-
2
-
-
0003964363
-
-
Available at, Accessed November 3, 2008
-
American Cancer Society: Cancer Facts & Figures 2004. 2005. Available at http://www.cancer.org/docroot/STT/stt_0_2004.asp?sitearea=SST&level=1. Accessed November 3, 2008.
-
(2004)
Cancer Facts & Figures
-
-
-
3
-
-
56749174771
-
-
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Non-Small Cell Lung Cancer, V.1.2009. Available at http://www.nccn.org/professionals/physician_gls/PDF/nscl.pdf, accessed April 7, 2008.
-
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Non-Small Cell Lung Cancer, V.1.2009. Available at http://www.nccn.org/professionals/physician_gls/PDF/nscl.pdf, accessed April 7, 2008.
-
-
-
-
4
-
-
10744224719
-
Molecular predictors of response to chemotherapy in lung cancer
-
Rosell R, Taron M, Ariza A et al. Molecular predictors of response to chemotherapy in lung cancer. Semin Oncol 2004;31(suppl 1):20-27.
-
(2004)
Semin Oncol
, vol.31
, Issue.SUPPL. 1
, pp. 20-27
-
-
Rosell, R.1
Taron, M.2
Ariza, A.3
-
5
-
-
0037050352
-
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
-
Schiller JH, Harrington D, Belani CP et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2002;346:92-98.
-
(2002)
N Engl J Med
, vol.346
, pp. 92-98
-
-
Schiller, J.H.1
Harrington, D.2
Belani, C.P.3
-
6
-
-
0028843552
-
Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials
-
Non-Small Cell Lung Cancer Collaborative Group
-
Non-Small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 1995;311:899-909.
-
(1995)
BMJ
, vol.311
, pp. 899-909
-
-
-
7
-
-
0042010018
-
Second-line chemotherapy for non-small cell lung cancer
-
Shepherd FA. Second-line chemotherapy for non-small cell lung cancer. Expert Rev Anticancer Ther 2003;3:435-442.
-
(2003)
Expert Rev Anticancer Ther
, vol.3
, pp. 435-442
-
-
Shepherd, F.A.1
-
8
-
-
3042673101
-
Cytotoxic chemotherapy in advanced non-small cell lung cancer: A review of standard treatment paradigms
-
Socinski MA. Cytotoxic chemotherapy in advanced non-small cell lung cancer: A review of standard treatment paradigms. Clin Cancer Res 2004;10:4210s-4214s.
-
(2004)
Clin Cancer Res
, vol.10
-
-
Socinski, M.A.1
-
9
-
-
56749131534
-
-
Taxotere® [prescribing information®. Bridgewater, NJ: Sanofi-Aventis.
-
Taxotere® [prescribing information®. Bridgewater, NJ: Sanofi-Aventis.
-
-
-
-
10
-
-
56749161419
-
-
prescribing information, Eli Lilly and Company
-
Alimta® [prescribing information]. Indianapolis, IN: Eli Lilly and Company.
-
Indianapolis
-
-
Alimta®1
-
11
-
-
20244381389
-
Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
-
Herbst RS, Johnson DH, Mininberg E et al. Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005;23:2544-2555.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2544-2555
-
-
Herbst, R.S.1
Johnson, D.H.2
Mininberg, E.3
-
12
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353:123-132.
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
13
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355:2542-2550.
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
14
-
-
36048982143
-
Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer
-
Herbst RS, Fehrenbacher L, Belani CP et al. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol 2007;25:4743-4750.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4743-4750
-
-
Herbst, R.S.1
Fehrenbacher, L.2
Belani, C.P.3
-
15
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997;18:4-25.
-
(1997)
Endocr Rev
, vol.18
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
16
-
-
0029127218
-
The role of vascular endothelial growth factor in pathological angiogenesis
-
Ferrara N. The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res Treat 1995;36:127-137.
