Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier K + currents in motor neuron-like cells

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Wu, Sheng Nan ^a   Hsu, Ming Chun ^a   Liao, Yu Kai ^a   Wu, Fang Tzu ^a   Jong, Yuh Jyh ^b   Lo, Yi Ching ^c  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; DELAYED RECTIFIER POTASSIUM CHANNEL; FLUPIRTINE; LINOPIRDINE; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG ACTIVITY; DRUG MECHANISM; EMBRYO; MOTONEURON; MOUSE; NERVE CELL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL;

EID: 84865035363     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/148403     Document Type: Article

References (26)

1. Harish S., Bhuvana K., Bengalorkar G. M., Kumar T., Flupirtine: clinical pharmacology Journal of Anaesthesiology Clinical Pharmacology 2012 28 2 172 177
2. Otto M., Cepek L., Ratzka P., Doehlinger S., Boekhoff I., Wiltfang J., Irle E., Pergande G., Ellers-Lenz B., Windl O., Kretzschmar H. A., Poser S., Prange H., Efficacy of flupirtine on cognitive function in patients with CJD: a double-blind study Neurology 2004 62 5 714 718 (Pubitemid 38298945)
3. Appleby B. S., Lyketsos C. G., Rapidly progressive dementias and the treatment of human prion diseases Expert Opinion on Pharmacotherapy 2011 12 1 1 12
4. Su T. R., Zei W. S., Su C. C., Hsiao G., Lin M. J., The effects of the KCNQ openers retigabine and flupirtine on myotonia in mammalian skeletal muscle induced by a chloride channel blocker Evidence-Based Complement and Alternative Medicine 2012 2012 9
5. Schwarz M., Block F., Pergande G., N-methyl-D-aspartate (NMDA)-mediated muscle relaxant action of flupirtine in rats NeuroReport 1994 5 15 1981 1984 (Pubitemid 24305437)
6. Osborne N. N., Cazevieille C., Wood J. P. M., Nash M. S., Pergande G., Block F., Kosinski C., Schwarz M., Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist General Pharmacology 1998 30 3 255 263 (Pubitemid 28046493)
7. Klinger F., Geier P., Dorostkar M. M., Chandaka G. K., Yousuf A., Salzer I., Kubista H., Boehm S., Concomitant facilitation of GABA A receptors and Kv7 channels by the non-opioid analgesic flupirtine British Journal of Pharmacology 2011 166 5 1631 1642
8. Chen H., Jassar B. S., Kurenny D. E., Smith P. A., Phorbol ester-induced M-current suppression in bull-frog sympathetic ganglion cells: insensitivity to kinase inhibitors British Journal of Pharmacology 1994 113 1 55 62 (Pubitemid 24271717)
9. Xiong Q., Gao Z., Wang W., Li M., Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds Trends in Pharmacological Sciences 2008 29 2 99 107
10. Brown D. A., Passmore G. M., Neural KCNQ (Kv7) channels British Journal of Pharmacology 2009 156 8 1185 1195
11. Maljevic S., Wuttke T. V., Lerche H., Nervous system KV7 disorders: breakdown of a subthreshold brake Journal of Physiology 2008 586 7 1791 1801 (Pubitemid 351997508)
12. Ryu H., Jeon G. S., Cashman N. R., Kowall N. W., Lee J., Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS Laboratory Investigation 2011 91 3 342 352
13. Hsu Y. Y., Chen C. S., Wu S. N., Jong Y. J., Lo Y. C., Berberine activates Nef2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells European Journal of Pharmaceutical Sciences 2012 46 5 415 425
14. Wu S. N., Yeh C. C., Huang H. C., So E. C., Lo Y. C., Electrophysiological characterization of sodium-activated potassium channels in NG108-15 and NSC-34 motor neuron-like cells. Acta Physiologica, 2012. In press
15. Huang C. W., Huang C. C., Lin M. W., Tsai J. J., Wu S. N., The synergistic inhibitory actions of oxcarbazepine on voltage-gated sodium and potassium currents in differentiated NG108-15 neuronal cells and model neurons International Journal of Neuropsychopharmacology 2008 11 5 597 610
16. Lin M. W., Wang Y. J., Liu S. I., Lin A. A., Lo Y. C., Wu S. N., Characterization of aconitine-induced block of delayed rectifier k + current in differentiated NG108-15 neuronal cells Neuropharmacology 2008 54 6 912 923
17. Wu S. N., Lo Y., Chen H., Li H. F., Chiang H. T., Rutaecarpine-induced block of delayed rectifier k + current in NG108-15 neuronal cells Neuropharmacology 2001 41 7 834 843 (Pubitemid 33001417)
18. Mishra S., Choudhary P., Joshi S., Bhatnagar S., Successful use of flupirtine in refractory neuropathic pain due to small fiber neuropathy. American Journal of Hospice Palliative Medicine. In press
19. Meves H., Schwarz J. R., Wulfsen I., Separation of M-like current and ERG current in NG108-15 cells British Journal of Pharmacology 1999 127 5 1213 1223 (Pubitemid 29326645)
20. Peretz A., Degani N., Nachman R., Uziyel Y., Gibor G., Shabat D., Attali B., Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties Molecular Pharmacology 2005 67 4 1053 1066 (Pubitemid 40410406)
21. Wang L. Y., Gan L., Forsythe I. D., Kaczmarek L. K., Contribution of the Kv3.1 potassium channel to high frequency firing in mouse auditory neurones Journal of Physiology 1998 509 1 183 194 (Pubitemid 28252021)
22. Miceli F., Soldovieri M. V., Martire M., Taglialatela M., Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs Current Opinion in Pharmacology 2008 8 1 65 74 (Pubitemid 351168693)
23. Wu S. N., Chen B. S., Lin M. W., Liu Y. C., Contribution of slowly inactivating potassium current to delayed firing of action potentials in NG108-15 neuronal cells: experimental and theoretical studies Journal of Theoretical Biology 2008 252 4 711 721
24. Sander S. E., Lemm C., Lange N., Hamann M., Richter A., Retigabine, a K V 7 (KCNQ) potassium channel opener, attenuates L-DOPA-induced dyskinesias in 6-OHDA-lesioned rats Neuropharmacology 2012 62 2 1052 1061
25. Mller W. E. G., Romero F. J., Perovic S., Pergande G., Pialoglou P., Protection of flupirtine on -amyloid-induced apoptosis in neuronal cells in vitro: prevention of amyloid-induced glutathione depletion Journal of Neurochemistry 1997 68 6 2372 2377
26. Mller W. E. G., Laplanche J. L., Ushijima H., Schrder H. C., Novel approaches in diagnosis and therapy of Creutzfeldt-Jakob disease Mechanisms of Ageing and Development 2000 116 2-3 193 218