메뉴 건너뛰기




Volumn 15, Issue 4, 2014, Pages 159-165

Differentiation therapy for solid tumors

Author keywords

Differentiation therapy; Epigenetics; Neoplastic stem cell; Solid tumor; Transcription factor

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HISTONE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; MICRORNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; TRANSCRIPTION FACTOR; VORINOSTAT;

EID: 84896289524     PISSN: 17512972     EISSN: 17512980     Source Type: Journal    
DOI: 10.1111/1751-2980.12122     Document Type: Article
Times cited : (29)

References (66)
  • 1
    • 84867326265 scopus 로고    scopus 로고
    • Solid tumor differentiation therapy - is it possible?
    • Cruz FD, Matushansky I. Solid tumor differentiation therapy - is it possible? Oncotarget 2012; 3: 559-567.
    • (2012) Oncotarget , vol.3 , pp. 559-567
    • Cruz, F.D.1    Matushansky, I.2
  • 2
    • 0008034799 scopus 로고
    • An in vitro and in vivo study of differentiation in teratocarcinomas
    • Pierce GB Jr, Verney EL. An in vitro and in vivo study of differentiation in teratocarcinomas. Cancer 1961; 14: 1017-1029.
    • (1961) Cancer , vol.14 , pp. 1017-1029
    • Pierce Jr., G.B.1    Verney, E.L.2
  • 3
    • 65549168747 scopus 로고    scopus 로고
    • Differentiation therapy of leukemia: 3 decades of development
    • Nowak D, Stewart D, Koeffler HP. Differentiation therapy of leukemia: 3 decades of development. Blood 2009; 113: 3655-3665.
    • (2009) Blood , vol.113 , pp. 3655-3665
    • Nowak, D.1    Stewart, D.2    Koeffler, H.P.3
  • 4
    • 0024780147 scopus 로고
    • Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
    • Huang ME, Ye YC, Chen SR etal. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Haematol Blood Transfus 1989; 32: 88-96.
    • (1989) Haematol Blood Transfus , vol.32 , pp. 88-96
    • Huang, M.E.1    Ye, Y.C.2    Chen, S.R.3
  • 6
    • 79958814654 scopus 로고    scopus 로고
    • The 12th International Conference on Differentiation Therapy: targeting the aberrant growth, differentiation and cell death programs of cancer cells
    • Pettersson F, Miller WH Jr, Nervi C etal. The 12th International Conference on Differentiation Therapy: targeting the aberrant growth, differentiation and cell death programs of cancer cells. Cell Death Differ 2011; 18: 1231-1233.
    • (2011) Cell Death Differ , vol.18 , pp. 1231-1233
    • Pettersson, F.1    Miller Jr., W.H.2    Nervi, C.3
  • 7
    • 33750584024 scopus 로고    scopus 로고
    • Tumour stem cell-targeted treatment: elimination or differentiation
    • Massard C, Deutsch E, Soria JC. Tumour stem cell-targeted treatment: elimination or differentiation. Ann Oncol 2006; 17: 1620-1624.
    • (2006) Ann Oncol , vol.17 , pp. 1620-1624
    • Massard, C.1    Deutsch, E.2    Soria, J.C.3
  • 8
    • 84868203536 scopus 로고    scopus 로고
    • All-trans-retinoic acid inhibits growth of head and neck cancer stem cells by suppression of Wnt/β-catenin pathway
    • Lim YC, Kang HJ, Kim YS, Choi EC. All-trans-retinoic acid inhibits growth of head and neck cancer stem cells by suppression of Wnt/β-catenin pathway. Eur J Cancer 2012; 48: 3310-3318.
    • (2012) Eur J Cancer , vol.48 , pp. 3310-3318
    • Lim, Y.C.1    Kang, H.J.2    Kim, Y.S.3    Choi, E.C.4
  • 10
    • 82755167828 scopus 로고    scopus 로고
    • Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy
    • Pham PV, Phan NL, Nguyen NT etal. Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy. J Transl Med 2011; 9: 209.
    • (2011) J Transl Med , vol.9 , pp. 209
    • Pham, P.V.1    Phan, N.L.2    Nguyen, N.T.3
  • 11
    • 44349152907 scopus 로고    scopus 로고
    • High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells
    • Desbordes SC, Placantonakis DG, Ciro A etal. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2008; 2: 602-612.
