Metformin protects against hyperglycemia-induced cardiomyocytes injury by inhibiting the expressions of receptor for advanced glycation end products and high mobility group box 1 protein

Molecular Biology Reports

Volumn 41, Issue 3, 2014, Pages 1335-1340

  Zhang, Ting ^a   Hu, Xiaorong ^b   Cai, Yuli ^a   Yi, Bo ^a   Wen, Zhongyuan ^a  

^a WUHAN UNIVERSITY   (China)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

High mobility group box 1 protein; Metformin; Reactive oxygen species; Receptor for advanced glycation end products

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; CREATINE KINASE; GLUCOSE; HIGH MOBILITY GROUP B1 PROTEIN; LACTATE DEHYDROGENASE; MALONALDEHYDE; METFORMIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL DAMAGE; CELL FUNCTION; CELL LEVEL; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HEART MUSCLE CELL; HYPERGLYCEMIA; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; WESTERN BLOTTING;

RATTUS;

ANIMALS; ANTIOXIDANTS; CREATINE KINASE; GENE EXPRESSION REGULATION; GLYCOSYLATION END PRODUCTS, ADVANCED; HMGB1 PROTEIN; HUMANS; HYPERGLYCEMIA; L-LACTATE DEHYDROGENASE; MALONDIALDEHYDE; METFORMIN; MYOCYTES, CARDIAC; RATS; RECEPTORS, IMMUNOLOGIC; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84896030682     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-013-2979-3     Document Type: Article

References (32)

