An open-label phase I/II study of tamibarotene in patients with advanced hepatocellular carcinoma

Hepatology International

Volumn 8, Issue 1, 2014, Pages 94-103

  Kanai, Fumihiko ^a   Obi, Shuntaro ^b   Fujiyama, Shigetoshi ^c   Shiina, Shuichiro ^d   Tamai, Hideyuki ^e   Mochizuki, Hitoshi ^f   Koike, Yukihiro ^g   Imamura, Jun ^h   Yamaguchi, Takayoshi ⁱ   Saida, Isamu ⁱ   Yokosuka, Osamu ^a   Omata, Masao ^f  

^a CHIBA UNIVERSITY   (Japan)

^b Kyoundo Hospital   (Japan)

^c Kumamoto Shinto General Hospital   (Japan)

^d JUNTENDO UNIVERSITY   (Japan)

^e WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^f Yamanashi Prefectural Central Hospital   (Japan)

^g The Mutualaid Association of Public School Teachers)   (Japan)

^h TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

ⁱ ZERIA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Chemotherapy; Hepatocellular carcinoma; Retinoic acid receptor; Retinoids; Tamibarotene

Indexed keywords

TAMIBAROTENE;

ADULT; ADVANCED CANCER; AGED; AREA UNDER THE CURVE; ARTERY THROMBOSIS; ARTICLE; CANCER CONTROL; CANCER INHIBITION; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DISTRIBUTION VOLUME; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; HISTOPATHOLOGY; HUMAN; HYPERCALCEMIA; HYPERTRIGLYCERIDEMIA; HYPERURICEMIA; INOPERABLE CANCER; INTERSTITIAL LUNG DISEASE; LIVER CELL CARCINOMA; MACULOPAPULAR RASH; MALE; MAXIMUM PLASMA CONCENTRATION; MAXIMUM TOLERATED DOSE; MILD HEPATIC IMPAIRMENT; MODERATE HEPATIC IMPAIRMENT; MYALGIA; OUTCOME ASSESSMENT; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PORTAL VEIN THROMBOSIS; PRIORITY JOURNAL; PROTEINURIA; RASH; RECOMMENDED DRUG DOSE; THROMBOSIS; TIME TO MAXIMUM PLASMA CONCENTRATION; VEIN THROMBOSIS; VOMITING;

EID: 84895906174     PISSN: 19360533     EISSN: 19360541     Source Type: Journal    
DOI: 10.1007/s12072-013-9459-7     Document Type: Article

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