-
2
-
-
33748931457
-
Central nervous system control of food intake and body weight
-
Morton GJ, Cummings DE, Baskin DG, et al. Central nervous system control of food intake and body weight. Nature 2006;443:289-95.
-
(2006)
Nature
, vol.443
, pp. 289-295
-
-
Morton, G.J.1
Cummings, D.E.2
Baskin, D.G.3
-
3
-
-
70449255388
-
The effects of lesions in the hypothalamus in parabiotic rats
-
Hervey GR. The effects of lesions in the hypothalamus in parabiotic rats. J Physiol 1959;145:336-52.
-
(1959)
J Physiol
, vol.145
, pp. 336-352
-
-
Hervey, G.R.1
-
4
-
-
0018139377
-
Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
-
Coleman DL. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978;14:141-8.
-
(1978)
Diabetologia
, vol.14
, pp. 141-148
-
-
Coleman, D.L.1
-
5
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
-
6
-
-
0029073613
-
Weightreducing effects of the plasma protein encoded by the obese gene
-
Halaas JL, Gajiwala KS, Maffei M, et al. Weightreducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543-6.
-
(1995)
Science
, vol.269
, pp. 543-546
-
-
Halaas, J.L.1
Gajiwala, K.S.2
Maffei, M.3
-
7
-
-
0033575993
-
Effects of recombinant leptin therapy in a child with congenital leptin deficiency
-
Farooqi IS, Jebb SA, Langmack G, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999;341:879-84.
-
(1999)
N Engl J Med
, vol.341
, pp. 879-884
-
-
Farooqi, I.S.1
Jebb, S.A.2
Langmack, G.3
-
8
-
-
0037847510
-
Characterization of the effects of pancreatic polypeptide in the regulation of energy balance
-
Asakawa A, Inui A, Yuzuriha H, et al. Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology 2003;124:1325-36.
-
(2003)
Gastroenterology
, vol.124
, pp. 1325-1336
-
-
Asakawa, A.1
Inui, A.2
Yuzuriha, H.3
-
9
-
-
0027190603
-
Pancreatic polypeptide infusions reduce food intake in Prader-Willi syndrome
-
Berntson GG, Zipf WB, O'Dorisio TM, et al. Pancreatic polypeptide infusions reduce food intake in Prader-Willi syndrome. Peptides 1993;14:497-503.
-
(1993)
Peptides
, vol.14
, pp. 497-503
-
-
Berntson, G.G.1
Zipf, W.B.2
O'Dorisio, T.M.3
-
10
-
-
0041882174
-
Pancreatic polypeptide reduces appetite and food intake in humans
-
Batterham RL, le Roux CW, Cohen MA, et al. Pancreatic polypeptide reduces appetite and food intake in humans. J Clin Endocrinol Metab 2003;88:3989-92.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 3989-3992
-
-
Batterham, R.L.1
Le Roux, C.W.2
Cohen, M.A.3
-
11
-
-
84855505560
-
Pharmacokinetics, adverse effects and tolerability of a novel analogue of human pancreatic polypeptide, PP 1420
-
Tan TM, Field BCT, Minnion JS, et al. Pharmacokinetics, adverse effects and tolerability of a novel analogue of human pancreatic polypeptide, PP 1420. Br J Clin Pharmacol 2012;73:232-9.
-
(2012)
Br J Clin Pharmacol
, vol.73
, pp. 232-239
-
-
Tan, T.M.1
Field, B.C.T.2
Minnion, J.S.3
-
12
-
-
33747763918
-
A double-blind, placebo-controlled trial assessing pramlintide treatment in the setting of intensive insulin therapy in type 1 diabetes
-
Edelman S, Garg S, Frias J, et al. A double-blind, placebo-controlled trial assessing pramlintide treatment in the setting of intensive insulin therapy in type 1 diabetes. Diabetes Care 2006;29:2189-95.
-
(2006)
Diabetes Care
, vol.29
, pp. 2189-2195
-
-
Edelman, S.1
Garg, S.2
Frias, J.3
-
13
-
-
69749086148
-
Enhanced weight loss with pramlintide/metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
-
Ravussin E, Smith SR, Mitchell JA, et al. Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy. Obesity 2009;17:1736-43.
-
(2009)
Obesity
, vol.17
, pp. 1736-1743
-
-
Ravussin, E.1
Smith, S.R.2
Mitchell, J.A.3
-
14
-
-
0016215903
-
Glucagon control of fasting glucose in man
-
Alford FP, Bloom SR, Nabarro JDN, et al. Glucagon control of fasting glucose in man. Lancet 1974;304: 974-7.
-
(1974)
Lancet
, vol.304
, pp. 974-977
-
-
Alford, F.P.1
Bloom, S.R.2
Nabarro, J.D.N.3
-
15
-
-
0001300387
-
Effect of glucagon on food intake and body weight in man
-
Schulman JL, Carleton JL, Whitney G, et al. Effect of glucagon on food intake and body weight in man. J Appl Physiol 1957;11:419-21.
