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Volumn 14, Issue 6, 2013, Pages 318-327

Regression effect of hepatocyte nuclear factor 4α on liver cirrhosis in rats

Author keywords

Hepatocyte nuclear factors; Liver cirrhosis; MAP kinase signaling system; Matrix metalloproteinases; Tissue inhibitor of metalloproteinases

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALVASCULIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; THIOACETAMIDE; TRANSCRIPTION FACTOR JUND; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84876991981     PISSN: 17512972     EISSN: 17512980     Source Type: Journal    
DOI: 10.1111/1751-2980.12042     Document Type: Article
Times cited : (7)

References (43)
  • 5
    • 77955472579 scopus 로고    scopus 로고
    • Evolving challenges in hepatic fibrosis
    • Friedman SL. Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol 2010; 7: 425-436.
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 425-436
    • Friedman, S.L.1
  • 7
    • 0036240890 scopus 로고    scopus 로고
    • Reversibility of liver fibrosis and cirrhosis following treatment for hepatitis C
    • Arthur MJ. Reversibility of liver fibrosis and cirrhosis following treatment for hepatitis C. Gastroenterology 2002; 122: 1525-1528.
    • (2002) Gastroenterology , vol.122 , pp. 1525-1528
    • Arthur, M.J.1
  • 8
    • 34147150694 scopus 로고    scopus 로고
    • Reversal of liver cirrhosis: a desirable clinical outcome and its pathogenic background
    • Bortolotti F, Guido M. Reversal of liver cirrhosis: a desirable clinical outcome and its pathogenic background. J Pediatr Gastroenterol Nutr 2007; 44: 401-406.
    • (2007) J Pediatr Gastroenterol Nutr , vol.44 , pp. 401-406
    • Bortolotti, F.1    Guido, M.2
  • 9
    • 33644875866 scopus 로고    scopus 로고
    • Comments on cirrhosis reversal
    • Desmet VJ. Comments on cirrhosis reversal. Dig Liver Dis 2005; 37: 909-916.
    • (2005) Dig Liver Dis , vol.37 , pp. 909-916
    • Desmet, V.J.1
  • 10
    • 0041664940 scopus 로고    scopus 로고
    • Reversal of cirrhosis: evidence-based medicine?
    • author reply 630-1.
    • Desmet VJ, Roskams T. Reversal of cirrhosis: evidence-based medicine? Gastroenterology 2003; 125: 629-630; author reply 630-1.
    • (2003) Gastroenterology , vol.125 , pp. 629-630
    • Desmet, V.J.1    Roskams, T.2
  • 11
    • 0035141324 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
    • Hayhurst GP, Lee YH, Lambert G, Ward JM, Gonzalez FJ. Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 2001; 21: 1393-1403.
    • (2001) Mol Cell Biol , vol.21 , pp. 1393-1403
    • Hayhurst, G.P.1    Lee, Y.H.2    Lambert, G.3    Ward, J.M.4    Gonzalez, F.J.5
  • 12
    • 23744472101 scopus 로고    scopus 로고
    • Adenovirus-mediated hepatocyte nuclear factor-4α overexpression maintains liver phenotype in cultured rat hepatocytes
    • Naiki T, Nagaki M, Asano T, Kimata T, Moriwaki H. Adenovirus-mediated hepatocyte nuclear factor-4α overexpression maintains liver phenotype in cultured rat hepatocytes. Biochem Biophys Res Commun 2005; 335: 496-500.
    • (2005) Biochem Biophys Res Commun , vol.335 , pp. 496-500
    • Naiki, T.1    Nagaki, M.2    Asano, T.3    Kimata, T.4    Moriwaki, H.5
  • 13
    • 0038241793 scopus 로고    scopus 로고
    • HNF4: a central regulator of hepatocyte differentiation and function
    • Watt AJ, Garrison WD, Duncan SA. HNF4: a central regulator of hepatocyte differentiation and function. Hepatology 2003; 37: 1249-1253.
    • (2003) Hepatology , vol.37 , pp. 1249-1253
    • Watt, A.J.1    Garrison, W.D.2    Duncan, S.A.3
  • 14
    • 0038757830 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis
    • Parviz F, Matullo C, Garrison WD etal. Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet 2003; 34: 292-296.
    • (2003) Nat Genet , vol.34 , pp. 292-296
    • Parviz, F.1    Matullo, C.2    Garrison, W.D.3
  • 15
    • 77149123633 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4α attenuates hepatic fibrosis in rats
    • Yue HY, Yin C, Hou JL etal. Hepatocyte nuclear factor 4α attenuates hepatic fibrosis in rats. Gut 2010; 59: 236-246.
    • (2010) Gut , vol.59 , pp. 236-246
    • Yue, H.Y.1    Yin, C.2    Hou, J.L.3
  • 16
    • 77957344834 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4α suppresses the development of hepatocellular carcinoma
