Synthesis and characterization of pH tolerant and mucoadhesive (Thiol-Polyethylene Glycol) chitosan graft polymer for drug delivery

Journal of Pharmaceutical Sciences

Volumn 103, Issue 2, 2014, Pages 594-601

  Hauptstein, Sabine ^a   Bonengel, Sonja ^a   Griessinger, Julia ^b   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b Thiomatrix Forschungs und Beratungs GmbH   (Austria)

Author keywords

Formulation vehicle; Mucoadhesion; Mucosal drug delivery; Pegylation; Polymeric drug carrier; Thiomers; Toxicity; Water soluble chitosan

Indexed keywords

(O (3 CARBOXYLPROPYL) O' (2(3 MERCAPTOPROPIONYLAMINO)ETHYL) POLYETHYLENEGLYCOL); AMIDE; CHITOSAN DERIVATIVE; MACROGOL; MUCIN; POLYMER; THIOL; THIOL POLYETHYLENEGLYCOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BIOCOMPATIBILITY; CHEMICAL BINDING; CHEMICAL STRUCTURE; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DISULFIDE BOND; DRUG DELIVERY SYSTEM; EXPERIMENTAL PIG; INTESTINE; MUCOADHESION; NONHUMAN; PH; RAT; SOLUBILITY; SYNTHESIS;

FORMULATION VEHICLE; MUCOADHESION; MUCOSAL DRUG DELIVERY; PEGYLATION; POLYMERIC DRUG CARRIER; THIOMERS; TOXICITY; WATER SOLUBLE CHITOSAN;

ALGORITHMS; ANIMALS; CACO-2 CELLS; CELL SURVIVAL; CHITOSAN; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; INTESTINAL MUCOSA; INTESTINES; OXAZINES; POLYETHYLENE GLYCOLS; RATS; SOLUBILITY; SULFHYDRYL COMPOUNDS; SWINE; TENSILE STRENGTH; THIOGLYCOLATES; TISSUE ADHESIVES; VISCOSITY; XANTHENES;

EID: 84895930997     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23832     Document Type: Article

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