-
(1957)
J Appl Physiol
, vol.11
, pp. 419-421
-
-
Schulman, J.L.1
Carleton, J.L.2
Whitney, G.3
-
16
-
-
77956313886
-
Gcg-XTEN: An improved glucagon capable of preventing hypoglycemia without increasing baseline blood glucose
-
Geething NC, To W, Spink BJ, et al. Gcg-XTEN: an improved glucagon capable of preventing hypoglycemia without increasing baseline blood glucose. PLoS ONE 2010;5:e10175.
-
(2010)
PLoS ONE
, vol.5
-
-
Geething, N.C.1
To, W.2
Spink, B.J.3
-
17
-
-
2942558193
-
Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time-and food-related cues
-
Cummings DE, Frayo RS, Marmonier C, et al. Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time-and food-related cues. Am J Physiol Endocrinol Metab 2004;287: E297-304.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
-
-
Cummings, D.E.1
Frayo, R.S.2
Marmonier, C.3
-
18
-
-
0035216623
-
Ghrelin enhances appetite and increases food intake in humans
-
Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001;86:5992-5.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 5992-5995
-
-
Wren, A.M.1
Seal, L.J.2
Cohen, M.A.3
-
19
-
-
55749097801
-
Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: A randomized trial
-
Nass R, Pezzoli SS, Oliveri MC, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med 2008;149:601-11.
-
(2008)
Ann Intern Med
, vol.149
, pp. 601-611
-
-
Nass, R.1
Pezzoli, S.S.2
Oliveri, M.C.3
-
20
-
-
4444260060
-
Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer
-
Helmling S, Maasch C, Eulberg D, et al. Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer. ProcNatl Acad Sci USA 2004;101:13174-9.
-
(2004)
ProcNatl Acad Sci USA
, vol.101
, pp. 13174-13179
-
-
Helmling, S.1
Maasch, C.2
Eulberg, D.3
-
21
-
-
32644448802
-
Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice
-
Shearman LP, Wang S-P, Helmling S, et al. Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice. Endocrinology 2006;147: 1517-26.
-
(2006)
Endocrinology
, vol.147
, pp. 1517-1526
-
-
Shearman, L.P.1
Wang, S.-P.2
Helmling, S.3
-
22
-
-
0021433344
-
Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats
-
West DB, Fey D,Woods SC. Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am J Physiol Regul Integr Comp Physiol 1984;246: R776-87.
-
(1984)
Am J Physiol Regul Integr Comp Physiol
, vol.246
-
-
West, D.B.1
Fey Dwoods, S.C.2
-
23
-
-
38349104637
-
Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients
-
Jordan J, Greenway FL, Leiter LA, et al. Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients. Clin Pharmacol Ther 2008;83:281-7.
-
(2008)
Clin Pharmacol Ther
, vol.83
, pp. 281-287
-
-
Jordan, J.1
Greenway, F.L.2
Leiter, L.A.3
-
24
-
-
0023638829
-
Glucagonlike peptide-1 7-36: A physiological incretin in man
-
Kreymann B, Williams G, Ghatei MA, et al. Glucagonlike peptide-1 7-36: a physiological incretin in man. Lancet 1987;330:1300-4.
-
(1987)
Lancet
, vol.330
, pp. 1300-1304
-
-
Kreymann, B.1
Williams, G.2
Ghatei, M.A.3
-
25
-
-
0027391607
-
Preserved incretin activity of glucagon-like peptide 1[7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
-
Nauck MA, Heimesaat MM, Ørskov C, et al. Preserved incretin activity of glucagon-like peptide 1[7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 1993;91:301-7.
-
(1993)
J Clin Invest
, vol.91
, pp. 301-307
-
-
Nauck, M.A.1
Heimesaat, M.M.2
Oslashrskov, C.3
-
26
-
-
13344282056
-
A role for glucagon-like peptide-1 in the central regulation of feeding
-
Turton MD, O'Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996;379:69-72.
-
(1996)
Nature
, vol.379
, pp. 69-72
-
-
Turton, M.D.1
O'Shea, D.2
Gunn, I.3
-
27
-
-
0037045845
-
Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: A parallel-group study
-
ZanderM,Madsbad S,Madsen JL, et al. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study. Lancet 2002;359:824-30.
-
(2002)
Lancet
, vol.359
, pp. 824-830
-
-
Zander, M.1
Madsbad, S.2
Madsen, J.L.3
-
28
-
-
84866125785
-
Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers
-
Adrian TE, Gariballa S, Parekh KA, et al. Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers. Diabetologia 2012;55:2343-7.
-
(2012)
Diabetologia
, vol.55
, pp. 2343-2347
-
-
Adrian, T.E.1
Gariballa, S.2
Parekh, K.A.3
-
29
-
-
84880611045
-
Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists
-
Dehmlow H, Alvarez Sánchez R, Bachmann S, et al. Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists. Bioorg Med Chem Lett 2013;23: 4627-32.