    • (2008) Cell Stem Cell , vol.2 , pp. 602-612
    • Desbordes, S.C.1    Placantonakis, D.G.2    Ciro, A.3
  • 12
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta PB, Onder TT, Jiang G etal. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009; 138: 645-659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3
  • 13
    • 84867488416 scopus 로고    scopus 로고
    • Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening
    • Mezencev R, Wang L, McDonald JF. Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening. J Ovarian Res 2012; 5: 30.
    • (2012) J Ovarian Res , vol.5 , pp. 30
    • Mezencev, R.1    Wang, L.2    McDonald, J.F.3
  • 14
    • 84872813986 scopus 로고    scopus 로고
    • High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells
    • Hothi P, Martins TJ, Chen L etal. High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells. Oncotarget 2012; 3: 1124-1136.
    • (2012) Oncotarget , vol.3 , pp. 1124-1136
    • Hothi, P.1    Martins, T.J.2    Chen, L.3
  • 15
    • 79960649307 scopus 로고    scopus 로고
    • Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
    • Sekiya S, Suzuki A. Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 2011; 475: 390-393.
    • (2011) Nature , vol.475 , pp. 390-393
    • Sekiya, S.1    Suzuki, A.2
  • 16
    • 79960637387 scopus 로고    scopus 로고
    • Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors
    • Huang P, He Z, Ji S etal. Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature 2011; 475: 386-389.
    • (2011) Nature , vol.475 , pp. 386-389
    • Huang, P.1    He, Z.2    Ji, S.3
  • 17
    • 84884144094 scopus 로고    scopus 로고
    • Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors
    • Yu B, He ZY, You P etal. Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors. Cell Stem Cell 2013; 13: 328-340.
    • (2013) Cell Stem Cell , vol.13 , pp. 328-340
    • Yu, B.1    He, Z.Y.2    You, P.3
  • 18
    • 80051940892 scopus 로고    scopus 로고
    • Role of transcription factors in differentiation and reprogramming of hematopoietic cells
    • Nakajima H. Role of transcription factors in differentiation and reprogramming of hematopoietic cells. Keio J Med 2011; 60: 47-55.
    • (2011) Keio J Med , vol.60 , pp. 47-55
    • Nakajima, H.1
  • 19
    • 0345017786 scopus 로고    scopus 로고
    • Transcription factors in liver development, differentiation, and regeneration
    • Costa RH, Kalinichenko VV, Holterman AX, Wang X. Transcription factors in liver development, differentiation, and regeneration. Hepatology 2003; 38: 1331-1347.
    • (2003) Hepatology , vol.38 , pp. 1331-1347
    • Costa, R.H.1    Kalinichenko, V.V.2    Holterman, A.X.3    Wang, X.4
  • 20
    • 10744227070 scopus 로고    scopus 로고
    • Control of pancreas and liver gene expression by HNF transcription factors
    • Odom DT, Zizlsperger N, Gordon DB etal. Control of pancreas and liver gene expression by HNF transcription factors. Science 2004; 303: 1378-1381.
    • (2004) Science , vol.303 , pp. 1378-1381
    • Odom, D.T.1    Zizlsperger, N.2    Gordon, D.B.3
  • 21
    • 83255162659 scopus 로고    scopus 로고
    • An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis
    • Hatziapostolou M, Polytarchou C, Aggelidou E etal. An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 2011; 147: 1233-1247.
    • (2011) Cell , vol.147 , pp. 1233-1247
    • Hatziapostolou, M.1    Polytarchou, C.2    Aggelidou, E.3
  • 22
    • 56149088742 scopus 로고    scopus 로고
    • Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4α gene
    • Yin C, Lin Y, Zhang X etal. Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4α gene. Hepatology 2008; 48: 1528-1539.
    • (2008) Hepatology , vol.48 , pp. 1528-1539
    • Yin, C.1    Lin, Y.2    Zhang, X.3
  • 23
    • 84888304473 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-4α reverses malignancy of hepatocellular carcinoma through regulating miR-134 in the DLK1-DIO3 region
    • Yin C, Wang PQ, Xu WP etal. Hepatocyte nuclear factor-4α reverses malignancy of hepatocellular carcinoma through regulating miR-134 in the DLK1-DIO3 region. Hepatology 2013; 58: 1964-1976.
