Antifibrotic effects of noscapine through activation of prostaglandin e2 receptors and protein kinase a

Journal of Biological Chemistry

Volumn 289, Issue 11, 2014, Pages 7505-7513

  Kach, Jacob ^a   Sandbo, Nathan ^b   La, Jennifer ^a   Denner, Darcy ^a   Reed, Eleanor B ^a   Akimova, Olga ^c   Koltsova, Svetlana ^c   Orlov, Sergei N ^c   Dulin, Nickolai O ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; ENZYMES; FIBROBLASTS; PROTEINS;

ALVEOLAR EPITHELIAL CELLS; ANTIFIBROTIC EFFECT; HUMAN LUNG FIBROBLASTS; MICROTUBULE DYNAMICS; MICROTUBULE POLYMERIZATION; PROSTACYCLIN RECEPTORS; RECEPTOR ANTAGONISTS; SERUM RESPONSE FACTORS;

LIPIDS;

COLLAGEN TYPE 1; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; NOSCAPINE; PROSTACYCLIN; PROSTAGLANDIN D2; PROSTAGLANDIN E RECEPTOR 2; SMAD PROTEIN; SMOOTH MUSCLE ACTIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFIBROTIC ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; FIBROGENESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG FIBROBLAST; LUNG FIBROSIS; MICROTUBULE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

FIBROSIS; MICROTUBULES; MYOFIBROBLAST; NOSCAPINE; PROSTAGLANDINS; PROTEIN KINASE A (PKA); SRF; STRESS FIBERS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTITUSSIVE AGENTS; BLEOMYCIN; CELL LINE, TUMOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA; FIBROBLASTS; FIBROSIS; GENE EXPRESSION REGULATION; HUMANS; HYDROXYPROLINE; LUCIFERASES; LUNG; MICE; MICE, INBRED C57BL; MICROTUBULES; MYOFIBROBLASTS; NEOPLASMS; NOSCAPINE; PULMONARY FIBROSIS; RECEPTORS, PROSTAGLANDIN E;

EID: 84896284555     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.546812     Document Type: Article

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