Incidence, risk factors and consequences of portal vein and systemic thromboses in hepatocellular carcinoma

Thrombosis Research

Volumn 122, Issue 3, 2008, Pages 299-306

  Connolly, Gregory C ^a   Chen, Rui ^b   Hyrien, Ollivier ^b   Mantry, Parvez ^b   Bozorgzadeh, Adel ^a   Abt, Peter ^a   Khorana, Alok A ^c  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; INCIDENCE; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MORBIDITY; PORTAL VEIN THROMBOSIS; PRIORITY JOURNAL; RISK FACTOR; SURVIVAL; VENOUS THROMBOEMBOLISM;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; INCIDENCE; KAPLAN-MEIERS ESTIMATE; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM STAGING; PORTAL VEIN; RETROSPECTIVE STUDIES; RISK FACTORS; THROMBOSIS;

EID: 45849133795     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2007.10.009     Document Type: Article

References (53)

1. Ambrus J.L., Ambrus C.M., Mink I.B., and Pickren J.W. Causes of death in cancer patients. J Med 6 1 (1975) 61-64
2. Sorensen H.T., Mellemkjaer L., Olsen J.H., and Baron J.A. Prognosis of cancers associated with venous thromboembolism. N Engl J Med 343 25 (Dec 21 2000) 1846-1850
3. Blom J.W., Doggen C.J., Osanto S., and Rosendaal F.R. Malignancies, prothrombotic mutations, and the risk of venous thrombosis. JAMA 293 6 (Feb 9 2005) 715-722
4. Heit J.A., Silverstein M.D., Mohr D.N., Petterson T.M., O'Fallon W.M., and Melton L.J. Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med 160 6 (Mar 27 2000) 809-815
5. Agnes Y., Lee Y., and levine M. Venous thomboembolism and cancer: risks and outcomes. Circulation 107 (2003) 117-121
6. Silverstein M.D., Heit J.A., Mohr D.N., Petterson T.M., O'Fallon W.M., and Melton L.J. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 158 6 (Mar 23 1998) 585-593
7. White RH. The epidemiology of venous thromboembolism. Circulation 107 23 Suppl 1 (Jun 17 2003) I4-I8
8. Llovet J.M., Burroughs A., and Bruix J. Hepatocellular carcinoma. Lancet 362 9399 (Dec 6 2003) 1907-1917
9. El-Serag H.B., and Mason A.C. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 340 10 (Mar 11 1999) 745-750
10. Tanaka Y., Hanada K., Mizokami M., Yeo A.E., Shih J.W., Gojobori T., et al. Inaugural Article: a comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades. Proc Natl Acad Sci U. S. A. 99 24 (Nov 26 2002) 15584-15589
11. Alter M.J. Hepatitis C virus infection in the United States. J Hepatol 31 Suppl 1 (1999) 88-91
12. Castells L., Vargas V., Gonzalez A., Esteban J., Esteban R., and Guardia J. Long interval between HCV infection and development of hepatocellular carcinoma. Liver 15 3 (Jun 1995) 159-163
13. Okuda K., Ohtsuki T., Obata H., Tomimatsu M., Okazaki N., Hasegawa H., et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer 56 4 (Aug. 15 1985) 918-928
14. Bruix J., and Llovet J.M. Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 35 3 (Mar 2002) 519-524
15. Takayama T., Makuuchi M., Hirohashi S., Sakamoto M., Yamamoto J., Shimada K., et al. Early hepatocellular carcinoma as an entity with a high rate of surgical cure. Hepatology 28 5 (Nov 1998) 1241-1246
16. Llovet J.M., Fuster J., and Bruix J. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation. Hepatology 30 6 (Dec 1999) 1434-1440
17. Arii S., Yamaoka Y., Futagawa S., Inoue K., Kobayashi K., Kojiro M., et al. Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology 32 6 (Dec 2000) 1224-1229