    • (2013) Hepatology , vol.58 , pp. 1964-1976
    • Yin, C.1    Wang, P.Q.2    Xu, W.P.3
  • 24
    • 77957344834 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4α suppresses the development of hepatocellular carcinoma
    • Ning BF, Ding J, Yin C etal. Hepatocyte nuclear factor 4α suppresses the development of hepatocellular carcinoma. Cancer Res 2010; 70: 7640-7651.
    • (2010) Cancer Res , vol.70 , pp. 7640-7651
    • Ning, B.F.1    Ding, J.2    Yin, C.3
  • 25
    • 77149123633 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4α attenuates hepatic fibrosis in rats
    • Yue HY, Yin C, Hou JL etal. Hepatocyte nuclear factor 4α attenuates hepatic fibrosis in rats. Gut 2010; 59: 236-246.
    • (2010) Gut , vol.59 , pp. 236-246
    • Yue, H.Y.1    Yin, C.2    Hou, J.L.3
  • 26
    • 84876991981 scopus 로고    scopus 로고
    • Regression effect of hepatocyte nuclear factor 4α on liver cirrhosis in rats
    • Fan TT, Hu PF, Wang J etal. Regression effect of hepatocyte nuclear factor 4α on liver cirrhosis in rats. J Dig Dis 2013; 14: 318-327.
    • (2013) J Dig Dis , vol.14 , pp. 318-327
    • Fan, T.T.1    Hu, P.F.2    Wang, J.3
  • 27
    • 82455171648 scopus 로고    scopus 로고
    • Recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibits hepatocellular carcinoma xenograft growth in mice
    • Zeng X, Lin Y, Yin C etal. Recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibits hepatocellular carcinoma xenograft growth in mice. Hepatology 2011; 54: 2036-2047.
    • (2011) Hepatology , vol.54 , pp. 2036-2047
    • Zeng, X.1    Lin, Y.2    Yin, C.3
  • 28
    • 84883746123 scopus 로고    scopus 로고
    • C/EBPα inhibits hepatocellular carcinoma by reducing Notch3/Hes1/p27 cascades
    • Shi YC, Zhao H, Yin C etal. C/EBPα inhibits hepatocellular carcinoma by reducing Notch3/Hes1/p27 cascades. Dig Liver Dis 2013; 45: 844-851.
    • (2013) Dig Liver Dis , vol.45 , pp. 844-851
    • Shi, Y.C.1    Zhao, H.2    Yin, C.3
  • 30
    • 84867495468 scopus 로고    scopus 로고
    • New gene therapy strategies for cancer treatment: a review of recent patents
    • Ortiz R, Melguizo C, Prados J etal. New gene therapy strategies for cancer treatment: a review of recent patents. Recent Pat Anticancer Drug Discov 2012; 7: 297-312.
    • (2012) Recent Pat Anticancer Drug Discov , vol.7 , pp. 297-312
    • Ortiz, R.1    Melguizo, C.2    Prados, J.3
  • 31
    • 84883450737 scopus 로고    scopus 로고
    • Regulatory evaluation of Glybera in Europe - two committees, one mission
    • Melchiorri D, Pani L, Gasparini P etal. Regulatory evaluation of Glybera in Europe - two committees, one mission. Nat Rev Drug Discov 2013; 12: 719.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 719
    • Melchiorri, D.1    Pani, L.2    Gasparini, P.3
  • 32
    • 0036744916 scopus 로고    scopus 로고
    • Evaluation of strategies for the intracellular delivery of proteins
    • Ye D, Xu D, Singer AU, Juliano RL. Evaluation of strategies for the intracellular delivery of proteins. Pharm Res 2002; 19: 1302-1309.
    • (2002) Pharm Res , vol.19 , pp. 1302-1309
    • Ye, D.1    Xu, D.2    Singer, A.U.3    Juliano, R.L.4
  • 33
    • 77954582967 scopus 로고    scopus 로고
    • Transcription factor-based modulation of neural stem cell differentiation using direct protein transduction
    • Stock K, Nolden L, Edenhofer F, Quandel T, Brüstle O. Transcription factor-based modulation of neural stem cell differentiation using direct protein transduction. Cell Mol Life Sci 2010; 67: 2439-2449.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 2439-2449
    • Stock, K.1    Nolden, L.2    Edenhofer, F.3    Quandel, T.4    Brüstle, O.5
  • 34
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med 2008; 358: 1148-1159.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 35
    • 77949409909 scopus 로고    scopus 로고
    • Epigenetic remodeling of chromatin architecture: exploring tumor differentiation therapies in mesenchymal stem cells and sarcomas
    • Siddiqi S, Mills J, Matushansky I. Epigenetic remodeling of chromatin architecture: exploring tumor differentiation therapies in mesenchymal stem cells and sarcomas. Curr Stem Cell Res Ther 2010; 5: 63-73.
