High expression of Tim-3 mRNA in urinary cells from kidney transplant recipients with acute rejection

American Journal of Transplantation

Volumn 7, Issue 6, 2007, Pages 1661-1665

  Renesto, P G ^a   Ponciano, V C ^a   Cenedeze, M A ^a   Câmara, N O Saraiva ^a,b   Pacheco Silva, A ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Graft rejection; Graft survival; Immune monitoring; Immune rejection; Renal transplantation; Tim 3

Indexed keywords

AZATHIOPRINE; CALCINEURIN INHIBITOR; CYCLOSPORIN; GAMMA INTERFERON; MESSENGER RNA; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PREDNISONE; STEROID; TACROLIMUS;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GRAFT RECIPIENT; HUMAN; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TH1 CELL; TIM 3 GENE; URINALYSIS;

CROSS-SECTIONAL STUDIES; DNA PRIMERS; DNA PROBES; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; RECEPTORS, VIRUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECIMEN HANDLING;

EID: 34248640135     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2007.01795.x     Document Type: Article

References (20)

1. Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med 2000 342 : 605 612.
2. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986 136 : 2348 2357.
3. Kupiec-Weglinski J, Wasowska B, Papp I et al. CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines. J Immunol 1993 151 : 5053 5061.
4. Chan SY, DeBruyne LA, Goodman RE, Eichwald EJ, Bishop DK. In vivo depletion of CD8+ T cells results in Th2 cytokine production and alternate mechanism of allograft rejection. Transplantation 1995 59 : 1155 1161.
5. Wang H, DeVries ME, Deng S et al. The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection. Nat Med 2000 6 : 549 555.
6. Monney L, Sabatos CA, Gaglia JL et al. Th-1 specific cell surface protein TIM-3 regulates macrophage activation and severity of an autoimmune disease. Nature 2002 415 : 536 541.
7. Kuchroo VK, Umetsu DT, DeKruyff RH, Freeman GJ. The TIM gene family: emerging roles in immunity and disease. Nat Rev Immunol 2003 3 : 454 462.
8. Chae SC, Park YR, Shim SC, Yoon KS, Chung HT. The polymorphism of Th1 cell surface TIM-3 are associated in a Korean population with rheumatoid arthritis. Immunol Lett 2004 95 : 91 95.
9. Feigelstock D, Thompson P, Mattoo P, Zhang Y, Kaplan GG. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J Virol 1998 72 : 6621 6628.
10. McIntire JJ, Umetsu SE, Akbari O et al. Identification of Tapr (an airway hyperrreactivity regulatory locus) and the linked Tim gene family. Nat Immunol 2001 2 : 1109 1116.
11. Sánchez-Fueyo A, Tian J, Picarella D et al. TIM-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nature Immunol 2003 4 : 1093 1101.
12. Khademi M, Illés Z, Gielen AW et al. T cell Ig- and Mucin-Domain-Containing Molecule-3 (TIM-3) and Tim-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple screrosis. J Immunol 2004 172 : 7169 7176.
13. Sabatos CA, Chakravarti S, Cha E et al. Interaction of TIM-3 and TIM-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nature Immunol 2003 4 : 1102 1110.
14. Soulillou JP. Immune monitoring for rejection of kidney transplants. N Engl J Med 2003 344 : 1006 1007.
15. Cecka JM. The UNOS Scientific Renal Transplant Registry. In : Cecka JM, Terasaki PI (eds). Clinical transplants. Los Angeles, CA : UCLA Immunogenetics Center, 2000 : 1 21.
16. Lipman ML, Stevens AC, Strom TB. Heightened intragraft CTL gene expression in acutely rejecting renal allografts. J Immunol 1994 152 : 5120 5127.
17. Strehlau J, Pavlakis M, Lipman M et al. Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation. Proc Natl Acad Sci USA 1997 94 : 695 700.
18. Vasconcellos LM, Schachter D, Zheng XX et al. Cytotoxic lymphocyte gene expression in peripheral blood leukocytes correlates with rejecting renal allografts. Transplantation 1998 66 : 562 66.
19. Li B, Hartono C, Ding R et al. Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. N Engl J Med 2001 344 : 947 954.
20. Dadhania D, Muthukumar T, Ding R et al. Molecular signatures of urinary cells distinguish acute rejection of renal allografts from urinary tract infection. Transplantation 2003 75 : 1752 1754.