-
1
-
-
0033604523
-
The IGF-1 receptor in cancer research
-
Baserga R. The IGF-1 receptor in cancer research. Exp Cell Res 1999; 253: 1-6.
-
(1999)
Exp Cell Res
, vol.253
, pp. 1-6
-
-
Baserga, R.1
-
3
-
-
2642518825
-
Co-targeting IGF-IR and c-kit: Synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells
-
Camirand A, Pollak M. Co-targeting IGF-IR and c-kit: Synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells. Br J Cancer 2004; 90: 1825-9.
-
(2004)
Br J Cancer
, vol.90
, pp. 1825-1829
-
-
Camirand, A.1
Pollak, M.2
-
4
-
-
0025166350
-
Insulin-like growth factor receptor expression and function in human breast cancer
-
Cullen KJ, Yee D, Sly WS et al. Insulin-like growth factor receptor expression and function in human breast cancer. Cancer Res 1990; 50: 58-63.
-
(1990)
Cancer Res
, vol.50
, pp. 58-63
-
-
Cullen, K.J.1
Yee, D.2
Sly, W.S.3
-
5
-
-
0842281886
-
Role of IGF-IR in mediating breast cancer invasion and metastasis
-
Kucab JE, Dunn SE. Role of IGF-IR in mediating breast cancer invasion and metastasis. Breast Dis 2003; 17: 41-7.
-
(2003)
Breast Dis
, vol.17
, pp. 41-47
-
-
Kucab, J.E.1
Dunn, S.E.2
-
6
-
-
0037092971
-
Expression of the type I insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease
-
Hellawell GO, Turner GO, Davies DR, Poulsom R, Brewster SF, Macaulay VM. Expression of the type I insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. Cancer Res 2000; 62: 2942-50.
-
(2000)
Cancer Res
, vol.62
, pp. 2942-2950
-
-
Hellawell, G.O.1
Turner, G.O.2
Davies, D.R.3
Poulsom, R.4
Brewster, S.F.5
Macaulay, V.M.6
-
7
-
-
0001938653
-
Insulin-like growth factor-1 (IGF-1) and insulin-like factor receptor (IGFr-1) in prostate cancer
-
Kurek R, Tunn UW, Aumueller G, Renneberg H. Insulin-like growth factor-1 (IGF-1) and insulin-like factor receptor (IGFr-1) in prostate cancer. J Urol 2000; 163 (Suppl): 35.
-
(2000)
J Urol
, vol.163
, Issue.SUPPL.
, pp. 35
-
-
Kurek, R.1
Tunn, U.W.2
Aumueller, G.3
Renneberg, H.4
-
8
-
-
4143074965
-
An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells. against drug-induced apoptosis
-
Alexia G, Fallot G, Lasfer M et al. An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis. Biochem Pharmacol 2004; 68: 1003-15.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 1003-1015
-
-
Alexia, G.1
Fallot, G.2
Lasfer, M.3
-
9
-
-
0036018897
-
The insulin-like growth factor system as a therapeutic target in colorectal cancer
-
Hassan AB, Macaulay VM. The insulin-like growth factor system as a therapeutic target in colorectal cancer. Ann Oncol 2002; 13: 349-56.
-
(2002)
Ann Oncol
, vol.13
, pp. 349-356
-
-
Hassan, A.B.1
Macaulay, V.M.2
-
10
-
-
0036961941
-
Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-1-cysteine
-
Kelly RG, Nally K, Shanahan F, O'Connell J. Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-1-cysteine. Ann N Y Acad Sci 2002; 973: 555-8.
-
(2002)
Ann N Y Acad Sci
, vol.973
, pp. 555-558
-
-
Kelly, R.G.1
Nally, K.2
Shanahan, F.3
O'Connell, J.4
-
11
-
-
0035947664
-
Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair
-
Heron-Milhavet L, Karas M, Goldsmith CM, Baum BJ, Leroith D. Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair. J Biol Chem 2002; 276: 18185-92.