    • (2010) Curr Stem Cell Res Ther , vol.5 , pp. 63-73
    • Siddiqi, S.1    Mills, J.2    Matushansky, I.3
  • 36
    • 0034045040 scopus 로고    scopus 로고
    • Histone deacetylases, transcriptional control, and cancer
    • Cress WD, Seto E. Histone deacetylases, transcriptional control, and cancer. J Cell Physiol 2000; 184: 1-16.
    • (2000) J Cell Physiol , vol.184 , pp. 1-16
    • Cress, W.D.1    Seto, E.2
  • 37
    • 79955148265 scopus 로고    scopus 로고
    • Cancer cells' epigenetic composition and predisposition to histone deacetylase inhibitor sensitization
    • Nalabothula N, Carrier F. Cancer cells' epigenetic composition and predisposition to histone deacetylase inhibitor sensitization. Epigenomics 2011; 3: 145-155.
    • (2011) Epigenomics , vol.3 , pp. 145-155
    • Nalabothula, N.1    Carrier, F.2
  • 38
    • 33644836549 scopus 로고    scopus 로고
    • Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies
    • O'Connor OA, Heaney ML, Schwartz L etal. Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies. J Clin Oncol 2006; 24: 166-173.
    • (2006) J Clin Oncol , vol.24 , pp. 166-173
    • O'Connor, O.A.1    Heaney, M.L.2    Schwartz, L.3
  • 39
    • 84874410182 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents
    • Ververis K, Hiong A, Karagiannis TC, Licciardi PV. Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents. Biologics 2013; 7: 47-60.
    • (2013) Biologics , vol.7 , pp. 47-60
    • Ververis, K.1    Hiong, A.2    Karagiannis, T.C.3    Licciardi, P.V.4
  • 40
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • Lim LP, Lau NC, Garrett-Engele P etal. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 2005; 433: 769-773.
    • (2005) Nature , vol.433 , pp. 769-773
    • Lim, L.P.1    Lau, N.C.2    Garrett-Engele, P.3
  • 41
    • 48949116262 scopus 로고    scopus 로고
    • miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    • Silber J, Lim DA, Petritsch C etal. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med 2008; 6: 14.
    • (2008) BMC Med , vol.6 , pp. 14
    • Silber, J.1    Lim, D.A.2    Petritsch, C.3
  • 42
    • 68849118992 scopus 로고    scopus 로고
    • The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation
    • Taulli R, Bersani F, Foglizzo V etal. The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation. J Clin Invest 2009; 119: 2366-2378.
    • (2009) J Clin Invest , vol.119 , pp. 2366-2378
    • Taulli, R.1    Bersani, F.2    Foglizzo, V.3
  • 43
    • 68849083270 scopus 로고    scopus 로고
    • MicroRNA reexpression as differentiation therapy in cancer
    • Mishra PJ, Merlino G. MicroRNA reexpression as differentiation therapy in cancer. J Clin Invest 2009; 119: 2119-2123.
    • (2009) J Clin Invest , vol.119 , pp. 2119-2123
    • Mishra, P.J.1    Merlino, G.2
  • 44
    • 84877263242 scopus 로고    scopus 로고
    • A microRNA miR-34a-regulated bimodal switch targets notch in colon cancer stem cells
    • Bu P, Chen KY, Chen JH etal. A microRNA miR-34a-regulated bimodal switch targets notch in colon cancer stem cells. Cell Stem Cell 2013; 12: 602-615.
    • (2013) Cell Stem Cell , vol.12 , pp. 602-615
    • Bu, P.1    Chen, K.Y.2    Chen, J.H.3
  • 45
    • 79959994661 scopus 로고    scopus 로고
    • Up-regulation of microRNA-145 promotes differentiation by repressing OCT4 in human endometrial adenocarcinoma cells
    • Wu Y, Liu S, Xin H etal. Up-regulation of microRNA-145 promotes differentiation by repressing OCT4 in human endometrial adenocarcinoma cells. Cancer 2011; 117: 3989-3998.
