Nonviral gene delivery of growth and differentiation factor 5 to human mesenchymal stem cells injected into a 3d bovine intervertebral disc organ culture system

Stem Cells International

Volumn , Issue , 2013, Pages

  Bucher, Christian ^a   Gazdhar, Amiq ^b   Benneker, Lorin M ^a   Geiser, Thomas ^b   Gantenbein Ritter, Benjamin ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; ALGINIC ACID; CELL DNA; GAG PROTEIN; GROWTH DIFFERENTIATION FACTOR 5; PAPAIN; PROTEOGLYCAN; TRANSCRIPTION FACTOR SOX9;

ADULT; AGED; ARTICLE; BONE MARROW BIOPSY; CATTLE; CELL ENCAPSULATION; CELL THERAPY; CHONDROGENESIS; CONTROLLED STUDY; DRUG MECHANISM; ELECTROPORATION; FEMALE; GDF5 GENE; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTERVERTEBRAL DISK DEGENERATION; MALE; MESENCHYMAL STEM CELL; MIDDLE AGED; MONOLAYER CULTURE; NONVIRAL GENE DELIVERY SYSTEM; NUCLEOTIDE SEQUENCE; ORGAN CULTURE TECHNIQUE; PRIORITY JOURNAL; TISSUE REGENERATION; UPREGULATION; VERY ELDERLY;

EID: 84896265961     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.1155/2013/326828     Document Type: Article

References (46)

