Dose-dependent sigma-1 receptor occupancy by donepezil in rat brain can be assessed with 11C-SA4503 and microPET

Psychopharmacology

Volumn 231, Issue 20, 2014, Pages 3997-4006

  Ramakrishnan, Nisha K ^a   Visser, Anniek K D ^a   Schepers, Marianne ^a   Luurtsema, Gert ^a   Nyakas, Csaba J ^b   Elsinga, Philip H ^a   Ishiwata, Kiichi ^c   Dierckx, Rudi A J O ^a   Van Waarde, Aren ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

11C SA4503; Donepezil; Kinetic analysis; microPET; Receptor occupancy; Sigma 1 receptor

Indexed keywords

CHOLINESTERASE INHIBITOR; CUTAMESINE; DONEPEZIL; INDAN DERIVATIVE; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR;

AGONISTS; ANIMAL; BRAIN; DOSE RESPONSE; DRUG EFFECTS; MALE; METABOLISM; RAT; SCINTISCANNING; WISTAR RAT;

ANIMALS; BRAIN; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; INDANS; MALE; PIPERAZINES; PIPERIDINES; RATS; RATS, WISTAR; RECEPTORS, SIGMA;

EID: 84896060285     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3533-2     Document Type: Article

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