1. Neeper M, Schmidt AM, Brett J, Yan SD, Wang F, Pan WC, Elliston K, Stern D, Shaw A (1992) Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem 267:14998-15004
2. Scaffidi P, Misteli T, Bianchi ME (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418:191-195 (Pubitemid 34773774)
3. Bonaldi T, Talamo F, Scaffidi P, Ferrera D, Portro A, Bachi A, Rubartelli A, Aqresti A, Bianchi ME (2003) Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBOJ 22:5551-5560 (Pubitemid 37279964)
4. Agnello D, Wang H, Yang H, Tracey KJ, Ghezzi P (2002) HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion. Cytokine 18:231-236 (Pubitemid 34775431)
5. Yang H, Ochani M, Li J, Qiang X, Tanovic M, Harris HE, Susarla SM, Ulloa L, Wang H, DiRaimo R, Czura CJ, Wang H, Roth J, Warren HS, Fink MP, Fenton MJ, Andersson U, Tracey KJ (2004) Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci USA 101:296-301 (Pubitemid 38084244)
6. Volz HC, Seidel C, Laohachewin D, Kaya Z, Müller OJ, Pleger ST, Lasitschka F, Bianchi ME, Remppis A, Bierhaus A, Katus HA, Andrassy M (2010) HMGB1: the missing link between diabetes mellitus and heart failure. Basic Res Cardiol 105:805-820
7. Hu X, Jiang H, Bai Q, Zhou X, Xu C, Lu Z, Cui B, Wen H (2009) Increased serum HMGB1 is related to the severity of coronary artery stenosis. Clin Chim Acta 406:139-142
8. Hu X, Zhou X, He B, Xu C, Wu L, Cui B, Wen H, Lu Z, Jiang H (2010) Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Eur J Pharmacol 638:84-89
9. Hu X, Zhou W, Bai Q, Wang J, Yang X, Xu C, Jing H (2011) Increased serum high mobility group box 1 protein in patients with atrial fibrillation. Biomed Aging Pathol 1:52-55
10. Abbasi F, Chu JW, McLaughlin T, Lamendola C, Leary ET, Reaven GM (2004) Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus. Metabolism 53:159-164 (Pubitemid 38168886)
11. UK Prospective Diabetes Study (UKPDS) Group (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS34). Lancet 352:854-865
12. Bonnefont-Rousselot D, Raji B, Walrand S, Gardès-Albert M, Jore D, Legrand A, Peynet J, Vasson MP (2003) An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress. Metabolism 52:586-589 (Pubitemid 36896285)
13. Ouslimani N, Mahrouf M, Peynet J, Bonnefont-Rousselot D, Cosson C, Legrand A, Beaudeux JL (2007) Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1. Metabolism 56:308-313 (Pubitemid 46209221)
14. Hou X, Song J, Li XN, Zhang L, Wang X, Chen L, Shen YH (2010) Metformin reduces intracellular reactive oxygen species levels by up regulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway. Biochem Biophys Res Commun 396:199-205
15. Tsoyi K, Jang HJ, Nizamutdinova IT, Kim YM, Lee YS, Kim HJ, Seo HG, Lee JH, Chang KC (2011) Metformin inhibits HMGB1 release in LPS-treated RAW264.7cells and increases survival rate of endotoxaemic mice. Br J Pharmacol 162:1498-1508
16. Yan L, Tang Q, Shen D, Peng S, Zheng Q, Guo H, Jiang M, Deng W (2008) SOCS-1 inhibits TNF-alpha-induced cardiomyocyte apoptosis via ERK1/2 pathway activation. Inflammation 31:180-188
17. Cai Y, Hu X, Yi B, Zhang T, Wen Z (2012) Glucagon-like peptide-1 protects against hyperglycemia-induced cardiomyocytes injury by inhibiting high group box 1 expression. Mol Biol Rep 39:10705-10711
18. Hu X, Cui B, Zhou X, Xu C, Lu Z, Jiang H (2012) Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Mol Biol Rep 39:227-231
19. Andrassy M, Volz HC, Igwe JC, Funke B, Eichberger SN, Kaya Z, Buss S, Autschbach F, Pleger ST, Lukic IK, Bea F, Hardt SE, Humpert PM, Bianchi ME, Mairbäurl H, Nawroth PP, Remppis A, Katus HA, Bierhaus A (2008) High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 117:3216-3226
20. Andrassy M, Volz HC, Bianchi ME (2008) The role of Hmgb1 in the development of diabetic cardiomyopathy. Circulation 118:S351-S352
21. Bell CW, Jiang W, Reich CF 3rd, Pisetsky DS (2006) The extracellular release of HMGB1 during apoptotic cell death. Am J Physiol Cell Physiol 291:C1318-C1325 (Pubitemid 44878603)
22. Xu H, Su Z, Wu J, Yang M, Penninger JM, Martin CM, Kvietys PR, Rui T (2010) The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipo polysaccharide-induced myocardial dysfunction via a TLR4/phosphatidy linositol 3-kinase c pathway. J Immunol 184:1492-1498
23. Nath N, Khan M, Paintlia MK, Singh I, Hoda MN, Giri S (2009) Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis. J Immunol 182:8005-8014
24. Tan BK, Adya R, Chen J, Farhatullah S, Heutling D, Mitchell D, Lehnert H, Randeva HS (2009) Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1. Cardiovasc Res 83:566-574
25. Gonzalez-Angulo AM, Meric-Bernstam F (2010) Metformin: a therapeutic opportunity in breast cancer. Clin Cancer Res 16:1695-1700
26. Ouslimani N, Peynet J, Bonnefont-Rousselot D, Thérond P, Legrand A, Beaudeux JL (2005) Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells. Metabolism 54:829-834 (Pubitemid 40725333)
27. Kalinina N, Aqrotis A, Antropova Y, DiVitto G, Kanellakis P, Kostolias G, Ilyinskaya O, Tararak E, Bobik A (2004) Increased expression of the DNA-binding cytokine HMGB1 in human atherosclerotic lesions: role of activated macrophages and cytokines. Arterioscler Thromb Vasc Biol 24:2320-2325 (Pubitemid 39658036)
28. Alhaider AA, Korashy HM, Sayed-Anmed MM, Mobark M, Kfoury H, Mansour MA (2011) Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression. Chem Biol Interact 192:233-242
29. Fidan E, Onder Ersoz H, Yilmaz M, Yilmaz H, Kocak M, Karahan C, Erem C (2011) The effects of rosiglitazone and metformin on inflammation and endothelial dysfunction in patients with type 2 diabetes mellitus. Acta Diabetol 48:297-302
30. Wang XF, Zhang JY, Li L, Zhao XY, Tao HL, Zhang L (2011) Metformin improves cardiac function in rats via activation of AMP-activated protein kinase. Clin Exp Pharmacol Physiol 38:94-101
31. Yao D, Brownlee M (2010) Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands. Diabetes 59:249-255
32. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage. Nature 404:787-790 (Pubitemid 30212409)