The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system

Subcellular Biochemistry

Volumn 67, Issue , 2013, Pages 235-247

  Heit, Claire ^a   Dong, Hongbin ^a   Chen, Ying ^a   Thompson, David C ^a   Deitrich, Richard A ^b   Vasiliou, Vasilis K ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

CNS; CYP2E1; Ethanol

Indexed keywords

ALCOHOL; CENTRAL DEPRESSANT AGENT; CYTOCHROME P450 2E1;

ANIMAL; CENTRAL NERVOUS SYSTEM; CHEMISTRY; ENZYMOLOGY; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYTOCHROME P-450 CYP2E1; ETHANOL; HUMANS;

EID: 84895913802     PISSN: 03060225     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-007-5881-0_8     Document Type: Article

References (52)

1. Abdulla D, Goralski KB et al (2006) The regulation of cytochrome P450 2E1 during LPS-induced in flammation in the rat. Toxicol Appl Pharmacol 216(1):1-10
2. Alfonso-Loeches S, Guerri C (2011) Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. Crit Rev Clin Lab Sci 48(1):19-47
3. Aragon CM, Rogan F et al (1992) Ethanol metabolism in rat brain homogenates by a catalase- H2O2 system. Biochem Pharmacol 44(1):93-98
4. Bansal S, Liu CP et al (2010) Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress. J Biol Chem 285(32):24609-24619
5. Beisswenger TB, Holmquist B et al (1985) chi-ADH is the sole alcohol dehydrogenase isozyme of mammalian brains: implications and inferences. Proc Natl Acad Sci USA 82(24):8369-8373
6. Bhave SV, Hoffman PL et al (2006) Gene array pro files of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice. Alcohol Clin Exp Res 30(10):1659-1669
7. Brust JC (2010) Ethanol and cognition: indirect effects, neurotoxicity and neuroprotection: a review. Int J Environ Res Public Health 7(4):1540-1557
8. Cheung C, Yu AM et al (2005) The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity. Drug Metab Dispos 33(3):449-457
9. Correa M, Arizzi MN et al (2003) Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate. Brain Res Bull 62(3):197-202
10. Correa M, Manrique HM et al (2008) Reduction in the anxiolytic effects of ethanol by centrally formed acetaldehyde: the role of catalase inhibitors and acetaldehyde-sequestering agents. Psychopharmacology (Berl) 200(4):455-464
11. Davis VE, Walsh MJ (1970) Alcohol, amines, and alkaloids: a possible biochemical basis for alcohol addiction. Science 167(3920):1005-1007
12. Deitrich RA (2004) Acetaldehyde: Deja vu du jour. J Stud Alcohol 65(5):557-572
13. Deitrich R (2011) Ethanol as a prodrug: brain metabolism of ethanol mediates its reinforcing effects-a commentary. Alcohol Clin Exp Res 35(4):581-583
14. Deitrich RA, Dunwiddie TV et al (1989) Mechanism of action of ethanol - initial central-nervoussystem actions. Pharmacol Rev 41(4):489-537
15. Deitrich R, Zimatkin S et al (2006) Oxidation of ethanol in the brain and its consequences. Alcohol Res Health 29(4):266-273
16. Dey A, Kumar SM (2011) Cytochrome P450 2E1 and hyperglycemia-induced liver injury. Cell Biol Toxicol 27(4):285-310
17. Edenberg HJ (1998) Genetics of alcoholism. Science 282(5392):1269
18. Estonius M, Svensson S et al (1996) Alcohol dehydrogenase in human tissues: localisation of transcripts coding for five classes of the enzyme. FEBS Lett 397(2-3):338-342
19. Galter D, Carmine A et al (2003) Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain. Eur J Biochem 270(6):1316-1326
20. Gill K, Menez JF et al (1992) Enzymatic production of acetaldehyde from ethanol in rat brain tissue. Alcohol Clin Exp Res 16(5):910-915
21. Ginter E, Simko V (2009) Alcoholism: recent advances in epidemiology, biochemistry and genetics. Bratisl Lek Listy 110(5):307-311
22. Hauser SR, Getachew B et al (2012) Nicotine modulates alcohol-seeking and relapse by alcoholpreferring (P) rats in a time-dependent manner. Alcohol Clin Exp Res 36(1):43-54
23. Howard LA, Ahluwalia JS et al (2003a) CYP2E1+1D regulatory polymorphism: association with alcohol and nicotine dependence. Pharmacogenetics 13(6):321-328
24. Howard LA, Miksys S et al (2003b) Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. Br J Pharmacol 138(7):1376-1386