-
(1995)
Breast Cancer Res Treat
, vol.36
, pp. 127-137
-
-
Ferrara, N.1
-
17
-
-
0035865450
-
Clinical implications of circulating angiogenic factors in cancer patients
-
Poon RT, Fan ST, Wong J. Clinical implications of circulating angiogenic factors in cancer patients. J Clin Oncol 2001;19:1207-1225.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1207-1225
-
-
Poon, R.T.1
Fan, S.T.2
Wong, J.3
-
18
-
-
0030969559
-
Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma
-
Fontanini G, Vignati S, Boldrini L et al. Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma. Clin Cancer Res 1997;3:861-865.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 861-865
-
-
Fontanini, G.1
Vignati, S.2
Boldrini, L.3
-
19
-
-
34248140107
-
Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: The Tarceva Lung Cancer Investigation Trial
-
Gatzemeier U, Pluzanska A, Szczesna A et al. Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: The Tarceva Lung Cancer Investigation Trial. J Clin Oncol 2007;25:1545-1552.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1545-1552
-
-
Gatzemeier, U.1
Pluzanska, A.2
Szczesna, A.3
-
20
-
-
24944440830
-
TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
-
Herbst RS, Prager D, Hermann R et al. TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2005;23:5892-5899.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5892-5899
-
-
Herbst, R.S.1
Prager, D.2
Hermann, R.3
-
21
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
-
Herbst RS, Giaccone G, Schiller JH et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2. J Clin Oncol 2004;22:785-794.
-
(2004)
J Clin Oncol
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
-
22
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
-
Giaccone G, Herbst RS, Manegold C et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1. J Clin Oncol 2004;22:777-784.
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
-
23
-
-
2942657615
-
Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
-
Johnson DH, Fehrenbacher L, Novotny WF et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004;22:2184-2191.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2184-2191
-
-
Johnson, D.H.1
Fehrenbacher, L.2
Novotny, W.F.3
-
24
-
-
35548962413
-
Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naïve patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704
-
388s
-
Manegold C, von Pawel J, Zatloukal P et al. Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naïve patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704. J Clin Oncol 2007;25(18 suppl):388s.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 SUPPL.
-
-
Manegold, C.1
von Pawel, J.2
Zatloukal, P.3
-
25
-
-
56749104008
-
-
Manegold C, von Pawel J, Zatloukal P et al. BO17704 (AVAiL): A phase III randomised study of first-line bevacizumab combined with cisplatin/gemcitabine (CG) in patients (pts) with advanced or recurrent non-squamous, non-small cell lung cancer (NSCLC). Ann Oncol 2008;19(suppl 8):viii1.
-
Manegold C, von Pawel J, Zatloukal P et al. BO17704 (AVAiL): A phase III randomised study of first-line bevacizumab combined with cisplatin/gemcitabine (CG) in patients (pts) with advanced or recurrent non-squamous, non-small cell lung cancer (NSCLC). Ann Oncol 2008;19(suppl 8):viii1.
-
-
-
-
26
-
-
0028955388
-
Epidermal growth factor-related peptides and their receptors in human malignancies
-
Salomon DS, Brandt R, Ciardiello F et al. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995;19:183-232.
-
(1995)
Crit Rev Oncol Hematol
, vol.19
, pp. 183-232
-
-
Salomon, D.S.1
Brandt, R.2
Ciardiello, F.3
-
27
-
-
0031979703
-
Do molecular markers predict survival in non-small-cell lung cancer?
-
Greatens TM, Niehans GA, Rubins JB et al. Do molecular markers predict survival in non-small-cell lung cancer? Am J Respir Crit Care Med 1998;157:1093-1097.
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 1093-1097
-
-
Greatens, T.M.1
Niehans, G.A.2
Rubins, J.B.3
-
28
-
-
18744434862
-
Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression
-
Ohsaki Y, Tanno S, Fujita Y et al. Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression. Oncol Rep 2000;7:603-607.
-
(2000)
Oncol Rep
, vol.7
, pp. 603-607
-
-
Ohsaki, Y.1
Tanno, S.2
Fujita, Y.3
-
31
-
-
0035884231
-
The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia
-
Arteaga CL. The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J Clin Oncol 2001;19(18 suppl):32S-40S.
-
(2001)
J Clin Oncol
, vol.19
, Issue.18 SUPPL.
-
-
Arteaga, C.L.1
-
32
-
-
0033063774
-
The epidermal growth factor receptor and its inhibition in cancer therapy
-
Woodburn JR. The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol Ther 1999;82:241-250.
