Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor

Molecular and Cellular Neuroscience

Volumn 60, Issue , 2014, Pages 26-35

  Hung, Victor K L ^a   Tai, Lydia W ^a   Qiu, Qiu ^a   Luo, Xin ^a   Wong, K L ^a,b   Chung, Sookja K ^a   Cheung, C W ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Allodynia; Astrocytes; Endothelin 1; Hyperalgesia; Neuropathic pain

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTHELIN TYPE A RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; UNCLASSIFIED DRUG; CYCLO(TRP-ASP-PRO-VAL-LEU); CYCLOPEPTIDE; ENDOTHELIN A RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; HYPERALGESIA; LATENT PERIOD; LUMBAR SPINAL CORD; MOUSE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SCIATIC NERVE; ANIMAL; C57BL MOUSE; DRUG EFFECTS; GENETICS; HEAT; METABOLISM; NEURALGIA; REACTION TIME; TOUCH;

ANIMALS; ASTROCYTES; ENDOTHELIN RECEPTOR ANTAGONISTS; ENDOTHELIN-1; HOT TEMPERATURE; HYPERALGESIA; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURALGIA; PEPTIDES, CYCLIC; PROTO-ONCOGENE PROTEINS C-AKT; REACTION TIME; RECEPTOR, ENDOTHELIN A; SCIATIC NERVE; TOUCH;

EID: 84896116089     PISSN: 10447431     EISSN: 10959327     Source Type: Journal    
DOI: 10.1016/j.mcn.2014.02.007     Document Type: Article

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