-
(2013)
Bioorg Med Chem Lett
, vol.23
, pp. 4627-4632
-
-
Dehmlow, H.1
Alvarez Sánchez, R.2
Bachmann, S.3
-
30
-
-
35649021752
-
Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass
-
le Roux CW, Welbourn R, Werling M, et al. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann Surg 2007;246:780-5.
-
(2007)
Ann Surg
, vol.246
, pp. 780-785
-
-
Le Roux, C.W.1
Welbourn, R.2
Werling, M.3
-
31
-
-
33745841347
-
The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR
-
Nygaard R, Nielbo S, Schwartz TW, et al. The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR. Biochemistry 2006;45:8350-7.
-
(2006)
Biochemistry
, vol.45
, pp. 8350-8357
-
-
Nygaard, R.1
Nielbo, S.2
Schwartz, T.W.3
-
32
-
-
0041859261
-
Inhibition of food intake in obese subjects by peptide YY3-36
-
Batterham RL, Cohen MA, Ellis SM, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 2003;349:941-8.
-
(2003)
N Engl J Med
, vol.349
, pp. 941-948
-
-
Batterham, R.L.1
Cohen, M.A.2
Ellis, S.M.3
-
33
-
-
34249862701
-
Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults
-
Gantz I, Erondu N, Mallick M, et al. Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults. J Clin Endocrinol Metab 2007;92:1754-7.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 1754-1757
-
-
Gantz, I.1
Erondu, N.2
Mallick, M.3
-
34
-
-
27844508598
-
Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively
-
Neary NM, Small CJ, Druce MR, et al. Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively. Endocrinology 2005;146:5120-7.
-
(2005)
Endocrinology
, vol.146
, pp. 5120-5127
-
-
Neary, N.M.1
Small, C.J.2
Druce, M.R.3
-
35
-
-
77954252801
-
PYY3x36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans
-
Field BCT, Wren AM, Peters V, et al. PYY3x36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans. Diabetes 2010;59: 1635-9.
-
(2010)
Diabetes
, vol.59
, pp. 1635-1639
-
-
Field, B.C.T.1
Wren, A.M.2
Peters, V.3
-
36
-
-
0019527355
-
'Enteroglucagon': A specific effect on gastric glands isolated from the rat fundus Evidence for an 'oxyntomodulin' action
-
Bataille D, Gespach C, Coudray AM, et al. 'Enteroglucagon': a specific effect on gastric glands isolated from the rat fundus. Evidence for an 'oxyntomodulin' action. Biosci Rep 1981;1:151-5.
-
(1981)
Biosci Rep
, vol.1
, pp. 151-155
-
-
Bataille, D.1
Gespach, C.2
Coudray, A.M.3
-
37
-
-
23644443678
-
Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: A double-blind, randomized, controlled trial
-
Wynne K, Park AJ, Small CJ, et al. Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial. Diabetes 2005;54:2390-5.
-
(2005)
Diabetes
, vol.54
, pp. 2390-2395
-
-
Wynne, K.1
Park, A.J.2
Small, C.J.3
-
38
-
-
0242288734
-
Oxyntomodulin suppresses appetite and reduces food intake in humans
-
Cohen MA, Ellis SM, le Roux CW, et al. Oxyntomodulin suppresses appetite and reduces food intake in humans. J Clin Endocrinol Metab 2003;88:4696-701.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4696-4701
-
-
Cohen, M.A.1
Ellis, S.M.2
Le Roux, C.W.3
-
39
-
-
33749339257
-
Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: A randomised controlled trial
-
Wynne K, Park AJ, Small CJ, et al. Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial. Int J Obes 2006;30:1729-36.
-
(2006)
Int J Obes
, vol.30
, pp. 1729-1736
-
-
Wynne, K.1
Park, A.J.2
Small, C.J.3
-
40
-
-
84875409178
-
Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia
-
Tan TM, Field BCT, McCullough KA, et al. Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia. Diabetes 2013;62:1131-8.
-
(2013)
Diabetes
, vol.62
, pp. 1131-1138
-
-
Tan, T.M.1
Field, B.C.T.2
McCullough, K.A.3
-
41
-
-
70349644658
-
Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice
-
Pocai A, Carrington PE, Adams JR, et al. Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice. Diabetes 2009;58:2258-66.
-
(2009)
Diabetes
, vol.58
, pp. 2258-2266
-
-
Pocai, A.1
Carrington, P.E.2
Adams, J.R.3
-
42
-
-
70349308687
-
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
-
Day JW, Ottaway N, Patterson JT, et al. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol 2009;5:749-57.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 749-757
-
-
Day, J.W.1
Ottaway, N.2
Patterson, J.T.3
-
43
-
-
84891375601
-
Activity of pramlintide, rat and human amylin but not Aβ1-42 at human amylin receptors
-
Gingell JJ, Burns ER, Hay DL. Activity of pramlintide, rat and human amylin but not Aβ1-42 at human amylin receptors. Endocrinology 2014;155:21-6.
-
(2014)
Endocrinology
, vol.155
, pp. 21-26
-
-
Gingell, J.J.1
Burns, E.R.2
Hay, D.L.3
|