-
(1999)
Pharmacol Ther
, vol.82
, pp. 241-250
-
-
Woodburn, J.R.1
-
34
-
-
0036016088
-
Anti-epidermal growth factor receptor drugs in cancer therapy
-
Ciardiello F, Tortora G. Anti-epidermal growth factor receptor drugs in cancer therapy. Expert Opin Investig Drugs 2002;11:755-768.
-
(2002)
Expert Opin Investig Drugs
, vol.11
, pp. 755-768
-
-
Ciardiello, F.1
Tortora, G.2
-
35
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-2139.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
36
-
-
22044453790
-
Erlotinib in lung cancer - molecular and clinical predictors of outcome
-
Tsao M, Sakurada A, Cutz JC et al. Erlotinib in lung cancer - molecular and clinical predictors of outcome. N Engl J Med 2005;353:133-144.
-
(2005)
N Engl J Med
, vol.353
, pp. 133-144
-
-
Tsao, M.1
Sakurada, A.2
Cutz, J.C.3
-
37
-
-
33947415279
-
Phase II trial of cetuximab in patients with previously treated non-small-cell lung cancer
-
Hanna N, Lilenbaum R, Ansari R et al. Phase II trial of cetuximab in patients with previously treated non-small-cell lung cancer. J Clin Oncol 2006;24:5253-5258.
-
(2006)
J Clin Oncol
, vol.24
, pp. 5253-5258
-
-
Hanna, N.1
Lilenbaum, R.2
Ansari, R.3
-
40
-
-
24144456717
-
A phase II trial of cetuximab as therapy for recurrent non-small cell lung cancer (NSCLC): Final results
-
Lilenbaum R, Bonomi P, Ansari R et al. A phase II trial of cetuximab as therapy for recurrent non-small cell lung cancer (NSCLC): Final results. J Clin Oncol 2005;23:7036.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7036
-
-
Lilenbaum, R.1
Bonomi, P.2
Ansari, R.3
-
41
-
-
56749178387
-
prescribing information]. Melville
-
NY:, Inc
-
Tarceva® [prescribing information]. Melville, NY: OSI Pharmaceuticals, Inc.
-
OSI Pharmaceuticals
-
-
Tarceva®1
-
42
-
-
56749173240
-
-
Tarceva® [European product information, Available at, Accessed November 3, 2008
-
Tarceva® [European product information]. London: European Medicines Agency, 2006. Available at http://www.emea.europa.eu/humandocs/PDFs/EPAR/ tarceva/H-618-PI.en.pdf. Accessed November 3, 2008.
-
(2006)
London: European Medicines Agency
-
-
-
43
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
Kris MG, Natale RB, Herbst RS et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial. JAMA 2003;290:2149-2158.
-
(2003)
JAMA
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
-
44
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
Thatcher N, Chang A, Parikh P et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005;366:1527-1537.
-
(2005)
Lancet
, vol.366
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
-
45
-
-
56749168929
-
-
Gefitinib (marketed as Iressa®) [patient information sheet]. Rockville, MD: U.S. Food and Drug Administration, 2005.
-
Gefitinib (marketed as Iressa®) [patient information sheet]. Rockville, MD: U.S. Food and Drug Administration, 2005.
-
-
-
-
46
-
-
41049090971
-
Results of a randomized phase III study to compare the overall survival of gefitinib versus docetaxel in Japanese patients with non-small-cell lung cancer who failed one or two chemotherapy regimens
-
387s
-
Niho S, Ichinose Y, Tamura T et al. Results of a randomized phase III study to compare the overall survival of gefitinib versus docetaxel in Japanese patients with non-small-cell lung cancer who failed one or two chemotherapy regimens. J Clin Oncol 2007;25(18 suppl):387s.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 SUPPL.
