae cell wall. Biochim Biophys Acta 2007;1774:131-137. (Pubitemid 46055312)
20. Morrison R, Boyd RN. Organic Chemistry,8th ed. Englewood Cliffs, N.J.: Prentice Hall; 1992.
21. Rao P, Smitha B, Sridhar S, Krishnaiah A. Preparation and performance of poly(vinyl alcohol)/polyethyleneimine blend membranes for the dehydration of 1,4-dioxane by pervaporation: Comparison with glutaraldehyde cross-linked membranes. Separation Purif Technol 2006;48:244-254. (Pubitemid 43344488)
22. Stuart B. Infrared Spectroscopy: Fundamentals and Applications. West Sussex, England: Wiley; 2004.
23. Lacombe R. Adhesion Measurement Methods. Boca Raton, Florida: CRC Press; 2006.
24. Chang Y, Tsaib C, Liangb H, Sung H. In vivo evaluation of cellular and acellular bovine pericardia fixed witha naturally occurring crosslinking agent (genipin). Biomaterials 2002;23:2447-2457.
25. Chanda M, Rempel GL. A new method of gel-coating polyethyleneimine (PEI) on organic resin beads. High capacity and fast kinetics of PEI gel-coated on polystyrene. Ind Eng Chem Res 2001;40:1624-1632.
26. Herget G, Kassaa M, Riedeb UN, Lua L, Brethnera L, Hassea J. Experimental use of an albumin-glutaraldehyde tissue adhesive for sealing pulmonary parenchyma and bronchial anastomoses. Eur J Cardio-Thorac Surg 2001;19:4-9. (Pubitemid 32036947)
27. Matsuda S, Iwata H, Se N, Ikada Y. Bioadhesion of gelatin films crosslinked with glutaraldehyde. J Biomed Mater Res 1999;45:20-27. (Pubitemid 29068434)
28. Rombers S, Menage J, Duance V, Wotton S, Ayad S. Collagen types around the cells of the intervertebral disc and cartilage end plate: An immunolocalization study. Spine 1991;16:1030-1038.
29. Godbey W, Wu KK, Mikos AG. Size matters: Molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle. J Biomed Mater Res 1999;45:268-275. (Pubitemid 29165943)
30. Bieber T, Elsasser HP. Preparation of a low molecular weight polyethylenimine for efficient cell transfection. Biotechniques 2001;30:74-81. (Pubitemid 32057893)
31. Nigel S, Hans M, Lowman A, Vernengo A, Fussell G. Method to Repair a Damaged Intervertebral Disc Through the Use of a Bioadhesive, Thermogelling Hydrogel. USA: Drexel University and Synthes, Assignee; 2006.
32. Wang Y, Chen P, Shen J. The development and characterization of a glutathione-sensitive cross-linked polyethylenimine gene vector. Biomaterials 2006;27:5292-5298. (Pubitemid 44080300)
33. Vinogradov S, Bronic TK, Kabanov AV. Nanosized cationic hydrogels for drug delivery: Preparation, properties, and interactions with cells. Adv Drug Deliv Rev 2002;54:153-1147 (Pubitemid 34075317)
34. Stile R, Burghardt WR, Healy KE. Synthesis and characterization of injectable poly(N-isopropylacrylamide)-based hydrogels that support tissue formation in vitro. Macromolecules 1999;32:7370-7379. (Pubitemid 30537680)
35. Qui Y, Park K. Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev 2001;53:321-339.
36. Bogduck N. Clinical Anatomy of the Lumbar Spine and Sacrum. London: Elsevier Churchill Livingstone; 2005.
37. Joshi A. Mechanical behavior of the human lumbar intervertebral disc with polymeric hydrogel nucleus implant: An experimental and finite element study. Philadelphia, PA: Drexel University; 2004.