-
(2002)
J Biol Chem
, vol.276
, pp. 18185-18192
-
-
Heron-Milhavet, L.1
Karas, M.2
Goldsmith, C.M.3
Baum, B.J.4
Leroith, D.5
-
12
-
-
0031034574
-
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
-
Kulik G, Klippel A, Weber MJ. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 1997; 17: 1595-606.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 1595-1606
-
-
Kulik, G.1
Klippel, A.2
Weber, M.J.3
-
13
-
-
2942513114
-
Systemic therapy for advanced hepatocellular carcinoma: A review
-
Nowak AK, Chow PK, Findlay M. Systemic therapy for advanced hepatocellular carcinoma: A review. Eur J Cancer 2004; 40: 1474-84.
-
(2004)
Eur J Cancer
, vol.40
, pp. 1474-1484
-
-
Nowak, A.K.1
Chow, P.K.2
Findlay, M.3
-
14
-
-
0346725866
-
The role of the IGF axis in hepatocarcinogenesis
-
Scharf JG, Braulke T. The role of the IGF axis in hepatocarcinogenesis. Horm Metab Res 2003; 35: 685-93.
-
(2003)
Horm Metab Res
, vol.35
, pp. 685-693
-
-
Scharf, J.G.1
Braulke, T.2
-
15
-
-
3042775027
-
The insulin like growth factor-1 receptor (IGF-IR) as a drug target: Novel approaches to cancer therapy
-
Bahr C, Groner B. The insulin like growth factor-1 receptor (IGF-IR) as a drug target: Novel approaches to cancer therapy. Growth Horm IGF Res 2004; 14: 287-95.
-
(2004)
Growth Horm IGF Res
, vol.14
, pp. 287-295
-
-
Bahr, C.1
Groner, B.2
-
16
-
-
0242624594
-
Growth factor receptors as therapeutic targets: Strategies to inhibit the insulin-like growth factor 1 receptor
-
Surmacz E. Growth factor receptors as therapeutic targets: Strategies to inhibit the insulin-like growth factor 1 receptor. Oncogene 2002; 22: 6589-97.
-
(2002)
Oncogene
, vol.22
, pp. 6589-6597
-
-
Surmacz, E.1
-
17
-
-
3142717695
-
Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity
-
Salatino M, Schillaci R, Proietti CJ et al. Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity. Oncogene 2004; 23: 5161-74.
-
(2004)
Oncogene
, vol.23
, pp. 5161-5174
-
-
Salatino, M.1
Schillaci, R.2
Proietti, C.J.3
-
18
-
-
0037366614
-
Effects of insulin-like growth factors-IR and -IIR antisense gene transfection on the biological behaviors of SMMC-7721 human hepatoma cells
-
Yang JM, Chen WS, Liu ZP, Luo YH, Liu WW. Effects of insulin-like growth factors-IR and -IIR antisense gene transfection on the biological behaviors of SMMC-7721 human hepatoma cells. J Gastroenterol Hepatol 2003; 18: 296-301.
-
(2003)
J Gastroenterol Hepatol
, vol.18
, pp. 296-301
-
-
Yang, J.M.1
Chen, W.S.2
Liu, Z.P.3
Luo, Y.H.4
Liu, W.W.5
-
19
-
-
0035377756
-
Blockage of IGF-IR signaling sensitizes urinary bladder cancer cells to mitomycin-mediated cytotoxicity
-
Sun HZ, Wu SH, Tu ZH. Blockage of IGF-IR signaling sensitizes urinary bladder cancer cells to mitomycin-mediated cytotoxicity. Cell Res 2001; 11: 107-15.
-
(2001)
Cell Res
, vol.11
, pp. 107-115
-
-
Sun, H.Z.1
Wu, S.H.2
Tu, Z.H.3
-
20
-
-
10844296820
-
Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer
-
Rochester MA, Riedemann J, Hellawell GO, Brewster SF, Macaulay VM. Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer. Cancer Gene Ther 2005; 12: 90-100.