18. Takayama T., Sekine T., Makuuchi M., Yamasaki S., Kosuge T., Yamamoto J., et al. Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial. Lancet 356 9232 (Sep 2 2000) 802-807
19. Wayne J.D., Lauwers G.Y., Ikai I., Doherty D.A., Belghiti J., Yamaoka Y., et al. Preoperative predictors of survival after resection of small hepatocellular carcinomas. Ann Surg 235 5 (May 2002) 722-730 [discussion 730-731]
20. Iwatsuki S., Starzl T.E., Sheahan D.G., Yokoyama I., Demetris A.J., Todo S., et al. Hepatic resection versus transplantation for hepatocellular carcinoma. Ann Surg 214 3 (Sep 1991) 221-228 [discussion 228-229]
21. Bismuth H., Majno P.E., and Adam R. Liver transplantation for hepatocellular carcinoma. Semin Liver Dis 19 3 (1999) 311-322
22. Jonas S., Bechstein W.O., Steinmuller T., Herrmann M., Radke C., Berg T., et al. Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 33 5 (May 2001) 1080-1086
23. Yao F.Y., Ferrell L., Bass N.M., Watson J.J., Bacchetti P., Venook A., et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology 33 6 (June 2001) 1394-1403
24. Rabe C., Pilz T., Klostermann C., Berna M., Schild H.H., Sauerbruch T., et al. Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma. World J Gastroenterol 7 2 (Apr 2001) 208-215
25. Schoniger-Hekele M., Muller C., Kutilek M., Oesterreicher C., Ferenci P., and Gangl A. Hepatocellular carcinoma in Austria: aetiological and clinical characteristics at presentation. Eur J Gastroenterol Hepatol 12 8 (Aug 2000) 941-948
26. Pirisi M., Avellini C., Fabris C., Scott C., Bardus P., Soardo G., et al. Portal vein thrombosis in hepatocellular carcinoma: age and sex distribution in an autopsy study. J Cancer Res Clin Oncol 124 7 (1998) 397-400
27. Ikai I., Itai Y., Okita K., Omata M., Kojiro M., Kobayashi K., et al. Report of the 15th follow-up survey of primary liver cancer. Hepatol Res 28 1 (Jan 2004) 21-29
28. Stuart K.E., Anand A.J., and Jenkins R.L. Hepatocellular carcinoma in the United States. Prognostic features, treatment outcome, and survival. Cancer 77 11 (Jun 1 1996) 2217-2222
29. Sakar B., Ustuner Z., Karagol H., Aksu G., Camlica H., and Aykan N.F. Prognostic features and survival of inoperable hepatocellular carcinoma in Turkish patients with cirrhosis. Am J Clin Oncol 27 5 (Oct 2004) 489-493
30. Grieco A., Pompili M., Caminiti G., Miele L., Covino M., Alfei B., et al. Prognostic factors for survival in patients with early-intermediate hepatocellular carcinoma undergoing non-surgical therapy: comparison of Okuda, CLIP, and BCLC staging systems in a single Italian centre. Gut 54 3 (Mar 2005) 411-418
31. A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: the Cancer of the Liver Italian Program (CLIP) investigators. Hepatology. Sep 1998;28(3):751-755.
32. Predictive factors for long term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. The Liver Cancer Study Group of Japan. Cancer. Nov 15 1994;74(10):2772-2780.
33. In: Greene F. (Ed). AJCC Cancer Staging Manual. 6th Edit. (2002), Springer-Verlag, USA
34. Bruix J., Sherman M., Llovet J.M., Beaugrand M., Lencioni R., Burroughs A.K., et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 35 3 (Sep 2001) 421-430
35. Levitan N., Dowlati A., Remick S.C., Tahsildar H.I., Sivinski L.D., Beyth R., et al. Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy. Risk analysis using Medicare claims data. Medicine (Baltimore) 78 5 (Sep 1999) 285-291
