Underlying mechanism of regulatory actions of diclofenac, a nonsteroidal anti-inflammatory agent, on neuronal potassium channels and firing: An experimental and theoretical study

Journal of Physiology and Pharmacology

Volumn 64, Issue 3, 2013, Pages

  Huang, C W ^a   Hung, T Y ^b   Liao, Y K ^c   Hsu, M C ^c   Wu, Sheng Nan ^c  

^a NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Action potential; Diclofenac; Nonsteroidal anti inflammatory drugs; Pyramidal neurons; Simulations

Indexed keywords

DICLOFENAC; NALOXONE; POTASSIUM CHANNEL; AGENTS AFFECTING WATER, MOLECULE OR ION TRANSPORT; ANTICONVULSIVE AGENT; ISOPROTEIN; NERVE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KCNQ; SHAW POTASSIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; EMBRYO; HIPPOCAMPUS; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MOUSE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PYRAMIDAL NERVE CELL; RAT; SPINAL GANGLION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CELL CULTURE; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; HIPPOCAMPAL CA1 REGION; KINETICS; METABOLISM; MOTONEURON;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICONVULSANTS; CA1 REGION, HIPPOCAMPAL; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; DICLOFENAC; GANGLIA, SPINAL; KCNQ POTASSIUM CHANNELS; KINETICS; MEMBRANE POTENTIALS; MEMBRANE TRANSPORT MODULATORS; MICE; MODELS, BIOLOGICAL; MOTOR NEURONS; NERVE TISSUE PROTEINS; POTASSIUM CHANNEL BLOCKERS; PROTEIN ISOFORMS; PYRAMIDAL CELLS; RATS; SHAW POTASSIUM CHANNELS;