-
-
Niho, S.1
Ichinose, Y.2
Tamura, T.3
-
47
-
-
37349092482
-
Gefitinib (IRESSA) versus docetaxel in patients with locally advanced or metastatic non-small-cell lung cancer pre-treated with platinum-based chemotherapy: A randomized, open-label Phase III study (INTEREST)
-
Douillard J-Y, Kim E, Hirsh V et al. Gefitinib (IRESSA) versus docetaxel in patients with locally advanced or metastatic non-small-cell lung cancer pre-treated with platinum-based chemotherapy: A randomized, open-label Phase III study (INTEREST). J Thorac Oncol 2007;2(suppl 4):S305-S306.
-
(2007)
J Thorac Oncol
, vol.2
, Issue.SUPPL. 4
-
-
Douillard, J.-Y.1
Kim, E.2
Hirsh, V.3
-
48
-
-
33745645399
-
Salvage therapy for advanced non-small cell lung cancer: Factors influencing treatment selection
-
Ramalingam S, Sandler AB. Salvage therapy for advanced non-small cell lung cancer: Factors influencing treatment selection. The Oncologist 2006;11:655-665.
-
(2006)
The Oncologist
, vol.11
, pp. 655-665
-
-
Ramalingam, S.1
Sandler, A.B.2
-
49
-
-
2442661845
-
Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
-
Hanna N, Shepherd FA, Fossella FV et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 2004;22:1589-1597.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1589-1597
-
-
Hanna, N.1
Shepherd, F.A.2
Fossella, F.V.3
-
50
-
-
0034069620
-
Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy
-
Shepherd FA, Dancey J, Ramlau R et al. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol 2000;18:2095-2103.
-
(2000)
J Clin Oncol
, vol.18
, pp. 2095-2103
-
-
Shepherd, F.A.1
Dancey, J.2
Ramlau, R.3
-
51
-
-
35548969264
-
Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: An evolving paradigm in clinical management
-
Lynch TJ Jr, Kim ES, Eaby B et al. Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: An evolving paradigm in clinical management. The Oncologist 2007;12:610-621.
-
(2007)
The Oncologist
, vol.12
, pp. 610-621
-
-
Lynch Jr, T.J.1
Kim, E.S.2
Eaby, B.3
-
52
-
-
10044284428
-
Treatment approaches in patients with advanced non-small cell lung cancer and poor performance status
-
Govindan R, Garfield DH. Treatment approaches in patients with advanced non-small cell lung cancer and poor performance status. Semin Oncol 2004;31(suppl 11):27-31.
-
(2004)
Semin Oncol
, vol.31
, Issue.SUPPL. 11
, pp. 27-31
-
-
Govindan, R.1
Garfield, D.H.2
-
53
-
-
0037420188
-
Chemotherapy for elderly patients with advanced non-small-cell lung cancer
-
Bunn PA Jr, Lilenbaum R. Chemotherapy for elderly patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2003;95:341-343.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 341-343
-
-
Bunn Jr, P.A.1
Lilenbaum, R.2
-
54
-
-
28044433677
-
Epidermal growth factor receptor and angiogenesis: Opportunities for combined anticancer strategies
-
van Cruijsen H, Giaccone G, Hoekman K. Epidermal growth factor receptor and angiogenesis: Opportunities for combined anticancer strategies. Int J Cancer 2005;117:883-888.
-
(2005)
Int J Cancer
, vol.117
, pp. 883-888
-
-
van Cruijsen, H.1
Giaccone, G.2
Hoekman, K.3
-
55
-
-
11344268358
-
Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor
-
Camp ER, Summy J, Bauer TW et al. Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor. Clin Cancer Res 2005;11:397-405.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 397-405
-
-
Camp, E.R.1
Summy, J.2
Bauer, T.W.3
-
56
-
-
0036252329
-
Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model
-
Jung YD, Mansfield PF, Akagi M et al. Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model. Eur J Cancer 2002;38:1133-1140.
-
(2002)
Eur J Cancer
, vol.38
, pp. 1133-1140
-
-
Jung, Y.D.1
Mansfield, P.F.2
Akagi, M.3
-
57
-
-
0033818695
-
Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
-
Ciardiello F, Bianco R, Damiano V et al. Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin Cancer Res 2000;6:3739-3747.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 3739-3747
-
-
Ciardiello, F.1
Bianco, R.2
Damiano, V.3
-
58
-
-
17944370631
-
Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors
-
Shaheen RM, Ahmad SA, Liu W et al. Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors. Br J Cancer 2001;85:584-589.