1. Rutges J., Creemers L. B., Dhert W., Milz S., Sakai D., Mochida J., Alini M., Grad S., Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration. Osteoarthritis and Cartilage 2010 18 3 416 423 2-s2.0-76549130659 10.1016/j.joca.2009.09.009
2. Minogue B. M., Richardson S. M., Zeef L. A., Freemont A. J., Hoyland J. A., Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes. Arthritis Research & Therapy 2010 12 1, article R22 2-s2.0-77949474632 10.1186/ar2929
3. Lee C. R., Sakai D., Nakai T., Toyama K., Mochida J., Alini M., Grad S., A phenotypic comparison of intervertebral disc and articular cartilage cells in the rat. European Spine Journal 2007 16 12 2174 2185 2-s2.0-37249032718 10.1007/s00586-007-0475-y (Pubitemid 350276086)
4. Sakai D., Nakai T., Mochida J., Alini M., Grad S., Differential phenotype of intervertebral disc cells: microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus. Spine 2009 34 14 1448 1456 2-s2.0-67651151247 10.1097/BRS.0b013e3181a55705
5. Miyazaki T., Kobayashi S., Takeno K., Meir A., Urban J., Baba H., A phenotypic comparison of proteoglycan production of intervertebral disc cells isolated from rats, rabbits, and bovine tails; Which animal model is most suitable to study tissue engineering and biological repair of human disc disorders? Tissue Engineering-Part A 2009 15 12 3835 3846 2-s2.0-72049125623 10.1089/ten.tea.2009.0250
6. Maroudas A., Stockwell R. A., Nachemson A., Urban J., Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. Journal of Anatomy 1975 120 part 1 113 130 2-s2.0-0016752270
7. Crevensten G., Walsh A. J. L., Ananthakrishnan D., Page P., Wahba G. M., Lotz J. C., Berven S., Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs. Annals of Biomedical Engineering 2004 32 3 430 434 2-s2.0-2942536282 10.1023/B:ABME. 0000017545.84833.7c
8. Richardson S. M., Hoyland J. A., Mobasheri R., Csaki C., Shakibaei M., Mobasheri A., Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering. Journal of Cellular Physiology 2010 222 1 23 32 2-s2.0-73949086464 10.1002/jcp.21915
9. Peng Y., Huang S., Cheng B., Nie X., Enhe J., Feng C., Fu X., Mesenchymal stem cells: a revolution in therapeutic strategies of age-related diseases. Ageing Research Reviews 2013 12 1 103 115 10.1016/j.arr.2012.04.005
10. Ménard C., Tarte K., Immunoregulatory properties of clinical grade mesenchymal stromal cells: evidence, uncertainties, and clinical application. Stem Cell Research & Therapy 2013 4 article 64 10.1186/scrt214
11. Sakai D., Stem cell regeneration of the intervertebral disk. Orthopedic Clinics of North America 2011 42 4 555 562 2-s2.0-80053195095 10.1016/j.ocl.2011.07.005
12. Meisel H. J., Schnöring M., Hohaus C., Minkus Y., Beier A., Ganey T., Mansmann U., Posterior lumbar interbody fusion using rhBMP-2. European Spine Journal 2008 17 12 1735 1744 2-s2.0-57049084000 10.1007/s00586-008-0799-2
13. Carragee E. J., Hurwitz E. L., Weiner B. K., A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. The Spine Journal 2011 11 6 471 491 2-s2.0-79959950769 10.1016/j.spinee.2011.04.023
14. Mern D. S., Beierfuß A., Thomé C., Hegewald A. A., Enhancing human nucleus pulposus cells for biological treatment approaches of degenerative intervertebral disc diseases: a systematic review. Journal of Tissue Engineering and Regenerative Medicine 2012 10.1002/term.1583
15. Nishida K., Kang J. D., Suh J.-K., Robbins P. D., Evans C. H., Gilbertson L. G., Adenovirus-mediated gene transfer to nucleus pulposus cells implications for the treatment of intervertebral disc degeneration. Spine 1998 23 22 2437 2442 2-s2.0-0032533617 10.1097/00007632-199811150-00016 (Pubitemid 28536066)
16. Wang H., Kroeber M., Hanke M., Ries R., Schmid C., Poller W., Richter W., Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cells. Journal of Molecular Medicine 2004 82 2 126 134 2-s2.0-1542284506 10.1007/s00109-003-0507-y (Pubitemid 38299711)
17. Evans C. H., Ghivizzani S. C., Robbins P. D., Orthopedic gene therapy-lost in translation? Journal of Cellular Physiology 2012 227 2 416 420 2-s2.0-82155171283 10.1002/jcp.23031
18. Stoyanov J. V., Gantenbein-Ritter B., Bertolo A., Aebli N., Baur M., Alini M., Grad S., Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells. European Cells & Materials 2011 21 533 547 2-s2.0-80053157000
19. 1 or rhGDF-5. European Spine Journal 2011 20 6 962 971 2-s2.0-80052575577 10.1007/s00586-010-1619-z
20. Feng G., Wan Y., Shen F. H., Li X., Nucleus pulposus explant culture model. Journal of Orthopaedic Research 2009 27 6 814 819 2-s2.0-66249111092 10.1002/jor.20803
21. Chujo T., An H. S., Akeda K., Miyamoto K., Muehleman C., Attawia M., Andersson G., Masuda K., Effects of growth differentiation factor-5 on the intervertebral disc-in vitro bovine study and in vivo rabbit disc degeneration model study. Spine 2006 31 25 2909 2917 2-s2.0-33845352083 10.1097/01.brs. 0000248428.22823.86 (Pubitemid 44885707)
22. Williams F. M. K., Popham M., Hart D. J., De Schepper E., Bierma-Zeinstra S., Hofman A., Uitterlinden A. G., Arden N. K., Cooper C., Spector T. D., Valdes A. M., Van Meurs J., GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women. Arthritis and Rheumatism 2011 63 3 708 712 2-s2.0-79953679565 10.1002/art.30169
23. Solchaga L. A., Penick K., Porter J. D., Goldberg V. M., Caplan A. I., Welter J. F., FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. Journal of Cellular Physiology 2005 203 2 398 409 2-s2.0-16344377055 10.1002/jcp.20238 (Pubitemid 40471774)
24. Reno C., Marchuk L., Sciore P., Frank C. B., Hart D. A., Rapid isolation of total RNA from small samples of hypocellular, dense connective tissues. BioTechniques 1997 22 6 1082 1086 2-s2.0-0030976489 (Pubitemid 27248981)