-
(2005)
Cancer Gene Ther
, vol.12
, pp. 90-100
-
-
Rochester, M.A.1
Riedemann, J.2
Hellawell, G.O.3
Brewster, S.F.4
Macaulay, V.M.5
-
21
-
-
10644258616
-
The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase C alpha-mediated negative regulation of Akt
-
Rose A, Froment P, Perrot V. The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase C alpha-mediated negative regulation of Akt. J Biol Chem 2004; 279: 52500-16.
-
(2004)
J Biol Chem
, vol.279
, pp. 52500-52516
-
-
Rose, A.1
Froment, P.2
Perrot, V.3
-
22
-
-
0242288111
-
Targeting the type 1 insulin-like growth factor receptor as anti-cancer treatment
-
Bohula EA, Playford MP, Macaulay VM. Targeting the type 1 insulin-like growth factor receptor as anti-cancer treatment. Anticancer Drugs 2003; 14: 669-82.
-
(2003)
Anticancer Drugs
, vol.14
, pp. 669-682
-
-
Bohula, E.A.1
Playford, M.P.2
Macaulay, V.M.3
-
23
-
-
0141988681
-
Genetic blockade of the insulin-like growth factor-I receptor: A promising strategy for human pancreatic cancer
-
Min Y, Adachi Y, Yamamota H et al. Genetic blockade of the insulin-like growth factor-I receptor: A promising strategy for human pancreatic cancer. Cancer Res 2003; 63: 6432-41.
-
(2003)
Cancer Res
, vol.63
, pp. 6432-6441
-
-
Min, Y.1
Adachi, Y.2
Yamamota, H.3
-
24
-
-
3042798431
-
Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo
-
Seely BL, Samimi G, Webster NJ. Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo. BMC Cancer 2002; 31: 2-15.
-
(2002)
BMC Cancer
, vol.31
, pp. 2-15
-
-
Seely, B.L.1
Samimi, G.2
Webster, N.J.3
-
25
-
-
9144234724
-
A fully human monoclonal antibody to the insulin-like growth factor 1 receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo
-
Burtrum D, Zhu ZP, Lu Dan et al. A fully human monoclonal antibody to the insulin-like growth factor 1 receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res 2003; 63: 8912-21.
-
(2003)
Cancer Res
, vol.63
, pp. 8912-8921
-
-
Burtrum, D.1
Zhu, Z.P.2
Lu, D.3
-
26
-
-
10344247119
-
A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts
-
Goetsch L, Gonzalez A, Leger O et al. A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts. Int J Cancer 2005; 113: 316-28.
-
(2005)
Int J Cancer
, vol.113
, pp. 316-328
-
-
Goetsch, L.1
Gonzalez, A.2
Leger, O.3
-
27
-
-
0032616876
-
Growth hormone and prostate cancer: Guilty by association?
-
Grimberg A, Cohen P. Growth hormone and prostate cancer: Guilty by association? J Endocrinol Invest 1999; 22: 64-73.
-
(1999)
J Endocrinol Invest
, vol.22
, pp. 64-73
-
-
Grimberg, A.1
Cohen, P.2
-
28
-
-
0033531765
-
Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF) -1 and IGF-binding protein-3
-
Ma J, Pollack MN, Giovannucci E et al. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF) -1 and IGF-binding protein-3. J Natl Cancer Inst 1999; 91: 620-5.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 620-625
-
-
Ma, J.1
Pollack, M.N.2
Giovannucci, E.3
-
29
-
-
0033585421
-
Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis
-
Yu H, Spitz MR, Mistry J, Gu J, Hong WK, Wu X. Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis. J Natl Cancer Inst 1999; 91: 151-6.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 151-156
-
-
Yu, H.1
Spitz, M.R.2
Mistry, J.3
Gu, J.4
Hong, W.K.5
Wu, X.6
-
30
-
-
0242650504
-
Circulating concentration of insulin-like growth factor-1 and risk of breast cancer
-
Hankinson SE, Willette WC, Colditz GA et al. Circulating concentration of insulin-like growth factor-1 and risk of breast cancer. Lancet 1998; 351: 1373-5.