-
(2001)
Br J Cancer
, vol.85
, pp. 584-589
-
-
Shaheen, R.M.1
Ahmad, S.A.2
Liu, W.3
-
59
-
-
12744270313
-
Gefitinib (Iressa, ZD1839) enhances the activity of the novel vascular-targeting agent ZD6126 in human colorectal cancer and non-small cell lung cancer (NSCLC) xenograft models
-
Guy SP, Ashton SE, Hughes G et al. Gefitinib (Iressa, ZD1839) enhances the activity of the novel vascular-targeting agent ZD6126 in human colorectal cancer and non-small cell lung cancer (NSCLC) xenograft models. Clin Cancer Res 2003;9:B13.
-
(2003)
Clin Cancer Res
, vol.9
-
-
Guy, S.P.1
Ashton, S.E.2
Hughes, G.3
-
60
-
-
33746911955
-
Combining targeted agents: Blocking the epidermal growth factor and vascular endothelial growth factor pathways
-
Sandler A, Herbst R. Combining targeted agents: Blocking the epidermal growth factor and vascular endothelial growth factor pathways. Clin Cancer Res 2006;12:4421s-4425s.
-
(2006)
Clin Cancer Res
, vol.12
-
-
Sandler, A.1
Herbst, R.2
-
61
-
-
35948989620
-
A phase II study of erlotinib (E) and bevacizumab (B) in patients (pts) with previously untreated stage IIIB/IV non-small cell lung cancer (NSCLC)
-
Groen HJ, Smit EF, Dingemans A. A phase II study of erlotinib (E) and bevacizumab (B) in patients (pts) with previously untreated stage IIIB/IV non-small cell lung cancer (NSCLC). J Clin Oncol 2007;25:7625.
-
(2007)
J Clin Oncol
, vol.25
, pp. 7625
-
-
Groen, H.J.1
Smit, E.F.2
Dingemans, A.3
-
62
-
-
22144471081
-
Randomized phase II/III Trial of paclitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC # 704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): An Eastern Cooperative Oncology Group (ECOG) Trial - E4599
-
Sandler AB, Gray R, Brahmer J et al. Randomized phase II/III Trial of paclitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC # 704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): An Eastern Cooperative Oncology Group (ECOG) Trial - E4599. J Clin Oncol 2005;23:LBA4.
-
(2005)
J Clin Oncol
, vol.23
-
-
Sandler, A.B.1
Gray, R.2
Brahmer, J.3
-
63
-
-
34247509357
-
Prospective correlative assessment of biomarkers in E4599 randomized phase II/III trial of carboplatin and paclitaxel ± bevacizumab in advanced non-small cell lung cancer (NSCLC)
-
Dowlati A. Prospective correlative assessment of biomarkers in E4599 randomized phase II/III trial of carboplatin and paclitaxel ± bevacizumab in advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2006;24:7027.
-
(2006)
J Clin Oncol
, vol.24
, pp. 7027
-
-
Dowlati, A.1
-
64
-
-
34248380395
-
Exploratory analyses EGFR, kRAS mutations and other molecular markers in tumors of NSCLC patients (pts) treated with chemotherapy +/- erlotinib (TALENT)
-
Gatzemeier U, Heller A, Foernzler D et al. Exploratory analyses EGFR, kRAS mutations and other molecular markers in tumors of NSCLC patients (pts) treated with chemotherapy +/- erlotinib (TALENT). J Clin Oncol 2005;23:7028.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7028
-
-
Gatzemeier, U.1
Heller, A.2
Foernzler, D.3
-
65
-
-
10844250444
-
Long survival of never smoking non-small cell lung cancer (NSCLC) patients (pts) treated with erlotinib HCl (OSI-774) and chemotherapy: Sub-group analysis of TRIBUTE
-
Miller VA, Herbst R, Prager D et al. Long survival of never smoking non-small cell lung cancer (NSCLC) patients (pts) treated with erlotinib HCl (OSI-774) and chemotherapy: Sub-group analysis of TRIBUTE. J Clin Oncol 2004;23(14 suppl):628.
-
(2004)
J Clin Oncol
, vol.23
, Issue.14 SUPPL.