    • Ning BF, Ding J, Yin C etal. Hepatocyte nuclear factor 4α suppresses the development of hepatocellular carcinoma. Cancer Res 2010; 70: 7640-7651.
    • (2010) Cancer Res , vol.70 , pp. 7640-7651
    • Ning, B.F.1    Ding, J.2    Yin, C.3
  • 17
    • 56149088742 scopus 로고    scopus 로고
    • Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4α gene
    • Yin C, Lin Y, Zhang X etal. Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4α gene. Hepatology 2008; 48: 1528-1539.
    • (2008) Hepatology , vol.48 , pp. 1528-1539
    • Yin, C.1    Lin, Y.2    Zhang, X.3
  • 18
    • 22844448409 scopus 로고    scopus 로고
    • Treatment of experimental hepatic fibrosis by combinational delivery of urokinase-type plasminogen activator and hepatocyte growth factor genes
    • Lin Y, Xie WF, Chen YX etal. Treatment of experimental hepatic fibrosis by combinational delivery of urokinase-type plasminogen activator and hepatocyte growth factor genes. Liver Int 2005; 25: 796-807.
    • (2005) Liver Int , vol.25 , pp. 796-807
    • Lin, Y.1    Xie, W.F.2    Chen, Y.X.3
  • 20
    • 34548162930 scopus 로고    scopus 로고
    • Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells
    • Cao Q, Mak KM, Lieber CS. Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells. J Hepatol 2007; 46: 124-133.
    • (2007) J Hepatol , vol.46 , pp. 124-133
    • Cao, Q.1    Mak, K.M.2    Lieber, C.S.3
  • 21
    • 33845650187 scopus 로고    scopus 로고
    • JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation
    • Smart DE, Green K, Oakley F etal. JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation. Hepatology 2006; 44: 1432-1440.
    • (2006) Hepatology , vol.44 , pp. 1432-1440
    • Smart, D.E.1    Green, K.2    Oakley, F.3
  • 23
    • 0036242165 scopus 로고    scopus 로고
    • Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C
    • Poynard T, McHutchison J, Manns M etal. Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology 2002; 122: 1303-1313.
    • (2002) Gastroenterology , vol.122 , pp. 1303-1313
    • Poynard, T.1    McHutchison, J.2    Manns, M.3
  • 24
    • 33751248252 scopus 로고    scopus 로고
    • Direct and indirect evidence for the reversibility of cirrhosis
    • Serpaggi J, Carnot F, Nalpas B etal. Direct and indirect evidence for the reversibility of cirrhosis. Hum Pathol 2006; 37: 1519-1526.
    • (2006) Hum Pathol , vol.37 , pp. 1519-1526
    • Serpaggi, J.1    Carnot, F.2    Nalpas, B.3
  • 25
    • 33644874907 scopus 로고    scopus 로고
    • Spontaneous regression of hepatitis B virus-associated cirrhosis developed in childhood
    • Bortolotti F, Guido M, Cadrobbi P etal. Spontaneous regression of hepatitis B virus-associated cirrhosis developed in childhood. Dig Liver Dis 2005; 37: 964-967.
    • (2005) Dig Liver Dis , vol.37 , pp. 964-967
    • Bortolotti, F.1    Guido, M.2    Cadrobbi, P.3
  • 26
    • 2942568157 scopus 로고    scopus 로고
    • Long-term benefit of interferon α therapy of chronic hepatitis D: regression of advanced hepatic fibrosis
    • Farci P, Roskams T, Chessa L etal. Long-term benefit of interferon α therapy of chronic hepatitis D: regression of advanced hepatic fibrosis. Gastroenterology 2004; 126: 1740-1749.
    • (2004) Gastroenterology , vol.126 , pp. 1740-1749
    • Farci, P.1    Roskams, T.2    Chessa, L.3
  • 27
    • 2942622398 scopus 로고    scopus 로고
    • Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking
    • Issa R, Zhou X, Constandinou CM etal. Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking. Gastroenterology 2004; 126: 1795-1808.
    • (2004) Gastroenterology , vol.126 , pp. 1795-1808
    • Issa, R.1    Zhou, X.2    Constandinou, C.M.3
  • 28
    • 4444269015 scopus 로고    scopus 로고
    • Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid
    • Reif S, Aeed H, Shilo Y etal. Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid. J Hepatol 2004; 41: 235-241.
    • (2004) J Hepatol , vol.41 , pp. 235-241
    • Reif, S.1    Aeed, H.2    Shilo, Y.3
  • 29
    • 56349107309 scopus 로고    scopus 로고
    • Hepatic fibrosis - overview
    • Friedman SL. Hepatic fibrosis - overview. Toxicology 2008; 254: 120-129.
    • (2008) Toxicology , vol.254 , pp. 120-129
    • Friedman, S.L.1
  • 31
    • 0001520008 scopus 로고
    • Hepatic lipocytes: the principal collagen-producing cells of normal rat liver