    • (2011) Cancer , vol.117 , pp. 3989-3998
    • Wu, Y.1    Liu, S.2    Xin, H.3
  • 46
    • 84875780020 scopus 로고    scopus 로고
    • Down-regulation of miR-21 induces differentiation of chemoresistant colon cancer cells and enhances susceptibility to therapeutic regimens
    • Yu Y, Sarkar FH, Majumdar AP. Down-regulation of miR-21 induces differentiation of chemoresistant colon cancer cells and enhances susceptibility to therapeutic regimens. Transl Oncol 2013; 6: 180-186.
    • (2013) Transl Oncol , vol.6 , pp. 180-186
    • Yu, Y.1    Sarkar, F.H.2    Majumdar, A.P.3
  • 47
    • 68949170622 scopus 로고    scopus 로고
    • Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
    • Ji J, Yamashita T, Budhu A etal. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 2009; 50: 472-480.
    • (2009) Hepatology , vol.50 , pp. 472-480
    • Ji, J.1    Yamashita, T.2    Budhu, A.3
  • 50
    • 84877091761 scopus 로고    scopus 로고
    • Molecular pathways: current role and future directions of the retinoic acid pathway in cancer prevention and treatment
    • Connolly RM, Nguyen NK, Sukumar S. Molecular pathways: current role and future directions of the retinoic acid pathway in cancer prevention and treatment. Clin Cancer Res 2013; 19: 1651-1659.
    • (2013) Clin Cancer Res , vol.19 , pp. 1651-1659
    • Connolly, R.M.1    Nguyen, N.K.2    Sukumar, S.3
  • 51
    • 1942518840 scopus 로고    scopus 로고
    • PPARs and the complex journey to obesity
    • Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med 2004; 10: 355-361.
    • (2004) Nat Med , vol.10 , pp. 355-361
    • Evans, R.M.1    Barish, G.D.2    Wang, Y.X.3
  • 52
    • 3042815666 scopus 로고    scopus 로고
    • Antineoplastic effects of peroxisome proliferator-activated receptor γ agonists
    • Grommes C, Landreth GE, Heneka MT. Antineoplastic effects of peroxisome proliferator-activated receptor γ agonists. Lancet Oncol 2004; 5: 419-429.
    • (2004) Lancet Oncol , vol.5 , pp. 419-429
    • Grommes, C.1    Landreth, G.E.2    Heneka, M.T.3
  • 53
    • 23044448369 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ agonists suppress adrenocortical tumor cell proliferation and induce differentiation
    • German and Austrian Adrenal Network.
    • Betz MJ, Shapiro I, Fassnacht M, Hahner S, Reincke M, Beuschlein F; German and Austrian Adrenal Network. Peroxisome proliferator-activated receptor-γ agonists suppress adrenocortical tumor cell proliferation and induce differentiation. J Clin Endocrinol Metab 2005; 90: 3886-3896.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3886-3896
    • Betz, M.J.1    Shapiro, I.2    Fassnacht, M.3    Hahner, S.4    Reincke, M.5    Beuschlein, F.6
  • 54
    • 33746218695 scopus 로고    scopus 로고
    • Differentiation and growth inhibition mediated via the RXR:PPARγ heterodimer in colon cancer
    • Cesario RM, Stone J, Yen WC, Bissonnette RP, Lamph WW. Differentiation and growth inhibition mediated via the RXR:PPARγ heterodimer in colon cancer. Cancer Lett 2006; 240: 225-233.
    • (2006) Cancer Lett , vol.240 , pp. 225-233
    • Cesario, R.M.1    Stone, J.2    Yen, W.C.3    Bissonnette, R.P.4    Lamph, W.W.5
  • 55
    • 0033616795 scopus 로고    scopus 로고
    • Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma
    • Demetri GD, Fletcher CD, Mueller E etal. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci U S A 1999; 96: 3951-3956.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3951-3956
    • Demetri, G.D.1    Fletcher, C.D.2    Mueller, E.3
  • 57
    • 84884812845 scopus 로고    scopus 로고
    • The role of aldehyde dehydrogenase (ALDH) in cancer drug resistance
    • Januchowski R, Wojtowicz K, Zabel M. The role of aldehyde dehydrogenase (ALDH) in cancer drug resistance. Biomed Pharmacother 2013; 67: 669-680.