-
(1998)
Lancet
, vol.351
, pp. 1373-1375
-
-
Hankinson, S.E.1
Willette, W.C.2
Colditz, G.A.3
-
31
-
-
0037326983
-
Chemosensitization of human prostate cancer using antisense agents targeting the type 1 insulin-like growth factor receptor
-
Hellawell GO, Ferguson DJ, Brewster SF, Macaulay VM. Chemosensitization of human prostate cancer using antisense agents targeting the type 1 insulin-like growth factor receptor. BJU Int 2003; 91: 271-7.
-
(2003)
BJU Int
, vol.91
, pp. 271-277
-
-
Hellawell, G.O.1
Ferguson, D.J.2
Brewster, S.F.3
Macaulay, V.M.4
-
32
-
-
0035811559
-
Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase
-
Macaulay VM, Salisbury AJ, Bohula EA, Playford MP, Smorodinsky NI, Shiloh Y. Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase. Oncogene 2001; 20: 4029-40.
-
(2001)
Oncogene
, vol.20
, pp. 4029-4040
-
-
Macaulay, V.M.1
Salisbury, A.J.2
Bohula, E.A.3
Playford, M.P.4
Smorodinsky, N.I.5
Shiloh, Y.6
-
33
-
-
0023946732
-
Insulin-like growth factor 1 binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver
-
Caro JP, Poulos J, Ittoop O, Flickinger EG, Sinha MK. Insulin-like growth factor 1 binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver. J Clin Invest 1998; 81: 976-81.
-
(1998)
J Clin Invest
, vol.81
, pp. 976-981
-
-
Caro, J.P.1
Poulos, J.2
Ittoop, O.3
Flickinger, E.G.4
Sinha, M.K.5
-
34
-
-
0032406079
-
Characterization of the insulin-like growth factor axis in a human hepatoma cell line (PLC)
-
Charf JG, Schmidt-Sandte W, Pahernik SA, Ramadori G, Braulke T, Hartmann H. Characterization of the insulin-like growth factor axis in a human hepatoma cell line (PLC). Carcinogenesis 1998; 19: 2121-8.
-
(1998)
Carcinogenesis
, vol.19
, pp. 2121-2128
-
-
Charf, J.G.1
Schmidt-Sandte, W.2
Pahernik, S.A.3
Ramadori, G.4
Braulke, T.5
Hartmann, H.6
-
35
-
-
4344690193
-
Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis
-
Steinbach JP, Eisenmann C, Klumpp A, Weller M. Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis. Biochem Biophys Res Commun 2004; 321: 524-30.
-
(2004)
Biochem Biophys Res Commun
, vol.321
, pp. 524-530
-
-
Steinbach, J.P.1
Eisenmann, C.2
Klumpp, A.3
Weller, M.4
-
36
-
-
0023951703
-
Evidence of autocrine regulation in human hepatoma cell lines
-
Tsai TF, Yauk YK, Chou CK, Ting LP, Chang C, Hu CP. Evidence of autocrine regulation in human hepatoma cell lines. Biochem Biophys Res Commun 1988; 153: 39-45.