25. Gantenbein B., Grünhagen T., Lee C. R., Van Donkelaar C. C., Alini M., Ito K., An in vitro organ culturing system for intervertebral disc explants with vertebral endplates: a feasibility study with ovine caudal discs. Spine 2006 31 23 2665 2673 2-s2.0-33750560439 10.1097/01.brs.0000244620.15386.df (Pubitemid 44673377)
26. Gantenbein-Ritter B., Chan S. C. W., The evolutionary importance of cell ratio between notochordal and nucleus pulposus cells: an experimental 3-D co-culture study. European Spine Journal 2011 21 6, supplement 1 7 2-s2.0-80053378015 10.1007/s00586-011-2026-9
27. Ginzinger D. G., Gene quantification using real-time quantitative PCR: an emerging technology hits the mainstream. Experimental Hematology 2002 30 6 503 512 2-s2.0-0036278859 10.1016/S0301-472X(02)00806-8 (Pubitemid 34626648)
28. Livak K. J., Schmittgen T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2-Δ Δ C T method. Methods 2001 25 4 402 408 2-s2.0-0035710746 10.1006/meth.2001.1262 (Pubitemid 34164012)
29. Lee C. R., Grad S., MacLean J. J., Iatridis J. C., Alini M., Effect of mechanical loading on mRNA levels of common endogenous controls in articular chondrocytes and intervertebral disk. Analytical Biochemistry 2005 341 2 372 375 2-s2.0-19444368764 10.1016/j.ab.2004.10.005 (Pubitemid 40724822)
30. Farndale R. W., Buttle D. J., Barrett A. J., Improved quantitation and discrimination of sulphate glycosaminoglycans by use of dimethylmethylene blue. Biochimica et Biophysica Acta 1986 883 2 173 177 2-s2.0-0022552896 (Pubitemid 16027978)
31. Enobakhare B. O., Bader D. L., Lee D. A., Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue. Analytical Biochemistry 1996 243 1 189 191 2-s2.0-0030561210 10.1006/abio.1996.0502 (Pubitemid 26418597)
32. Chan S. C. W., Gantenbein-Ritter B., Preparation of intact bovine tail intervertebral discs for organ culture. Journal of Visualized Experiments 2012 60 1 7 2-s2.0-84856988419 10.3791/3490 e3490
33. Chan S. C. W., Walser J., Käppeli P., Shamsollahi M. J., Ferguson S. J., Gantenbein-Ritter B., Region specific response of intervertebral disc cells to complex dynamic loading: an organ culture study using a dynamic torsion-compression bioreactor. PLoS One 2013 8 8 e72489 10.1371/journal.pone. 0072489
34. Bertolo A., Ettinger L., Aebli N., Haschtmann D., Baur M., Berlemann U., Ferguson S. J., Stoyanov J. V., The in vitro effects of dexamethasone, insulin and triiodothyronine on degenerative human intervertebral disc cells under normoxic and hypoxic conditions. European Cells & Materials 2011 21 221 229 2-s2.0-79961006896
35. Shintani N., Hunziker E. B., Differential effects of dexamethasone on the chondrogenesis of mesenchymal stromal cells: influence of microenvironment, tissue origin and growth factor. European Cells & Materials 2011 22 302 320 2-s2.0-84857946770
36. Yang X., Li X., Nucleus pulposus tissue engineering: a brief review. European Spine Journal 2009 18 11 1564 1572 10.1007/s00586-009-1092-8
37. Bertolo A., Baur M., Aebli N., Ferguson S. J., Stoyanov J., Physiological testosterone levels enhance chondrogenic extracellular matrix synthesis by male intervertebral disc cells in vitro, but not by mesenchymal stem cells. The Spine Journal 2013 10.1016/j.spinee.2013.10.018
38. Leskelä H.-V., Olkku A., Lehtonen S., Mahonen A., Koivunen J., Turpeinen M., Uusitalo J., Pelkonen O., Kangas L., Selander K., Lehenkari P., Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts. Bone 2006 39 5 1026 1034 2-s2.0-33749510640 10.1016/j.bone.2006.05.003 (Pubitemid 44528379)
39. Tsumaki N., Tanaka K., Arikawa-Hirasawa E., Nakase T., Kimura T., Terrig Thomas J., Ochi T., Luyten F. P., Yamada Y., Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation. Journal of Cell Biology 1999 144 1 161 173 2-s2.0-0033545218 10.1083/jcb.144.1.161 (Pubitemid 29047019)
40. Buxton P., Edwards C., Archer C. W., Francis-West P., Growth/differentiation factor-5 (GDF-5) and skeletal development. The Journal of Bone and Joint Surgery 2001 83 1, supplement 1 S23 S30 2-s2.0-0010546206
41. Francis-West P. H., Abdelfattah A., Chen P., Allen C., Parish J., Ladher R., Allen S., MacPherson S., Luyten F. P., Archer C. W., Mechanisms of GDF-5 action during skeletal development. Development 1999 126 6 1305 1315 2-s2.0-0032905901 (Pubitemid 29182125)
42. Storm E. E., Kingsley D. M., Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. Development 1996 122 12 3969 3979 2-s2.0-0030481707 (Pubitemid 27033891)
43. Polinkovsky A., Robin N. H., Thomas J. T., Irons M., Lynn A., Goodman F. R., Reardon W., Kant S. G., Brunner H. G., van der Burgt I., Chitayat D., McGaughran J., Donnai D., Luyten F. P., Warman M. L., Mutations in CDMP1 cause autosomal dominant brachydactyly type C. Nature Genetics 1997 17 1 18 19 2-s2.0-0031230465
44. Thomas J. T., Kilpatrick M. W., Lin K., Erlacher L., Lembessis P., Costa T., Tsipouras P., Luyten F. P., Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1. Nature Genetics 1997 17 1 58 64 2-s2.0-0030763771 10.1038/ng0997-58 (Pubitemid 27377532)
45. Thomas J. T., Lin K., Nandedkar M., Camargo M., Cervenka J., Luyten F. P., A human chondrodysplasia due to a mutation in a TGF- β super-family member. Nature Genetics 1996 12 3 315 317 2-s2.0-0029936784
46. Faiyaz-Ul-Haque M., Ahmad W., Zaidi S. H. E., Haque S., Teebi A. S., Ahmad M., Cohn D. H., Tsui L.-C., Mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene in a kindred affected with fibular hypoplasia and complex brachydactyly (DuPan syndrome). Clinical Genetics 2002 61 6 454 458 2-s2.0-12244257526 10.1034/j.1399-0004.2002.610610.x (Pubitemid 36372684)