36. Komrokji R.S., Uppal N.P., Khorana A.A., Lyman G.H., Kaplan K.L., Fisher R.I., et al. Venous thromboembolism in patients with diffuse large B-cell lymphoma. Leuk Lymphoma 47 6 (Jun 2006) 1029-1033
37. Mohren M., Markmann I., Jentsch-Ullrich K., Koenigsmann M., Lutze G., and Franke A. Increased risk of thromboembolism in patients with malignant lymphoma: a single-centre analysis. Br J Cancer 92 8 (Apr 25 2005) 1349-1351
38. Ottinger H., Belka C., Kozole G., Engelhard M., Meusers P., Paar D., et al. Deep venous thrombosis and pulmonary artery embolism in high-grade non Hodgkin's lymphoma: incidence, causes and prognostic relevance. Eur J Haematol 54 3 (Mar 1995) 186-194
39. Khorana A.A., Francis C.W., Culakova E., and Lyman G.H. Risk factors for chemotherapy-associated venous thromboembolism in a prospective observational study. Cancer 104 12 (Dec 15 2005) 2822-2829
40. Lee A.Y., and Levine M.N. Venous thromboembolism and cancer: risks and outcomes. Circulation 107 23 Suppl 1 (Jun 17 2003) I17-I21
41. Khorana A.A., and Fine R.L. Pancreatic cancer and thromboembolic disease. Lancet Oncol 5 11 (Nov 2004) 655-663
42. Khorana A.A., Francis C.W., Culakova E., Fisher R.I., Kuderer N.M., and Lyman G.H. Thromboembolism in hospitalized neutropenic cancer patients. J Clin Oncol 24 3 (Jan 20 2006) 484-490
43. Okuda K., Ohnishi K., Kimura K., Matsutani S., Sumida M., Goto N., et al. Incidence of portal vein thrombosis in liver cirrhosis. An angiographic study in 708 patients. Gastroenterology 89 2 (Aug 1985) 279-286
44. Nonami T., Yokoyama I., Iwatsuki S., and Starzl T.E. The incidence of portal vein thrombosis at liver transplantation. Hepatology 16 5 (Nov 1992) 1195-1198
45. Valla D.C., and Condat B. Portal vein thrombosis in adults: pathophysiology, pathogenesis and management. J Hepatol 32 5 (May 2000) 865-871
46. Ogren M., Bergqvist D., Bjorck M., Acosta S., Eriksson H., and Sternby N.H. Portal vein thrombosis: prevalence, patient characteristics and lifetime risk: a population study based on 23,796 consecutive autopsies. World J Gastroenterol 12 13 (Apr 7 2006) 2115-2119
47. Northup P.G., McMahon M.M., Ruhl A.P., Altschuler S.E., Volk-Bednarz A., Caldwell S.H., et al. Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism. Am J Gastroenterol 101 7 (Jul 2006) 1524-1528 [quiz 1680]
48. Castelino D.J., and Salem H.H. Natural anticoagulants and the liver. J Gastroenterol Hepatol 12 1 (Jan 1997) 77-83
49. Caldwell S.H., Hoffman M., Lisman T., Macik B.G., Northup P.G., Reddy K.R., et al. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatology 44 4 (Oct 2006) 1039-1046
50. Khorana A.A., Ahrendt S.A., Ryan C.K., Francis C.W., Hruban R.H., Hu Y.C., et al. Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer. Clin Cancer Res 13 10 (May 15 2007) 2870-2875
51. Uno K., Homma S., Satoh T., Nakanishi K., Abe D., Matsumoto K., et al. Tissue factor expression as a possible determinant of thromboembolism in ovarian cancer. Br J Cancer 96 2 (Jan 29 2007) 290-295
52. Poon R.T., Lau C.P., Ho J.W., Yu W.C., Fan S.T., and Wong J. Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma. Clin Cancer Res 9 14 (Nov 1 2003) 5339-5345
53. Kaido T., Oe H., Yoshikawa A., Mori A., Arii S., and Imamura M. Tissue factor is a useful prognostic factor of recurrence in hepatocellular carcinoma in 5-year survivors. Hepato-gastroenterol 52 65 (Sep-Oct 2005) 1383-1387