Intrathecal endothelin-1 has antinociceptive effects in rat model of postoperative pain

European Journal of Pharmacology

Volumn 697, Issue 1-3, 2012, Pages 40-46

  Chen, Guihua ^a   Tanabe, Kumiko ^a   Yanagidate, Fumi ^a   Kawasaki, Yasuhiko ^b   Zhang, Lianxi ^a   Dohi, Shuji ^c   Iida, Hiroki ^a  

^a GIFU UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c Muroran City General Hospital   (Japan)

Author keywords

Dorsal root ganglion neuron; Endothelin 1; Extracellular signal regulated protein kinase; Microglia; Postoperative pain

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CELL COUNT; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; INCISION; MALE; MICROGLIA; NERVE CELL STIMULATION; NONHUMAN; PAIN THRESHOLD; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RAT; SPINAL CORD NERVE CELL; SPINAL GANGLION;

ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GANGLIA, SPINAL; INJECTIONS, SPINAL; MALE; MICROGLIA; OLIGOPEPTIDES; PAIN MEASUREMENT; PAIN THRESHOLD; PAIN, POSTOPERATIVE; PEPTIDES, CYCLIC; PHOSPHORYLATION; PIPERIDINES; POSTERIOR HORN CELLS; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; TIME FACTORS;

EID: 84869487551     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.09.035     Document Type: Article

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