25. Karahanian E, Quintanilla ME et al (2011) Ethanol as a prodrug: brain metabolism of ethanol mediates its reinforcing effects. Alcohol Clin Exp Res 35(4):606-612
26. Kerr JT, Maxwell DS et al (1989) Immunocytochemistry of alcohol dehydrogenase in the rat central nervous system. Alcohol Clin Exp Res 13(6):730-736
27. Knockaert L, Fromenty B et al (2011) Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity. FEBS J 278(22):4252-4260
28. Lee SS, Buters JT et al (1996) Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 271(20):12063-12067
29. Lieber CS (1999) Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)-a review. Alcohol Clin Exp Res 23(6):991-1007
30. Martinez SE, Vaglenova J et al (2001) Distribution of alcohol dehydrogenase mRNA in the rat central nervous system. Consequences for brain ethanol and retinoid metabolism. Eur J Biochem 268(19):5045-5056
31. McBride WJ, Li TK et al (2002) Involvement of acetaldehyde in alcohol addiction. Alcohol Clin Exp Res 26(1):114-119
32. Melchior CL, Myers RD (1977) Preference for alcohol evoked by tetrahydropapaveroline (THP) chronically infused in the cerebral ventricle of the rat. Pharmacol Biochem Behav 7(1):19-35
33. Mokdad AH, Marks JS et al (2004) Actual causes of death in the United States, 2000. JAMA 291(10):1238-1245
34. Person RE, Chen H et al (2000) Enzymic catalysis of the accumulation of acetaldehyde from ethanol in human prenatal cephalic tissues: Evaluation of the relative contributions of CYP2E1, alcohol dehydrogenase, and catalase/peroxidases. Alcohol Clin Exp Res 24(9):1433-1442
35. Quertemont E, Tambour S et al (2004) Behavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects. Psychopharmacology (Berl) 177(1-2):84-92
36. Quintanilla ME, Tampier L et al (2007) Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective. Am J Physiol Endocrinol Metab 293(2):E531-E537
37. Raza H, Prabu SK et al (2004) Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-speci fic variations and roles in oxidative stress. Diabetes 53(1):185-194
38. Robin MA, Anandatheerthavarada HK et al (2001) Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial speci fic electron transfer proteins for activity. J Biol Chem 276(27):24680-24689
39. Robin MA, Anandatheerthavarada HK et al (2002) Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation. J Biol Chem 277(43):40583-40593
40. Rodd-Henricks ZA, Melendez RI et al (2002) The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats. Pharmacol Biochem Behav 72(1-2):55-64
41. Sarc L, Wraber B et al (2011) Ethanol and acetaldehyde disturb TNF-alpha and IL-6 production in cultured astrocytes. Hum Exp Toxicol 30(9):1256-1265
42. Tabakoff B, Anderson RA et al (1976) Brain acetaldehyde after ethanol administration. Biochem Pharmacol 25(11):1305-1309
43. Thurman RG, Ley HG et al (1972) Hepatic microsomal ethanol oxidation. Hydrogen peroxide formation and the role of catalase. Eur J Biochem 25(3):420-430
44. Tindberg N, Baldwin HA et al (1996) Induction of cytochrome P450 2E1 expression in rat and gerbil astrocytes by in flammatory factors and ischemic injury. Mol Pharmacol 50(5):1065-1072
45. Vangipuram SD, Lyman WD (2010) Ethanol alters cell fate of fetal human brain-derived stem and progenitor cells. Alcohol Clin Exp Res 34(9):1574-1583
46. Vasiliou V, Ziegler TL et al (2006) CYP2E1 and catalase in fluence ethanol sensitivity in the central nervous system. Pharmacogenet Genomics 16(1):51-58
47. Vemuri MC, Chetty CS (2005) Alcohol impairs astrogliogenesis by stem cells in rodent neurospheres. Neurochem Int 47(1-2):129-135
48. Westcott JY, Weiner H et al (1980) In vivo acetaldehyde in the brain of the rat treated with ethanol. Biochem Pharmacol 29(3):411-417
49. Zakhari S (2006) Overview: how is alcohol metabolized by the body? Alcohol Res Health 29(4):245-254
50. Zimatkin SM (1991) Histochemical study of aldehyde dehydrogenase in the rat CNS. J Neurochem 56(1):1-11
51. Zimatkin SM, Pronko SP et al (2006) Enzymatic mechanisms of ethanol oxidation in the brain. Alcohol Clin Exp Res 30(9):1500-1505
52. Zimatkin SM, Oganesian NA et al (2011) Acetate-dependent mechanisms of inborn tolerance to ethanol. Alcohol Alcohol 46(3):233-238