    • Friedman SL, Roll FJ, Boyles J, Bissell DM. Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci U S A 1985; 82: 8681-8685.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 8681-8685
    • Friedman, S.L.1    Roll, F.J.2    Boyles, J.3    Bissell, D.M.4
  • 32
    • 0036107548 scopus 로고    scopus 로고
    • Transcriptional regulation of hepatic stellate cell activation
    • Mann DA, Smart DE. Transcriptional regulation of hepatic stellate cell activation. Gut 2002; 50: 891-896.
    • (2002) Gut , vol.50 , pp. 891-896
    • Mann, D.A.1    Smart, D.E.2
  • 33
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000; 275: 2247-2250.
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 34
    • 0034814405 scopus 로고    scopus 로고
    • Extracellular matrix degradation and the role of hepatic stellate cells
    • Benyon RC, Arthur MJ. Extracellular matrix degradation and the role of hepatic stellate cells. Semin Liver Dis 2001; 21: 373-384.
    • (2001) Semin Liver Dis , vol.21 , pp. 373-384
    • Benyon, R.C.1    Arthur, M.J.2
  • 35
    • 7944219811 scopus 로고    scopus 로고
    • Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27
    • de Boer RA, Pokharel S, Flesch M etal. Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27. J Mol Med (Berl) 2004; 82: 678-687.
    • (2004) J Mol Med (Berl) , vol.82 , pp. 678-687
    • de Boer, R.A.1    Pokharel, S.2    Flesch, M.3
  • 36
    • 34548424486 scopus 로고    scopus 로고
    • 1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways
    • 1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways. Am J Physiol Lung Cell Mol Physiol 2007; 293: L790-799.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293
    • Martin, M.M.1    Buckenberger, J.A.2    Jiang, J.3
  • 37
    • 34250795558 scopus 로고    scopus 로고
    • Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway
    • Vepachedu R, Gorska MM, Singhania N, Cosgrove GP, Brown KK, Alam R. Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway. J Immunol 2007; 179: 682-690.
    • (2007) J Immunol , vol.179 , pp. 682-690
    • Vepachedu, R.1    Gorska, M.M.2    Singhania, N.3    Cosgrove, G.P.4    Brown, K.K.5    Alam, R.6
  • 38
    • 33749649808 scopus 로고    scopus 로고
    • Differential expression genes analyzed by cDNA array in the regulation of rat hepatic fibrogenesis
    • Qiang H, Lin Y, Zhang X etal. Differential expression genes analyzed by cDNA array in the regulation of rat hepatic fibrogenesis. Liver Int 2006; 26: 1126-1137.
    • (2006) Liver Int , vol.26 , pp. 1126-1137
    • Qiang, H.1    Lin, Y.2    Zhang, X.3
  • 39
    • 72949095659 scopus 로고    scopus 로고
    • Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats
    • Zhong W, Shen WF, Ning BF etal. Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats. Hepatology 2009; 50: 1524-1536.
    • (2009) Hepatology , vol.50 , pp. 1524-1536
    • Zhong, W.1    Shen, W.F.2    Ning, B.F.3
  • 40
    • 0344845283 scopus 로고    scopus 로고
    • Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-κB, AP-1 and Sp1
    • Takahra T, Smart DE, Oakley F, Mann DA. Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-κB, AP-1 and Sp1. Int J Biochem Cell Biol 2004; 36: 353-363.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 353-363
    • Takahra, T.1    Smart, D.E.2    Oakley, F.3    Mann, D.A.4
  • 41
    • 65449130742 scopus 로고    scopus 로고
    • Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats
    • Mejias M, Garcia-Pras E, Tiani C, Miquel R, Bosch J, Fernandez M. Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats. Hepatology 2009; 49: 1245-1256.
    • (2009) Hepatology , vol.49 , pp. 1245-1256
    • Mejias, M.1    Garcia-Pras, E.2    Tiani, C.3    Miquel, R.4    Bosch, J.5    Fernandez, M.6
  • 42
    • 65449167923 scopus 로고    scopus 로고
    • Antiangiogenic therapy: not just for cancer anymore?
    • Shah VH, Bruix J. Antiangiogenic therapy: not just for cancer anymore? Hepatology 2009; 49: 1066-1068.
    • (2009) Hepatology , vol.49 , pp. 1066-1068
    • Shah, V.H.1    Bruix, J.2
  • 43
    • 79955081875 scopus 로고    scopus 로고
    • Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice
    • Van Steenkiste C, Ribera J, Geerts A etal. Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice. Hepatology 2011; 53: 1629-1640.
    • (2011) Hepatology , vol.53 , pp. 1629-1640
    • Van Steenkiste, C.1    Ribera, J.2    Geerts, A.3


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