Increased expression of tim-3 and its ligand Galectin-9 in rat allografts during acute rejection episodes

Biochemical and Biophysical Research Communications

Volumn 445, Issue 3, 2014, Pages 542-548

  Qiao, Xinwei ^a   Jiang, Ke ^a   Nie, Jun ^a   Fan, Kai ^a   Zheng, Zhikun ^a   Wang, Jianjun ^a   Li, Jinsong ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Acute rejection; Galectin 9; Lung transplantation; Tim 3

Indexed keywords

BETA ACTIN; ECALECTIN; GAMMA INTERFERON; INTERLEUKIN 17; MEMBRANE PROTEIN; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN 3; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; EARLY DIAGNOSIS; HISTOPATHOLOGY; LUNG GRAFT REJECTION; LUNG TRANSPLANTATION; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TH1 CELL; TH17 CELL; UPREGULATION;

RATTUS;

ACUTE REJECTION; GALECTIN-9; LUNG TRANSPLANTATION; TIM-3;

ALLOGRAFTS; ANIMALS; CD4-CD8 RATIO; GALECTINS; GRAFT REJECTION; LUNG TRANSPLANTATION; MALE; RATS; RATS, INBRED F344; RATS, INBRED LEW; RECEPTORS, CELL SURFACE; RNA, MESSENGER; UP-REGULATION;

EID: 84896319734     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.01.167     Document Type: Article

References (30)