    • (2013) Biomed Pharmacother , vol.67 , pp. 669-680
    • Januchowski, R.1    Wojtowicz, K.2    Zabel, M.3
  • 58
    • 0036554932 scopus 로고    scopus 로고
    • Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-γ and inhibitors of histone deacetylase in adenocarcinoma of the lung
    • Chang TH, Szabo E. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-γ and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res 2002; 8: 1206-1212.
    • (2002) Clin Cancer Res , vol.8 , pp. 1206-1212
    • Chang, T.H.1    Szabo, E.2
  • 59
    • 79952029974 scopus 로고    scopus 로고
    • Phase I trial of ATRA-IV and Depakote in patients with advanced solid tumor malignancies
    • David KA, Mongan NP, Smith C, Gudas LJ, Nanus DM. Phase I trial of ATRA-IV and Depakote in patients with advanced solid tumor malignancies. Cancer Biol Ther 2010; 9: 678-684.
    • (2010) Cancer Biol Ther , vol.9 , pp. 678-684
    • David, K.A.1    Mongan, N.P.2    Smith, C.3    Gudas, L.J.4    Nanus, D.M.5
  • 60
    • 84890630904 scopus 로고    scopus 로고
    • Mathematical optimization of the combination of radiation and differentiation therapies for cancer
    • Bachman JW, Hillen T. Mathematical optimization of the combination of radiation and differentiation therapies for cancer. Front Oncol 2013; 3: 52.
    • (2013) Front Oncol , vol.3 , pp. 52
    • Bachman, J.W.1    Hillen, T.2
  • 61
    • 34247152663 scopus 로고    scopus 로고
    • Combination of cytotoxic-differentiation therapy with 5-fluorouracil and phenylbutyrate in patients with advanced colorectal cancer
    • Sung MW, Waxman S. Combination of cytotoxic-differentiation therapy with 5-fluorouracil and phenylbutyrate in patients with advanced colorectal cancer. Anticancer Res 2007; 27: 995-1001.
    • (2007) Anticancer Res , vol.27 , pp. 995-1001
    • Sung, M.W.1    Waxman, S.2
  • 62
    • 84855818081 scopus 로고    scopus 로고
    • Strategies for cancer stem cell elimination: insights from mathematical modeling
    • Vainstein V, Kirnasovsky OU, Kogan Y, Agur Z. Strategies for cancer stem cell elimination: insights from mathematical modeling. J Theor Biol 2012; 298: 32-41.
    • (2012) J Theor Biol , vol.298 , pp. 32-41
    • Vainstein, V.1    Kirnasovsky, O.U.2    Kogan, Y.3    Agur, Z.4
  • 63
    • 0035132140 scopus 로고    scopus 로고
    • Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia
    • Ferrara FF, Fazi F, Bianchini A etal. Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia. Cancer Res 2001; 61: 2-7.
    • (2001) Cancer Res , vol.61 , pp. 2-7
    • Ferrara, F.F.1    Fazi, F.2    Bianchini, A.3
  • 64
    • 84934438073 scopus 로고    scopus 로고
    • Modeling microRNA-transcription factor networks in cancer
    • Aguda BD. Modeling microRNA-transcription factor networks in cancer. Adv Exp Med Biol 2013; 774: 149-167.
    • (2013) Adv Exp Med Biol , vol.774 , pp. 149-167
    • Aguda, B.D.1
  • 65
    • 34249737896 scopus 로고    scopus 로고
    • Transcription factor networks in embryonic stem cells and testicular cancer and the definition of epigenetics
    • Schulz WA, Hoffmann MJ. Transcription factor networks in embryonic stem cells and testicular cancer and the definition of epigenetics. Epigenetics 2007; 2: 37-42.
    • (2007) Epigenetics , vol.2 , pp. 37-42
    • Schulz, W.A.1    Hoffmann, M.J.2
  • 66
    • 84857055686 scopus 로고    scopus 로고
    • Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer
    • Aghdassi A, Sendler M, Guenther A etal. Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer. Gut 2012; 61: 439-448.
    • (2012) Gut , vol.61 , pp. 439-448
    • Aghdassi, A.1    Sendler, M.2    Guenther, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.