, pp. 628
-
-
Miller, V.A.1
Herbst, R.2
Prager, D.3
-
66
-
-
24944497744
-
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
-
Eberhard DA, Johnson BE, Amler LC et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005;23:5900-5909.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5900-5909
-
-
Eberhard, D.A.1
Johnson, B.E.2
Amler, L.C.3
-
67
-
-
15744372810
-
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
-
Pao W, Wang TY, Riely GJ et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med 2005;2:e17.
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Wang, T.Y.2
Riely, G.J.3
-
68
-
-
34249821410
-
An analysis of the prognostic and predictive importance of K-ras mutation status in the National Cancer Institute of Canada Clinical Trials Group BR. 21 study of erlotinib versus placebo in the treatment of non-small cell lung cancer
-
Tsao M, Zhu A, Sakurada T et al. An analysis of the prognostic and predictive importance of K-ras mutation status in the National Cancer Institute of Canada Clinical Trials Group BR. 21 study of erlotinib versus placebo in the treatment of non-small cell lung cancer. J Clin Oncol 2006;24(18 suppl):7005.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 SUPPL.
, pp. 7005
-
-
Tsao, M.1
Zhu, A.2
Sakurada, T.3
-
69
-
-
10844294506
-
Cigarette smoking history predicts sensitivity to erlotinib: Results of a phase II trial in patients with bronchioloalveolar carcinoma (BAC)
-
Kris M, Sandler A, Miller V et al. Cigarette smoking history predicts sensitivity to erlotinib: Results of a phase II trial in patients with bronchioloalveolar carcinoma (BAC). J Clin Oncol 2004;22(14 suppl):628.
-
(2004)
J Clin Oncol
, vol.22
, Issue.14 SUPPL.
, pp. 628
-
-
Kris, M.1
Sandler, A.2
Miller, V.3
-
70
-
-
1842509828
-
Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer
-
Miller VA, Kris MG, Shah N et al. Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer. J Clin Oncol 2004;22:1103-1109.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1103-1109
-
-
Miller, V.A.1
Kris, M.G.2
Shah, N.3
-
71
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial)
-
Fukuoka M, Yano S, Giaccone G et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial). J Clin Oncol 2003;21:2237-2246.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
-
72
-
-
24644471788
-
Smoking history is more predictive of survival benefit from erlotinib for patients with non-small cell lung cancer (NSCLC) than EGFR expression
-
628s
-
Clark GM, Zborowski D, Santabárbara P et al. Smoking history is more predictive of survival benefit from erlotinib for patients with non-small cell lung cancer (NSCLC) than EGFR expression. J Clin Oncol 2005;23(16 suppl):628s.
-
(2005)
J Clin Oncol
, vol.23
, Issue.16 SUPPL.
-
-
Clark, G.M.1
Zborowski, D.2
Santabárbara, P.3
-
73
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Jänne PA, Lee JC et al. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 2004;304:1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Jänne, P.A.2
Lee, J.C.3
-
74
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004;101:13306-13311.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
-
75
-
-
20144386787
-
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
-
Shigematsu H, Takahashi T, Nomura M et al. Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res 2005;65:1642-1646.
-
(2005)
Cancer Res
, vol.65
, pp. 1642-1646
-
-
Shigematsu, H.1
Takahashi, T.2
Nomura, M.3
-
76
-
-
20244388126
-
Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
-
Mitsudomi T, Kosaka T, Endoh H et al. Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol 2005;23:2513-2520.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2513-2520
-
-
Mitsudomi, T.1
Kosaka, T.2
Endoh, H.3
-
77
-
-
19944426858
-
High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan
-
Huang SF, Liu HP, Li LH et al. High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. Clin Cancer Res 2004;10:8195-8203.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8195-8203
-
-
Huang, S.F.1
Liu, H.P.2
Li, L.H.3
-
78
-
-
29244463359
-
Mutational analysis of K-RAS and EGFR implicates K-RAS as a resistance marker in the Southwest Oncology Group (SWOG) trial S0126 of bronchioalveolar carcinoma (BAC) patients (pts) treated with gefitinib
-
623s
-
Gumerlock PH, Holland WS, Chen H et al. Mutational analysis of K-RAS and EGFR implicates K-RAS as a resistance marker in the Southwest Oncology Group (SWOG) trial S0126 of bronchioalveolar carcinoma (BAC) patients (pts) treated with gefitinib. J Clin Oncol 2005;23(16 suppl):623s.