EID: 84895915692     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Sanchez-Hernandez MC, Delgado J, Navarro AM, Orta JC, Hernandez M, Conde J. Seizures induced NSAID. Allergy 1999; 54: 90-91.
2. Ng SC, Chan FK. NSAID-induced gastrointestinal and cardiovascular injury. Curr Opin Gastroenterol 2010; 26: 611-617.
3. Ortiz MI, Torres-Lopez JE, Castaneda-Hernandez G, Rosas R, Vidal-Cantu G, Granados-Soto V. Pharmacological evidence for the activation of K+ channels by diclofenac. Eur J Phamacol 2002; 438: 85-91.
4. Liu LY, Fei XW, Li ZM, Zhang ZH, Mei YA. Diclofenac, a nonsteroidal anti-inflammatory drug, activates the transient outward K+ current in rat cerebellar granule cells. Neuropharmacology 2005; 48: 918-926.
5. Miceli F, Soldovieri MV, Martire M, Taglialatela M. Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs. Curr Opin Pharmacol 2008; 8: 65-74.
6. Villalonga N, David M, Bielanska J, et al. Immunomodulatory effects of diclofenac in leukocytes through the targeting of KV1.3 voltage-dependent potassium channels. Biochem Pharmacol 2010; 80: 858-866.
7. Takahashi Y, Kaba H. Muscarinic receptor type 1 (M1) stimulation, probably through KCNQ/Kv7 channel closure, increases spontaneous GABA release at the dendrodendritic synapse in the mouse accessory olfactory bulb. Brain Res 2010; 1339: 26-40.
8. Brueggemann LI, Mackie AR, Martin JL, Cribbs LL, Byron KL. Diclofenac distinguishes among homomeric and heteromeric potassium channels composed of KCNQ4 and KCNQ5 subunits. Mol Pharmacol 2011; 79: 10-23.
9. Brown DA, Passmore GM. Neural KCNQ (Kv7) channels. Br J Pharmacol 2009; 156: 1185-1195.
10. Soldovieri MV, Miceli F, Taglialatela M. Driving with no brakes: molecular pathophysiology of Kv7 potassium channels. Physiology 2011; 25: 365-376.
11. Cooper EC. Potassium channels: how genetic studies of epileptic syndrome open paths to new therapeutic targets and drugs. Epilepsia 2001; 42(Suppl. 5): 49-54.
12. Gunthorpe MJ, Large CH, Sankar R. The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy. Epilepsia 2012; 53: 412-424.
13. Large CH, Sokal DM, Nehlig A, et al. The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: implications for clinical use. Epilepsia 2012; 53: 425-436.
14. Yu F, Liu Y, Wang Y, et al. Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures. Epilepsia Res 2011; 97: 64-72.
15. Wu SN, Hsu MC, Liao YK, Wu FT, Jong YJ, Lo YC. Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier K+ currents in motor neuron-like cells. Evid Based Complement Alternat Med 2012; 2012: 148403.
16. Hsu SH, Lai MC, Er TK, et al. Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) regulates the level of SMN expression through ubiquitination in primary spinal muscular atrophy fibroblasts. Clin Chimica Acta 2010; 411: 1920-1928.
17. Hsu YY, Chen CS, Wu SN, Jong YJ, Lo YC. Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells. Eur J Pharmaceut Sci 2012; 46: 415-425.
18. Wu SN, Lo YC, Chen BS, So EC, Chen LT. Contribution of blocked potassium current conductance and increased conductance of persistent sodium current to the afterdischarge in myelinated neuron. Muscle Nerve 2012; 46: 297-299.
19. Wu SN, Yeh CC, Huang HC, So EC, Lo YC. Electrophysiological characterization of sodium-activated potassium channels in NG108-15 and NSC-34 motor neuron-like cells. Acta Physiol 2012; 206: 120-134.
20. Bocksteins E, Van de Vijver G, Van Bogaert PP, Snyders DJ. Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons. Am J Physiol Cell Physiol 2012; 303: C406-C415.
21. Huang CW, Wu SN, Cheng JT, Tsai JJ, Huang CC. Diazoxide reduces status epilepticus neuron damage in diabetes. Neurotox Res 2010; 17: 305-316.
22. Golomb D, Yue C, Yaari Y. Contribution of persistent Na+ current and M-type K+ current to somatic bursting in CA1 pyramidal cells: combined experimental and modeling study. J Neurophysiol 2006; 96: 1912-1926.
23. Lin MW, Wang YJ, Liu SI, Lin AA, Lo YC, Wu SN. Characterization of aconitine-induced block of delayed rectifier K+ current in differentiated NG108-15 neuronal cells. Neuropharmacology 2008; 54: 912-923.
24. Wu SN, Chen BS, Lin MW, Liu YC. Contribution of slowly inactivating potassium current to delayed firing of action potentials in NG108-15 neuronal cells: experimental and theoretical studies. J Theor Biol 2008; 252: 711-721.
25. Ermentrout GB. Simulating, Analyzing, and Animating Dynamical Systems: A Guide to XPPAUT for Researchers and Students. Philadelphia, Society for Industrial Mathematics (SIAM), 2002.
26. Chen BS, Wu SN. Functional role of the activity of ATP-sensitive potassium channels in electrical behavior of hippocampal neurons: experimental and theoretical studies. J Theor Biol 2011; 272: 16-25.
27. Wu SN. Simulations of the cardiac action potential based on the Hodgkin-Huxley kinetics with the use of Microsoft Excel spreadsheets. Chin J Physiol 2004; 47: 15-22.
28. Baranauskas G. Ionic channel function in action potential generation: current perspective. Mol Neurobiol 2007; 35: 129-150.
29. Wu SN, Lo YK, Chen H, Li HF, Chiang HT. Rutaecarpine-induced block of delayed rectifier K+ current in NG108-15 neuronal cells. Neuropharmacology 2001; 41: 834-843.
30. Chen BS, Lo YC, Peng H, Hsu TI, Wu SN. Effects of ranolazine, a novel anti-anginal drug, on ion currents and membrane potential in pituitary tumor GH3 cells and NG108-15 neuronal cells. J Pharmacol Sci 2009; 110: 295-305.
31. Yeung SY, Thompson D, Wang Z, Fedida D, Robertson B. Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies. J Neurosci 2005; 25: 8735-8745.
32. Björkman R. Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat. Acta Anaesthesiol Scand (Suppl) 1995; 103: 1-44.
33. Xiong Q, Gao Z, Wang W, Li M. Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds. Trends Pharmacol Sci 2008; 29: 99-107.
34. Peretz A, Degani N, Nachman R, et al. Meclofenamic acid and diclofenac, a novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol 2005; 67: 1053-1066.
35. Meves H, Schwarz JR, Wulfsen I. Separation of M-like current and ERG current in NG108-15 cells. Br J Pharmacol 1999; 127: 1213-1223.
36. Huang CW, Huang CC, Lin MW, Tsai JJ, Wu SN. The synergistic inhibitory actions of oxcarbazepine on voltage-gated sodium and potassium currents in differentiated NG108-15 neuronal cells and model neurons. Int J Neuropsychopharmacol 2008; 11: 597-610.
37. Akemann W, Knopfel T. Interaction of Kv3 potassium channels and resurgent sodium current influences the rate of spontaneous firing of Purkinje neurons. J Neurosci 2006; 26: 4602-4612.
38. Linley JE, Rose K, Patil M, Robertson B, Akopian AN, Gamper N. Inhibition of M current in sensory neurons by exogenous proteases: a signaling pathway mediating inflammatory nociception. J Neurosci 2008; 28: 11240-11249.
39. De Sarro G, Di Paola ED, Conte G, Pasculli MP, De Sarro A. Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice. Naunyn Schmiedebergs Arch Pharmacol 2001; 363: 330-336.
40. Friederich P, Urban BW. Interaction of intravenous anesthetics with human neuronal potassium currents in relation to clinical concentrations. Anesthesiology 1999; 91: 1853-1860.
41. Nagano Y, Matsui H, Shimokawa O, et al. Rebamipide attenuates nonsteroidal anti-inflammatory drugs (NSAID) induced lipid peroxidation by the manganese superoxide dismutase (MnSOD) overexpression in gastrointestinal epithelial cells. J Physiol Pharmacol 2012; 63: 137-142.
42. Wu YJ, Dworetzky SI. Recent developments on KCNQ potassium channel openers. Curr Med Chem 2005; 12: 453-460.
43. Pattnaik BR, Hughes BA. Effects of KCNQ channel modulators on the M-type potassium current in primate retinal pigment epithelium. Am J Physiol Cell Physiol 2012; 302: C821-833.
44. Huang CW, Tsai JJ, Huang CC, Wu SN. Experimental and simulation studies on the mechanisms of levetiracetam-mediated inhibition of delayed-rectifier potassium current (KV3.1): contribution to the firing of action potentials. J Physiol Pharmacol 2009; 60: 37-47.
45. Wang YJ, Lin MW, Lin AA, Peng H, Wu SN. Evidence for state-dependent block of DPI 201-106, a synthetic inhibitor of Na+ channel inactivation, on delayed-rectifier K+ current in pituitary tumor (GH3) cells. J Physiol Pharmacol 2008; 59: 409-423