-
(1988)
Biochem Biophys Res Commun
, vol.153
, pp. 39-45
-
-
Tsai, T.F.1
Yauk, Y.K.2
Chou, C.K.3
Ting, L.P.4
Chang, C.5
Hu, C.P.6
-
37
-
-
1642402228
-
Orthotopic implantation of human hepatocellular carcinoma in mice: Analysis of tumor progression and establishment of the BCLC-9 cell line
-
Armengol C, Tarafa G, Bolx L et al. Orthotopic implantation of human hepatocellular carcinoma in mice: Analysis of tumor progression and establishment of the BCLC-9 cell line. Clin Cancer Res 2004; 10: 2150-7.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2150-2157
-
-
Armengol, C.1
Tarafa, G.2
Bolx, L.3
-
38
-
-
0034719335
-
DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination
-
Tarafa G, Villanueva A, Farre L et al. DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination. Oncogene 2000; 19: 546-55.
-
(2000)
Oncogene
, vol.19
, pp. 546-555
-
-
Tarafa, G.1
Villanueva, A.2
Farre, L.3
-
39
-
-
0030727705
-
Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice
-
Dunn SE, Kari FW, French J et al. Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res 1997; 7: 4667-72.
-
(1997)
Cancer Res
, vol.7
, pp. 4667-4672
-
-
Dunn, S.E.1
Kari, F.W.2
French, J.3
-
40
-
-
0023721910
-
Insulin and insulin-like growth factor 1 regulate the same biological functions in HEP-G2 cells via their own specific receptors
-
Verspohl EL, Maddux BA, Goldfine ID. Insulin and insulin-like growth factor 1 regulate the same biological functions in HEP-G2 cells via their own specific receptors. J Clin Endocrinol Metab 1988; 67: 169-74.
-
(1988)
J Clin Endocrinol Metab
, vol.67
, pp. 169-174
-
-
Verspohl, E.L.1
Maddux, B.A.2
Goldfine, I.D.3
-
41
-
-
0029937307
-
Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo
-
Burfeind P, Chernicky CL, Rininsland F, Ilan J. Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo. Proc Natl Acad Sci USA 1996; 93: 7263-8.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7263-7268
-
-
Burfeind, P.1
Chernicky, C.L.2
Rininsland, F.3
Ilan, J.4
-
42
-
-
0027977941
-
Paracrine growth stimulation by hepatocyte-derived insulin-like growth factor-1: A regulatory mechanism for carcinoma cells metastatic to the liver
-
Long L, Nip J, Brodt P. Paracrine growth stimulation by hepatocyte-derived insulin-like growth factor-1: A regulatory mechanism for carcinoma cells metastatic to the liver. Cancer Res 1994; 54: 3732-7.
-
(1994)
Cancer Res
, vol.54
, pp. 3732-3737
-
-
Long, L.1
Nip, J.2
Brodt, P.3
-
43
-
-
0031844617
-
Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor
-
Long L, Rubin R, Brodt P. Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor. Exp Cell Res 1998; 238: 116-21.
-
(1998)
Exp Cell Res
, vol.238
, pp. 116-121
-
-
Long, L.1
Rubin, R.2
Brodt, P.3
-
44
-
-
0034668185
-
Inhibition of the type I insulin-like growth factor receptor expression and signaling: Novel strategies for antimetastatic therapy
-
Brodt P, Samani A, Navab R. Inhibition of the type I insulin-like growth factor receptor expression and signaling: Novel strategies for antimetastatic therapy. Biochem Pharmacol 2000; 60: 1101-7.
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 1101-1107
-
-
Brodt, P.1
Samani, A.2
Navab, R.3
-
45
-
-
0036203231
-
Alpha-fetoprotein mRNA in the circulation as a predictor of postsurgical recurrence of hepatocellular carcinoma: A prospective study
-
Ijichi M, Takayama T, Matsumura M, Shiratori Y, Omata M, Makuuchi M. Alpha-fetoprotein mRNA in the circulation as a predictor of postsurgical recurrence of hepatocellular carcinoma: A prospective study. Hepatology 2003; 35: 853-60.
-
(2003)
Hepatology
, vol.35
, pp. 853-860
-
-
Ijichi, M.1
Takayama, T.2
Matsumura, M.3
Shiratori, Y.4
Omata, M.5
Makuuchi, M.6
|