-
(2005)
J Clin Oncol
, vol.23
, Issue.16 SUPPL.
-
-
Gumerlock, P.H.1
Holland, W.S.2
Chen, H.3
-
79
-
-
33745643240
-
EGFR mutation, immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH) as predictors of sensitivity to erlotinib and gefitinib in patients (pts) with NSCLC
-
628s
-
Miller VA, Zakowski M, Riely GJ et al. EGFR mutation, immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH) as predictors of sensitivity to erlotinib and gefitinib in patients (pts) with NSCLC. J Clin Oncol 2005;23(16 suppl):628s.
-
(2005)
J Clin Oncol
, vol.23
, Issue.16 SUPPL.
-
-
Miller, V.A.1
Zakowski, M.2
Riely, G.J.3
-
80
-
-
32944466837
-
Evaluation of epidermal growth factor receptor (EGFR) mutations and gene copy numbers as predictors of clinical outcomes in Japanese patients with recurrent non-small-cell lung cancer (NSCLC) receiving gefitinib
-
628s
-
Takano T, Ohe Y, Yoshida T et al. Evaluation of epidermal growth factor receptor (EGFR) mutations and gene copy numbers as predictors of clinical outcomes in Japanese patients with recurrent non-small-cell lung cancer (NSCLC) receiving gefitinib. J Clin Oncol 2005;23(16 suppl):628s.
-
(2005)
J Clin Oncol
, vol.23
, Issue.16 SUPPL.
-
-
Takano, T.1
Ohe, Y.2
Yoshida, T.3
-
81
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao W, Miller VA, Politi KA et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005;2:e73.
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
-
82
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi S, Boggon TJ, Dayaram T et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 2005;352:786-792.
-
(2005)
N Engl J Med
, vol.352
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
-
83
-
-
28444488046
-
A comparison of the antitumor efficacy of ZD 6474 and gefitinib (Iressa) in patients with NSCLC: Results of a randomized, double-blind, phase II study
-
Natale R, Bodkin D, Govindan R et al. A comparison of the antitumor efficacy of ZD 6474 and gefitinib (Iressa) in patients with NSCLC: Results of a randomized, double-blind, phase II study. Lung Cancer 2005;49(suppl 2):S37.
-
(2005)
Lung Cancer
, vol.49
, Issue.SUPPL. 2
-
-
Natale, R.1
Bodkin, D.2
Govindan, R.3
-
84
-
-
54249138858
-
Sorafenib plus carboplatin/paclitaxel in chemonaive patients with stage IIIB-IV non-small cell lung cancer (NSCLC): Interim analysis (IA) results from the phase III, randomized, double-blind, placebo-controlled, ESCAPE (Evaluation of Sorafenib, Carboplatin, and Paclitaxel Efficacy in NSCLC) trial
-
Scagliotti G, von Pawel J, Reck M et al. Sorafenib plus carboplatin/paclitaxel in chemonaive patients with stage IIIB-IV non-small cell lung cancer (NSCLC): Interim analysis (IA) results from the phase III, randomized, double-blind, placebo-controlled, ESCAPE (Evaluation of Sorafenib, Carboplatin, and Paclitaxel Efficacy in NSCLC) trial. J Thorac Oncol 2008;3(suppl 1):S97.
-
(2008)
J Thorac Oncol
, vol.3
, Issue.SUPPL. 1
-
-
Scagliotti, G.1
von Pawel, J.2
Reck, M.3
-
85
-
-
44649150549
-
The current status and evolving role of sunitinib in non-small cell lung cancer
-
Socinski MA. The current status and evolving role of sunitinib in non-small cell lung cancer. J Thorac Oncol 2008;3(suppl 2):S119-S123.
-
(2008)
J Thorac Oncol
, vol.3
, Issue.SUPPL. 2
-
-
Socinski, M.A.1
|