The effect of mGluR5 antagonism during binge drinking on subsequent ethanol intake in C57BL/6J mice: Sex- and age-induced differences

Alcoholism: Clinical and Experimental Research

Volumn 38, Issue 3, 2014, Pages 730-738

  Cozzoli, Debra K ^a   Strong Kaufman, Moriah N ^a   Tanchuck, Michelle A ^a   Hashimoto, Joel G ^a,b   Wiren, Kristine M ^a,b   Finn, Deborah A ^a,b,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Adolescent; Adult; Alcohol; Glutamate; MTEP

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; ALCOHOL; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; PHOSPHATIDYLINOSITOL 3 KINASE; 3-((2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL)PYRIDINE; GRM5 PROTEIN, MOUSE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

ADOLESCENT; ADULT; ALCOHOL ABSTINENCE; ALCOHOL CONSUMPTION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINGE DRINKING; C57BL 6 MOUSE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE; MALE; MOUSE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SUBUNIT; REPEATED DRUG DOSE; SEX DIFFERENCE; AGE; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; DRUG THERAPY; GENE EXPRESSION; GENETICS; PATHOPHYSIOLOGY; SEX FACTOR;

AGE FACTORS; ANIMALS; BINGE DRINKING; ETHANOL; FEMALE; GENE EXPRESSION; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; NUCLEUS ACCUMBENS; PYRIDINES; RECEPTOR, METABOTROPIC GLUTAMATE 5; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SEX FACTORS; THIAZOLES;

EID: 84896262797     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12292     Document Type: Article

References (35)