1. Christie J.D., Edwards L.B., Kucheryavaya A.Y., Benden C., Dobbels F., Kirk R., Rahmel A.O., Stehlik J., Hertz M.I. The registry of the international society for heart and lung transplantation: twenty-eighth adult lung and heart-lung transplant report-2011. J. Heart Lung Transplant. 2011, 30:1104-1122.
2. Husain A.N., Siddiqui M.T., Holmes E.W., Chandrasekhar A.J., McCabe M., Radvany R., Garrity E.R. Analysis of risk factors for the development of bronchiolitis obliterans syndrome. Am. J. Respir. Crit. Care Med. 1999, 159:829-833.
3. Valentine V.G., Robbins R.C., Berry G.J., Patel H.R., Reichenspurner H., Reitz B.A., Theodore J. Actuarial survival of heart-lung and bilateral sequential lung transplant recipients with obliterative bronchiolitis. J. Heart Lung Transplant. 1996, 15:371-383.
4. Stewart S., Fishbein M.C., Snell G.I., Berry G.J., Boehler A., Burke M.M., Glanville A., Gould F.K., Magro C., Marboe C.C., McNeil K.D., Reed E.F., Reinsmoen N.L., Scott J.P., Studer S.M., Tazelaar H.D., Wallwork J.L., Westall G., Zamora M.R., Zeevi A., Yousem S.A. Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection. J. Heart Lung Transplant. 2007, 26:1229-1242.
5. Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T., Manning S., Greenfield E.A., Coyle A.J., Sobel R.A., Freeman G.J., Kuchroo V.K. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 2002, 415:536-541.
6. Khademi M., Illes Z., Gielen A.W., Marta M., Takazawa N., Baecher-Allan C., Brundin L., Hannerz J., Martin C., Harris R.A., Hafler D.A., Kuchroo V.K., Olsson T., Piehl F., Wallstrom E. T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J. Immunol. 2004, 172:7169-7176.
7. Zhu C., Anderson A.C., Schubart A., Xiong H., Imitola J., Khoury S.J., Zheng X.X., Strom T.B., Kuchroo V.K. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat. Immunol. 2005, 6:1245-1252.
8. Nakae S., Iwakura Y., Suto H., Galli S.J. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J. Leukoc. Biol. 2007, 81:1258-1268.
9. Freeman G.J., Casasnovas J.M., Umetsu D.T., DeKruyff R.H. TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol. Rev. 2010, 235:172-189.
10. Zhang J., Gu Y., Xu C., Qu X. Increased T cell immunoglobulin mucin-3 and its ligand in acquired aplastic anemia. Eur. J. Haematol. 2008, 81:130-139.
11. Sanchez-Fueyo A., Tian J., Picarella D., Domenig C., Zheng X.X., Sabatos C.A., Manlongat N., Bender O., Kamradt T., Kuchroo V.K., Gutierrez-Ramos J.C., Coyle A.J., Strom T.B. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat. Immunol. 2003, 4:1093-1101.
12. Ponciano V.C., Renesto P.G., Nogueira E., Rangel É.B., Cenedeze M.A., Franco M.F., Câmara N.O.S., Pacheco-Silva A. Tim-3 expression in human kidney allografts. Transpl. Immunol. 2007, 17:215-222.
13. Renesto P.G., Ponciano V.C., Cenedeze M.A., Saraiva Camara N.O., Pacheco-Silva A. High expression of Tim-3 mRNA in urinary cells from kidney transplant recipients with acute rejection. Am. J. Transplant. 2007, 7:1661-1665.
14. Manfro R.C., Aquino-Dias E.C., Joelsons G., Nogare A.L., Carpio V.N., Goncalves L.F. Noninvasive Tim-3 messenger RNA evaluation in renal transplant recipients with graft dysfunction. Transplantation 2008, 86:1869-1874.
15. Guo H., Nie J., Fan K., Zheng Z., Qiao X., Li J., Wang J., Jiang K. Improvements of surgical techniques in a rat model of an orthotopic single lung transplant. Eur. J. Med. Res. 2013, 18:1.
16. Graf R., Schiesser M., Lussi A., Went P., Scheele G.A., Bimmler D. Coordinate regulation of secretory stress proteins (PSP/reg, PAP I, PAP II, and PAP III) in the rat exocrine pancreas during experimental acute pancreatitis. J. Surg. Res. 2002, 105:136-144.
17. Wang W., Liu K., Zhang F., Cao G., Zhang Y., Liu R., Wu S. Recombinant human hepatocyte growth factor transfection alleviates hyperkinetic pulmonary artery hypertension in rabbit models. J. Thorac. Cardiovasc. Surg. 2013, 146:198-205.
18. Blocher S., Wilker S., Sucke J., Pfeil U., Dietrich H., Weimer R., Steger K., Kaufmann A., Hirschburger M., Plotz C., Padberg W., Grau V. Acute rejection of experimental lung allografts: characterization of intravascular mononuclear leukocytes. Clin. Immunol. 2007, 124:98-108.
19. Takehisa Y., Sakiyama S., Uyama T., Sumitomo M., Tamaki M., Hino H., Takehisa M., Liu M., Kondo K., Monden Y. Progressive increase of CD4(+)/CD45RC(-) lymphocytes after allograft rat lung transplantation: a marker of acute rejection. J. Thorac. Cardiovasc. Surg. 2002, 124:675-683.
20. Shenoy K.V., Solomides C., Cordova F., Rogers T.J., Ciccolella D., Criner G.J. Low CD4/CD8 ratio in bronchus-associated lymphoid tissue is associated with lung allograft rejection. J. Transplant. 2012, 2012:928081.
21. Hirashima M., Kashio Y., Nishi N., Yamauchi A., Imaizumi T.A., Kageshita T., Saita N., Nakamura T. Galectin-9 in physiological and pathological conditions. Glycoconj. J. 2004, 19:593-600.
22. Sabatos C.A., Chakravarti S., Cha E., Schubart A., Sanchez-Fueyo A., Zheng X.X., Coyle A.J., Strom T.B., Freeman G.J., Kuchroo V.K. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat. Immunol. 2003, 4:1102-1110.
23. Ponciano V.C., Renesto P.G., Nogueira E., Rangel E.B., Cenedeze M.A., Franco M.F., Camara N.O., Pacheco-Silva A. Tim-3 expression in human kidney allografts. Transpl. Immunol. 2007, 17:215-222.
24. Naka E.L., Ponciano V.C., Cenedeze M.A., Pacheco-Silva A., Camara N.O. Detection of the Tim-3 ligand, galectin-9, inside the allograft during a rejection episode. Int. Immunopharmacol. 2009, 9:658-662.
25. Vanaudenaerde B.M., Dupont L.J., Wuyts W.A., Verbeken E.K., Meyts I., Bullens D.M., Dilissen E., Luyts L., Van Raemdonck D.E., Verleden G.M. The role of interleukin-17 during acute rejection after lung transplantation. Eur. Respir. J. 2006, 27:779-787.
26. Yoshida S., Haque A., Mizobuchi T., Iwata T., Chiyo M., Webb T.J., Baldridge L.A., Heidler K.M., Cummings O.W., Fujisawa T., Blum J.S., Brand D.D., Wilkes D.S. Anti-type V collagen lymphocytes that express IL-17 and IL-23 induce rejection pathology in fresh and well-healed lung transplants. Am. J. Transplant. 2006, 6:724-735.
27. Seki M., Oomizu S., Sakata K.M., Sakata A., Arikawa T., Watanabe K., Ito K., Takeshita K., Niki T., Saita N., Nishi N., Yamauchi A., Katoh S., Matsukawa A., Kuchroo V., Hirashima M. Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin. Immunol. 2008, 127:78-88.
28. Wang F., He W., Zhou H., Yuan J., Wu K., Xu L., Chen Z.K. The Tim-3 ligand galectin-9 negatively regulates CD8+ alloreactive T cell and prolongs survival of skin graft. Cell. Immunol. 2007, 250:68-74.
29. He W., Fang Z., Wang F., Wu K., Xu Y., Zhou H., Du D., Gao Y., Zhang W.N., Niki T., Hirashima M., Yuan J., Chen Z.K. Galectin-9 significantly prolongs the survival of fully mismatched cardiac allografts in mice. Transplantation 2009, 88:782-790.
30. Oomizu S., Arikawa T., Niki T., Kadowaki T., Ueno M., Nishi N., Yamauchi A., Hirashima M. Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner. Clin Immunol 2012, 143:51-58.