1. Anderson JJ, Bradbury MJ, Giracello DR, Chapman DF, Holtz G, Roppe J, King C, Cosford NDP, Varney MA (2003) In vivo receptor occupancy of mGluR5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridine-2-ylethynyl)pyridine). Eur J Pharmacol 473:35-40.
2. Bäckström P, Bachteler D, Koch S, Hyytiä P, Spanagel R (2004) mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29:921-928.
3. Besheer J, Grondin JJ, Cannady R, Sharko AC, Faccidomo S, Hodge CW (2010) Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake. Biol Psychiatry 67:812-822.
4. Bouchery EE, Harwood HJ, Sacks JJ, Simon CJ, Brewer RD (2011) Economic costs of excessive alcohol consumption in the US, 2006. Am J Prev Med 41:516-524.
5. Broadwater M, Varlinskaya EI, Spear LP (2013) Effects of voluntary access to sweetened ethanol during adolescence on intake in adulthood. Alcohol Clin Exp Res 37:1048-1055.
6. Carrara-Nascimento PF, Lopez MF, Becker HC, Olive MF, Camarini R (2013) Similar ethanol drinking in adolescent and adult C57BL/6J mice after chronic ethanol exposure and withdrawal. Alcohol Clin Exp Res 37:961-968.
7. Centers for Disease Control and Prevention (CDC) (2012) Vital signs: binge drinking prevalence, frequency, and intensity among adults- United States, 2010. MMWR Morb Mortal Wkly Rep 61:14-19.
8. Centers for Disease Control and Prevention (CDC) (2013) Vital signs: binge drinking among women and high school girls- United States, 2011. MMWR Morb Mortal Wkly Rep 62:9-13.
9. Coleman LG Jr, He J, Lee J, Styner M, Crews FT (2011) Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice. Alcohol Clin Exp Res 35:671-688.
10. Cowen MS, Djouma E, Lawrence AJ (2005) The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1, 3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems. J Pharmacol Exp Ther 315:590-600.
11. Cowen MS, Krstew E, Lawrence AJ (2007) Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/6J mice under operant conditions: regulation by mGlu5 receptor antagonism. Psychopharmacology 190:21-29.
12. Cozzoli DK, Courson J, Caruana AL, Miller BW, Greentree DI, Thompson AB, Wroten MG, Zhang PW, Xiao B, Hu JH, Klugmann M, Metten P, Worley PF, Crabbe JC, Szumlinski KK (2012) Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Alcohol Clin Exp Res 36:1623-1633.
13. Cozzoli DK, Courson J, Wroten MG, Greentree DI, Lum EN, Campbell RR, Thompson AB, Maliniak D, Worley PF, Jonquieres G, Klugmann M, Finn DA, Szumlinski KK (2013) Binge alcohol drinking by mice requires intact Group1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala. Neuropsychopharmacology doi: 10.1038/npp.2013.214 [Epub ahead of print].
14. Cozzoli DK, Goulding SP, Zhang PW, Xiao B, Hu J-H, Ary AW, Obara I, Rahn A, Abou-Ziab H, Tyrrel B, Marini C, Yoneyama N, Metten P, Snelling C, Dehoff MH, Crabbe JC, Finn DA, Klugmann M, Worley PF, Szumlinski KK (2009) Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. J Neurosci 29:8655-8668.
15. Finn DA, Belknap JK, Cronise K, Yoneyama N, Murillo A, Crabbe JC (2005) A procedure to produce high alcohol intake in mice. Psychopharmacology 178:471-480.
16. Finn DA, Snelling C, Fretwell AM, Tanchuck MA, Underwood L, Cole M, Crabbe JC, Roberts AJ (2007) Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41). Alcohol Clin Exp Res 31:939-949.
17. Gass JT, Olive MF (2008) Transcriptional profiling of the rat frontal cortex following administration of the mGluR5 receptor antagonists MPEP and MTEP. Eur J Pharmacol 584:253-262.
18. Gass JT, Olive MF (2009) Role of protein kinase C epsilon (PKCε) in the reduction of ethanol reinforcement due to MGluR5 antagonism in the nucleus accumbens shell. Psychopharmacology 204:587-597.
19. Hashimoto JG, Beadles-Bohling AS, Wiren KM (2004) Comparison of RiboGreen and 18S rRNA quantitation for normalizing real-time RT-PCR expression analysis. Biotechniques 36:58-60.
20. Hashimoto JG, Forquer MR, Tanchuck MA, Finn DA, Wiren KM (2011) Importance of genetic background for risk of relapse shown in altered prefrontal cortex gene expression during abstinence following chronic alcohol intoxication. Neuroscience 173:57-75.
21. Hodge CW, Miles MF, Sharko AC, Stevenson RA, Hillmann JR, Lepoutre V, Besheer J, Schroeder JP (2006) The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL6/6J mice. Psychopharmacology 183:429-438.
22. Lominac KD, Kapasova Z, Hannun RA, Patterson C, Middaugh LD, Szumlinski KK (2006) Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties. Drug Alcohol Depend 85:142-156.
23. McMillen BA, Crawford MS, Kulers CM, Williams HL (2005) Effects of a metabotropic, mGlu5, glutamate receptor antagonist on ethanol consumption by genetic drinking rats. Alcohol Alcohol 40:494-497.
24. Moore EM, Mariani JN, Lisenbardt DN, Melon LC, Boehm SL (2010) Adolescent C57BL/6J (but not DBA/2J) mice consume greater amounts of limited-access ethanol compared to adults and display continued elevated ethanol intake into adulthood. Alcohol Clin Exp Res 34:734-742.
25. Olive MF, McGeehan AJ, Kinder JR, McMahon T, Hodge CW, Janak PH, Messing RO (2005) The mGluR5 antagonist 6-methyl-2-(phenylethynyl) pyridine decreases ethanol consumption via a protein kinase Cε-dependent mechanism. Mol Pharmacol 67:349-355.
26. Pascual M, Boix J, Felipo V, Guerri C (2009) Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat. J Neurochem 108:920-931.
27. Paxinos G, Franklin K (2001) The Mouse Brain in Stereotaxic Coordinates. 2nd ed. Academic Press, San Diego, CA.
28. Schroeder JP, Overstreet DH, Hodge CW (2005) The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacology 179:262-270.
29. Siciliano D, Smith RF (2001) Periadolescent alcohol alters adult behavioral characteristics in the rat. Physiol Behav 74:637-643.
30. Sinclair CM, Cleva RM, Hood LE, Olive MF, Gass JT (2012) mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior. Pharmacol Biochem Behav 101:329-335.
31. Spear LP (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24:417-463.
32. Strong MN, Yoneyama N, Fretwell AM, Snelling C, Tanchuck MA, Finn DA (2010) "Binge" drinking experience in adolescent mice shows sex differences and elevated ethanol intake in adulthood. Horm Behav 58:82-90.
33. U.S. Department of Health and Human Services, National Institute on Alcohol Abuse and Alcoholism (2004) NIAAA Newsletter (No. 3). National Institute on Alcohol Abuse and Alcoholism, Rockville, MD.
34. U.S. Department of Health and Human Services, National Institute on Alcohol Abuse and Alcoholism (2006) Underage Drinking: Why do Adolescents Drink, What are the Risks, and How Can Underage Drinking Be Prevented? (Alcohol Alert No. 67). National Institute on Alcohol Abuse and Alcoholism, Rockville, MD.
35. Yoneyama N, Crabbe JC, Ford MM, Murillo A, Finn DA (2008) Voluntary ethanol consumption in 22 inbred mouse strains. Alcohol 42:149-160.